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Yahoo Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

Week 16 daily fantasy football lineup picks and NFL DFS cheat sheet for Yahoo. DFS lineup targets and sleepers for GPPs / cash games at RB, WR, QB, TE, and DEF.

Happy Holidays RotoBallers! In this article, I will be taking a look at some of my favorite Yahoo DFS lineups picks for the Week 16 slate. These DFS picks are based on a multitude of factors including matchup, talent, recent performance, Vegas odds, and pricing on Yahoo.

In a bit of a departure from their normal setup, Yahoo's main slate covers just the 12 games being played on Sunday. That leaves a few intriguing offenses, namely the Pittsburgh Steelers, off of the slate. As usual, the focus here isn't to point out that Rob Gronkowski and Le'Veon Bell are great plays because you already know that. Instead, the goal is to point out some good value plays along with some underpriced stars.

Good luck this week, hopefully Santa leaves a bag of cash in your account at the end of Sunday's action!

 

Quarterback Picks for Yahoo DFS

Cam Newton, Carolina Panthers vs. TB, $39

Newton turned in a huge game against the Packers in Week 15, slicing their defense for 242 yards and four passing touchdowns. The former league MVP is playing his best football since his MVP season back in 2015 and draws a fantastic matchup against a Tampa Bay pass defense that is one of the worst in the league. The Buccaneers are allowing 278 passing yards per game this season and their pass defense ranks 29th in the league in DVOA. Newton should have no trouble moving the ball in Week 16. As an added bonus, he has been rushing the ball more frequently lately, having taken 25 carries over the past two weeks.

Dak Prescott, Dallas Cowboys vs. SEA, $28

Prescott is in play for those who want to pay down at quarterback in cash games on a slate where there isn't a ton of value at the position unless you like Jameis Winston or trust Marcus Mariota against the Rams (I don't). Prescott will take on a banged up Seattle defense in a game that will see Ezekiel Elliott return to the offense. Prescott was playing MVP-level football earlier in the season before Elliott was suspended for six games. While the absence of Zeke can't fully explain Prescott's struggles, it will help to have the star runner back on the field. The Seahawks have allowed opposing quarterbacks to pass for either 268 yards or two touchdowns in three straight games.

 

Running Back Picks for Yahoo DFS

Dion Lewis, New England Patriots vs. BUF, $26

The injury to Rex Burkhead thrusts Lewis into a prime spot against what has been one of the worst run defenses in the league. While he may lose some passing work to James White, Lewis should operate as the Patriots' lead back in Week 16 against a Buffalo run defense that has allowed the most rushing touchdowns and the most fantasy points per game to opposing running backs. While the Patriots haven't used Lewis as a pass-catcher very frequently, he did show the ability to catch passes back in 2015 before he tore his ACL. At just $26, Lewis shapes up as an excellent option who would presumably see all the clock-killing carries when the Patriots inevitably get out to a big lead against Buffalo.

Kenyan Drake, Miami Dolphins @ KC, $21

Drake remains an excellent running back option who you will want to have plenty of exposure to this weekend. The second-year running back has operated as a true bell-cow back since Damien Williams got injured, having played in 93% of his team's offensive snaps over the past two weeks. Even if Williams returns this week, Drake has certainly shown enough to remain locked in as the team's starting running back. Yahoo has been slow to adjust Drake's price, meaning you can get a borderline RB1 at a significant discount. The Chiefs have struggled against the run this season, ranking 31st in run defense DVOA.

 

Wide Receiver Picks for Yahoo DFS

Michael Thomas, New Orleans Saints vs. ATL, $29

Thomas is significantly underpriced on Yahoo, checking in at a full $10 below Keenan Allen, the most expensive receiver on the slate. While we haven't seen a ton of ceiling games from Thomas in this new run-first New Orleans offense, he has been one of the most consistent receivers in the league this season. Thomas has seen at least eight targets in nine straight games while dipping below 70 receiving yards just twice over that span. The Falcons had no answer for him two weeks ago when these two teams met, allowing him to catch 10 passes for 117 yards and a touchdown. Thomas is one of the receivers who I am building cash lineups around this weekend.

Larry Fitzgerald, Arizona Cardinals vs. NYG, $26

Fitzgerald is another rock-solid cash game option who possesses enough upside to use in tournaments as well. Similar to Michael Thomas, Fitzgerald's target share is one of the most consistent in the league. The veteran pass catcher has seen at least seven targets in seven straight games while topping 60 receiving yards in five of those contests. He draws a tasty Week 16 matchup against a Giants defense that mailed it in a long time ago. New York's pass defense is allowing the second-most passing yards per game this season and ranks 25th in DVOA according to Football Outsiders.

 

Tight End Picks for Yahoo DFS

Delanie Walker, Tennessee Titans vs. LAR, $17

Walker brings overall TE1 upside to the table but at a fraction of the cost of Rob Gronkowski or Travis Kelce. While the Titans' pass offense has struggled at times this season, Walker has remained one of the more consistent options at a tight end position that can be tough to find players to trust. The matchup against the Rams isn't an easy one but the Titans will likely have to abandon their "exotic smash mouth" run-first offense early to keep up with an explosive Rams offense.

Cameron Brate, Tampa Bay Buccaneers @ CAR, $11

Brate stands to see a huge increase in target share with rookie tight end O.J. Howard landing on injured reserve earlier in the week. Without Howard around to steal targets from him, Brate should be on the field running pass routes for most of the game against the rival Carolina Panthers. He isn't a sure thing, but we know Jameis Winston likes to target him in the red zone. At just $1 over the minimum salary on Yahoo, Brate opens up plenty of funds to use on studs elsewhere when setting lineups.

 

Defense/Special Teams Pick for Yahoo DFS

Carolina Panthers vs. TB, $17

The Panthers are a strong play this week in a home game against a turnover-prone Jameis Winston. Tampa Bay's offense has been a huge disappointment this season. On the year, the Buccaneers have 21 giveaways, seventh-highest in the league. The Panthers are massive 10-point home favorites against a Buccaneers team that has an implied team total of 18.25 points. They are a strong play in both cash games and tournaments.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

Denny Hamlin

Goes from the Back to Victory at Michigan
Erik Jones

Earns his Best Finish of the 2026 Season So Far at Michigan
NASCAR

Bubba Wallace Moves up the Standings After Finishing Third at Michigan
Chase Elliott

Wrecks In the Final Stage at Michigan After Leading the Most Laps
Tyler Reddick

Crashes Out at Michigan After Winning A Stage
Bijan Robinson

Is Bijan Robinson's Dynasty Value Limited by Questionable Offensive Environment?
Woody Marks

Carries Buy-Low Appeal for Dynasty Managers Entering 2026
Antonio Williams

Poised for Dynasty Breakout in Washington?
Tyler Warren

Poised for Expanded Role in Indianapolis?
Seth McGowan

"Right in the Thick" of RB2 Battle in Indianapolis
Ashton Dulin

Poised to Win Starting Role in Indianapolis?
CFB

Brendan Sorsby Receives Injunction, Eligible for 2026 College Football Season
Gabriel Bonfim

Shines At UFC Vegas 118
Belal Muhammad

Suffers Third Consecutive Loss
Chris Rodriguez Jr.

Is Chris Rodriguez Jr. Falling Behind in Jaguars Running Back Battle?
Edmen Shahbazyan

Suffers Unanimous-Decision Loss
Edmen Shahbazyan

Brendan Allen Gets Unanimous-Decision Win Over Edmen Shahbazyan
Drew Allar

a Smart Stash in the Middle Rounds of Dynasty Rookie Drafts
Chris Olave

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Tom Nolan

Extends Win Streak
Farés Ziam

Fares Ziam Drops Decision At UFC Vegas 118
Jayden Higgins

"Going to Have a Great Year"
Jacoby Brissett

Expected to Report to Minicamp
Tarik Skubal

Dominates in Rehab Start, Return Appears Imminent
Mitchell Robinson

Available for Game 3
Chicago Bulls

Bulls Hire Alex Kaufman as Windy City Bulls General Manager
E.J. Liddell

Agrees to Two-Year Deal with Greek Club Aris
Konnor Griffin

is Looking at Extended Absence
Matas Buzelis

Will Play for Lithuania This Summer
Kenley Jansen

to Begin Rehab Assignment on Tuesday
Giannis Antetokounmpo

Has Concerns About Heat Roster If Traded to Miami
Casey Mize

to Make Rehab Start on Tuesday
Bobby Witt Jr.

Exits Early with Knee Soreness
Mitchell Robinson

Has Technical Foul Rescinded After Game 2 Win
Jarquez Hunter

Is it Time for Dynasty Managers to Move on From Jarquez Hunter?
Elijah Arroyo

Worth Buying Low on in Dynasty Formats?
Tre Tucker

Profiles as a Dynasty Sell-High Candidate Entering 2026
Jack Bech

Should Dynasty Managers Target Jack Bech as a Buy-Low Candidate?
Jaydon Blue

a Dynasty Buy-Low Candidate After Underwhelming Rookie Year?
Saquon Barkley

in Line for Larger Pass-Catching Role in 2026?
Max Fried

Nearing Return to Mound Work?
Karl-Anthony Towns

Eligible for Massive Extension
Isaiah Stewart

Could Draw Trade Interest
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Michigan?
Philadelphia 76ers

Jameer Nelson Promoted to Executive Vice President
Domantas Sabonis

Could be Traded This Summer
Ty Gibbs

Is Ty Gibbs Worth Rostering at Michigan This Week for DFS?
William Byron

Will Start at the Rear at Michigan After Unapproved Adjustments
NASCAR

Should DFS Managers Roster Bubba Wallace at Michigan?
Joey Logano

Is Joey Logano Worth Rostering In DFS Lineups for Michigan
Daniel Suarez

Might Have Tournament Appeal for Michigan DFS Lineups
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William Carrier

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Sebastian Aho

Records Two Assists in Losing Effort
Alex Lange

Earns Third Save, Quickly Entering Must-Roster Status
Keaton Mitchell

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Jordan Staal

Scores in Third Consecutive Game
Shea Theodore

Caps Multi-Point Effort With Game-Winning Goal Saturday
Kayshon Boutte

Will Attend Mandatory Minicamp
Denny Hamlin

Puts DFS Managers in Tough Spot for Michigan
Chase Elliott

Can Chase Elliott Get Back to His Old Ways at Michigan?
Chris Buescher

Looking for Another Solid Run at Michigan
Tomas Hertl

Collects Two Points in Overtime Win
Carson Hocevar

Qualifies Second, Seeking Redemption at Michigan
Ross Chastain

Can DFS Managers Trust Ross Chastain at Michigan?
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Brad Keselowski

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Will Smith

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Auston Matthews

Maple Leafs Confident of Keeping Auston Matthews
Andrei Vasilevskiy

Wins Second Vezina Trophy
Brayden McNabb

Uncertain for Game 3 Against Hurricanes
Hunter Greene

Could Return Before the All-Star Break
Dylan Harper

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De'Aaron Fox

Shoots Well in a Loss to the Knicks
Victor Wembanyama

Scores 29 Points in Game 2 Loss
OG Anunoby

Anchors Knicks' Defense in Finals Game 2
Mikal Bridges

Helps Knicks Secure a Game 2 Victory
Karl-Anthony Towns

Records Another Finals Double-Double
Jalen Brunson

Overcomes Cold Night to Seal Game 2
Michael Harris II

Dealing With Back Tightness, Not Believed to be Serious
Byron Buxton

Suffers Shoulder Contusion After Colliding With the Wall
Sacramento Kings

Kings Want to Trade Their Larger Contracts
Chicago Bulls

Darius Acuff Jr. Works Out for Bulls
Jaime Jaquez Jr.

Could Get Traded
MIN

Marcus Johansson Returning to Europe
Thomas White

Likely to Miss Rest of Season With Shoulder Capsular Sprain
Mitchell Robinson

is Upgraded to Available for Game 2
Cole Caufield

Earns Lady Byng Trophy
Nick Suzuki

Lands Selke Trophy
Jose Altuve

Astros Reinstate Jose Altuve From the Injured List
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Reed Harris Hoping to Fill Void in Arizona State Receiving Room
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Nick Marsh Gearing Up for Breakout
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Drew Mestemaker Looking to Catapult Oklahoma State Offense in 2026
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Rocco Becht Brings Experience to New-Look Nittany Lions
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Can Trey White, Adam Trick Keep Texas Tech's Defensive Front Elite?
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Devon Dampier is Key to Success for Morgan Scalley in Year 1
Aaron Judge

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Francisco Lindor

Expected to Return in "About a Couple Weeks"
Corey Seager

Rangers Activate Corey Seager From the Injured List
Gabriel Bonfim

Set For UFC Vegas 118 Main Event
Belal Muhammad

In Dire Need Of Win
Edmen Shahbazyan

An Underdog At UFC Vegas 118
Shayne Gostisbehere

Dishes Out Two Power-Play Assists in Comeback Win
Brendan Allen

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Seth Jarvis

Ties Finals With Power-Play Goal
Mark Stone

Scores Sixth Playoff Goal in Overtime Defeat
Tom Nolan

Searches For His Fifth Consecutive Win
Mitch Marner

Records Two Assists in Game 2 Loss
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Brayden McNabb

Hospitalized After Taking Puck to Face
Aaron Judge

Diagnosed with Stress Fracture, Out 4-6 Weeks
Shohei Ohtani

has "Small" Blister, a "Non-Issue" for his Pitching Starts
Brent Rooker

Out on Thursday Due to Knee Soreness
Frederik Andersen

Hurricanes Retain Confidence in Frederik Andersen
Vincent Trocheck

Maple Leafs Interested in Vincent Trocheck
Dylan Larkin

Requests Trade From Red Wings
Corey Seager

Expected to Return This Weekend
Lucas Erceg

Royals to Mix and Match in Ninth With Lucas Erceg Struggling
Rickie Fowler

Looks To Continue Resurgent Season At Memorial
CFB

Can Eric Singleton Jr. Fully Break Out at Third School?
CFB

Katin Houser Steps into QB1 Role for Illinois
CFB

Savion Hiter an Immediate Impact Freshman for Michigan
CFB

Isaiah Horton Set to Take Over KC Concepcion's Role
CFB

UCLA Transfer Karson Gordon Signs with Austin Peay
CFB

Will Muschamp Bringing New Intensity to Texas Practices
Gary Woodland

Brings Boom-or-Bust Potential to Memorial
Jordan Spieth

Still Searching for a Breakthrough
Alex Smalley

Brings Elite Form to Memorial Tournament
Justin Rose

Looks to Recapture Memorial Tournament Success
Cameron Young

Looks to Get Back to His Contending Ways at Murifield Village
Chris Gotterup

Needs to Find Fairways at Muirfield Village
Si Woo Kim

Looks to Stay Hot at Memorial Tournament
Matt Fitzpatrick

Positioned for Success at Muirfield Village
Keegan Bradley

Looking for Another Strong Finish at Muirfield
Justin Thomas

is an Exciting Play This Week in Ohio
Scottie Scheffler

Looks to Win Memorial Tournament for Third Consecutive Year
Rory McIlroy

Looking for Better Performance at Muirfield Village
Russell Henley

Coming to Ohio on the Heels of Latest Victory
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF