Starts and Sits - All Starting Pitcher Matchups for Fantasy Baseball (April 21 - April 27)

April 27, 2025

Nick's fantasy baseball starts/sits, expert advice for all starting pitcher matchups for April 21 - April 27 (2025). Set your winning fantasy baseball lineups.

We've gotten a few looks at most pitchers by now and the data is beginning to feel more robust as we build out our starting pitcher starts/sits for fantasy baseball Week 4- Monday, April 21 through Sunday, April 27. How are those early pitching stats looking for your teams? Bookmark us for every start/sit option and possible two-start decisions for your rosters.

For 13 years running, we have been writing this Starting Pitcher Starts and Sits series weekly here at RotoBaller. I'm Nick Mariano, and I'll lead you through the 2025 season. All kinds of firepower go into supplying this piece each week to produce a beloved series for our readers.

New readers should absorb the section below to learn the column's aim and how best to use the tool, while veterans can proceed to the goods. We wish you the best of luck with your fantasy baseball starting pitcher lineup decisions to stay hot as April rolls on. We're crushing it all year long right here!

• Fantasy baseball draft kit
• Fantasy baseball rankings
• Team Sync platform and Draft Assistant
• Fantasy baseball mock draft simulator
• Fantasy baseball draft cheat sheets
• Fantasy baseball closer depth charts
• Fantasy baseball prospects

Start/Sit Data Overview

Ahead of each week of the fantasy baseball season, we publish the table below. We have the probable starters for every game of the week and a grade for them on a 0-100 scale. The intent is to give you advice and inspire confidence (or lack thereof) in your decisions to start or sit certain pitchers.

Please note that beyond the usual "Start" and "Sit" labels, we've expanded on the old "context-dependent" section to break it down further with "Lean Sit," "Lean Start," and true 50/50 "Coin Flip" designations. This is because different leagues call for different actions, and those in start-sit purgatory may be worth the gamble to some.

Also, we put the arms best projected to start or get bulk innings or actionable arms who may return from the injured list or be called up. Still, some situations are fluid, and we update ASAP to reflect accurate information. The early season means plenty of jostling around as injuries crop up and managers settle into routines, so check back frequently!

The "starts" category includes pitchers you'd likely start in every league. The "sits" are pitchers you likely sit in every league.

The 40-60 range will mean it is close, and it's up to you to decide based on your league settings or team needs (wins, strikeouts, etc.), how deep your league is, which roto/points categories are scored, and so on.

Here are your starts and sits for what we're calling Week 4 of the fantasy season, which covers April 21 through April 27. Let's get to it!

Week 4 Start/Sit Recommendations (April 21 - April 27)

Updated start/sit recommendations for this week's MLB games. This chart is updated daily as probable starters are constantly changing with postponements, injuries, etc. Scroll down further for a color-coded chart. If you can't see the chart below, click here to see the starts/sits on a separate page:

Start/Sit Color-Coded Matchups Chart (April 21 - April 27)

The below grid shows the same data but as a color-coded grid:

More Fantasy Baseball Analysis