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DraftKings, FanDuel Daily Fantasy Baseball Picks (9/17/22): Today's Top MLB DFS Lineups

Yordan Alvarez - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 17, 2022. Mike Marteny's MLB DFS analysis and sleepers for building optimal DFS rosters.

Today's MLB slates are split up as is the norm for September baseball. Half the guys I think will play will not, so you have to be as flexible as Gumby to play MLB DFS in September, but that also means that there is a lot of money out there should you dare to dive in those waters. That's why we're here.

There are nine games on the main slate for tonight's action. Two pitchers tip the scales on DraftKings at five figures. Five of them weigh in over that mark on FanDuel. So, hey...at least we have some nice pitching on this slate! That makes it easier.

As always, this article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel. Saturday's main slate locks at 7:10 pm EST on 9/17/2022. The lineup picks will range from some elite high-priced players to mid-priced options and value plays. I'll give you a few of my top pitching options and then some infielders, outfielders, and teams to stack! You can also read more DFS advice and lineup picks for other sports here. It's also essential to monitor injury news and today's MLB starting lineups. Now that we got all of that out of the way, it's onto the picks!

Black Friday Special! Save 50% on any Big-4 Sports Premium Pass using discount code SMASH. Win more with our DFS, Betting and Season-Long Premium Pass, get expert tools and advice for NBA, NFL, MLB, NHL from from proven winners! Dan Palyo leads the team with exclusive picks for DFS picks, Props, betting. Enhance your game with industry-leading tools like our Lineup Optimizers, Team Sync Platform, DFS Cheat Sheets and more. GAIN ACCESS

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Shohei Ohtani vs. SEA ($10,400 DK and FD)

It should come as a surprise to no one that Seattle has not hit Ohtani well. Not this year. Not ever. This year the M's have been even worse against Ohtani though. Ohtani boasts 14 strikeouts with just two runs allowed on ten hits in 12 innings against Seattle. That low WHIP counts for more on DK, but those K ratios play big on both sites. Don't overthink this. In cash, you need Ohtani.

George Kirby at LAA ($8,000 DK, $9,300 FD)

It's counterintuitive to use pitchers against each other on DraftKings, but I'm seriously considering it. Kirby has dominated the Angels this year, striking out 21 Halos in 17.2 innings while allowing six runs. I particularly like the high strikeout numbers and will pivot to Kirby in GPP formats. I prefer the larger savings on DraftKings, but you can't argue with the results. Kirby's ERA is still below 3 on the season.

Also consider: Chris Bassitt, Joe Musgrove, Jose Urquidy

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's Jon Anderson on DraftKings - join in on the winning!

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Freddie Freeman - 1B, LAD at John Brebbia ($5,600 DK, $4,300 FD)

Brebbia is just the opener, but it's not like it matters. Freeman is running hot right now. Freeman is hitting .395 with four homers, ten RBI, and just five strikeouts to seven walks over the last ten games. Freeman is having a September to remember so far. He should keep it up against the Giants in a bullpen game for them.

Eduardo Escobar - 3B, NYM vs. Bryse Wilson ($4,000 DK, $3,100 FD)

Escobar had a rough August, but he is on a roll of late with five homers already in September to go with a .373 average and nine RBI. Since Austin Riley is in the midst of a God-awful slump, I'll save some pennies and drop down to the red-hot Escobar.

Willy Adames - SS, MIL vs. Jameson Taillon ($5,000 DK, $3,400 FD)

Adames comes at a nice discount on FanDuel, but again, he's running so hot I'll use him anywhere. The former Rays prospect is hitting .351 with three homers and 10 RBI in the last week! Taillon has been had a few times this year. In fact, his last start was the first time since July 28 that he didn't allow a homer. I'll say Adames gets him today.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Yordan Alvarez - OF, HOU vs. Cole Irvin ($6,400 DK, $4,300 FD)

I really love the price drop on Alvarez on FD, but I'll use him anywhere right now. He has double-digit fantasy points in each of the last five games he has played in. He homered in his first three at-bats last night. The odds of him doing that again? Not terrible. Yordan is 8-for-17 with a pair of homers in his career against Irvin. By the way, he is hitting .426 with six homers and 12 RBI against anyone unfortunate enough to wear an A's uniform against him this year.

Ronald Acuna Jr. -OF, ATL vs. Aaron Nola ($5,600 DK, $3,700 FD)

There are a few Braves that hit Nola well. One of them is Austin Riley, who is colder than Antarctica in January right now. The other is Acuna, who is 11-for-32 with three homers and seven walks in his career against Nola. I don't make it a point to go after pitchers like Nola, but I do when it offers leverage. Most will ignore the Braves here, but Acuna gets on base and hasn't struck out much against Nola. That's a good combination.

Aristides Aquino - OF, CIN at Jose Quintana ($2,100 DK, $2,500 FD)

Aquino is too cheap on DraftKings. He is hitting .306 with a pair of homers and four RBI this week. Quintana usually isn't a victim of gopher balls, but Aquino's raw power is among the best in the league. He just can't hit righties. Fortunately for us and our budget, Quintana is a lefty. I'll ride a warm Aquino against a lefty any day.

 

DraftKings, FanDuel MLB DFS Stacks

Here are my top stacks for tonight (in the order in which I like them):

Los Angeles Dodgers - Any time an offense like this goes up against any team's bullpen, they have my attention. The Dodgers are expensive for a reason. Try some Cody Bellinger or Justin Turner for some much-needed salary relief to afford the rest of this stack.

New York Mets - Bryse Wilson has allowed at least three runs in every start for the last six weeks. I already talked about Escobar's hot streak, but Pete Alonso, Jeff McNeil, and Francisco Lindor are also running hot.

Honorable mention: Arizona Diamondbacks

I hope I gave you a head start on your research today and I wish you the best of luck! If you ever have questions about DFS or fantasy baseball, my DMs are always open and I appreciate you taking the time to read my picks today.



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REAL-TIME FANTASY NEWS

Paul George

Won't Play Wednesday Night
Onyeka Okongwu

Available on Tuesday
Joel Embiid

Listed as Doubtful for Wednesday
Jalen Suggs

Available Tuesday
Zaccharie Risacher

Ruled Out With Hip Contusion vs. Pistons
Odell Beckham Jr.

Officially Reinstated by NFL Commissioner
Kristaps Porzingis

Ruled Out on Tuesday Night
Buddy Hield

Available for Tuesday's Matchup With Orlando
Matt Murray

to Miss Six Weeks With Lower-Body Injury
Ilya Lyubushkin

Out on Tuesday
Giannis Antetokounmpo

Out 1-2 Weeks With Groin Strain
Jamie Benn

Makes Season Debut Tuesday
Stephon Castle

Sidelined 1-2 Weeks
Evgenii Dadonov

on Track to Return Tuesday
Dougie Hamilton

a Game-Time Call Tuesday
Anthony Cirelli

Expected to Return Against Devils
Victor Hedman

Questionable for Tuesday
LeBron James

Aims to Make Season Debut Tuesday
Auston Matthews

to Miss at Least Two More Games
Grayson Allen

Sidelined on Tuesday
Gabe Vincent

Set to Suit Up Tuesday
C.J. Stroud

Expected to Return in Week 13 Against Colts
C.J. Stroud

to Miss Another Game
Jonathan Kuminga

Remains Out Tuesday
Keegan Murray

Could Make his Season Debut This Week
Caris LeVert

Liston as Out on Tuesday
Tobias Harris

Could Return Thursday
Ausar Thompson

Questionable Again on Tuesday
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
Cade Cunningham

is Questionable Tuesday in Atlanta
Jaylen Warren

Mike Tomlin Optimistic About Jaylen Warren's Availability for Week 12
C.J. Stroud

Not Expected to Play on Thursday Night
Aaron Rodgers

Won't Need Surgery on Fractured Wrist, Could Play in Week 12?
Davis Mills

Prepping for Third Straight Start in Week 12?
CFB

Sam Leavitt Set to Enter Transfer Portal?
Mason Rudolph

Could Make His First Start of 2025 in Week 12
Brock Wright

Sets Career-High in Targets; Lined Up for More Work?
Stephon Castle

Out Against Grizzlies
Kimani Vidal

Struggles Again and Faces Role Uncertainty After Bye
Dak Prescott

in Full Command Monday Night With Four Touchdown Passes
Quentin Johnston

Posts Zero Catches During Offensive Collapse
George Pickens

Erupts for 144 Yards, Touchdown in Monday Night Win
Jrue Holiday

Unlikely to Play Tuesday
CeeDee Lamb

George Pickens Benched for First Drive
LeBron James

Officially Listed as Questionable for Tuesday
Jose Altuve

Undergoes Foot Surgery
Alex Singleton

Broncos Optimistic Patrick Surtain, Alex Singleton Will Return After the Bye
Trey Hendrickson

Doubtful Again in Week 12
Shedeur Sanders

Expected to Make First Career Start in Week 12
Josh Jacobs

Dealing With Knee Contusion
Mikael Granlund

Unavailable Monday
Alex Bregman

Red Sox Going for Either Alex Bregman or Pete Alonso?
Conor Garland

Misses Monday's Game
Eetu Luostarinen

Out on Monday
Drake London

Considered "Week-to-Week"
Drew Doughty

Listed as Week-to-Week
Ja'Marr Chase

Being Suspended for One Game for Unsportsmanlike Conduct
John Carlson

a Game-Time Call Monday
Viktor Arvidsson

Out Week-to-Week
Charlie McAvoy

Out Against Hurricanes
CFB

James Franklin to be Virginia Tech's Next Head Coach
CFB

Fernando Mendoza the Clear Heisman Trophy Favorite?
CFB

Beau Pribula Has Chance to Face Oklahoma on Saturday
Mitchell Marner

Establishes Vegas Record Sunday
Mats Zuccarello

Logs Two Assists in Overtime Victory
Lucas Raymond

Leads Red Wings to Victory at MSG
Quinn Hughes

Delivers Four Assists in Sunday's Win
Conor Garland

Limited to Handful of Minutes Sunday
Ryan Hartman

Suffers Lower-Body Injury
Jack Della Maddalena

Gets Dominated
Islam Makhachev

Claims UFC Welterweight Belt
Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
Justin Thomas

Will Miss Start Of 2026 After Undergoing Back Surgery
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Michael Morales

Looks To Remain Undefeated
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Carlos Prates

A Favorite At UFC 322
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again
Raisel Iglesias

Dodgers Interested in Signing Raisel Iglesias
Pete Alonso

Orioles Could be in the Mix to Sign Pete Alonso
Félix Bautista

Felix Bautista Could Return in Second Half in 2026
Kodai Senga

Attracting Trade Interest, Will the Mets Move him?
Yordan Alvarez

Expected to be Ready for Spring Training
Byron Buxton

Could Waive his No-Trade Clause
Paul Skenes

the Unanimous NL Cy Young Winner
Tarik Skubal

Wins AL Cy Young for Second Straight Year

RANKINGS

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RB
WR
TE
K
DEF
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C
1B
2B
3B
SS
OF
SP
RP