X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


DraftKings, FanDuel Daily Fantasy Baseball Picks (9/22/22): MLB DFS Lineups

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 22nd, 2022. John Brubaker's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Thursday RotoBallers! This is John Brubaker dropping some of my favorite plays for today's slate. After a bit of a bigger slate last week relative to the weeks before, we have a very solid slate tonight, with an eight-game slate on DraftKings and FanDuel. It is nicer to have a bit of a larger player pool tonight than in previous weeks.

We don't have any slate differences tonight, which is always a good thing. That way I don't have to make selections that may be on one slate and not the other. I have big ideas for tonight's slate, so let's get right to it.

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel at 6:35 pm on 9/22/2022. The lineup picks will range from some elite players to mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. It's also essential to monitor injury news and today's MLB starting lineups. Now that we got all of that out of the way, it's onto the picks!

Featured Promo! Save 50% on any PGA Premium Pass using discount code MASTERS, this week only! Win more with our DFS and Betting Packages, get expert tools and advice from proven winners including the Lineup Optimizer, Research Station, betting/props cheat sheet and more. GAIN FULL ACCESS HERE

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Shane Bieber, CLE at CWS ($10,100 DK, $10,800 FD)

We'll start tonight's slate off with Shane Bieber. Bieber has been on a heater of late, logging at least 25 DraftKings points and 45 FanDuel points in each of his last five starts. While my projections don't have him reaching those marks tonight, I'm still high on him this evening against a White Sox team that never seemed to get their footing this season. Bieber is 7-4 with a 2.66 ERA against the Sox in his career, and projects to a 3.26 xFIP and 26.31% strikeout rate against them tonight.

DraftKings Projection: 21.1

FanDuel Projection: 38.5

Hayden Wesneski, CHC at PIT ($6,900 DK, $8,100 FD)

I'll be taking a look at Hayden Wesneski tonight, who's making just his fourth start. He's had two really good starts and one not-so-good start thus far, but I'm projecting that he'll have one of those "good" starts tonight. I project Wesneski to a 3.64 xFIP and 25.64% strikeout rate this evening, and I expect him to silence the Pirates bats tonight en route to a quality start and potentially a win.

DraftKings Projection: 18.2

FanDuel Projection: 29.7

Also consider: Justin Verlander, Max Fried

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's Jon Anderson on DraftKings - join in on the winning!

🍾 BOOM!! A huge congrats to Jon, winning a juicy $50k last night!

Be sure to read his premium MLB #DFS articles 3x a week, all his other excellent analysis, and give a follow @JonPgh - all very much worth it 👌

Win Big With #RotoBaller ➡️ https://t.co/1uotAV6253 https://t.co/ipSgrl5dOr

— RotoBaller (@RotoBaller) May 10, 2022

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Austin Riley - 3B, ATL vs. Ranger Suarez ($5,300 DK, $3,800 FD)

As far as hitters go, I'll start off with Austin Riley. I'll always make a point to make sure I play Riley whenever he faces a lefty. He's absolutely crushed left-handed pitchers this year, with a .854 wOBA + ISO against them. He projects to a 42.46% hard contact rate and .662 wOBA + ISO against Phillies starter Ranger Suarez's pitch types. Riley is just 2-9 with a double off of Suarez but has drawn three walks. He now has to see Riley and Braves for the second consecutive start, something that seems to never bode well for pitchers.

DraftKings Projection: 10.9

FanDuel Projection: 13.8

Willy Adames - SS, MIL vs. Hunter Greene ($4,700 DK, $3,500 FD)

I'll look at Willy Adames at the shortstop position tonight. Adames draws a solid matchup against Cincinnati right-hander Hunter Greene. He projects to a 36.98% hard contact rate and a whopping .763 wOBA + ISO against the fireballer. He's had some past success against Greene as well, going 2-6 with two homers and two walks against the 23-year-old righty.

DraftKings Projection: 10.3

FanDuel Projection: 13.1

Jonathan Aranda - 2B, TB  vs. Jose Berrios ($2,400 DK, $2,100 FD)

If we're looking for value, we don't need to look much further than Rays second baseman Jonathan Aranda. Aranda has logged just 50 at-bats this season and comes into this game hitting .260 with a .739 OPS. He projects to a 34.78% hard contact rate and .693 wOBA + ISO against Berrios's pitch types.

DraftKings Projection: 7.6

FanDuel Projection: 9.3

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Yordan Alvarez - OF, HOU vs. Kyle Bradish ($6,300 DK, $4,700 FD)

As far as outfielders go we'll go right back to where we went last week, Yordan Alvarez. Yordan had gone on a heater since I wrote him up last, going 10-24 with four homers in the last week. After a quiet night last night, he'll look to get back in form tonight against Baltimore righty Kyle Bradish, with whom he projects a 44.61% hard contact rate and .753 wOBA + ISO against his pitch types. He's 0-2 with a walk in just three at-bats against the righty, but that should change tonight.

DraftKings Projection: 12.1

FanDuel Projection: 15.8

Hunter Renfroe - OF, MIL vs. Hunter Greene ($4,000 DK, $2,900 FD)

I'll speak more on the Brewers as a whole in a bit, but I'll be taking a look at Hunter Renfroe tonight. Renfroe has been relatively quiet this season, coming into this game with a .248 average and .783 OPS. He projects to a whopping 16% home run rate, among the highest on the slate, as well as a 38.14% hard contact rate and .654 wOBA + ISO against Hunter Greene's pitch types. Renfroe's among the top of the board in terms of value tonight on both sites.

DraftKings Projection: 10.1

FanDuel Projection: 13.4

David Peralta - OF, TB vs. Jose Berrios ($3,100 DK, $2,500 FD)

I'll finish things off tonight with Rays outfielder David Peralta. Things haven't necessarily worked out for me when rostering Peralta this season, but I'll look for that to change tonight. He projects to a 35.06% hard contact rate and .635 wOBA + ISO against Jose Berrios's pitch types. Peralta's just 1-5 with a walk against Berrios in his career, but I think the Rays are a sneaky stack on this slate, and for me, where the Rays go, Peralta goes.

DraftKings Projection: 7.7

FanDuel Projection: 9.7

 

DraftKings, FanDuel MLB DFS Stacks

Milwaukee Brewers vs. Hunter Greene

I'll start off my favorite stack with the top-rated stack according to my model tonight, the Milwaukee Brewers. They'll take on Hunter Greene, a starter that has had his struggles against the Brew Crew this season. Greene is 0-2 with a 9.69 ERA against Milwaukee this season. The Brewers have done their part against righties this season as well, ranking 5th in OPS (.750) and wOBA (.326), tied for 9th in wRC+ (109).

Favorite Plays: Willy Adames, Hunter Renfroe, Christian Yelich, Rowdy Tellez, Tyrone Taylor

Houston Astros vs. Kyle Bradish

I'll look to Baltimore for the second stack of the night, the Houston Astros. The Astros technically rank fourth in terms of stack value on my model but have the all-around numbers including pitch-type data for me to bump them up to my second favorite on the slate. Orioles starter Kyle Bradish tossed his best start of the season against the Stros back on August 26, going eight shutout innings and allowing just two hits while striking out six. However, I'll back Houston here as they rank 7th in OPS (.732), 8th in wOBA (.319), and are tied with the Brewers and Cardinals for 6th in wRC+ (109).

Favorite Plays: Yordan Alvarez, Alex Bregman, Trey Mancini, Kyle Tucker, Jeremy Pena, Aledmys Diaz

Also Consider: Boston Red Sox, Tampa Bay Rays



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!



MLB DFS News and Injury Alerts

More DFS Lineup Picks and Analysis




REAL-TIME FANTASY NEWS

Bijan Robinson

Is Bijan Robinson's Dynasty Value Limited by Questionable Offensive Environment?
Woody Marks

Carries Buy-Low Appeal for Dynasty Managers Entering 2026
Antonio Williams

Poised for Dynasty Breakout in Washington?
Tyler Warren

Poised for Expanded Role in Indianapolis?
Seth McGowan

"Right in the Thick" of RB2 Battle in Indianapolis
Ashton Dulin

Poised to Win Starting Role in Indianapolis?
CFB

Brendan Sorsby Receives Injunction, Eligible for 2026 College Football Season
Gabriel Bonfim

Shines At UFC Vegas 118
Belal Muhammad

Suffers Third Consecutive Loss
Chris Rodriguez Jr.

Is Chris Rodriguez Jr. Falling Behind in Jaguars Running Back Battle?
Edmen Shahbazyan

Suffers Unanimous-Decision Loss
Edmen Shahbazyan

Brendan Allen Gets Unanimous-Decision Win Over Edmen Shahbazyan
Drew Allar

a Smart Stash in the Middle Rounds of Dynasty Rookie Drafts
Chris Olave

Still a High-Upside Dynasty Swing for the Risk Tolerant
Tom Nolan

Extends Win Streak
Farés Ziam

Fares Ziam Drops Decision At UFC Vegas 118
Jayden Higgins

"Going to Have a Great Year"
Jacoby Brissett

Expected to Report to Minicamp
Tarik Skubal

Dominates in Rehab Start, Return Appears Imminent
Mitchell Robinson

Available for Game 3
Chicago Bulls

Bulls Hire Alex Kaufman as Windy City Bulls General Manager
E.J. Liddell

Agrees to Two-Year Deal with Greek Club Aris
Konnor Griffin

is Looking at Extended Absence
Matas Buzelis

Will Play for Lithuania This Summer
Kenley Jansen

to Begin Rehab Assignment on Tuesday
Giannis Antetokounmpo

Has Concerns About Heat Roster If Traded to Miami
Casey Mize

to Make Rehab Start on Tuesday
Bobby Witt Jr.

Exits Early with Knee Soreness
Mitchell Robinson

Has Technical Foul Rescinded After Game 2 Win
Jarquez Hunter

Is it Time for Dynasty Managers to Move on From Jarquez Hunter?
Elijah Arroyo

Worth Buying Low on in Dynasty Formats?
Tre Tucker

Profiles as a Dynasty Sell-High Candidate Entering 2026
Jack Bech

Should Dynasty Managers Target Jack Bech as a Buy-Low Candidate?
Jaydon Blue

a Dynasty Buy-Low Candidate After Underwhelming Rookie Year?
Saquon Barkley

in Line for Larger Pass-Catching Role in 2026?
Max Fried

Nearing Return to Mound Work?
Karl-Anthony Towns

Eligible for Massive Extension
Isaiah Stewart

Could Draw Trade Interest
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Michigan?
Philadelphia 76ers

Jameer Nelson Promoted to Executive Vice President
Domantas Sabonis

Could be Traded This Summer
Ty Gibbs

Is Ty Gibbs Worth Rostering at Michigan This Week for DFS?
William Byron

Will Start at the Rear at Michigan After Unapproved Adjustments
NASCAR

Should DFS Managers Roster Bubba Wallace at Michigan?
Joey Logano

Is Joey Logano Worth Rostering In DFS Lineups for Michigan
Daniel Suarez

Might Have Tournament Appeal for Michigan DFS Lineups
Jonah Coleman

Is Jonah Coleman the Most Valuable Broncos Running Back in Dynasty Leagues?
William Carrier

Suffers Upper-Body Injury in Game 3 Versus Golden Knights
Darius Slayton

Will Darius Slayton Be Phased Out of New-Look Giants Offense?
Sebastian Aho

Records Two Assists in Losing Effort
Alex Lange

Earns Third Save, Quickly Entering Must-Roster Status
Keaton Mitchell

Can Keaton Mitchell Carve Out a Large Enough Role for a Fantasy Breakout?
Jordan Staal

Scores in Third Consecutive Game
Shea Theodore

Caps Multi-Point Effort With Game-Winning Goal Saturday
Kayshon Boutte

Will Attend Mandatory Minicamp
Denny Hamlin

Puts DFS Managers in Tough Spot for Michigan
Chase Elliott

Can Chase Elliott Get Back to His Old Ways at Michigan?
Chris Buescher

Looking for Another Solid Run at Michigan
Tomas Hertl

Collects Two Points in Overtime Win
Carson Hocevar

Qualifies Second, Seeking Redemption at Michigan
Ross Chastain

Can DFS Managers Trust Ross Chastain at Michigan?
Mitch Marner

Scores Fastest Hat Trick in Finals History
Brad Keselowski

Has Been Solid at Michigan
Will Smith

Scratched With Neck Stiffness, Expected to Return on Sunday
Auston Matthews

Maple Leafs Confident of Keeping Auston Matthews
Andrei Vasilevskiy

Wins Second Vezina Trophy
Brayden McNabb

Uncertain for Game 3 Against Hurricanes
Hunter Greene

Could Return Before the All-Star Break
Dylan Harper

Remains a Bright Spot for San Antonio
De'Aaron Fox

Shoots Well in a Loss to the Knicks
Victor Wembanyama

Scores 29 Points in Game 2 Loss
OG Anunoby

Anchors Knicks' Defense in Finals Game 2
Mikal Bridges

Helps Knicks Secure a Game 2 Victory
Karl-Anthony Towns

Records Another Finals Double-Double
Jalen Brunson

Overcomes Cold Night to Seal Game 2
Michael Harris II

Dealing With Back Tightness, Not Believed to be Serious
Byron Buxton

Suffers Shoulder Contusion After Colliding With the Wall
Sacramento Kings

Kings Want to Trade Their Larger Contracts
Chicago Bulls

Darius Acuff Jr. Works Out for Bulls
Jaime Jaquez Jr.

Could Get Traded
MIN

Marcus Johansson Returning to Europe
Thomas White

Likely to Miss Rest of Season With Shoulder Capsular Sprain
Mitchell Robinson

is Upgraded to Available for Game 2
Cole Caufield

Earns Lady Byng Trophy
Nick Suzuki

Lands Selke Trophy
Jose Altuve

Astros Reinstate Jose Altuve From the Injured List
CFB

Reed Harris Hoping to Fill Void in Arizona State Receiving Room
CFB

Nick Marsh Gearing Up for Breakout
CFB

Drew Mestemaker Looking to Catapult Oklahoma State Offense in 2026
CFB

Rocco Becht Brings Experience to New-Look Nittany Lions
CFB

Can Trey White, Adam Trick Keep Texas Tech's Defensive Front Elite?
CFB

Devon Dampier is Key to Success for Morgan Scalley in Year 1
Aaron Judge

Yankees Officially Place Aaron Judge on Injured List With Fractured Rib
Francisco Lindor

Expected to Return in "About a Couple Weeks"
Corey Seager

Rangers Activate Corey Seager From the Injured List
Gabriel Bonfim

Set For UFC Vegas 118 Main Event
Belal Muhammad

In Dire Need Of Win
Edmen Shahbazyan

An Underdog At UFC Vegas 118
Shayne Gostisbehere

Dishes Out Two Power-Play Assists in Comeback Win
Brendan Allen

Looks For His Third Win In A Row
Seth Jarvis

Ties Finals With Power-Play Goal
Mark Stone

Scores Sixth Playoff Goal in Overtime Defeat
Tom Nolan

Searches For His Fifth Consecutive Win
Mitch Marner

Records Two Assists in Game 2 Loss
Farés Ziam

Fares Ziam A Favorite At UFC Vegas 118
Brett Howden

Matches Franchise Record With Another Productive Outing
Brayden McNabb

Hospitalized After Taking Puck to Face
Aaron Judge

Diagnosed with Stress Fracture, Out 4-6 Weeks
Shohei Ohtani

has "Small" Blister, a "Non-Issue" for his Pitching Starts
Brent Rooker

Out on Thursday Due to Knee Soreness
Frederik Andersen

Hurricanes Retain Confidence in Frederik Andersen
Vincent Trocheck

Maple Leafs Interested in Vincent Trocheck
Dylan Larkin

Requests Trade From Red Wings
Corey Seager

Expected to Return This Weekend
Lucas Erceg

Royals to Mix and Match in Ninth With Lucas Erceg Struggling
Rickie Fowler

Looks To Continue Resurgent Season At Memorial
CFB

Can Eric Singleton Jr. Fully Break Out at Third School?
CFB

Katin Houser Steps into QB1 Role for Illinois
CFB

Savion Hiter an Immediate Impact Freshman for Michigan
CFB

Isaiah Horton Set to Take Over KC Concepcion's Role
CFB

UCLA Transfer Karson Gordon Signs with Austin Peay
CFB

Will Muschamp Bringing New Intensity to Texas Practices
Gary Woodland

Brings Boom-or-Bust Potential to Memorial
Jordan Spieth

Still Searching for a Breakthrough
Alex Smalley

Brings Elite Form to Memorial Tournament
Justin Rose

Looks to Recapture Memorial Tournament Success
Cameron Young

Looks to Get Back to His Contending Ways at Murifield Village
Chris Gotterup

Needs to Find Fairways at Muirfield Village
Si Woo Kim

Looks to Stay Hot at Memorial Tournament
Matt Fitzpatrick

Positioned for Success at Muirfield Village
Keegan Bradley

Looking for Another Strong Finish at Muirfield
Justin Thomas

is an Exciting Play This Week in Ohio
Scottie Scheffler

Looks to Win Memorial Tournament for Third Consecutive Year
Rory McIlroy

Looking for Better Performance at Muirfield Village
Russell Henley

Coming to Ohio on the Heels of Latest Victory
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF