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Top MLB Betting Picks for Today's Slate (5/21/19)

Nate Duffett's MLB betting picks for 5/21/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Tuesday, May 21st, we see a huge 15 game MLB slate. The day starts with a 6:10 PM game between the Oakland Athletics and Cleveland Indians, and ends with a 10:10 PM game between the Arizona Diamondbacks and San Diego Padres.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Tuesday, May 21st. Good luck!

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Boston Red Sox (-150) @ Toronto Blue Jays | O/U: 9

We see a considerable change in the odds from yesterday's game, as the Red Sox drop to only -150 favorites against the Blue Jays. This is due in part to Marcus Stroman's 2.95 ERA and Ace status in the Blue Jays rotation. I will look to the numbers to see that this could be a bit of mispricing, as the Blue Jays have been 2-8 straight up when Stroman starts the game.

These results make Stroman the fifth-least profitable pitcher in the Majors. When it comes to recent form, the Blue Jays have only managed four wins over their last 10 games, while the Red Sox have been hot with seven wins in their last 10. Oddly enough, the Blue Jays have also struggled at the Rogers Centre this season, coming in with an abysmal 6-15 record.

My Picks: Red Sox (-150)

 

Cincinnati Reds @ Milwaukee Brewers (-135) | O/U: 8.5

We have another mispricing here in this game with the Brewers coming in at -135 favorites against the Cincinnati Reds. For starters, the Brewers have Gio Gonzalez taking the mound with his 2-0 record and 1.69 ERA, while the Reds counter with Sonny Gray and his 0-4 record and 4.30 ERA.

The Brewers have played their best baseball at home, boasting a 16-7 record, while the Reds have struggled outside of Cincinnati, putting up a 9-15 record. There isn't much else to say here except lock in the Brewers while these odds still exist.

My Picks: Brewers (-135), Brewers -1.5 

 

Colorado Rockies (-116) @ Pittsburgh Pirates | O/U: 7.5

This number seems too good to be true in this matchup. German Marquez has struggled in his last two starts on the road, allowing nine runs over 13 innings. Chris Archer has been a shell of his former self, allowing six earned runs in each of his last two starts, and failing to make it past the fourth inning in either outing.

Rockies games have gone over in seven of the last ten games, while the Pirates have gone over in four of their last five. This total number could hit before the starters even come out of the game, so I will be locking in the Over. Both teams have team totals of 3.5, so I would be interested in sprinkling a bit of cash on both of these numbers as well considering the struggles that each starting pitcher have had in the past month.

My Picks:  Over 7.5, Rockies Team Total O3.5, Pirates Team Total O3.5

 

Miami Marlins @ Detroit Tigers (-107) | O/U: 7.5

There's nothing I hate more than betting the under and rooting for a pitching duel, so if you see me picking an under, you should know that the numbers are there to back it up. Betting the under on a 7.5 total is one of the worst feelings ever, but you have to consider it when two of the worst offences in baseball face off. Spencer Turnbull has had some outstanding outings against teams that are a lot better than the Marlins, so I can't see them getting much off of him in this matchup.

The Marlins will send their best starter, Caleb Smith, who hasn't given up more than 2 earned runs since early April. The Tigers have scored 11 runs in their last five games, while the Marlins have only managed 13 in their last five, with eight of those runs coming in one outlier of a game against the Mets. This could be a snoozefest of a game unless you like watching hitters fail, so my suggestion is to lock in this bet and check the score when it's over.

My Pick: Under 7.5

 

Arizona Diamondbacks @ San Diego Padres (-107) | O/U: 7

The oddsmakers have this game billed as a toss-up which is understandable since both of these teams have been struggling with identical 3-7 records in their last 10 games. The thing that stands out to me is that the Diamondbacks 14-10 away from home while the Padres are 11-14 at Petco Park.

Zack Greinke takes the hill for the Diamondbacks, and he has been dealing in his past six starts, allowing one or fewer runs in all except for a three-run game at Coors Field. Meanwhile, Matt Strahm has been doing good as well allowing two runs in each of his last four starts, but I will take the more experienced Greinke here who will be determined to get his team back on the winning track.

My Pick: Diamondbacks (-101)

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REAL-TIME FANTASY NEWS

CFB

Arizona State QB Sam Leavitt Probable For Saturday
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to Remain Out Thursday
Dmitry Kulikov

to Miss Five Months Following Surgery
Darcy Kuemper

Day-to-Day With Lower-Body Injury
Anze Kopitar

Listed as Day-to-Day
Jacob Markstrom

Out for "Couple of Weeks"
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Slated to be Sidelined With Knee Injury
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Out on Wednesday
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Misses Wednesday's Game
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Calling it a Career After Nine NBA Seasons
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Russell Westbrook Inks Deal With Kings
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Chargers Open 21-Day Practice Window for Khalik Mack
Quentin Johnston

Will Practice Wednesday
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Jaguars Plan to Expand Travis Hunter's Role on Offense
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Undergoes Left-Shoulder Surgery
Deshaun Watson

"a Good Month Away" From Practicing
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Jayden Gibson No Longer with Oklahoma Program
David Njoku

Not Practicing Wednesday
Rashee Rice

Chiefs "Allocating a Heavy Workload" for Rashee Rice Right Away
Puka Nacua

a "Long Shot" to Play in Week 7
Emeka Egbuka

is Expected to Miss Week 7
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Participates in Contact Drills
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Progresses to Five-on-Five Work
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to Miss 1-2 Weeks
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Sustains Knee Contusion Tuesday
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Karlo Matkovic Hurts Elbow in Loss to Houston
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Returns to Action Against Cavaliers
Stuart Skinner

Records Eighth Career Shutout
Matthew Knies

Dishes Out Three Assists in Tuesday's Win
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Likely Out on Friday
Brett Howden

Dealing With Lower-Body Injury
Adin Hill

Sustains Lower-Body Injury Versus Flames
Matt Duchene

Injured in Tuesday's Win
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to be Banished for Life After Gambling Allegations?
Alex Bregman

Plans to Opt Out of Contract With Red Sox
Jalen Green

Reinjures Hamstring, Will be Reevaluated in 10 Days
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Set to Suit Up Tuesday
Joel Embiid

Could Play in Friday's Preseason Finale
Alexey Toropchenko

to Remain Out Wednesday
Jake Walman

Targeting Season Debut for Thursday
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Expected to Make Season Debut Wednesday
Paul George

Participates in Team Activities During Practice on Tuesday
Steven Lorentz

Misses Tuesday's Action
Jaccob Slavin

Unavailable Versus Sharks
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Out on Tuesday
Kris Letang

a Game-Time Call Tuesday
Brady Tkachuk

Expected to Miss at Least One Month
CeeDee Lamb

"Looking Good" for Week 7
Kevin Huerter

Could Be an Option Thursday
Tre Jones

Nursing a Foot Problem
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Set for Lakers Debut Tuesday
Jimmy Butler III

Sits Out Tuesday's Preseason Game
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Logs 18 Minutes in Preseason Debut
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Breaks Out for 175 Total Yards and Touchdown in Win
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Luka Doncic Set to Make Preseason Debut on Tuesday
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Sam Leavitt Viewed as Day-to-Day with Undisclosed Injury
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Could Sit for the "Long Haul"
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has a Chance to Play in Week 7
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Mike Shildt Retires as a Manager
Tennessee Titans

Titans Fire Head Coach Brian Callahan
Mateusz Gamrot

Suffers Second-Round Submission Loss
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Gets Back In The Win Column
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Drops Decision
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Gets Split-Decision Victory
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Remains Undefeated
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Le'Veon Moss Not Believed to Have Suffered Season-Ending Injury
Ricardo Ramos

Suffers First-Round Submission Loss
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Not Expected to Return in Week 7
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Not Expected to Return in Week 7
Puka Nacua

Rams Think Puka Nacua has Avoided a Long-Term Injury
Kaan Ofli

Scores Comeback Win
CFB

Bill Belichick Says he's Committed to North Carolina
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Undergoes Back Surgery
CFB

UAB Fires Head Coach Trent Dilfer After 2.5 Seasons In Birmingham
CFB

Penn State Fires Head Coach James Franklin After 10.5 Seasons
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Penn State QB Drew Allar Will Miss The Rest Of 2025 Season With Ankle Injury
Brandon Woodruff

Will Not be on NLCS Roster
Max Scherzer

Added to ALCS Roster
Bryan Woo

Makes ALCS Roster
Bo Bichette

Won't Make ALCS Roster
Christopher Bell

the Favorite to Win at Las Vegas
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Bubba Wallace Should Contend at Las Vegas
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Looking for Improvement at Las Vegas
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has Definitely Improved on Intermediate Tracks
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Syracuse QB Steve Angeli Will Miss Significant Time
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Plans to Opt Out of Contract
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Munetaka Murakami Will be Posted This Winter
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Syracuse QB Steve Angeli Will Miss Remainder of 2025 Season With Torn Achilles
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Sam Leavitt Not Expected to Play for Arizona State on Saturday

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