👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

FanDuel MLB DFS Lineup Picks (4/21/21): Daily Fantasy Baseball Advice

Mike Marteny highlights the top FanDuel MLB DFS lineup picks for 4/21/21, and a couple of sleepers to consider while building daily rosters.

It's getaway day in MLB, so only six games permeate the main night slate. Only one pitcher tips the five-figure scale. Can we get away with a fade here? Are there enough other options to gain an advantage by using a cheaper pitcher? We'll get into that.

Rain could affect the start time of the Yankees game, but they should be able to get the game in after an initial delay. The only thing to worry about would be if they can't keep the field in good shape when it rains throughout the afternoon. I do expect it to play and the wind should be blowing heavily out to right. Use pitching at your own risk in that one. They are going to have problems getting the Boston game in. It's possible that the rain will miss Boston, but right now it doesn't look promising.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel main slate on 4/21/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's DraftKings MLB DFS lineup picks, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

FanDuel DFS Pitchers

Cash Game/GPP Anchor Play:

Aaron Civale – CWS at CLE($10,200)

Civale beat the White Sox just five days ago, but he only picked up four strikeouts. The lack of strikeout potential is a bit of a ding on him, but he is 3-0 with a 2.18 ERA so far this year. Civale hasn't gone less than six innings in any start this year. That alone gives him the highest floor on this slate. Civale isn't a high strikeout guy so I can get on board with a fade here. The big issue is that there aren't many good secondary options.

Potential Alternate Play

Tyler Mahle – CIN vs. ARI($8,800)   

The issue with Mahle over the course of his career has been his ability to get through the order a second time. He simply doesn't go deep into games. Over the course of 64 career starts, Mahle averages just a shade over five innings per start. That's not much time to accumulate points. This season has been much of the same with Mahle only pitching 14 innings across three starts. It has nothing to do with his effectiveness because in the start in which he only lasted four innings, Mahle did not give up a run. That was against tonight's opponent, Arizona. Mahle still picked up 30 FanDuel points in that game. The thing that has me leaning towards Mahle is the 22 strikeouts in 14 innings. That's something I can work with.

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

FanDuel DFS Infielders

Joey Votto – 1B, CIN vs. AZ ($2,800)

It has been a rough start for Merrill Kelly again this year. A small ballpark with the wind blowing out wont help him either. Votto has only been shut out in one game this season and just got done with a series in which he destroyed Cleveland pitching. The Arizona staff and bullpen is significantly worse. Votto makes a lot of hard contact against the fastball and changeup that Kelly throws, which comprises almost 70% of his pitches to lefties. He should be able to stay hot here.

Ozzie Albies – 2B, ATL at NYY ($3,000)

Corey Kluber has really struggled this year and this is a terrible matchup for him anyway. Kluber's fastball velocity is down a bit which could explain the struggles. Still, this is not a team you want to struggle against. I'm not going hard after Kluber since the Yankees bullpen has one again been a strength. Albies profiles well and is reasonably priced.

Jose Ramirez – 3B, CLE vs. CWS ($3,300)

This feels cheap for Ramirez, especially when you consider that the White Sox basically turning this into a bullpen game. Ramirez started slowly, but he has 78.4 FanDuel points over the last five games. I'm not scared of Jonathan Stiever or the White Sox bullpen. Stiever struggled in his cup of coffee in 2020 and he didn't have a strong spring either. ATTACK!

Javier Baez – SS, CHC vs. NYM ($3,800)

Kris Bryant has been the talk of the Cubs this year and for good reason. However, he doesn't profile nearly as well as Baez does. Baez absolutely destroys sliders with a 72.7% hard contact rate. The only thing he doesn't profile well against is changeups. All eight home runs that David Peterson has allowed in his career have been given up to righties. If anyone is hitting one in Wrigley tonight, the metrics strongly suggest that it will be Baez.

 

FanDuel DFS Outfielders

Jesse Winker – OF, CIN vs. AZ ($3,700)

Winker is leading off a potent offense against a pitcher that has given up a run per inning so far this year in a small ballpark with the wind blowing out. The Arizona bullpen has been one of the better units so far this year, but I'm banking on the Reds putting up some big numbers against Kelly before they knock him out of the game.

Franmil Reyes – OF, CLE vs. CWS ($3,200)

Reyes has the rawest power of anyone on the team. Reyes made up for his cold series on the Southside last week in which he went 0-13 by picking up three hits and a walk in the first game of the series in Cleveland. We don't really know who or what the White Sox are going to throw at Cleveland tonight. We only know that Jonathan Stievers will be part of it. That's good enough for me knowing he has a bullpen with an ERA on the wrong side of 4 backing him up.

Jorge Soler – OF, KC vs. TB($2,600)

Soler is quite familiar with Michael Wacha. He started his career with the Cubs when Wacha was with the Cardinals. Then Soler moved to Kansas City where they play the Cardinals in the I-70 series every year. Wacha is 5-12 with three homers, seven runs, and seven RBI in his career against Wacha. BvP worked for those of us last night who threw a struggling Mitch Moreland out there against Matt Shoemaker. This could work for a struggling Soler as well.

 

FanDuel DFS Stacks Options

  • Cincinnati Reds
  • Kansas City Royals
  • Cleveland Indians
  • Chicago Cubs right-handers



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Nino Niederreiter

Rejoins Jets Lineup
Brandon Hagel

Sits Out Third Consecutive Game
DAL

Nathan Bastian to Miss 3-4 Weeks
Mike Trout

Held Out of Series Opener Against Braves
Sam Merrill

Set to Suit Up on Monday
Donovan Mitchell

Ruled Out Monday
Alejandro Kirk

to Undergo Thumb Surgery on Tuesday
James Harden

Out Monday
Juan Soto

Mets Place Juan Soto on 10-Day Injured List
Matthew Boyd

Cubs Putting Matthew Boyd on 15-Day Injured List With Biceps Strain
Mickey Moniak

Goes Yard Twice Against his Old Team
Brent Rooker

Homers Twice, Drives in Six in Win Over Astros
Mike Trout

Considered Day-to-Day With Hand Contusion
New York Giants

Dexter Lawrence Requests a Trade, Won't Take Part in Offseason Program
Brooks Koepka

Needs his Putter to Work at Augusta National
Cameron Young

Playing Incredibly Well Heading into 2026 Masters
Kyle Williams

Is Kyle Williams the Latest Patriots Draft Bust at Wide Receiver?
Elic Ayomanor

Should Benefit from Improved Quarterback Play
Isaac TeSlaa

Unlikely to Repeat Touchdown Efficiency
Deebo Samuel Sr.

Remains Unsigned
Darius Slayton

Where Does Darius Slayton Fit Among a Crowd of Giants Pass-Catchers?
Vít Krejčí

Vit Krejci Still Sidelined Monday
Bruce Brown

Likely Available vs. Portland
Spencer Jones

Remains Sidelined Monday
Isaiah Stewart

Remains Out Monday vs. Orlando
Dillon Brooks

Risks Suspension After 18th Technical Foul
Daniel Gafford

Leaves Game Early with Shoulder Injury
Luka Dončić

Luka Doncic to Undergo Hamstring Treatment in Europe
Will Cuylle

Grabs First Career Hat Trick in Blowout Win
Jacob Markstrom

Records First Shutout of the Season
Brady Tkachuk

Scores Twice Against Hurricanes
Sidney Crosby

Registers Three Points in Sunday's Win
Robert Thomas

Pots First Career Hat Trick
Valeri Nichushkin

Labeled Day-to-Day
Chris Duncan

Suffers Second-Round Submission Loss
Renato Moicano

Gets Back In The Win Column
Tabatha Ricci

Gets Outgrappled
Virna Jandiroba

Bounces Back
Brendson Ribeiro

Suffers First-Round Submission Loss
Abdul-Rakhman Yakhyaev

Earns First-Round Submission Win
Rafael Estevam

Suffers His First Loss
Ethyn Ewing

Dominates At UFC Vegas 115
Pat Bryant

Year 2 Breakout No Longer in the Cards?
Troy Franklin

Set to Take a Step Backward in 2026?
Sam Howell

Joe Milton III to Compete for Backup Role
Cameron Ward

Working in the Building, Making Good Progress
Will Levis

Titans to Trade Will Levis Before the Draft?
Jacob Markstrom

Shuts Out the Canadiens
Brady Tkachuk

Scores Twice on Sunday
Cameron Payne

Out at Least Two Weeks
Duncan Robinson

Iffy for Monday
Jerami Grant

Out Again Monday
Tobias Harris

Questionable Vs. Magic
Karl-Anthony Towns

Back Against Atlanta
Joel Embiid

Available Monday Vs. Spurs
Mike Trout

Exits Early After Getting Hit by Pitch
Brandon Williams

Good to Go Sunday
Marvin Bagley III

Available Sunday Against Lakers
Moussa Diabaté

Moussa Diabate Back in Lineup Sunday
Kirill Kaprizov

Bags Sixth Career Hat Trick Sunday
Stuart Skinner

Nursing Upper-Body Injury
Charlie Lindgren

Gets the Nod Sunday
Pavel Buchnevich

Ready to Play Sunday Night
Jordan Staal

Jordan Martinook Unavailable Sunday
Frederik Andersen

Takes on Senators Sunday
Linus Ullmark

Faces Hurricanes Sunday
Trevor Lawrence

Can a Dynamic Surrounding Cast Lead Trevor Lawrence to Another Career Year?
Malik Willis

Dolphins Want to Build Around Malik Willis
Courtland Sutton

Has Courtland Sutton's Dropping Dynasty Value Made Him a Buy-Low Candidate?
Ryan Rollins

Available Against Grizzlies
David Njoku

One of the Top Remaining Free Agents
Leonard Miller

Matas Buzelis Out Sunday, Leonard Miller Joins Starting Lineup
Tyler Warren

has Room to Grow in Year 2
Pete Fairbanks

Serving as Opener Before Going on Paternity List
George Klassen

Called Up to Start on Sunday
Stephon Gilmore

Announces his Retirement
Hunter Brown

Placed on 15-Day Injured List with Right-Shoulder Strain
Matthew Stafford

Rams to Put Matthew Stafford on Pitch Count Ahead of 2026 Season?
Isaiah Likely

John Harbaugh "Certain" Isaiah Likely Will Break Out
New York Jets

Jets "Leaning Toward" Arvell Reese at No. 2 Overall
Cleveland Browns

Browns Targeting Carnell Tate at No. 6 Overall?
Jesús Luzardo

Jesus Luzardo Dominates Rockies on Saturday
Byron Buxton

Back in Sunday's Lineup
Mookie Betts

Heading to the Injured List With Oblique Strain
Cade Horton

Cubs Place Cade Horton on 15-Day Injured List With Forearm Strain
Clayton Keller

Collects Four Points Against Canucks
Jack Eichel

Records Three Assists in Saturday's Win
Gabe Perreault

Nets First Career Hat Trick
Mookie Betts

Considered Day-to-Day, Heading for an MRI on Saturday
Juan Soto

Day-to-Day With Minor Groin Strain, No Decision on IL Yet
MLB

Cubs-Guardians Game Postponed on Saturday
Mookie Betts

Leaves Early With Back Injury
Alejandro Kirk

Placed on 10-Day Injured List With Thumb Fracture
Juan Soto

Mets Concerned About Juan Soto's Calf Injury
Chris Duncan

Set For UFC Vegas 115 Main Event
Renato Moicano

An Underdog At UFC Vegas 115
Tabatha Ricci

Set For UFC Vegas 115 Co-Main Event
Virna Jandiroba

Looks To Bounce Back
Brendson Ribeiro

In Desperate Need Of Win
Abdul-Rakhman Yakhyaev

Looks To Remain Unbeaten
Ethyn Ewing

Set For His Second UFC Bout
Rafael Estevam

Looks To Remain Undefeated
CFB

Gunner Stockton Looking "Great" After Offseason Injury
CFB

Sam Leavitt Showing "Encouraging Signs" at LSU Practice
J.J. Spaun

Needs the Putter to Cooperate in San Antonio
Thorbjorn Olesen

Trending Up in San Antonio
Denny McCarthy

Carrying Momentum into San Antonio
Chris Kirk

Has Course History on His Side in San Antonio
Billy Horschel

a Volatile Option at the Valero Texas Open
Joe Highsmith

Still Searching for Form in San Antonio
Christiaan Bezuidenhout

Looks to Find Form at the Valero Texas Open
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF