Who Should I Start for Fantasy Football Week 16? Quentin Johnston, Chris Godwin Jr., Darius Slayton, Zay Flowers, Keenan Allen, Tee Higgins, Jonathan Taylor, Chimere Dike, Isiah Pacheco, Josh Downs

Quentin Johnston, WR, Los Angeles Chargers

Los Angeles Chargers wide receiver Quentin Johnston (groin) was limited during Thursday's practice. He has now been a limited participant for two days in a row. At this point, it remains unclear whether Johnston will return from last week's absence and play in Sunday's Week 16 contest against the Dallas Cowboys. The TCU product was one of the biggest surprises at the start of the season, ranking as the overall WR4 in PPR leagues from Weeks 1 through 4. However, he has come back down to earth since then, catching three or fewer passes in four of his last six games.

He continues to face competition for targets in a crowded wide receiver room that also includes Ladd McConkey, Keenan Allen, and Tre' Harris (hip). He gets a favorable matchup this week against a Dallas secondary allowing the most fantasy points, the most touchdowns, and the third-most receiving yards to opposing wide receivers in 2025. Managers should get more clarity on his Week 16 availability when the Chargers publish their final injury report on Friday afternoon.

Tee Higgins, WR, Cincinnati Bengals

Cincinnati Bengals wide receiver Tee Higgins (concussion) will be questionable for Sunday's game against the Miami Dolphins in Week 16, according to Mike Petraglia. Higgins was limited in practices on Wednesday and Thursday and still has one more hurdle to clear to pass through the league's concussion protocol. For context, the 26-year-old wideout has had two concussions in the last several weeks, and the Bengals could be extra hesitant to throw him back out there now that they've been eliminated from the playoffs.

Higgins' first concussion occurred late in the Week 12 loss to the New England Patriots, and he experienced more concussion symptoms following the Week 14 loss to the Buffalo Bills. He's missed two of the last three games and could miss another contest this Sunday. When active, Higgins is a must-start in fantasy with a 46-667-9 line on 81 targets this year.

Josh Downs, WR, Indianapolis Colts

In 44-year-old quarterback Philip Rivers' first NFL game in five years with the Indianapolis Colts in Sunday's 18-16 loss to the hosting Seattle Seahawks, wide receiver Josh Downs caught his lone touchdown pass. Downs played a season-high 72% of the offensive snaps in Week 15 in Rivers' first game replacing Daniel Jones, who is out for the year with a torn Achilles. The 24-year-old wideout was tied for second on the team with five targets, catching three of them for only 13 yards and his fourth touchdown of the year.

All in all, it wasn't anything special for fantasy football production, but it was notable that Downs tied Michael Pittman Jr. in targets, with Alec Pierce seeing just one look from Rivers. With Rivers shotputting balls to his receivers, Downs could become a more attractive short-area target over Pierce to close out the season, making him worth a look off the waiver wire as WR depth. Downs is rostered in 43% of Yahoo leagues.

Chris Godwin Jr., WR, Tampa Bay Buccaneers

Tampa Bay Buccaneers wide receiver Chris Godwin Jr. has stepped back into a meaningful role after missing five games with a fibula injury earlier this season. Godwin has worked his way back into the mix, with 12 catches over the last three games for a total of 153 yards and a touchdown. His touchdown came on Thursday Night Football against the Falcons in Week 15, when he hauled in four of his five targets for 20 yards.

Godwin and the Bucs have a big divisional matchup against the Panthers this week in Week 16, and they'll meet again in Week 18. In between, they'll face the Dolphins, so Godwin has solid potential working out of the slot over the next few games. He clearly has the trust of Baker Mayfield and will continue to be a fringe PPR option for the next few weeks.