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FanDuel NFL DFS Lineup Picks (Week 6): Daily Fantasy Football Advice

Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 6, and a couple of sleepers to consider while building daily rosters.

RotoBallers, welcome to Week 6 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 6 of the NFL season. You can also click here to find more DFS analysis articles and tools.

The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.

Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 6! Find me @DFS_Tom if you have any questions.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

FanDuel Quarterbacks - Week 6 DFS Picks

Deshaun Watson - QB, HOU vs BUF (FD - $8,100)

Watson could go a bit overlooked this week since this game comes in with an over-under set at 41, which is one of the two lowest games on the slate. Regardless of that, Watson has shown to be viable in all formats each week, with a solid floor and a good ceiling. He has over 300 yards in four straight games and has multiple touchdowns in three of his last four games. Watson also has 16 rushing attempts in his last two games, showing he is getting back to what we saw from him last season. He has the rushing touchdown upside, which is always great in tournaments.

Jameis Winston - QB, TB @ ATL (FD - $7,400)

Winston is being talked up by many across the industry as a cash game play this week since he has a few different things going in his favor. First off, this game has an over-under 58, which is highest on the slate, so plenty of fantasy points to go around. Second, he is up against the Falcons, who come in with the 28th DVOA versus the pass and the 31st DVOA vs the rush. Winston has always shown the ability to throw for over 300 yards and multiple touchdowns, but it may come with an interception or two.

 

FanDuel Running Backs - Week 6 DFS Picks

Carlos Hyde - RB, CLE vs LAC (FD - $6,600)

Hyde has seen 17 or more total touches in every single game this season and is now up against the Chargers, who come in with the 21st DVOA vs the rush and the 16th DVOA vs the pass. We have this game coming in with an over-under set at 44.5 and is being talked up as a game which could hit the over. He only played on 35% of the snaps last week, but prior to that, he was at or above 58% of the snaps for three straight weeks.

Tevin Coleman - RB, ATL vs TB (FD - $6,300)

Coleman may be seeing the starting role again for Atlanta since Devonta Freeman is dealing with yet another injury. When Freeman was out earlier in the year, Coleman played on 63%, 78%, and 57% of the snaps in Weeks 2-4. This game has an over-under set at 58, so you want, no, need to be getting exposure to this game somehow, and Coleman is a great option. He had double-digit rushing attempts in that three-week span, along with 10 total targets.

 

FanDuel Wide Receivers - Week 6 DFS Picks

Quincy Enunwa - WR, NYJ vs IND (FD - $5,800)

Enuwa had a bad game last week, but the Jets put up over 300 yards on the ground, so he really didn't have to do too much. Feeling a big bounce-back game for him this week, as he still has 29% of the teams total market share. That target share is massive and shown by his eight or more targets in the first four weeks of the season. He should see a good amount of Colts cornerback Quincy Wilson, who is giving up 0.68 fantasy points per route run this season.

Tyler Boyd - WR, CIN vs PIT (FD - $6,300)

This game also has a higher over-under which is set at 52.5, so plenty of offense to go around here. Boyd has seven or more targets in each of his last four games and is being targeted on in the passing game on 24% of his routes run. With that usage, he has been able to rack up 0.47 fantasy points per route run, which should put him in a prime spot, since A.J. Green will most likely be shadowed by Joe Haden.

 

FanDuel Tight End - Week 6 DFS Pick

Kyle Rudolph - TE, MIN vs ARI (FD - $6,200)

Tight ends are generally pretty tough to get right on a week to week basis, but Rudolph has shown to be pretty consistent as of late. He has five or more receptions in four straight games, 48 or more yards in three of those games, but only one touchdown in that span. When the Vikings are in the red zone this season, he is their go-to guy, with a 32% market share of targets.

 

FanDuel Defense - Week 6 DFS Pick

Carolina Panthers at Washington Redskins (FD - $3,900)

The Panthers are the 10th most expensive defense on the slate this week, so you really aren't paying up for some potential points. The have three sacks and six intercetions in the past two weeks and while the intercpetion rate isn't sustainable, the QB pressure is what you should be after. Thisg game only has an over-under at 44.5, which isn't too high, so a nice spot to fade some of the more expensive teams in lower scoring games, ie, Jaguars, Vikings.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

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Exits Early Sunday
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Has a Quiet Offensive Night on Sunday
Shai Gilgeous-Alexander

Held Under 20 Points in Game 4
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Hands Out Six Assists in Game 4 Win
Devin Vassell

Tallies 13 Points in Game 4 Win
De'Aaron Fox

Records Double-Double as Spurs Even Series
Victor Wembanyama

Sets Tone Early as Spurs Force a Pivotal Game 5
Isaac Guerendo

Could be a Drop Candidate in Dynasty Leagues in 2026
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' Dynasty Arrow is Pointing Up With Clear Path to WR2 Role in Houston
Jakobi Meyers

a Sell-High Candidate in Dynasty Formats?
Drake Maye

to Make a Big Leap in 2026 in Second Season With Josh McDaniels?
Jamal Murray

Earns First Career All-NBA Selection
Kevin Durant

Becomes First Player to Make All-NBA Team With Five Franchises
Shai Gilgeous-Alexander

Victor Wembanyama Lead All-NBA First Team
Taylor Hall

Enjoying Life in Carolina
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Returns to Action Sunday
Cale Makar

Rejoins Avalanche Lineup Sunday
Cason Wallace

Joins Starting Unit Sunday
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Christian Watson

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Drake Maye

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Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

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the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
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Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
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Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

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Austin Dillon

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Orioles-Tigers Game Postponed on Saturday
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Rays-Yankees Postponed on Saturday
Nazem Kadri

Contributes an Assist in Losing Effort
Ross Colton

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Jack Eichel

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Jackson Merrill

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LSU Hires Ed Orgeron As Special Assistant
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North Carolina and South Carolina Cancel Home-And-Home Series
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Confidence High in Mississippi State's Kamario Taylor
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Reds-Cardinals Game Postponed on Friday
Trevor Story

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Roman Anthony

Dealing With Sprained Ligament in his Finger
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
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Tom Kim

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Ezavier Crowell has Immediate Opportunity at Alabama
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Mark Bowman a Day 1 Impact Player for USC?
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Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
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