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DraftKings, FanDuel Daily Fantasy Baseball Picks (9/17/22): Today's Top MLB DFS Lineups

Yordan Alvarez - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 17, 2022. Mike Marteny's MLB DFS analysis and sleepers for building optimal DFS rosters.

Today's MLB slates are split up as is the norm for September baseball. Half the guys I think will play will not, so you have to be as flexible as Gumby to play MLB DFS in September, but that also means that there is a lot of money out there should you dare to dive in those waters. That's why we're here.

There are nine games on the main slate for tonight's action. Two pitchers tip the scales on DraftKings at five figures. Five of them weigh in over that mark on FanDuel. So, hey...at least we have some nice pitching on this slate! That makes it easier.

As always, this article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel. Saturday's main slate locks at 7:10 pm EST on 9/17/2022. The lineup picks will range from some elite high-priced players to mid-priced options and value plays. I'll give you a few of my top pitching options and then some infielders, outfielders, and teams to stack! You can also read more DFS advice and lineup picks for other sports here. It's also essential to monitor injury news and today's MLB starting lineups. Now that we got all of that out of the way, it's onto the picks!

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DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Shohei Ohtani vs. SEA ($10,400 DK and FD)

It should come as a surprise to no one that Seattle has not hit Ohtani well. Not this year. Not ever. This year the M's have been even worse against Ohtani though. Ohtani boasts 14 strikeouts with just two runs allowed on ten hits in 12 innings against Seattle. That low WHIP counts for more on DK, but those K ratios play big on both sites. Don't overthink this. In cash, you need Ohtani.

George Kirby at LAA ($8,000 DK, $9,300 FD)

It's counterintuitive to use pitchers against each other on DraftKings, but I'm seriously considering it. Kirby has dominated the Angels this year, striking out 21 Halos in 17.2 innings while allowing six runs. I particularly like the high strikeout numbers and will pivot to Kirby in GPP formats. I prefer the larger savings on DraftKings, but you can't argue with the results. Kirby's ERA is still below 3 on the season.

Also consider: Chris Bassitt, Joe Musgrove, Jose Urquidy

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's Jon Anderson on DraftKings - join in on the winning!

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Freddie Freeman - 1B, LAD at John Brebbia ($5,600 DK, $4,300 FD)

Brebbia is just the opener, but it's not like it matters. Freeman is running hot right now. Freeman is hitting .395 with four homers, ten RBI, and just five strikeouts to seven walks over the last ten games. Freeman is having a September to remember so far. He should keep it up against the Giants in a bullpen game for them.

Eduardo Escobar - 3B, NYM vs. Bryse Wilson ($4,000 DK, $3,100 FD)

Escobar had a rough August, but he is on a roll of late with five homers already in September to go with a .373 average and nine RBI. Since Austin Riley is in the midst of a God-awful slump, I'll save some pennies and drop down to the red-hot Escobar.

Willy Adames - SS, MIL vs. Jameson Taillon ($5,000 DK, $3,400 FD)

Adames comes at a nice discount on FanDuel, but again, he's running so hot I'll use him anywhere. The former Rays prospect is hitting .351 with three homers and 10 RBI in the last week! Taillon has been had a few times this year. In fact, his last start was the first time since July 28 that he didn't allow a homer. I'll say Adames gets him today.

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Yordan Alvarez - OF, HOU vs. Cole Irvin ($6,400 DK, $4,300 FD)

I really love the price drop on Alvarez on FD, but I'll use him anywhere right now. He has double-digit fantasy points in each of the last five games he has played in. He homered in his first three at-bats last night. The odds of him doing that again? Not terrible. Yordan is 8-for-17 with a pair of homers in his career against Irvin. By the way, he is hitting .426 with six homers and 12 RBI against anyone unfortunate enough to wear an A's uniform against him this year.

Ronald Acuna Jr. -OF, ATL vs. Aaron Nola ($5,600 DK, $3,700 FD)

There are a few Braves that hit Nola well. One of them is Austin Riley, who is colder than Antarctica in January right now. The other is Acuna, who is 11-for-32 with three homers and seven walks in his career against Nola. I don't make it a point to go after pitchers like Nola, but I do when it offers leverage. Most will ignore the Braves here, but Acuna gets on base and hasn't struck out much against Nola. That's a good combination.

Aristides Aquino - OF, CIN at Jose Quintana ($2,100 DK, $2,500 FD)

Aquino is too cheap on DraftKings. He is hitting .306 with a pair of homers and four RBI this week. Quintana usually isn't a victim of gopher balls, but Aquino's raw power is among the best in the league. He just can't hit righties. Fortunately for us and our budget, Quintana is a lefty. I'll ride a warm Aquino against a lefty any day.

 

DraftKings, FanDuel MLB DFS Stacks

Here are my top stacks for tonight (in the order in which I like them):

Los Angeles Dodgers - Any time an offense like this goes up against any team's bullpen, they have my attention. The Dodgers are expensive for a reason. Try some Cody Bellinger or Justin Turner for some much-needed salary relief to afford the rest of this stack.

New York Mets - Bryse Wilson has allowed at least three runs in every start for the last six weeks. I already talked about Escobar's hot streak, but Pete Alonso, Jeff McNeil, and Francisco Lindor are also running hot.

Honorable mention: Arizona Diamondbacks

I hope I gave you a head start on your research today and I wish you the best of luck! If you ever have questions about DFS or fantasy baseball, my DMs are always open and I appreciate you taking the time to read my picks today.



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REAL-TIME FANTASY NEWS

Jerami Grant

May Miss Saturday's Game
Jrue Holiday

Questionable for Saturday
Aaron Gordon

Likely to Face Wizards
Jamal Murray

Listed as Probable for Saturday
Stephon Castle

Questionable for Saturday
Keon Ellis

Out Friday Night
Tari Eason

Still Out Friday
Deni Avdija

Unlikely to Play Against Lakers
Deandre Ayton

Questionable for Saturday's Tilt
Luka Dončić

Luka Doncic Won't Play Saturday
Domantas Sabonis

Officially Active Friday
Cade Cunningham

Considered Probable for Saturday
Jaime Jaquez Jr.

to Sit Out Second Consecutive Game
Tyler Herro

Questionable to Play Saturday
Jalen Brunson

Iffy for Meeting With Suns
Devin Booker

Uncertain for Saturday
Nicolas Batum

Starting Against Raptors
Julian Phillips

Returns From Two-Game Absence
Kevin Huerter

Available Against Nets
Ivica Zubac

Upgraded to Available
John Collins

Good to Go Friday
Atlanta Falcons

Kevin Stefanski the Favorite for Falcons Head-Coaching Job
Matt Boldy

Placed on Injured Reserve
Ross Colton

Good to Go Friday
Will Smith

Returns Against Red Wings
Shayne Gostisbehere

Out Friday
Brad Marchand

Remains Out Friday
Joel Armia

Returns From Five-Game Absence
Chris Kreider

a Game-Time Call Friday
Troy Terry

Cutter Gauthier Available Friday
Leo Carlsson

Sits Out Second Consecutive Game
CFB

Darian Mensah Entering Transfer Portal
Sam Darnold

Seahawks "Optimistic" That Sam Darnold Will Play on Saturday
Nico Collins

Officially Ruled Out for Divisional Round
Rome Odunze

Questionable for Divisional Round
J.T. Realmuto

Signs Three-Year Deal to Return to Phillies
Bo Bichette

Agrees to Three-Year Contract With Mets
CFB

Weber State Signs former Ohio State, Cal Quarterback Devin Brown
Bo Bichette

Phillies the "Overwhelming" Favorite to Sign Bo Bichette
Mark Scheifele

Leads Jets to Victory Thursday
Tage Thompson

Records Season-High Five Points Thursday
Jack Eichel

Notches Four Points Thursday
Ilya Sorokin

Shuts Out Oilers With 35 Saves
Andrew Peeke

Not Expected to Be Out Long-Term
William Nylander

Aggravates Lower-Body Injury Thursday
Ross Colton

Uncertain for Friday
Josh Lowe

Angels Acquire Josh Lowe in Three-Team Trade
Kyle Tucker

Signs Four-Year Contract With Dodgers
Ricky Pearsall

Questionable to Play on Saturday Night
Sam Darnold

Questionable With Oblique Injury, Expected to Play
Damon Severson

Back for Blue Jackets Thursday
Adin Hill

Available Thursday Night
Brandon Montour

Activated From Injured Reserve
Joel Eriksson Ek

Misses Third Straight Game Thursday
Jonas Brodin

Placed on Injured Reserve, Out Week-to-Week
Clayton Kershaw

to Pitch for Team USA in World Baseball Classic
Patrick Mahomes

Says Rehab Going "Great," Goal is 2026 Week 1 Return
Nico Collins

a "Long Shot" to Play in Divisional Round
CFB

Auburn, Ohio State the Lead Suitors for Kyle Parker
CFB

Oregon QB Transfer Bryson Beaver Linked to Georgia, Kentucky
CFB

Jake Merklinger Commits to UConn
New York Giants

John Harbaugh Finalizing Deal With Giants
Ben Griffin

Looks To Stay Hot In 2026
New York Giants

Giants Making "Massive Push" to Hire John Harbaugh on Wednesday
Ranger Suárez

Ranger Suarez Agrees to Five-Year Deal With Red Sox
CFB

Dante Moore Not Entering 2026 NFL Draft, Will Return to Oregon
NFL

Mike Tomlin Doesn't Plan to Coach in 2026
Travis Hunter

Expected to Play More Defense in 2026
CFB

FBS Coaches Unanimously Vote to Expand Redshirt Eligibility to Nine Games
CFB

Ohio State Transfer Mylan Graham Signs with Notre Dame
CFB

Caden Durham Withdraws from Transfer Portal, Will Stay at LSU
Jordan Spieth

Perhaps the Most Intriguing Player at Sony Open
Aaron Rai

Looking For Putting Confidence at Waialae Country Club
Collin Morikawa

Isn't The Safe Play He Used to Be Ahead of Sony Open
Kurt Kitayama

Needs His Putting to Turn Around For Success at Year's First Event
Ryan Weathers

Yankees Add Rotation Depth, Acquire Ryan Weathers in Four-Player Deal
Los Angeles Chargers

Chargers Fire Offensive Coordinator Greg Roman
Pittsburgh Steelers

Mike Tomlin Stepping Down as Steelers Head Coach
CFB

Georgia Tech the Favorite to Land Justice Haynes?
Nolan Arenado

Cardinals Trade Nolan Arenado to Diamondbacks
Tom Kim

Desperately Needs a Solid Week at Sony Open
Billy Horschel

Hoping For a Fast Start to New Season at Sony Open
Corey Conners

Looks to Have a Return to Form in 2026
PGA

Chris Gotterup a Decent Play at Sony Open
Gary Woodland

Could Prosper at the Sony Open
Keith Mitchell

Unlikely to Contend at Sony Open
Robert MacIntyre

Looking for a Good Performance at the Sony Open
Michael Kim

Hopes to Start Sony Open Better This Week
Tom Hoge

Tries to Erase Poor 2025 Second Half in Hawaii
Brian Harman

Seeks Fresh Start in Hawaii
Eric Cole

Looks to Last Year for Success at Sony Open
Daniel Berger

Starts Off 2026 at Sony Open
Nico Collins

Suffers Concussion Against Steelers
Nico Collins

Carted to Locker Room for Concussion Evaluation
Kyle Tucker

Mets Meet With Kyle Tucker
Dalton Kincaid

"Should be Fine" for Divisional Round
Brooks Koepka

Officially Returning To PGA Tour
Tucker Kraft

Hopes to be Ready for Week 1 of Next Season
CFB

Georgia Lands Kentucky Transfer Dante Dowdell
Matthew Stafford

has "Little Sprain," Should be "Good to Go"
CFB

Sam Leavitt Expected to Sign with LSU
Green Bay Packers

Packers Expected to Work Out New Deal With Matt LaFleur in the "Coming Days"
CFB

Dylan Raiola Commits to Oregon
CFB

Isaiah Horton Landing with Texas A&M
George Kittle

Suffers Torn Achilles on Sunday
MacKenzie Gore

Yankees Pursuing Trade for MacKenzie Gore
Alex Bregman

Cubs Sign Alex Bregman to Five-Year, $175 Millon Contract

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP