🖥 TAP TO SAVE 50% WITH CODE THANKS
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

FanDuel MLB DFS Lineup Picks (4/21/21): Daily Fantasy Baseball Advice

Mike Marteny highlights the top FanDuel MLB DFS lineup picks for 4/21/21, and a couple of sleepers to consider while building daily rosters.

It's getaway day in MLB, so only six games permeate the main night slate. Only one pitcher tips the five-figure scale. Can we get away with a fade here? Are there enough other options to gain an advantage by using a cheaper pitcher? We'll get into that.

Rain could affect the start time of the Yankees game, but they should be able to get the game in after an initial delay. The only thing to worry about would be if they can't keep the field in good shape when it rains throughout the afternoon. I do expect it to play and the wind should be blowing heavily out to right. Use pitching at your own risk in that one. They are going to have problems getting the Boston game in. It's possible that the rain will miss Boston, but right now it doesn't look promising.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel main slate on 4/21/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's DraftKings MLB DFS lineup picks, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

FanDuel DFS Pitchers

Cash Game/GPP Anchor Play:

Aaron Civale – CWS at CLE($10,200)

Civale beat the White Sox just five days ago, but he only picked up four strikeouts. The lack of strikeout potential is a bit of a ding on him, but he is 3-0 with a 2.18 ERA so far this year. Civale hasn't gone less than six innings in any start this year. That alone gives him the highest floor on this slate. Civale isn't a high strikeout guy so I can get on board with a fade here. The big issue is that there aren't many good secondary options.

Potential Alternate Play

Tyler Mahle – CIN vs. ARI($8,800)   

The issue with Mahle over the course of his career has been his ability to get through the order a second time. He simply doesn't go deep into games. Over the course of 64 career starts, Mahle averages just a shade over five innings per start. That's not much time to accumulate points. This season has been much of the same with Mahle only pitching 14 innings across three starts. It has nothing to do with his effectiveness because in the start in which he only lasted four innings, Mahle did not give up a run. That was against tonight's opponent, Arizona. Mahle still picked up 30 FanDuel points in that game. The thing that has me leaning towards Mahle is the 22 strikeouts in 14 innings. That's something I can work with.

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

FanDuel DFS Infielders

Joey Votto – 1B, CIN vs. AZ ($2,800)

It has been a rough start for Merrill Kelly again this year. A small ballpark with the wind blowing out wont help him either. Votto has only been shut out in one game this season and just got done with a series in which he destroyed Cleveland pitching. The Arizona staff and bullpen is significantly worse. Votto makes a lot of hard contact against the fastball and changeup that Kelly throws, which comprises almost 70% of his pitches to lefties. He should be able to stay hot here.

Ozzie Albies – 2B, ATL at NYY ($3,000)

Corey Kluber has really struggled this year and this is a terrible matchup for him anyway. Kluber's fastball velocity is down a bit which could explain the struggles. Still, this is not a team you want to struggle against. I'm not going hard after Kluber since the Yankees bullpen has one again been a strength. Albies profiles well and is reasonably priced.

Jose Ramirez – 3B, CLE vs. CWS ($3,300)

This feels cheap for Ramirez, especially when you consider that the White Sox basically turning this into a bullpen game. Ramirez started slowly, but he has 78.4 FanDuel points over the last five games. I'm not scared of Jonathan Stiever or the White Sox bullpen. Stiever struggled in his cup of coffee in 2020 and he didn't have a strong spring either. ATTACK!

Javier Baez – SS, CHC vs. NYM ($3,800)

Kris Bryant has been the talk of the Cubs this year and for good reason. However, he doesn't profile nearly as well as Baez does. Baez absolutely destroys sliders with a 72.7% hard contact rate. The only thing he doesn't profile well against is changeups. All eight home runs that David Peterson has allowed in his career have been given up to righties. If anyone is hitting one in Wrigley tonight, the metrics strongly suggest that it will be Baez.

 

FanDuel DFS Outfielders

Jesse Winker – OF, CIN vs. AZ ($3,700)

Winker is leading off a potent offense against a pitcher that has given up a run per inning so far this year in a small ballpark with the wind blowing out. The Arizona bullpen has been one of the better units so far this year, but I'm banking on the Reds putting up some big numbers against Kelly before they knock him out of the game.

Franmil Reyes – OF, CLE vs. CWS ($3,200)

Reyes has the rawest power of anyone on the team. Reyes made up for his cold series on the Southside last week in which he went 0-13 by picking up three hits and a walk in the first game of the series in Cleveland. We don't really know who or what the White Sox are going to throw at Cleveland tonight. We only know that Jonathan Stievers will be part of it. That's good enough for me knowing he has a bullpen with an ERA on the wrong side of 4 backing him up.

Jorge Soler – OF, KC vs. TB($2,600)

Soler is quite familiar with Michael Wacha. He started his career with the Cubs when Wacha was with the Cardinals. Then Soler moved to Kansas City where they play the Cardinals in the I-70 series every year. Wacha is 5-12 with three homers, seven runs, and seven RBI in his career against Wacha. BvP worked for those of us last night who threw a struggling Mitch Moreland out there against Matt Shoemaker. This could work for a struggling Soler as well.

 

FanDuel DFS Stacks Options

  • Cincinnati Reds
  • Kansas City Royals
  • Cleveland Indians
  • Chicago Cubs right-handers



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Deandre Ayton

May Skip Meeting With Jazz
Cole Anthony

Iffy for Thursday's Action
AJ Green

at Risk of Missing Another Game
Peyton Watson

Questionable for Thursday
Kyle Kuzma

Questionable for Thursday Due to Illness
Tim Hardaway Jr.

Questionable With Illness
Lauri Markkanen

Picks Up Questionable Tag Ahead of Thursday
Tristan da Silva

Questionable for Thursday
Pelle Larsson

Misses Second Straight Game
Nikola Jović

Nikola Jovic Unavailable Against Nets
Pat Spencer

Ruled Out for Thursday
Norman Powell

Misses Practice, Uncertain for Thursday
Jakob Poeltl

Listed as Probable for Thursday
Al Horford

Ruled Out for Thursday, Nearing Return
Tim Hardaway Jr.

Battling Illness, Questionable for Thursday
Bo Bichette

Willing to Make the Move to Second Base
Brandon Williams

Questionable with Achilles Issue
D'Angelo Russell

Questionable for Thursday
Mitchell Robinson

Tagged as Questionable for Thursday
Josh Hart

Uncertain for Thursday
Brandon Clarke

Active Against Timberwolves
Isaiah Hartenstein

Resting on Thursday Night
Davante Adams

Doubtful to Play Thursday Night
Matthew Tkachuk

Status Uncertain for Winter Classic
Tyson Foerster

Ruled Out for Five Months
Quinton Byfield

Back From One-Game Absence Wednesday
Gustav Forsling

Available Against Kings
Pavel Dorofeyev

Good to Go Wednesday
Shea Theodore

Out Against Devils
Jack Eichel

Misses First Game of the Season Wednesday
Brett Pesce

Back in Action Wednesday
Devin Neal

Ruled Out for Sunday
Christian Watson

"Should be Good" to Face the Bears on Saturday
Geno Smith

has "a Good Chance" to Return in Week 16
Saquon Barkley

Back at Practice on Wednesday
Brady Cook

Will Start Again in Week 16
Patrick Mahomes

Rehabbing ACL, LCL Tears
Rashee Rice

Won't Practice Due to Concussion
Marvin Harrison Jr.

to Take Part in Wednesday's Walkthrough Practice
Drake London

Day-to-Day, Will Practice on Wednesday
CFB

Jeremiyah Love Officially Heading to NFL Draft
Quinn Ewers

Making First Career Start in Week 16
Tua Tagovailoa

Being Benched by Dolphins
CFB

Jake Merklinger Leaving Tennessee for Transfer Portal
Jeremy Ruckert

Jets, Jeremy Ruckert Agree to a Two-Year Extension
Thatcher Demko

Shuts Out Rangers With 23 Saves
Macklin Celebrini

Notches Four Points in Tuesday's Win
Leon Draisaitl

Reaches Special Milestone During Four-Point Night
Shea Theodore

Questionable for Wednesday Night
Jack Eichel

Battling Illness
Darcy Kuemper

Placed on Injured Reserve
Brandon Montour

Hurt on Tuesday
Mike Trout

Angels Open to Mike Trout Playing Center Field in 2026
Saquon Barkley

Misses Practice With Stinger
RJ Harvey

Dealing With Rib Injury
Josh Jacobs

Intends to Play Against Bears on Saturday
Zach Bogosian

Misses Tuesday's Game
Marcus Johansson

Unavailable Tuesday
Artyom Levshunov

Scratched for Tuesday
Mathew Barzal

a Game-Time Call Tuesday
Joseph Woll

Returns to Action Tuesday
Mike Matheson

Won't Play on Tuesday
Bam Knight

Cardinals Place Bam Knight on Injured Reserve
CFB

Kansas State's Jayce Brown Intends to Transfer
CFB

Nation's Leading Passer Drew Mestemaker to Enter Transfer Portal
Justin Crawford

Phillies Planning to Start Justin Crawford in Center Field
CFB

Jayden Maiava Signs New Deal to Return to USC
CFB

Aidan Mizell Won't Return to Florida, Entering Transfer Portal
CFB

East Carolina Targeting Jordan Davis as Next Offensive Coordinator
Patrick Mahomes

Targeting Week 1 Return in 2026
CFB

Michigan QB Jadyn Davis Set to Enter Transfer Portal
CFB

Travis Williams Joining Texas A&M Defensive Staff
Darren Waller

Hauls in Two Touchdowns in Monday Night Loss
Rome Odunze

Considered Week-to-Week With Foot Injury
Davante Adams

Considered Week-to-Week With Hamstring Injury
CFB

Dylan Raiola Entering His Name into Transfer Portal
CFB

Cincinnati's Brendan Sorsby Plans to Transfer When Portal Opens
Adolis García

Adolis Garcia, Phillies Finalizing One-Year Deal on Monday
Brandon Royval

Suffers First-Round TKO Loss
CFB

Baylor, LSU, Miami Among Potential Suitors for DJ Lagway
CFB

Aidan Chiles Will Enter Transfer Portal
Manel Kape

Shines At UFC Vegas 112
Kevin Vallejos

Gets Second-Round Knockout Win
Giga Chikadze

Suffers His First Career Knockout Loss
CFB

Quarterback DJ Lagway Entering Transfer Portal
Cesar Almeida

Gets Dominated
Cezary Oleksiejczuk

Wins Sixth Fight In A Row
Morgan Charrière

Morgan Charriere Suffers First-Round Knockout Loss
Melquizael Costa

Gets First-Round Knockout Win
Marcus Buchecha

Still Winless In The UFC
Kennedy Nzechukwu

And Marcus Buchecha Fight To Draw
Lance Gibson jr

Lance Gibson Jr. Drops Decision In His UFC Debut
King Green

Gets Back In The Win Column
Kenley Jansen

Agrees to One-Year Deal With Tigers
Merrill Kelly

Returns to Diamondbacks on Two-Year Deal
Jorge Polanco

Agrees to Two-Year Deal With Mets
CFB

LaNorris Sellers to Return to South Carolina in 2026
CFB

Washington State Expected to Hire Kirby Moore as Next Head Coach
CFB

Kyle Whittingham Stepping Down as Utah Head Coach
Manel Kape

Set For UFC Vegas 112 Main Event
Brandon Royval

An Underdog At UFC Vegas 112
Kevin Vallejos

Set For His Third UFC Fight
Giga Chikadze

In Dire Need Of Victory
Cesar Almeida

Set To Welcome Cezary Oleksiejczuk To The UFC
Cezary Oleksiejczuk

Set To Make His UFC Debut
Maikel Garcia

Royals Agree on Five-Year Extension
Melquizael Costa

Looks To Extend His Win Streak
Morgan Charrière

Morgan Charriere Looks to Win Second Consecutive Fights
Marcus Buchecha

Looks To Bounce Back
CFB

Sherrone Moore Charged with Home Invasion, Among Other Charges
CFB

Freddie Kitchens Fired from North Carolina Coaching Staff

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP