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DraftKings, FanDuel Daily Fantasy Baseball Picks (9/22/22): MLB DFS Lineups

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 22nd, 2022. John Brubaker's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Thursday RotoBallers! This is John Brubaker dropping some of my favorite plays for today's slate. After a bit of a bigger slate last week relative to the weeks before, we have a very solid slate tonight, with an eight-game slate on DraftKings and FanDuel. It is nicer to have a bit of a larger player pool tonight than in previous weeks.

We don't have any slate differences tonight, which is always a good thing. That way I don't have to make selections that may be on one slate and not the other. I have big ideas for tonight's slate, so let's get right to it.

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel at 6:35 pm on 9/22/2022. The lineup picks will range from some elite players to mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. It's also essential to monitor injury news and today's MLB starting lineups. Now that we got all of that out of the way, it's onto the picks!

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DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Shane Bieber, CLE at CWS ($10,100 DK, $10,800 FD)

We'll start tonight's slate off with Shane Bieber. Bieber has been on a heater of late, logging at least 25 DraftKings points and 45 FanDuel points in each of his last five starts. While my projections don't have him reaching those marks tonight, I'm still high on him this evening against a White Sox team that never seemed to get their footing this season. Bieber is 7-4 with a 2.66 ERA against the Sox in his career, and projects to a 3.26 xFIP and 26.31% strikeout rate against them tonight.

DraftKings Projection: 21.1

FanDuel Projection: 38.5

Hayden Wesneski, CHC at PIT ($6,900 DK, $8,100 FD)

I'll be taking a look at Hayden Wesneski tonight, who's making just his fourth start. He's had two really good starts and one not-so-good start thus far, but I'm projecting that he'll have one of those "good" starts tonight. I project Wesneski to a 3.64 xFIP and 25.64% strikeout rate this evening, and I expect him to silence the Pirates bats tonight en route to a quality start and potentially a win.

DraftKings Projection: 18.2

FanDuel Projection: 29.7

Also consider: Justin Verlander, Max Fried

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DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Austin Riley - 3B, ATL vs. Ranger Suarez ($5,300 DK, $3,800 FD)

As far as hitters go, I'll start off with Austin Riley. I'll always make a point to make sure I play Riley whenever he faces a lefty. He's absolutely crushed left-handed pitchers this year, with a .854 wOBA + ISO against them. He projects to a 42.46% hard contact rate and .662 wOBA + ISO against Phillies starter Ranger Suarez's pitch types. Riley is just 2-9 with a double off of Suarez but has drawn three walks. He now has to see Riley and Braves for the second consecutive start, something that seems to never bode well for pitchers.

DraftKings Projection: 10.9

FanDuel Projection: 13.8

Willy Adames - SS, MIL vs. Hunter Greene ($4,700 DK, $3,500 FD)

I'll look at Willy Adames at the shortstop position tonight. Adames draws a solid matchup against Cincinnati right-hander Hunter Greene. He projects to a 36.98% hard contact rate and a whopping .763 wOBA + ISO against the fireballer. He's had some past success against Greene as well, going 2-6 with two homers and two walks against the 23-year-old righty.

DraftKings Projection: 10.3

FanDuel Projection: 13.1

Jonathan Aranda - 2B, TB  vs. Jose Berrios ($2,400 DK, $2,100 FD)

If we're looking for value, we don't need to look much further than Rays second baseman Jonathan Aranda. Aranda has logged just 50 at-bats this season and comes into this game hitting .260 with a .739 OPS. He projects to a 34.78% hard contact rate and .693 wOBA + ISO against Berrios's pitch types.

DraftKings Projection: 7.6

FanDuel Projection: 9.3

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Yordan Alvarez - OF, HOU vs. Kyle Bradish ($6,300 DK, $4,700 FD)

As far as outfielders go we'll go right back to where we went last week, Yordan Alvarez. Yordan had gone on a heater since I wrote him up last, going 10-24 with four homers in the last week. After a quiet night last night, he'll look to get back in form tonight against Baltimore righty Kyle Bradish, with whom he projects a 44.61% hard contact rate and .753 wOBA + ISO against his pitch types. He's 0-2 with a walk in just three at-bats against the righty, but that should change tonight.

DraftKings Projection: 12.1

FanDuel Projection: 15.8

Hunter Renfroe - OF, MIL vs. Hunter Greene ($4,000 DK, $2,900 FD)

I'll speak more on the Brewers as a whole in a bit, but I'll be taking a look at Hunter Renfroe tonight. Renfroe has been relatively quiet this season, coming into this game with a .248 average and .783 OPS. He projects to a whopping 16% home run rate, among the highest on the slate, as well as a 38.14% hard contact rate and .654 wOBA + ISO against Hunter Greene's pitch types. Renfroe's among the top of the board in terms of value tonight on both sites.

DraftKings Projection: 10.1

FanDuel Projection: 13.4

David Peralta - OF, TB vs. Jose Berrios ($3,100 DK, $2,500 FD)

I'll finish things off tonight with Rays outfielder David Peralta. Things haven't necessarily worked out for me when rostering Peralta this season, but I'll look for that to change tonight. He projects to a 35.06% hard contact rate and .635 wOBA + ISO against Jose Berrios's pitch types. Peralta's just 1-5 with a walk against Berrios in his career, but I think the Rays are a sneaky stack on this slate, and for me, where the Rays go, Peralta goes.

DraftKings Projection: 7.7

FanDuel Projection: 9.7

 

DraftKings, FanDuel MLB DFS Stacks

Milwaukee Brewers vs. Hunter Greene

I'll start off my favorite stack with the top-rated stack according to my model tonight, the Milwaukee Brewers. They'll take on Hunter Greene, a starter that has had his struggles against the Brew Crew this season. Greene is 0-2 with a 9.69 ERA against Milwaukee this season. The Brewers have done their part against righties this season as well, ranking 5th in OPS (.750) and wOBA (.326), tied for 9th in wRC+ (109).

Favorite Plays: Willy Adames, Hunter Renfroe, Christian Yelich, Rowdy Tellez, Tyrone Taylor

Houston Astros vs. Kyle Bradish

I'll look to Baltimore for the second stack of the night, the Houston Astros. The Astros technically rank fourth in terms of stack value on my model but have the all-around numbers including pitch-type data for me to bump them up to my second favorite on the slate. Orioles starter Kyle Bradish tossed his best start of the season against the Stros back on August 26, going eight shutout innings and allowing just two hits while striking out six. However, I'll back Houston here as they rank 7th in OPS (.732), 8th in wOBA (.319), and are tied with the Brewers and Cardinals for 6th in wRC+ (109).

Favorite Plays: Yordan Alvarez, Alex Bregman, Trey Mancini, Kyle Tucker, Jeremy Pena, Aledmys Diaz

Also Consider: Boston Red Sox, Tampa Bay Rays



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REAL-TIME FANTASY NEWS

Peyton Watson

Remains Sidelined Against Thunder
Mo Bamba

Signs Second 10-Day Deal with Jazz
T.J. McConnell

Exits Early with Right Hamstring Injury
Collin Sexton

Leaves with Leg Injury After 28-Point Burst
Ryan Waldschmidt

Reassigned to Minor-League Camp
Isaiah Collier

Returning to Jazz Lineup Monday
Tage Thompson

Picks Up Four Points Against Lightning
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Signs Record Four-Year, $124 Million Extension With Rams
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has Three-Point Performance on Sunday
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Available Against Jazz
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to Remain Out Monday Night
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Won't Play Against Jazz
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to Skip Monday's Game
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Iffy for Monday
Collin Murray-Boyles

to Sit Out At Least Two More Games
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Misses Meeting With Hornets
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Could Make Another Start in World Baseball Classic
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Nelson Velazquez Could Get Increased Reps
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to be Placed on Injured List
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Should Return to WBC Lineup on Monday
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to Return on Monday
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Appears "Motivated" to Return for a 14th NFL Season
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is Returning on Sunday
Matas Buzelis

is Available on Sunday
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Returns With Minutes Restriction
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Set to Return on Monday
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Misses Sunday's Action
Chet Holmgren

Questionable to Suit Up Monday
Isaiah Hartenstein

Won't Play Against Nuggets
Egor Demin

to Remain Sidelined on Monday
Jamal Murray

Considered Questionable for Monday
Andrew Abbott

Gets Opening Day Nod
Shane Smith

is Named Opening Day Starter
Merrill Kelly

Throws Batting Practice Session on Sunday
Gavin Lux

to Make Spring Debut on Tuesday
Cedric Mullins

Resumes Baseball Activities
Yandy Díaz

Yandy Diaz Remains Out with Hand Soreness
Zack Littell

Nationals Agree to a Deal
Bryce Miller

to Throw a Bullpen on Sunday
Emil Lilleberg

to Miss Two Weeks Due to Facial Fracture
Spencer Knight

Won't Play Sunday
John Carlson

Not Ready for Ducks Debut Sunday
Zach Whitecloud

Injured Saturday Night
Khalil Mack

Returning to the Chargers for 2026
Jaden Schwartz

Forced to Exit Early After Taking Skate Blade to Face
Jake Sanderson

Sustains Upper-Body Injury Versus Kraken
Ryan Blaney

is Always A Top Favorite to Compete for the Win At Phoenix
Denny Hamlin

Is Denny Hamlin Worth Rostering for Phoenix?
Christopher Bell

is Likely to have Another Solid Phoenix Run
Chase Briscoe

has Plenty of Upside for DFS Lineups at Phoenix
Joey Logano

Could Dominate at Phoenix This Weekend
Chase Elliott

has Plenty of Upside for Sunday's Race at Phoenix
Chris Buescher

Is Chris Buescher Worth Rostering For Phoenix DFS Lineups?
Ross Chastain

Has Found Speed Again at Phoenix
Josh Berry

a Solid Sleeper at Phoenix
Brad Keselowski

Skips Qualifying After Practice Crash at Phoenix
Tyler Reddick

Spins in Practice at Phoenix
William Byron

Should Be a Contender at Phoenix
Kyle Larson

Is Always a Threat at Phoenix
NASCAR

Could Bubba Wallace Be Playable for Phoenix DFS Lineups?
Anthony Alfredo

Is A Favorable DFS Option In A Substitution Role At Phoenix
Andrei Vasilevskiy

Defeats the Maple Leafs on Saturday
Nikita Kucherov

Picks Up Four Assists
Romy Gonzalez

Could Require Surgery
Kyle Tucker

is Expected to Return on Sunday
Brandon Woodruff

Wants to be Ready for Opening Day
Orion Kerkering

Throws Successful Bullpen Session
Chandler Simpson

Rays Being Overly Cautious with Chandler Simpson
Roope Hintz

to Miss At Least a Couple of Weeks
Dylan Larkin

Ruled Out for Sunday
Adam Larsson

Ryan Lindgren Iffy for Saturday
Travis Konecny

Remains Out Saturday
Mikhail Sergachev

a Game-Time Call Saturday
Mason Marchment

Ready to Face Mammoth
Zach Werenski

Available Saturday
Andrei Kuzmenko

Done for Regular Season
Josh Morrissey

Activated From Injured Reserve
Jiri Kulich

Unlikely to Return This Season
Shayne Gostisbehere

Exits Early Friday
Maxx Crosby

Traded to Baltimore in Blockbuster Deal
Dalton Schultz

Texans, Dalton Schultz Agree on One-Year Extension
Joe Mixon

Texans Release Joe Mixon
Max Holloway

A Favorite At UFC 326
Charles Oliveira

Set For BMF Title Fight
Las Vegas Raiders

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Reinier de Ridder

Reinier De Ridder Looks To Bounce Back
Caio Borralho

Set For UFC 326 Co-Main Event
Rob Font

Looks To Get Back In The Win Column
Raul Rosas Jr.

Looks For His Fifth Consecutive Win
Drew Dober

Returns At UFC 326
Michael Johnson

Looks To Extend His Win Streak
Geno Smith

Raiders Release Geno Smith
Danielle Hunter

Texans, Danielle Hunter Agree to One-Year, $40.1 Million Extension
DJ Moore

Bears Working to Finalize Deal to Send DJ Moore to Buffalo
Stefon Diggs

Patriots Releasing Stefon Diggs
Trent McDuffie

Chiefs Sending Trent McDuffie to Rams in Blockbuster Deal
Taylor Moore

Looking to Build on Cognizant Classic Finish
Robert MacIntyre

Brings Solid Form to Bay Hill
Scottie Scheffler

the Tournament Favorite at Bay Hill
Xander Schauffele

Trending Well Ahead of API
Si Woo Kim

Looking to Return to Top Form at Bay Hill
Ben Griffin

Looking to Return to Form at Arnold Palmer Invitational
PGA

Nico Echavarria Looks to Build on Cognizant Classic Win at Arnold Palmer
Sam Burns

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Daniel Berger

Offers Sneaky Upside at Bay Hill
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NASCAR

Collin Morikawa Hopes To Better Last Year's Runner-Up Finish at API
Tommy Fleetwood

Isn't As Confident of a Start at Bay Hill as Previous Weeks
Kyler Murray

Will be Released
Trey Hendrickson

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Daniel Jones

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Adam Scott

Might Endure Tough Times at Bay Hill
Aldrich Potgieter

Extremely Risky When it Comes to Bay Hill
PGA

Sungjae Im to Make Season Debut at Arnold Palmer Invitational
Jordan Spieth

an All-or-Nothing Option at Bay Hill
Harry Hall

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Ryan Gerard

Needs Better Start at Bay Hill
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Still Plagued by Bad Putting Ahead of Arnold Palmer Invititational
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Colts Expected to Use Transition Tag on Daniel Jones
Breece Hall

Jets Placing Franchise Tag on Breece Hall
CFB

Mark Stoops Joining Texas Coaching Staff
Jason Day

Attempts to Bounce Back from The Genesis Invitational
Jacob Bridgeman

Rolling into Arnold Palmer Invitational
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