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Top MLB Betting Picks for Today's Slate (5/25/19)

Nate Duffett's MLB betting picks for 5/25/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including money-lines, spreads and totals.

Welcome to the Saturday, May 25th edition of Rotoballer's MLB Betting Picks. I will be serving up some of my top options on today's 16 game slate. Due to a prior commitment, the picks will have an earlier submission. Sorry in advance for any discrepancies in odds due to the timing of this article.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Saturday, May 25th. Good luck!

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New York Yankees (-152) @ Kansas City Royals

O/U: 10 (Second Game of Doubleheader)

I will be highlighting the second game of this doubleheader tomorrow because of the pitching matchup we see on the mound. The Yankees send Chad Green with his 12.41 ERA, and the Royals send Jakob Junis with his 5.69 ERA. Neither of the pitching matchups in these two games tomorrow are too intriguing, but this one has the most possibility of hitting the over.

The Yankees have shattered the total in each of their last five games by an average of 5.4 runs. The Royals have seen the over hit in 15 of their 24 home games, while the over has hit in 17 of 21 Yankees road games.

My Pick: Over 10

 

Cincinnati Reds @ Chicago Cubs (-155)

O/U: TBD

The Cubs are a tough team to go back to after their bullpen blew the lead for us on yesterday's slate. However, Yu Darvish has been looking good his last couple of starts, and the Cubs 17-8 record at home would suggest they don't lose two in a row very often. If the taste in their mouths is as sour as it is for me after yesterday's result, they should have the motivation to get this one back on their home field.

My Pick: Cubs (-155)

 

Baltimore Orioles @ Colorado Rockies (-188)

O/U: 11.5

No one feels comfortable when picking the Orioles, so I will give the facts here and let you guys do with it what you want. I would call this risky pick a lean as I wouldn't hold it against you if you left this one off your betting card. The facts are that Kyle Freeland has struggled mightily in his home ballpark, allowing a 7.36 ERA and his team has lost two of the four games he has started at Coors Field.

One of the games they did win, was a 12-11 final score. The Orioles are 1-9 in their last ten, but they did play the Yankees extremely close in the last series. Let's get freaky and sprinkle some money on the Orioles here. I promise it's the only time I will tell you to do that for the rest of the season.

My Pick: Orioles (+163)

 

San Diego Padres (-115) @ Toronto Blue Jays

O/U: 9.5

Here is one of the spots where the odds could have changed quickly by the time you read this article. With the way the Blue Jays have been playing, they shouldn't be this close in odds to anyone. Especially, when they are sending Edwin Jackson to the mound. The Padres have won four in a row and counter with Cal Quantrill who makes the start at the ballpark where he grew up watching the game.

If I know anything by living in Canada and watching the Blue Jays, Canadians enjoy coming home to play (i.e. James Paxton's no-hitter last year), so it wouldn't surprise me to see the Padres win one for Quantrill here again today.

My Pick: Padres (-115)

 

Tampa Bay Rays @ Cleveland Indians

O/U: 8

The first two games of this series have seen both teams win a game each. Carlos Carrasco has been very inconsistent, having four starts where he allowed zero runs but having six starts where he was chased early and had his ERA raised to 4.30. I find it hard to pick the Indians or a side on the total here with that inconsistency. So, I will side with the much more consistent Charlie Morton, who is 4-0 with a 2.65 ERA and facing an Indians team that has lost four of their last five games.

My Pick: Rays (+107) 

More Fantasy Baseball Analysis




REAL-TIME FANTASY NEWS

Giannis Antetokounmpo

Magic Reportedly Have Giannis Antetokounmpo on Their Radar
Ajay Mitchell

Won't Play Sunday
Dylan Harper

Not on Injury Report for Game 4
De'Aaron Fox

Off the Injury Report Ahead of Game 4
Jalen Williams

Questionable for Sunday Night
Ja'Tavion Sanders

a Dynasty Dart Throw With Potential Untapped Upside
Geno Smith

a Low-Cost Dynasty Add Who Still Comes with Risk
C.J. Stroud

Still a Capable and Undervalued Dynasty QB2
Bhayshul Tuten

More Big Plays in 2026 Could Transform Bhayshul Tuten into a Dynasty Steal
Joe Mixon

Is Joe Mixon's NFL Career Over?
MLB

Orioles-Tigers Game Postponed on Saturday
RJ Harvey

to be Relegated to Third-Down Role After Rookie RB Addition?
Baker Mayfield

A Lot of Uncertainty Surrounding Baker Mayfield Going into Fourth Year in Tampa
Brian Robinson Jr.

a Must-Have Handcuff in Dynasty Leagues?
Sam LaPorta

Could be Excellent Buy-Low Candidate for Risk-Tolerant Managers
Jordyn Tyson

on a "Maintenance Plan" During Offseason Workouts
Kenneth Walker III

One of Dynasty's Biggest Risers for 2026
D'Andre Swift

an Underappreciated Dynasty Buy Candidate
Ray Davis

Still a Dynasty Stash Despite a Lack of Standalone Value
Travis Kelce

Now a Low-Cost Dynasty Rental
DJ Moore

a Reasonable Buy Candidate Now That Dynasty Market Has Cooled
MLB

Rays-Yankees Postponed on Saturday
Devin Vassell

Posts 20 Points in Game 3 Loss
De'Aaron Fox

Struggles From Deep in Friday's Loss
Victor Wembanyama

Held to Four Rebounds in Game 3 Loss
Jaylin Williams

Catches Fire From Deep Friday
Jared McCain

Drops Playoff-High 24 Points in Game 3
Nazem Kadri

Contributes an Assist in Losing Effort
Shai Gilgeous-Alexander

Guides Thunder to 2-1 Series Lead
Ajay Mitchell

Does Not Return in Game 3 Win
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Jordan James

Most Likely to be 49ers' RB2 in 2026
Mickey Moniak

Heads to Injured List With Ankle Sprain
Rudy Gobert

Earns Eighth All-Defensive First-Team Selection
Victor Wembanyama

Headlines 2025-26 All-Defensive First Team
Ajay Mitchell

Starting Game 3 Against Spurs
Dylan Harper

Available for Game 3 Against Thunder
De'Aaron Fox

Returns to Action Friday
Jalen Williams

Won't Play Friday Night
Derrick Henry

Remains in RB1 Discussion
Ladd McConkey

is Solid Buy-Low Candidate
Ryan Flournoy

an Intriguing Dynasty Stash Option
Jalen Nailor

is Expected to Have Larger Role in Las Vegas
Frederik Andersen

Hurricanes Keep Faith in Frederik Andersen
Devon Levi

Attracting Interest From Senators
Jacoby Brissett

Cardinals Not Close to a Reworked Deal
Scott Wedgewood

Starting Game 2 Against Golden Knights
Ben Hutton

Scratched for Game 2 Against Avalanche
Mark Stone

Won't Play Friday
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
Cale Makar

Remains Out Friday
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Evan Mobley

Fills the Box Score in Game 2 Loss
James Harden

Held to Two Assists Thursday
Donovan Mitchell

Leads Cavaliers in Scoring in Game 2 Defeat
Sebastian Aho

Picks Up an Assist in Series-Opening Loss
Seth Jarvis

Needs 33 Seconds to Score in Game 1 Loss
Jaccob Slavin

Struggles in Game 1 Against Canadiens
Jakub Dobes

Sharp in Game 1 Victory
Cole Caufield

Bags Two Points in Impressive Road Win
Juraj Slafkovsky

Opens Conference Finals With Three-Point Performance
Nick Suzuki

Notches Three Assists in Game 1 Win Over Hurricanes
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Alex Tuch

Hopes to Remain in Buffalo
Sidney Crosby

Wants to Play for "as Many Years as Possible"
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Corey Seager

Going on Injured List With Back Injury
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
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