👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

FanDuel MLB DFS Lineup Picks (4/21/21): Daily Fantasy Baseball Advice

Mike Marteny highlights the top FanDuel MLB DFS lineup picks for 4/21/21, and a couple of sleepers to consider while building daily rosters.

It's getaway day in MLB, so only six games permeate the main night slate. Only one pitcher tips the five-figure scale. Can we get away with a fade here? Are there enough other options to gain an advantage by using a cheaper pitcher? We'll get into that.

Rain could affect the start time of the Yankees game, but they should be able to get the game in after an initial delay. The only thing to worry about would be if they can't keep the field in good shape when it rains throughout the afternoon. I do expect it to play and the wind should be blowing heavily out to right. Use pitching at your own risk in that one. They are going to have problems getting the Boston game in. It's possible that the rain will miss Boston, but right now it doesn't look promising.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel main slate on 4/21/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's DraftKings MLB DFS lineup picks, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

FanDuel DFS Pitchers

Cash Game/GPP Anchor Play:

Aaron Civale – CWS at CLE($10,200)

Civale beat the White Sox just five days ago, but he only picked up four strikeouts. The lack of strikeout potential is a bit of a ding on him, but he is 3-0 with a 2.18 ERA so far this year. Civale hasn't gone less than six innings in any start this year. That alone gives him the highest floor on this slate. Civale isn't a high strikeout guy so I can get on board with a fade here. The big issue is that there aren't many good secondary options.

Potential Alternate Play

Tyler Mahle – CIN vs. ARI($8,800)   

The issue with Mahle over the course of his career has been his ability to get through the order a second time. He simply doesn't go deep into games. Over the course of 64 career starts, Mahle averages just a shade over five innings per start. That's not much time to accumulate points. This season has been much of the same with Mahle only pitching 14 innings across three starts. It has nothing to do with his effectiveness because in the start in which he only lasted four innings, Mahle did not give up a run. That was against tonight's opponent, Arizona. Mahle still picked up 30 FanDuel points in that game. The thing that has me leaning towards Mahle is the 22 strikeouts in 14 innings. That's something I can work with.

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

FanDuel DFS Infielders

Joey Votto – 1B, CIN vs. AZ ($2,800)

It has been a rough start for Merrill Kelly again this year. A small ballpark with the wind blowing out wont help him either. Votto has only been shut out in one game this season and just got done with a series in which he destroyed Cleveland pitching. The Arizona staff and bullpen is significantly worse. Votto makes a lot of hard contact against the fastball and changeup that Kelly throws, which comprises almost 70% of his pitches to lefties. He should be able to stay hot here.

Ozzie Albies – 2B, ATL at NYY ($3,000)

Corey Kluber has really struggled this year and this is a terrible matchup for him anyway. Kluber's fastball velocity is down a bit which could explain the struggles. Still, this is not a team you want to struggle against. I'm not going hard after Kluber since the Yankees bullpen has one again been a strength. Albies profiles well and is reasonably priced.

Jose Ramirez – 3B, CLE vs. CWS ($3,300)

This feels cheap for Ramirez, especially when you consider that the White Sox basically turning this into a bullpen game. Ramirez started slowly, but he has 78.4 FanDuel points over the last five games. I'm not scared of Jonathan Stiever or the White Sox bullpen. Stiever struggled in his cup of coffee in 2020 and he didn't have a strong spring either. ATTACK!

Javier Baez – SS, CHC vs. NYM ($3,800)

Kris Bryant has been the talk of the Cubs this year and for good reason. However, he doesn't profile nearly as well as Baez does. Baez absolutely destroys sliders with a 72.7% hard contact rate. The only thing he doesn't profile well against is changeups. All eight home runs that David Peterson has allowed in his career have been given up to righties. If anyone is hitting one in Wrigley tonight, the metrics strongly suggest that it will be Baez.

 

FanDuel DFS Outfielders

Jesse Winker – OF, CIN vs. AZ ($3,700)

Winker is leading off a potent offense against a pitcher that has given up a run per inning so far this year in a small ballpark with the wind blowing out. The Arizona bullpen has been one of the better units so far this year, but I'm banking on the Reds putting up some big numbers against Kelly before they knock him out of the game.

Franmil Reyes – OF, CLE vs. CWS ($3,200)

Reyes has the rawest power of anyone on the team. Reyes made up for his cold series on the Southside last week in which he went 0-13 by picking up three hits and a walk in the first game of the series in Cleveland. We don't really know who or what the White Sox are going to throw at Cleveland tonight. We only know that Jonathan Stievers will be part of it. That's good enough for me knowing he has a bullpen with an ERA on the wrong side of 4 backing him up.

Jorge Soler – OF, KC vs. TB($2,600)

Soler is quite familiar with Michael Wacha. He started his career with the Cubs when Wacha was with the Cardinals. Then Soler moved to Kansas City where they play the Cardinals in the I-70 series every year. Wacha is 5-12 with three homers, seven runs, and seven RBI in his career against Wacha. BvP worked for those of us last night who threw a struggling Mitch Moreland out there against Matt Shoemaker. This could work for a struggling Soler as well.

 

FanDuel DFS Stacks Options

  • Cincinnati Reds
  • Kansas City Royals
  • Cleveland Indians
  • Chicago Cubs right-handers



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Tyler Bass

Close to Full Health, Ready to Return to Fantasy Relevance?
Ronald Acuña Jr.

Ronald Acuna Jr. Back in Leadoff Spot on Tuesday After Injury Scare
New England Patriots

Patriots Targeting Eli Stowers in the NFL Draft?
CFB

Ashton Daniels Named Florida State's Starting Quarterback
Aaron Rodgers

Mike McCarthy has Confidence in Aaron Rodgers if he Re-Signs
Daniel Jones

is Dropping Back and Passing in his Rehab
Juan Soto

Expected to Return on Wednesday
NFL

Jermod McCoy Could Fall in Draft Due to Long-Term Knee Concerns
NFL

Ty Simpson Could Fall Out of the First Round
Washington Commanders

Jeremiyah Love Could Unlock Commanders Offense
Royce Lewis

Twins Reinstate Royce Lewis From Injured List on Tuesday
Adley Rutschman

Activated From Injured List on Tuesday
Nnamdi Madubuike

Doctors Think Nnamdi Madubuike Can Resume his Playing Career
Kayshon Boutte

Not Present for Voluntary Workouts
Tetairoa McMillan

Working on "Power" and Weight/Muscle Gain
Ashton Jeanty

a Top Dynasty Buy Ahead of the NFL Draft?
Tyler Shough

Poised to Get a Wide Receiver Upgrade in the NFL Draft?
Mason Taylor

a Sneaky Buy in Dynasty Leagues as NFL Draft Approaches?
Devin Neal

a Sneaky Buy Ahead of the NFL Draft
Dylan Cease

Continues Strong Start With 12-Strikeout Performance
Ricky Pearsall

Not Yet Ready to Make the WR1 Leap
NFL

Chris Brazzell II a Fringe First-Rounder in Fantasy Rookie Drafts
Raisel Iglesias

Placed on 15-Day Injured List with Shoulder Inflammation
Tory Horton

Is Tory Horton a Sneaky, Low-Cost Buy Before the NFL Draft?
Zach Charbonnet

a Volatile Buy Heading into NFL Draft
NFL

Can Emmett Johnson Sneak into First Round of Rookie Drafts?
NFL

Jonah Coleman Could Be a Steal in Second Round of Rookie Drafts
NFL

Elijah Sarratt Brings Boom-or-Bust Volatility to the Second Round of Rookie Drafts
Jake Sanderson

Records Two Assists in Losing Effort
Brock Faber

Bags Two Goals in Monday's Defeat
Wyatt Johnston

Notches Two Goals in Game 2 Win
Troy Terry

Has Special Playoffs Debut
Dan Vladar

Leads Flyers to Victory With 27-Save Shutout
Yakov Trenin

Suffers Upper-Body Injury in Game 2
Rasmus Sandin

to Miss Start of 2026-27
CJ McCollum

Shines at MSG in Game 2
Donovan Mitchell

Extends 30-Point Streak
Jakob Poeltl

Gets Benched in Second Half
Brandon Ingram

Continues to Struggle
Al Horford

Undecided on Future
Brandin Podziemski

Wants to Stay With Warriors Long-Term
Max Muncy

With Another Two-Homer Game, Becoming Must-Add Off Waiver Wire
Jordan McLaughlin

Ruled Out for Game 2
Ron Harper Jr.

Probable for Game 2
Austin Reaves

to Remain Out Tuesday
Luka Dončić

Luka Doncic Still Out Tuesday
Anthony Edwards

Active on Monday Night
Kevin Durant

a Game-Time Decision on Tuesday
Ronald Acuña Jr.

Ronald Acuna Jr. Day-to-Day After Being Hit on the Hand on Monday
Mick Abel

Injury Described as "Not Too Serious"
Brendan Donovan

Mariners Place Brendan Donovan on Injured List With Groin Strain
Joel Embiid

is Officially Ruled Out for Game 2
Sonny Gray

Heading to the Injured List With Hamstring Injury
Victor Wembanyama

Wins Defensive Player of the Year
OG Anunoby

is Available to Play for Monday's Game 2
Onyeka Okongwu

is Cleared to Play During Game 2 on Monday
Immanuel Quickley

is Ruled Out for Game 2
Edwin Díaz

Edwin Diaz Expected to Miss Around Three Months
Edwin Uceta

Shut Down for 2-3 Weeks; Is he Still Stash-Worthy?
Charle-Edouard D'Astous

Doubtful for Game 2
Brad Keller

Will "Probably" Earn First Save Situation in Modified Phillies Bullpen
Roope Hintz

to Miss at Least Two More Games
Edwin Díaz

Edwin Diaz Placed on 15-Day Injured List with Elbow Injury
Ross Johnston

Won't Play in Game 1 Against Oilers
Artem Zub

Considered a Game-Time Decision Monday
Tyler Kleven

Remains Out Monday
Jason Dickinson

a Game-Time Call Monday
Leon Draisaitl

Expected to Return Monday
Tyler Reddick

Earns His Fifth Win of the 2026 Season at Kansas
Kyle Larson

Finishes as the Runner-Up at Kansas
Chase Briscoe

Rallies for A New Career-Best Finish at Kansas
Denny Hamlin

Leads the Most Laps at Kansas but Misses Out on Victory
Christopher Bell

Falls Out of Contention for Kansas Victory on Final Restart
Mike Malott

Scores Third-Round TKO Win
Sonny Gray

Leaves Monday's Start Early With Hamstring Tightness
Gilbert Burns

Retires After UFC Winnipeg Loss
Charles Jourdain

Extends Winning Streak
Mick Abel

Twins Placing Mick Abel on Injured List With Elbow Inflammation
Kyler Phillips

Drops Decision At UFC Winnipeg
Mandel Nallo

Suffers First-Round TKO Loss In His UFC Debut
Jai Herbert

Scores First-Round TKO Win
Karine Silva

Gets Dominated at UFC Winnipeg
Jasmine Jasudavicius

Dominates Karine Silva
Deni Avdija

Posts 30-Point Double-Double in Loss
Paolo Banchero

Leads Magic in Game 1 Win
Jalen Duren

Posts Quiet Line in Series Opener
Cade Cunningham

Erupts for 39 Points in Playoff Opener
Logan Cooley

Scores Mammoth's First-Ever Playoff Goal
David Pastrnak

Finishes Game 1 Loss With Three Points
Tage Thompson

Bags Three Points in Postseason Debut
Jake Guentzel

Records Three Assists Sunday
Juraj Slafkovsky

Nets Unique Hat Trick in Playoff Opener
Charle-Edouard D'Astous

Hurt in Game 1 Loss
Leon Draisaitl

Could Be Ready for Game 1 Against Ducks
Corbin Carroll

Expected Back Tuesday; Injury Concern Appears Minor
Juan Soto

is on Track to Return Next Homestand
Corbin Carroll

Exits Sunday's Game with Back Tightness
Tarik Skubal

Fans 10 in Win Over Red Sox on Saturday
Kyle Larson

Should not be Underestimated for the Win at Kansas
Denny Hamlin

Can Denny Hamlin Dominate at Kansas Again?
NASCAR

Christoper Bell Should Contend for First Win at Kansas
Tyler Reddick

Fastest in Practice and Qualifying for Kansas Race
Ryan Blaney

Could Score another Top-10 Finish at Kansas
Ty Gibbs

Poised to Continue Hot Streak at Kansas
Chris Buescher

Always Consistent, Has Speed Heading Into Kansas
William Byron

is A Solid DFS Option for Kansas Lineups
Carson Hocevar

Poised for Career-Best Run at Kansas
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Kansas?
Chase Elliott

Is A Favorable DFS Option for Kansas Lineups
Joey Logano

Could Joey Logano be Considered Playable In DFS This Week at Kansas?
NASCAR

Bubba Wallace is A Favorable Driver to Consider for Kansas Lineups
Ross Chastain

Is Ross Chastain A Worthy DFS Option for Kansas?
Brad Keselowski

Could Brad Keselowski be A Sneaky DFS Option for Kansas?
Daniel Suarez

Should DFS Managers Roster Daniel Suarez at Kansas?
Mike Malott

A Favorite At UFC Winnipeg
Gilbert Burns

Set For UFC Winnipeg Main Event
Kyler Phillips

Set UFC Winnipeg Co-Main Event
Charles Jourdain

Looks To Extend His Win Streak
Jai Herbert

An Underdog At UFC Winnipeg
Mandel Nallo

Set For His UFC Debut
Karine Silva

Looks To Get Back In The Win Column
Jasmine Jasudavicius

Looks To Bounce Back
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF