X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (9/22/22): MLB DFS Lineups

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 22nd, 2022. John Brubaker's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Thursday RotoBallers! This is John Brubaker dropping some of my favorite plays for today's slate. After a bit of a bigger slate last week relative to the weeks before, we have a very solid slate tonight, with an eight-game slate on DraftKings and FanDuel. It is nicer to have a bit of a larger player pool tonight than in previous weeks.

We don't have any slate differences tonight, which is always a good thing. That way I don't have to make selections that may be on one slate and not the other. I have big ideas for tonight's slate, so let's get right to it.

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel at 6:35 pm on 9/22/2022. The lineup picks will range from some elite players to mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. It's also essential to monitor injury news and today's MLB starting lineups. Now that we got all of that out of the way, it's onto the picks!

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Shane Bieber, CLE at CWS ($10,100 DK, $10,800 FD)

We'll start tonight's slate off with Shane Bieber. Bieber has been on a heater of late, logging at least 25 DraftKings points and 45 FanDuel points in each of his last five starts. While my projections don't have him reaching those marks tonight, I'm still high on him this evening against a White Sox team that never seemed to get their footing this season. Bieber is 7-4 with a 2.66 ERA against the Sox in his career, and projects to a 3.26 xFIP and 26.31% strikeout rate against them tonight.

DraftKings Projection: 21.1

FanDuel Projection: 38.5

Hayden Wesneski, CHC at PIT ($6,900 DK, $8,100 FD)

I'll be taking a look at Hayden Wesneski tonight, who's making just his fourth start. He's had two really good starts and one not-so-good start thus far, but I'm projecting that he'll have one of those "good" starts tonight. I project Wesneski to a 3.64 xFIP and 25.64% strikeout rate this evening, and I expect him to silence the Pirates bats tonight en route to a quality start and potentially a win.

DraftKings Projection: 18.2

FanDuel Projection: 29.7

Also consider: Justin Verlander, Max Fried

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's Jon Anderson on DraftKings - join in on the winning!

🍾 BOOM!! A huge congrats to Jon, winning a juicy $50k last night!

Be sure to read his premium MLB #DFS articles 3x a week, all his other excellent analysis, and give a follow @JonPgh - all very much worth it 👌

Win Big With #RotoBaller ➡️ https://t.co/1uotAV6253 https://t.co/ipSgrl5dOr

— RotoBaller (@RotoBaller) May 10, 2022

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Austin Riley - 3B, ATL vs. Ranger Suarez ($5,300 DK, $3,800 FD)

As far as hitters go, I'll start off with Austin Riley. I'll always make a point to make sure I play Riley whenever he faces a lefty. He's absolutely crushed left-handed pitchers this year, with a .854 wOBA + ISO against them. He projects to a 42.46% hard contact rate and .662 wOBA + ISO against Phillies starter Ranger Suarez's pitch types. Riley is just 2-9 with a double off of Suarez but has drawn three walks. He now has to see Riley and Braves for the second consecutive start, something that seems to never bode well for pitchers.

DraftKings Projection: 10.9

FanDuel Projection: 13.8

Willy Adames - SS, MIL vs. Hunter Greene ($4,700 DK, $3,500 FD)

I'll look at Willy Adames at the shortstop position tonight. Adames draws a solid matchup against Cincinnati right-hander Hunter Greene. He projects to a 36.98% hard contact rate and a whopping .763 wOBA + ISO against the fireballer. He's had some past success against Greene as well, going 2-6 with two homers and two walks against the 23-year-old righty.

DraftKings Projection: 10.3

FanDuel Projection: 13.1

Jonathan Aranda - 2B, TB  vs. Jose Berrios ($2,400 DK, $2,100 FD)

If we're looking for value, we don't need to look much further than Rays second baseman Jonathan Aranda. Aranda has logged just 50 at-bats this season and comes into this game hitting .260 with a .739 OPS. He projects to a 34.78% hard contact rate and .693 wOBA + ISO against Berrios's pitch types.

DraftKings Projection: 7.6

FanDuel Projection: 9.3

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Yordan Alvarez - OF, HOU vs. Kyle Bradish ($6,300 DK, $4,700 FD)

As far as outfielders go we'll go right back to where we went last week, Yordan Alvarez. Yordan had gone on a heater since I wrote him up last, going 10-24 with four homers in the last week. After a quiet night last night, he'll look to get back in form tonight against Baltimore righty Kyle Bradish, with whom he projects a 44.61% hard contact rate and .753 wOBA + ISO against his pitch types. He's 0-2 with a walk in just three at-bats against the righty, but that should change tonight.

DraftKings Projection: 12.1

FanDuel Projection: 15.8

Hunter Renfroe - OF, MIL vs. Hunter Greene ($4,000 DK, $2,900 FD)

I'll speak more on the Brewers as a whole in a bit, but I'll be taking a look at Hunter Renfroe tonight. Renfroe has been relatively quiet this season, coming into this game with a .248 average and .783 OPS. He projects to a whopping 16% home run rate, among the highest on the slate, as well as a 38.14% hard contact rate and .654 wOBA + ISO against Hunter Greene's pitch types. Renfroe's among the top of the board in terms of value tonight on both sites.

DraftKings Projection: 10.1

FanDuel Projection: 13.4

David Peralta - OF, TB vs. Jose Berrios ($3,100 DK, $2,500 FD)

I'll finish things off tonight with Rays outfielder David Peralta. Things haven't necessarily worked out for me when rostering Peralta this season, but I'll look for that to change tonight. He projects to a 35.06% hard contact rate and .635 wOBA + ISO against Jose Berrios's pitch types. Peralta's just 1-5 with a walk against Berrios in his career, but I think the Rays are a sneaky stack on this slate, and for me, where the Rays go, Peralta goes.

DraftKings Projection: 7.7

FanDuel Projection: 9.7

 

DraftKings, FanDuel MLB DFS Stacks

Milwaukee Brewers vs. Hunter Greene

I'll start off my favorite stack with the top-rated stack according to my model tonight, the Milwaukee Brewers. They'll take on Hunter Greene, a starter that has had his struggles against the Brew Crew this season. Greene is 0-2 with a 9.69 ERA against Milwaukee this season. The Brewers have done their part against righties this season as well, ranking 5th in OPS (.750) and wOBA (.326), tied for 9th in wRC+ (109).

Favorite Plays: Willy Adames, Hunter Renfroe, Christian Yelich, Rowdy Tellez, Tyrone Taylor

Houston Astros vs. Kyle Bradish

I'll look to Baltimore for the second stack of the night, the Houston Astros. The Astros technically rank fourth in terms of stack value on my model but have the all-around numbers including pitch-type data for me to bump them up to my second favorite on the slate. Orioles starter Kyle Bradish tossed his best start of the season against the Stros back on August 26, going eight shutout innings and allowing just two hits while striking out six. However, I'll back Houston here as they rank 7th in OPS (.732), 8th in wOBA (.319), and are tied with the Brewers and Cardinals for 6th in wRC+ (109).

Favorite Plays: Yordan Alvarez, Alex Bregman, Trey Mancini, Kyle Tucker, Jeremy Pena, Aledmys Diaz

Also Consider: Boston Red Sox, Tampa Bay Rays



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!



MLB DFS News and Injury Alerts

More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Jakobi Meyers

Vying for Top Spot in Jacksonville Receiver Room
Jayden Higgins

Faces Obstacles in Second Season
Sam LaPorta

New Offensive Philosophy Could Help Sam LaPorta Break Back into Top Tier of Tight Ends
Jaylon Tyson

Unavailable Against Magic
Noah Gray

Remains Buried on Kansas City Depth Chart
Jarrett Allen

Still Out Tuesday
Anthony Black

Remains Out Tuesday
Jalen Suggs

to Miss Second Consecutive Game
Kon Knueppel

Probable Tuesday
Nique Clifford

Kings Plan to Re-Evaluate Nique Clifford in One Week
Moses Moody

Stretchered Off With Knee Injury
Luke Clanton

Might Have a Problem in Houston
Sam Stevens

Happy to See Houston This Week
Keith Mitchell

Tries to Rebound After THE PLAYERS Championship
Will Zalatoris

Returning This Week at Houston
Wyndham Clark

Trending in the Wrong Direction Heading to Houston
Shane Lowry

Seeking Better Luck in Houston This Weekend
Kurt Kitayama

Poised to Bounce Back at the Houston Open
Jake Knapp

More Suited for a Course Like the Houston Open
Tony Finau

Continues Playing Well Heading to Texas Children's Houston Open
Scottie Scheffler

Returns to Action for Texas Children's Houston Open
Sam Burns

Looks to Carry Momentum Into Houston
Pete Crow-Armstrong

Cubs, Pete Crow-Armstrong Finalizing Long-Term Extension
Cam Thomas

Bucks Waive Cam Thomas
Kyle Kuzma

Won't Play Against Clippers
John Collins

Misses Monday's Action
Kawhi Leonard

Available Monday Night
Caleb Martin

Brandon Williams Remain Out Monday
Brandon Ingram

a Late Scratch Versus Jazz
Sahith Theegala

to Rebound at Texas Children's Houston Open
De'Anthony Melton

Moses Moody, De'Anthony Melton Available Monday
Kristaps Porzingis

Ready to Rock Monday
Cody Williams

Ruled Out Monday
Immanuel Quickley

Jamal Shead Starting With Immanuel Quickley Out
Stephan Jaeger

Hopes to Jumpstart Season at Texas Children's Houston Open
Collin Murray-Boyles

Rejoins Raptors Lineup
Adam Scott

Hopes to Get Back on Track in Houston
Drake Powell

Slated to Miss Monday's Matchup With Portland
Peyton Watson

Ruled Out Tuesday
Blake Snell

Targeting a May Return
Obi Toppin

Cleared to Play Against Magic
PGA

Sungjae Im Looks to Carry Hot Play to Houston
Nicolai Hojgaard

to Get Back on Track in Houston
Hunter Greene

Reds Place Hunter Greene on 60-Day Injured List
Chris Gotterup

to be a Popular Choice at Texas Children's Houston Open
Blake Whiteheart

Returns to the Browns
Min Woo Lee

Looks to Keep Strong Season Going in Title Defense in Houston
J.J. Wetherholt

JJ Wetherholt Makes Cardinals Opening Day Roster
NFL

Ty Simpson Expected to be a First-Round Pick
Jake Bobo

Seahawks Match Offer Sheet for Jake Bobo
Tommy DeVito

Becomes QB2 in New England
Quentin Johnston

Chargers Unlikely to Trade Quentin Johnston?
Nick Pivetta

to Start on Opening Day for Padres
Brandon Woodruff

Makes Brewers Opening Day Rotation
Zack Wheeler

to Start Rehab Assignment on Saturday
Carson Benge

Makes Mets Opening Day Roster
D'Andre Swift

Facing Playing-Time Questions Heading into 2026
Travis Kelce

Officially Signs New Contract With the Chiefs
NFL

Can Denzel Boston Overcome Speed and Athleticism Concerns at the NFL Level?
NFL

Jadarian Price's Dynasty Stock is Rising as the 2026 Draft Approaches
NFL

Can Chris Bell Make an Immediate Impact in the NFL?
Seiya Suzuki

to Start the Season on the Injured List
Travis Homer

Signs With Steelers as RB Depth
Lerone Murphy

Suffers His First Loss
Dennis Santana

Won't be Pirates' Primary Closer
Movsar Evloev

Edges Out Lerone Murphy
CFB

Notre Dame Ranks No. 1 in Returning Production for 2026
Michael Aswell

Jr. Drops Decision At UFC London
Michael Aswell

Luke Riley Outclasses Michael Aswell Jr.
DeVonta Smith

Wide Range of Possible Outcomes for DeVonta Smith in 2026
Woody Marks

to Serve as Backup in Sophomore Season?
Puka Nacua

Extension for Puka Nacua isn't Expected Soon
Sam Patterson

Suffers Unanimous-Decision Loss
Michael Page

Wins Lackluster Decision
Austen Lane

Suffers First-Round TKO Loss
Joshua Dobbs

Patriots Planning to Release Joshua Dobbs
Spencer Strider

to Start the Season on Injured List
Iwo Baraniewski

Delivers 28-Second TKO
Lawson Crouse

Picks Up Three Points in Overtime Win
Jahmyr Gibbs

in Line for a Career Workload
Filip Forsberg

Takes Predators Past Blackhawks
Jaxon Smith-Njigba

Becomes Highest-Paid Wide Receiver in NFL History
Alex Ovechkin

Scores 1,000th Career Goal
Nate Schmidt

Exits Early Due to Illness
Matt Grzelcyk

to Miss Four-Game Road Trip
Mikko Rantanen

to Return to Full Practice
A.J. Greer

Handed a Three-Game Suspension
Troy Terry

Wins it for Anahiem
Tyler Reddick

Overcomes Adversity for Fourth Victory of the Season At Darlington
Brad Keselowski

Falls Short of Darlington Victory Despite Domination
Ryan Blaney

Recovers From Pit-Road Struggles to Score Career-Best Darlington Finish
Carson Hocevar

Rallies to Finish Fourth at Darlington
Kyle Larson

Decent Performance Ends with Technical Issues At Darlington
Ilya Sorokin

Earns Shutout Over Columbus
Ethen Frank

Sustains Lower-Body Injury Sunday
Grayson Rodriguez

to Open Season on Injured List
Brett Pesce

Questionable to Return This Season
Stefan Noesen

Done for the Season
Yan Kuznetsov

Misses Fourth Consecutive Game Sunday
Connor Zary

Out Sunday
Mike Trout

Returns on Sunday
Anthony Duclair

Misses Sunday's Game
Ryan Pulock

Unavailable Sunday
Nick Lodolo

Exits Early With a Blister
Jeremy Peña

Astros Not Ruling Out Jeremy Pena for Opening Day
Cristopher Sánchez

Phillies Sign Cristopher Sanchez to a Six-Year Extension
Tyler Reddick

the Clear Favorite at Darlington
Kyle Stowers

Placed on Injured List with Hamstring Strain
Kyle Larson

a High-Risk, High-Reward Driver at Darlington
Ryan Blaney

Is Getting Better at Darlington
NASCAR

Bubba Wallace Not Slowing Down at Darlington
Chris Buescher

Should be a Top-10 Contender at Darlington
Austin Cindric

a Sleeper at Darlington
Erik Jones

Quickest in Practice at Darlington
Morgan Geekie

Records Three Assists Against Red Wings
Steven Stamkos

Notches Three Points in Win Over Golden Knights
Cole Caufield

Records Career-High Five Points in Saturday's Win
Denny Hamlin

Qualifies Ninth for this Week's Cup Race at Darlington
Chase Briscoe

Is One of the Top DFS Options of the Week for Darlington
Nikita Kucherov

Takes Over Scoring Lead With Four-Point Effort
Tyler Tucker

Out Week-to-Week
William Byron

Is William Byron A Playable DFS Option for Darlington Lineups?
Christopher Bell

Could Christopher Bell be Considered A Decent DFS Option for Darlington?
Chase Elliott

Is Chase Elliott Worth Rostering At Darlington This Week For DFS?
Joey Logano

May Not Have the Speed to Warrant A Darlington DFS Lineup Spot
Ross Chastain

Should DFS Players Trust Ross Chastain at Darlington?
Kyle Busch

Could Kyle Busch Be A Worthy DFS Option for Darlington?
Brad Keselowski

May be A Contriarian DFS Tournament Option At Darlington
Seiya Suzuki

Won't be Ready for Opening Day
Gleyber Torres

Clear to Return on Monday
Konnor Griffin

Assigned to Minor-League Camp
Gleyber Torres

Scratched From Lineup on Saturday With Lower-Back Tightness
Lerone Murphy

Set For UFC London Main Event
Movsar Evloev

Looks To Remain Unbeaten
Michael Aswell

Jr. An Underdog At UFC London
Luke Riley

Set For UFC London Co-Main Event
Sam Patterson

Looks To Extend His Win Streak
Michael Page

Set For Welterweight Bout
Austen Lane

In Dire Need Of Victory
Iwo Baraniewski

A Favorite At UFC London
Akshay Bhatia

Withdraws From Valspar Championship
CFB

Alberto Mendoza Drawing Positive Reviews at Georgia Tech
CFB

Anthony Colandrea Impressing in Nebraska's Spring Practices
J.J. Spaun

Offers Upside Despite Poor Course History at Innisbrook
Aaron Rai

Looks to Bounce Back at Valspar Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF