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NFL Predictions for Week 16: Picks for Every Game

Courtland Sutton - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Denver Broncos 23, Los Angeles Chargers 20 (Thursday Night Football)

We kick off Week 16 with a Thursday night matchup between AFC West rivals. This one could have serious playoff ramifications, as both the Broncos and Chargers are jockeying for position and looking to solidify themselves in the AFC draw.

The Chargers beat the Broncos back in Week 6, but now face a Denver squad that’s won four in a row, while Jim Harbaugh’s bunch has lost three of their last four. Justin Herbert and the L.A. offense have struggled to get much going since losing running back J.K. Dobbins to an injury weeks ago, and I don’t love their chances of finding success against a rugged Broncos defense that leads the NFL in sacks and is tied (with the Chargers) for allowing the league’s fewest points per game.

Patrick Mahomes - Fantasy Football Rankings, Draft Sleepers, Waiver Wire Pickups

Houston Texans 17, Kansas City Chiefs 14 (Saturday)

The outlook for this special Saturday matchup revolves around Patrick Mahomes. As of this writing, the Chiefs’ superstar appears questionable at best to suit up against Houston due to a high ankle sprain. With KC facing an ultra-quick turnaround for a Christmas Day matchup, I look for Andy Reid to protect his quarterback in Week 16.

Assuming Mahomes sits, Houston’s chances of winning this game (obviously) increase dramatically. The Chiefs would have Carson Wentz under center in Mahomes absence and the former Eagles/Colts/Commanders/Rams turnover machine can’t be trusted behind a shoddy Chiefs offensive line that’s facing a frisky Texans pass rush. It’s tough to pick against KC at Arrowhead, but Houston is a quality opponent that can get the job done without Mahomes in the lineup.

Lamar Jackson - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Baltimore Ravens 21, Pittsburgh Steelers 17 (Saturday)

A classic AFC North rivalry, the Ravens enter Week 16 looking for revenge against a Steelers squad that beat them just over a month ago. Pittsburgh limps in off being soundly defeated by the Eagles last week and Mike Tomlin’s squad has injury concerns surrounding two key players in T.J. Watt and George Pickens.

If either Pickens or Watt misses, it would be a major blow for the 10-4 Steelers. If both are out, it would be catastrophic against a talented and highly motivated Ravens team. Despite Pittsburgh’s surprising dominance over this rivalry – the Steelers are 8-1 against Baltimore since 2020 – Baltimore should find just enough offense behind Lamar Jackson and Derrick Henry to pull out a close one this time around.

Joe Burrow - Fantasy Football Rankings, NFL Injury News, DFS and Betting Picks

Cincinnati Bengals 28, Cleveland Browns 16

Despite their disappointing 6-8 record, Bengals superstars Joe Burrow and Ja’Marr Chase have played MVP-caliber ball this year. Cincinnati has also received excellent production from running back Chase Brown, who has evolved into a workhorse back in Zack Moss’ absence.

Allowing just over 25 points per game in 2024, the Cleveland defense is far from the dominant unit we saw last year. Add in the team’s puzzling decision to bench quarterback Jameis Winston in favor of Dorian Thompson-Robinson – a player who averaged less than four yards per pass attempt in eight appearances last season – and we should see the Bengals climb another game closer to .500.

Michael Penix Jr. - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Atlanta Falcons 23, New York Giants 17

Sitting at 7-7 and still in the NFC South hunt, Atlanta made the surprising announcement that they will start rookie Michael Penix Jr. at quarterback in Week 16. This decision signals that their $180 million offseason investment in veteran Kirk Cousins was likely a very expensive mistake.

Luckily for Penix and the Falcons, they draw a Giants squad that’s been abysmal by nearly every measure in 2024. New York has been playing musical quarterbacks since the departure of Daniel Jones and as of this writing, it’s unclear if it will be Tommy DeVito, Drew Lock, or Tim Boyle under center for the G-Men. Let’s be honest…it shouldn’t matter in this one, as the Falcons and their home crowd should be energized by the insertion of Penix into the starting lineup.

Jahmyr Gibbs - Fantasy Football, Rankings, Draft, Sleeper, DFS, Running Back

Detroit Lions 35, Chicago Bears 20

The injuries just keep mounting for Dan Campbell and the Detroit Lions. The 12-2 squad lost at home to the Bills last week, but more notably, lost running back David Montgomery, d-lineman Alim McNeill, and cornerback Carlton Davis to serious injuries. These names are added to an already lengthy list of hurt Lions that includes superstar edge rusher Aidan Hutchinson.

Luckily for Detroit, they draw a soft Week 16 landing spot against a Bears team that is in the midst of an eight-game freefall. Some thought the mid-season firing of head coach Matt Eberflus might spark Caleb Williams and the Bears, but the team actually appears to have regressed in recent weeks, as they come into this one after being outscored a combined 68-25 across their last two. Even in their seriously banged-up state, Detroit will take care of business.

Jonathan Taylor - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Indianapolis Colts 20, Tennessee Titans 16

It looks as though the Titans have pulled the plug on the Will Levis experiment, as the second-year turnover machine was benched last week and Mason Rudolph has been announced as the starter for this week’s matchup against the Colts. It’s unclear if Rudolph – who completed 21 of 26 passes for 209 yards, two TDs, and a pick in relief of Levis last week – can spark the long-dormant Tennessee offense, but hey, he can’t be much worse.

The Colts repeatedly shot themselves in the foot last week in a road loss at Denver, but this Indy squad has been a better team in the friendly confines of Lucas Oil Stadium. Even with Anthony Richardson’s effectiveness highly debatable, I look for the Colts to be able to do enough to sneak past the Titans at home.

James Conner - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Arizona Cardinals 28, Carolina Panthers 23

One of the NFL’s most unpredictable teams, the Arizona Cardinals travel to Carolina in Week 16 still clinging to playoff hopes, and with a slim chance of stealing a divisional title. A Week 15 win over the Patriots brought the Cards to 7-7 and will have them competing full throttle against a Panthers squad that was routed by the Cowboys last week.

While the improved play of Bryce Young has kept Carolina largely competitive in recent weeks, this Panthers squad is far from being a “good” football team. The Panthers’ defense has been sieve-like against the run, relinquishing an NFL-worst 173.0 rushing yards per game. James Conner – fresh off a monster 110-rushing yard, two TD performance against New England – should dominate this juicy matchup.

Jalen Hurts - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Philadelphia Eagles 27, Washington Commanders 17

It’s hard to win every game in the NFL – just ask the Detroit Lions – but the Eagles show no signs of slowing down. Philly dominated the Pittsburgh Steelers last week for their tenth consecutive victory and will look to stay hot while taking care of some divisional business against the Commanders in Week 16.

The Eagles ignited their long-dormant passing attack last week, but I expect the Philadelphia offense to return to pounding the rock with Saquon Barkley and put another “W” on the board against a Washington defensive front that’s relinquishing 189.6 rushing yards per game this season.

Kyren Williams - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Los Angeles Rams 27, New York Jets 24

The Rams escaped a Thursday night slugfest against the Niners in Week 15 and now control their own destiny in the NFC West. They’ll need to take care of business against a Jets squad that has long been eliminated from playoff contention but has shown some fight in recent weeks.

Aaron Rodgers and Davante Adams put forth a throwback performance in New York’s win over the Jaguars last week. Rodgers finished with 289 passing yards and three TDs, while Adams posted 198 yards and two scores on nine catches. Unfortunately, the Jets’ once-vaunted defense has rarely proven themselves to be up to the task in 2024, and with a fully healthy receiving duo of Puka Nacua and Cooper Kupp, Matthew Stafford and the Rams offense should find success.

Minnesota Vikings 24, Seattle Seahawks 20

Minnesota continued its stellar 2024 campaign with a dominant Monday night win over Chicago. The Vikings now stand at 12-2, and with Detroit’s Week 15 loss, both the NFC North title and No. 1 seed remain very much in play for Kevin O’Connell’s upstart squad.

The Vikes have now won seven straight and head to Seattle to face a Seahawks squad that was dominated by Green Bay last week and could be without quarterback Geno Smith. Assuming Smith does suit up in Week 16, he’ll face creative blitzes from the aggressive Vikings defense behind an offensive line that’s shaky at best. Seattle running back Kenneth Walker III also remains a question mark as of this writing and the ‘Hawks might just be too banged up to come out on top against a confident Minnesota group.

Five Fantasy Football Overvalued Quarterbacks

Buffalo Bills 31, New England Patriots 14

Ok…what can’t Josh Allen do? The MVP frontrunner has gone full “Superman Mode” in recent weeks. Allen has thrown for 704 yards and five TDs – as well as ran for five scores – across Buffalo’s last two games.

I don’t believe the New England defense possesses any kryptonite to slow Allen’s MVP march down this week. While rookie quarterback Drake Maye has been a bright spot for the rebuilding Patriots, his supporting cast leaves much to be desired. Traveling to Buffalo to face a superior team, New England poses little threat to the AFC East champion Bills.

Brian Thomas Jr - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Jacksonville Jaguars 20, Las Vegas Raiders 13

This game gets the undisputed title of Week 16’s ugliest matchup. Sporting a combined record of 5-23, the Jags and Raiders are simply playing out the string at this point. Both squads have been forced to play without their starting quarterbacks as of late. While Jacksonville’s Mac Jones has his faults, he’s certainly superior to Las Vegas’ Desmond Ridder.

Jones has been “not terrible” over the last three weeks, throwing for a combined 749 yards since Week 15. He’s formed a nice rapport with rookie stud and future superstar Brian Thomas Jr., who should have his way with the Raiders’ secondary. Offensively, Las Vegas has little chance of getting anything going as long as Ridder is under center, even against the Jags, who are one of the NFL’s worst defensive units.

Jauan Jennings - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

San Francisco 49ers 21, Miami Dolphins 20

An ugly Week 15 loss to the Rams sent the Niners playoff hopes tanking to less than 1%. It’s been a miserable, injury-plagued campaign for a San Francisco team that reached last year’s Super Bowl and was expected to once again be a serious title contender in 2024.

The Miami Dolphins have struggled through a similarly dreadful season. At one point this year the Dolphins lost six of seven, an ugly stretch that can largely be blamed on Tua Tagovailoa’s trip to Injured Reserve. Miami has been better since Tua’s return, but it can’t be ignored that their most quality win of the season came against the Rams. Mike McDaniel and the Dolphins hold a record of 0-5 against teams with better-than-.500 records this year. While the Niners aren’t ahead in the win-loss column for the season, they will still be too much for Miami to handle this week.

Mike Evans, Baker Mayfield - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Tampa Bay Bucs 28, Dallas Cowboys 23 (Sunday Night Football)

The previously lifeless Cowboys have shown some fight while winning three of their last four. However, their most recent loss came at the hands of the Cincinnati Bengals, a team with a high-powered passing attack. They draw a similar Week 16 matchup against the Bucs and a Baker Mayfield-led offense that ranks fourth in the NFL in passing yards per game.

Despite any incremental improvements they’ve made over the past month, this ‘Boys defense is still hemorrhaging points and yards to their opponents. Dallas ranks 29th in the NFL at 27.1 points allowed per game this year. Fighting for the NFC South title, Mayfield and company have scored 26 or more points in four straight. They should feast on a Cowboys secondary that will now be without Trevon Diggs for the remainder of the season.

Josh Jacobs - Fantasy Football Rankings, NFL Injury News, DFS Picks

Green Bay Packers 27, New Orleans Saints 13 (Monday Night Football)

I’m sure football fans wish Week 16 closed out with a more dramatic matchup on Monday Night Football, but it’s the Packers and Saints we’ll get. At least there will be fantasy points to sweat, as the game itself is a mismatch on paper that shouldn’t be close.

Green Bay comes in off a Week 15 destruction of Seattle. The Packers have been running the ball at an elite level with offseason acquisition Josh Jacobs and should control this game from the outset against a Saints run defense that’s getting smashed for 134.4 rushing yards per game on average. As if this wasn’t enough of a mismatch, New Orleans will likely be without both Derek Carr and Alvin Kamara for this trip to Lambeau Field.

POPULAR FANTASY TOOLS

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REAL-TIME FANTASY NEWS

San Francisco Giants

Tony Vitello Named New Manager of the Giants
Anthony Edwards

Active Against Trail Blazers
Grayson Allen

Active for Suns’ Opening Night Game
Kevin Porter Jr.

Won't Return on Wednesday Evening
Anthony Edwards

a Game-Time Decision for Wednesday
Daniel Gafford

Ruled Out for Mavericks Season Opener
Alexander Romanov

Expected to Miss Two More Games
Pierre Engvall

Ruled Out for the Season
Luguentz Dort

Questionable for Thursday Versus Pacers
Adin Hill

Out Week-to-Week
Patrik Laine

Sits Out Another Game Wednesday
Caris LeVert

Cleared for Wednesday's Game
Marco Rossi

Available Wednesday Night
Cody Glass

Out on Wednesday
Ryan Kalkbrenner

Starting on Wednesday
Stefan Noesen

Makes Season Debut Wednesday
Jaylen Brown

Available Versus Philadelphia
OG Anunoby

Available to Play in Season Opener
Alex Caruso

Placed in Concussion Protocol Wednesday
Joel Embiid

on a Minutes Cap Versus Boston
Kel'el Ware

Available for Season Opener
De'Andre Hunter

Absent on Wednesday
Karl-Anthony Towns

to Play in Season Opener
Jaylen Waddle

Dolphins Don't Have Plans to Trade Jaylen Waddle
Francisco Lindor

has Elbow Surgery, Expected to be Ready for Spring Training
Mike Conley

Moves to Bench to Start Season
Aaron Jones Sr.

Considered Questionable to Play on Thursday
Donte DiVincenzo

Opening Season as a Starter
Giannis Antetokounmpo

Dowgraded to Probable on Wednesday
Karl-Anthony Towns

Upgraded to Questionable For Season Opener
PGA

Alex Noren is a Smash Play at Bank of Utah Championship
Jalen Suggs

Good to Go on Wednesday Night
Karl-Anthony Towns

Now Doubtful for the Opener
Mike Evans

Could be Back in Under Eight Weeks
Bucky Irving

Will Not Play in Week 8
Jayden Daniels

Will Not Play on Monday Night Against Chiefs
Darren Waller

Dolphins Place Darren Waller on Injured Reserve
Maverick McNealy

Look Out For Maverick McNealy This Week in Utah
Justin Lower

Unlikely to Flip The Script at Bank of Utah Championship
Stephan Jaeger

Looking for Repeat Performance in Utah
CFB

Behren Morton Will be Listed as Questionable on Wednesday
Max McGreevy

a Longer Shot to Contend in Utah
Jackson Suber

on the Bubble for the PGA in 2026
Greyson Sigg

Improving at the Right Time This Fall
Seamus Power

Hopes to Make More Birdies This Week
Patton Kizzire

May Struggle Once Again in Utah
Beau Hossler

Up and Down Heading to Bank of Utah Championship
Adam Hadwin

Looking to Find the Weekend in Utah
Christiaan Bezuidenhout

Enjoying the Fall Golf Season
Brad Marchand

Delivers Two Assists on Special Night
Adrian Kempe

Lifts Kings to Victory Tuesday
Justin Brazeau

Records Three Points Against Canucks
Jack Hughes

Pots Third Career Hat Trick
TOR

Chris Tanev Could Miss Time With Upper-Body Injury
Jack McBain

Evaluated for Upper-Body Injury
Tom Hoge

Sputtering into Bank of Utah Championship
Sahith Theegala

On the Upswing Heading into Utah
Andrew Putnam

Looks to Find Form in Utah
Matt McCarty

Looks to Defend Title in Utah
Ben Kohles

a Strong Value Play at Bank of Utah Championship
Max Homa

Trending Up Entering the Bank of Utah Championship
Nick Dunlap

Searching for Spark at Bank of Utah Championship
Quade Cummins

Struggling to Find Form Ahead of Bank of Utah Championship
Maxx Crosby

Raiders Won't Trade Maxx Crosby
Jonathan Marchessault

Remains Absent Against Ducks
Darcy Kuemper

Available Tuesday
Corey Perry

Makes Season Debut Tuesday
Matt Duchene

Misses Tuesday's Action
Alexander Romanov

Unavailable Versus Sharks
Brock Boeser

Remains Out Tuesday
Jared McCann

Out on Tuesday
Jason Day

Making a Spot Start at Bank of Utah Championship
Los Angeles Angels

Kurt Suzuki to be the Angels' Next Manager
Bo Bichette

Plans to be Ready for World Series
Tyrod Taylor

Aaron Glenn "Moving Toward" Naming Tyrod Taylor the Starting QB
Zach Charbonnet

Finds the End Zone Twice on Monday Night
Jaxon Smith-Njigba

Continues Elite Production
Chris Godwin

Bucky Irving May Not Play This Week
Michael Penix Jr.

Expected to Be "Good to Go" for Sunday
Nick Foligno

Back With Blackhawks
Nico Collins

Ruled Out Late on Monday Night With Concussion
Nico Collins

Suffers Head Injury on Monday Night
Jahmyr Gibbs

Blows Up For 218 Total Yards, Two Touchdowns in Win
Mike Evans

to Miss Most of the Year With Broken Clavicle
Brandon Woodruff

Expects to Be Ready for Opening Day
Mike Evans

Ruled Out Monday With Concussion, Shoulder Injury
Mike Evans

Making his Return in Primetime Against Detroit
Emeka Egbuka

Officially Active on Monday Night
Michael Penix Jr.

Dealing With Bone Bruise in Foot, Considered Day-to-Day
Jayden Daniels

Avoids Long-Term Injury, Status Unknown for Week 8
Reinier de Ridder

Reinier De Ridder Suffers His First UFC Loss
Brendan Allen

Wins Back-To-Back Fights
Kevin Holland

Drops Decision
Mike Malott

Wins Third Fight In A Row
Marlon Vera

Loses Third Consecutive Fight
Aiemann Zahabi

Gets A Razor-Thin Split Decision Win
Jasmine Jasudavicius

Suffers First-Round TKO Loss
Manon Fiorot

Gets Back In The Win Column
Davey Grant

Suffers Submission Loss
Charles Jourdain

Gets First-Round Submission Win
Matt Frevola

Gets Dominated At UFC Vancouver
Matt Frevola

Kyle Nelson Dominates Matt Frevola
George Springer

Returns to Lineup for Game 6 of ALCS
CFB

Colorado State Fires Head Coach Jay Norvell After Four Seasons
CFB

Florida Fires Head Coach Billy Napier After Four Years
Chase Elliott

Can Chase Elliott Deliver Another Clutch Win to Make Championship 4?
William Byron

Seeks First Win at Talladega to Overcome Las Vegas Crash
Chase Briscoe

Likely to Finish Worse Than he Starts
Kyle Larson

Despite No Wins on Drafting Tracks, Kyle Larson is Improving
Tyler Reddick

Despite Winning at Talladega, Tyler Reddick's Drafting Record Is Not So Hot
Ross Chastain

Poor Qualifying Makes him a Strong DFS Option at Talladega
Chris Buescher

Excellent Crash Avoidance Could Reap Dividends at Talladega
Ty Gibbs

If Ty Gibbs' Team Executes a Better Strategy, he Could Win at Talladega
Daniel Suarez

Hopes for Clutch Talladega Win to Remain in the NASCAR Cup Series
Josh Berry

Might Contend at Talladega
Austin Dillon

Doesn't Lead Enough at Talladega to Contend for Wins
Brendan Donovan

Undergoes Sports Hernia Surgery
George Springer

Exits Game 5 Early After HBP on his Knee
Jackson Chourio

Back in Game 4 Lineup Against Dodgers
Iván Herrera

Ivan Herrera Has Bone Spurs Removed From his Elbow
Brendan Allen

Set For UFC Vancouver Main Event
Reinier de Ridder

Reinier De Ridder A Favorite At UFC Vancouver
Mike Malott

Looks For His Third Consecutive Win
Kevin Holland

Set For UFC Vancouver Co-Main Event
Aiemann Zahabi

Looks For His Seventh Consecutive Win
Marlon Vera

Returns At UFC Vancouver
Jasmine Jasudavicius

Looks To Extend Her Win Streak
Manon Fiorot

Looks To Bounce Back
Aoriqileng

Aori Aoriqileng Looks To Rebound

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