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San Francisco 49ers tight end George Kittle (hamstring) remains on injured reserve after exiting in Week 1. Kittle scored an early touchdown before leaving the game and was placed on IR shortly afterward. His earliest return date is Week 6 against the Tampa Bay Buccaneers, though his fantasy outlook is now clouded in the 49ers' crowded receiver room. With rookie Ricky Pearsall emerging, Jauan Jennings performing when healthy, and Christian McCaffrey leading the team in targets, Kittle may not return to the same dominant workload he had in 2024. Brandon Aiyuk is also tracking toward a late-season return, which could further limit his target share. While Kittle still carries name value and touchdown upside, he might not reclaim elite fantasy status. If he returns strong in midseason, he could be a smart sell-high candidate before the 49ers' offense becomes even more crowded.--Nathan Harvey
Source: Pro Football Reference
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