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Yahoo Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

Week 16 daily fantasy football lineup picks and NFL DFS cheat sheet for Yahoo. DFS lineup targets and sleepers for GPPs / cash games at RB, WR, QB, TE, and DEF.

Happy Holidays RotoBallers! In this article, I will be taking a look at some of my favorite Yahoo DFS lineups picks for the Week 16 slate. These DFS picks are based on a multitude of factors including matchup, talent, recent performance, Vegas odds, and pricing on Yahoo.

In a bit of a departure from their normal setup, Yahoo's main slate covers just the 12 games being played on Sunday. That leaves a few intriguing offenses, namely the Pittsburgh Steelers, off of the slate. As usual, the focus here isn't to point out that Rob Gronkowski and Le'Veon Bell are great plays because you already know that. Instead, the goal is to point out some good value plays along with some underpriced stars.

Good luck this week, hopefully Santa leaves a bag of cash in your account at the end of Sunday's action!

 

Quarterback Picks for Yahoo DFS

Cam Newton, Carolina Panthers vs. TB, $39

Newton turned in a huge game against the Packers in Week 15, slicing their defense for 242 yards and four passing touchdowns. The former league MVP is playing his best football since his MVP season back in 2015 and draws a fantastic matchup against a Tampa Bay pass defense that is one of the worst in the league. The Buccaneers are allowing 278 passing yards per game this season and their pass defense ranks 29th in the league in DVOA. Newton should have no trouble moving the ball in Week 16. As an added bonus, he has been rushing the ball more frequently lately, having taken 25 carries over the past two weeks.

Dak Prescott, Dallas Cowboys vs. SEA, $28

Prescott is in play for those who want to pay down at quarterback in cash games on a slate where there isn't a ton of value at the position unless you like Jameis Winston or trust Marcus Mariota against the Rams (I don't). Prescott will take on a banged up Seattle defense in a game that will see Ezekiel Elliott return to the offense. Prescott was playing MVP-level football earlier in the season before Elliott was suspended for six games. While the absence of Zeke can't fully explain Prescott's struggles, it will help to have the star runner back on the field. The Seahawks have allowed opposing quarterbacks to pass for either 268 yards or two touchdowns in three straight games.

 

Running Back Picks for Yahoo DFS

Dion Lewis, New England Patriots vs. BUF, $26

The injury to Rex Burkhead thrusts Lewis into a prime spot against what has been one of the worst run defenses in the league. While he may lose some passing work to James White, Lewis should operate as the Patriots' lead back in Week 16 against a Buffalo run defense that has allowed the most rushing touchdowns and the most fantasy points per game to opposing running backs. While the Patriots haven't used Lewis as a pass-catcher very frequently, he did show the ability to catch passes back in 2015 before he tore his ACL. At just $26, Lewis shapes up as an excellent option who would presumably see all the clock-killing carries when the Patriots inevitably get out to a big lead against Buffalo.

Kenyan Drake, Miami Dolphins @ KC, $21

Drake remains an excellent running back option who you will want to have plenty of exposure to this weekend. The second-year running back has operated as a true bell-cow back since Damien Williams got injured, having played in 93% of his team's offensive snaps over the past two weeks. Even if Williams returns this week, Drake has certainly shown enough to remain locked in as the team's starting running back. Yahoo has been slow to adjust Drake's price, meaning you can get a borderline RB1 at a significant discount. The Chiefs have struggled against the run this season, ranking 31st in run defense DVOA.

 

Wide Receiver Picks for Yahoo DFS

Michael Thomas, New Orleans Saints vs. ATL, $29

Thomas is significantly underpriced on Yahoo, checking in at a full $10 below Keenan Allen, the most expensive receiver on the slate. While we haven't seen a ton of ceiling games from Thomas in this new run-first New Orleans offense, he has been one of the most consistent receivers in the league this season. Thomas has seen at least eight targets in nine straight games while dipping below 70 receiving yards just twice over that span. The Falcons had no answer for him two weeks ago when these two teams met, allowing him to catch 10 passes for 117 yards and a touchdown. Thomas is one of the receivers who I am building cash lineups around this weekend.

Larry Fitzgerald, Arizona Cardinals vs. NYG, $26

Fitzgerald is another rock-solid cash game option who possesses enough upside to use in tournaments as well. Similar to Michael Thomas, Fitzgerald's target share is one of the most consistent in the league. The veteran pass catcher has seen at least seven targets in seven straight games while topping 60 receiving yards in five of those contests. He draws a tasty Week 16 matchup against a Giants defense that mailed it in a long time ago. New York's pass defense is allowing the second-most passing yards per game this season and ranks 25th in DVOA according to Football Outsiders.

 

Tight End Picks for Yahoo DFS

Delanie Walker, Tennessee Titans vs. LAR, $17

Walker brings overall TE1 upside to the table but at a fraction of the cost of Rob Gronkowski or Travis Kelce. While the Titans' pass offense has struggled at times this season, Walker has remained one of the more consistent options at a tight end position that can be tough to find players to trust. The matchup against the Rams isn't an easy one but the Titans will likely have to abandon their "exotic smash mouth" run-first offense early to keep up with an explosive Rams offense.

Cameron Brate, Tampa Bay Buccaneers @ CAR, $11

Brate stands to see a huge increase in target share with rookie tight end O.J. Howard landing on injured reserve earlier in the week. Without Howard around to steal targets from him, Brate should be on the field running pass routes for most of the game against the rival Carolina Panthers. He isn't a sure thing, but we know Jameis Winston likes to target him in the red zone. At just $1 over the minimum salary on Yahoo, Brate opens up plenty of funds to use on studs elsewhere when setting lineups.

 

Defense/Special Teams Pick for Yahoo DFS

Carolina Panthers vs. TB, $17

The Panthers are a strong play this week in a home game against a turnover-prone Jameis Winston. Tampa Bay's offense has been a huge disappointment this season. On the year, the Buccaneers have 21 giveaways, seventh-highest in the league. The Panthers are massive 10-point home favorites against a Buccaneers team that has an implied team total of 18.25 points. They are a strong play in both cash games and tournaments.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

Yordan Alvarez

Continues Homer Barrage With Two More Long Balls on Wednesday
Cristopher Sánchez

Cristopher Sanchez Makes History With Seven More Shutout Innings Against Padres
Teoscar Hernández

Teoscar Hernandez Lifted From Wednesday's Game Early With Hamstring Strain
Younghoe Koo

Jets Sign Kicker Younghoe Koo on Wednesday
Quinn Ewers

Looks Good in Wednesday's OTA Practice
Kenley Jansen

Exits Relief Appearance on Wednesday With Groin Injury
Ty Johnson

Taking Part in OTAs
Ja'Tavion Sanders

Cutting Laterally at OTAs
Tre' Harris

has Been a Top-Three Receiver During Offseason Program
Makai Lemon

Already Working With Starters in OTAs
AJ Barner

Undergoes Offseason Procedures, Not Taking Part in OTAs
Zach Charbonnet

Might Not Return Until Midseason
Von Miller

"For Sure" Plans to Play in 2026
Alvin Kamara

Not at OTAs But Preparing for the 2026 Season
Lamar Jackson

"Absolutely" Wants to Stay With Ravens Long-Term
Mason Plumlee

NBA Upgrades Mason Plumlee's Foul to a Flagrant 1
Victor Wembanyama

Receives Warning From NBA
Atlanta Hawks

Hawks Promote Onsi Saleh to President of Basketball Operations
Jalen Williams

Listed as Questionable for Game 6
Ajay Mitchell

Ruled Out for Game 6
Michael Penix Jr.

Not Cleared for 11-on-11 Work
Jacoby Brissett

Still Absent From OTAs This Week
George Kittle

Still Hoping to be Ready for Week 1
Micah Parsons

Expected to Open Training Camp on the PUP List
Tucker Kraft

Packers Hopeful Tucker Kraft Will Participate in Training Camp
Jacory Croskey-Merritt

Held Out of OTAs on Wednesday
Jayden Daniels

Participating in Commanders OTAs
Chris Bell

No Timetable for Chris Bell's Return from Knee Surgery
De'Von Achane

Limited in OTAs Due to Recovery From Shoulder Injury
MarShawn Lloyd

Participating in Packers OTAs
Eury Pérez

Eury Perez Pulled Early on Wednesday With Hamstring Issue
CFB

Drew Mestemaker a Top Big 12 Quarterback Right Away?
PGA

Sungjae Im Remains Boom-or-Bust at Colonial
PGA

Michael Thorbjornsen Trending in Wrong Direction Entering Colonial
De'Aaron Fox

Limited to Nine Points in Game 5 Loss
Russell Henley

a Top Option at Colonial
Harry Hall

Hoping Putter Carries Him at Colonial
Julian Champagnie

Notches 22 Points With Four Triples Tuesday
Stephon Castle

Leads Spurs in Scoring Tuesday Night
Rickie Fowler

Looks to Regain Momentum at Colonial
Victor Wembanyama

Struggles in Game 5 Loss to Thunder
Alex Caruso

a Difference-Maker Again in Game 5
Pierceson Coody

Looking to Stay Hot at Colonial
Jared McCain

Produces 20 Points in First Playoff Start
Shai Gilgeous-Alexander

Scores Game-High 32 Points in Game 5 Win
Martin Necas

Collects an Assist in Game 4 Loss to Golden Knights
Gabriel Landeskog

Scores Only Avalanche Goal in Season-Ending Loss
Carter Hart

Finishes Series-Clincher With 20 Saves
Dylan Coghlan

Continues Unlikely Success Story
Cole Smith

Scores Series-Clincher Tuesday Night
Mark Stone

Nets Another Goal as Golden Knights Finish Off Avalanche
Ludvig Aberg

Looking to Exchange Momentum for a Victory in Fort Worth
Stephan Jaeger

Trending Upward as PGA Heads to Fort Worth
Max Homa

Comes Off Awful Putting Performance at PGA Championship
Tony Finau

Faces Different Test at the Colonial
Robert MacIntyre

Seeks Better Beginning in Fort Worth
Tom Hoge

Ups and Downs Could Continue at Colonial
Brian Harman

Not Having the Best Golf Season in 2026
Austin Eckroat

Struggling Too Often Heading to Charles Schwab Challenge
Zach Bauchou

Tries to Keep Momentum Rolling at Colonial
Keegan Bradley

Looking to Rebound at Colonial
Jared McCain

Moves into Starting Five
Boston Celtics

Joe Mazzulla Wins Coach of the Year
Jalen Williams

is Ruled Out for Game 5 on Tuesday
Zion Williamson

to See More Versatile Role
Cleveland Cavaliers

Kenny Atkinson to Remain Cavaliers Head Coach Next Season
Claude Giroux

Planning to Return for 20th NHL Campaign
Carter Hart

Aiming for Sixth Consecutive Win Tuesday
Evgeni Malkin

Inks New One-Year Deal With Penguins
Mackenzie Blackwood

in Net for Game 4 Against Golden Knights
Valeri Nichushkin

a Game-Time Call Tuesday
Nathan MacKinnon

Will Suit Up Tuesday
Ben Griffin

Looking to Repeat This Week at Colonial
Rasmus Hojgaard

a Player to Avoid at Charles Schwab Challenge
Hideki Matsuyama

Needs Solid Driving Week at Charles Schwab Challenge
Justin Thomas

Trending Well Ahead of Charles Schwab Challenge
Akshay Bhatia

Lacking Driving Prowess Needed at Colonial Country Club
CFB

DJ Lagway Looking to Rebound at Baylor
CFB

Josh Hoover Tasked With Leading Indiana Back to the Playoffs
CFB

Braylon Staley the Next 1,000-Yard Tennessee Receiver?
CFB

Ahmad Hardy's Return Timeline Remains Unclear
Evan Mobley

Finishes Season-Ending Loss With 15 Points
James Harden

Wants to Stay in Cleveland
Donovan Mitchell

Remains Committed to Cavaliers
Mikal Bridges

Cools Off in Game 4 Against Cavaliers
Ivan Demidov

Contributes an Assist in Losing Effort
Lane Hutson

Records Power-Play Goal in Game 3 Loss
Frederik Andersen

Enjoys Another Easy Night at the Office in Game 3
Shayne Gostisbehere

Scores First Postseason Goal
Taylor Hall

Ends Four-Game Goal Drought
Andrei Svechnikov

Scores Game 3 Winner in Overtime
Gage Jump

Athletics to Promote Top Pitching Prospect Gage Jump to Major Leagues
Tatsuya Imai

Two Relievers Combine to No-Hit the Rangers on Monday
Valeri Nichushkin

Nathan MacKinnon, Valeri Nichushkin Uncertain for Game 4
Oliver Kapanen

Sitting as Healthy Scratch Monday
Max Domi

Out Indefinitely Due to Offseason Surgery Complications
Dylan Cease

Heading to Injured List With Hamstring Injury
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
MLB

Orioles-Tigers Game Postponed on Saturday
MLB

Rays-Yankees Postponed on Saturday
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF