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Yahoo Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

Week 16 daily fantasy football lineup picks and NFL DFS cheat sheet for Yahoo. DFS lineup targets and sleepers for GPPs / cash games at RB, WR, QB, TE, and DEF.

Happy Holidays RotoBallers! In this article, I will be taking a look at some of my favorite Yahoo DFS lineups picks for the Week 16 slate. These DFS picks are based on a multitude of factors including matchup, talent, recent performance, Vegas odds, and pricing on Yahoo.

In a bit of a departure from their normal setup, Yahoo's main slate covers just the 12 games being played on Sunday. That leaves a few intriguing offenses, namely the Pittsburgh Steelers, off of the slate. As usual, the focus here isn't to point out that Rob Gronkowski and Le'Veon Bell are great plays because you already know that. Instead, the goal is to point out some good value plays along with some underpriced stars.

Good luck this week, hopefully Santa leaves a bag of cash in your account at the end of Sunday's action!

 

Quarterback Picks for Yahoo DFS

Cam Newton, Carolina Panthers vs. TB, $39

Newton turned in a huge game against the Packers in Week 15, slicing their defense for 242 yards and four passing touchdowns. The former league MVP is playing his best football since his MVP season back in 2015 and draws a fantastic matchup against a Tampa Bay pass defense that is one of the worst in the league. The Buccaneers are allowing 278 passing yards per game this season and their pass defense ranks 29th in the league in DVOA. Newton should have no trouble moving the ball in Week 16. As an added bonus, he has been rushing the ball more frequently lately, having taken 25 carries over the past two weeks.

Dak Prescott, Dallas Cowboys vs. SEA, $28

Prescott is in play for those who want to pay down at quarterback in cash games on a slate where there isn't a ton of value at the position unless you like Jameis Winston or trust Marcus Mariota against the Rams (I don't). Prescott will take on a banged up Seattle defense in a game that will see Ezekiel Elliott return to the offense. Prescott was playing MVP-level football earlier in the season before Elliott was suspended for six games. While the absence of Zeke can't fully explain Prescott's struggles, it will help to have the star runner back on the field. The Seahawks have allowed opposing quarterbacks to pass for either 268 yards or two touchdowns in three straight games.

 

Running Back Picks for Yahoo DFS

Dion Lewis, New England Patriots vs. BUF, $26

The injury to Rex Burkhead thrusts Lewis into a prime spot against what has been one of the worst run defenses in the league. While he may lose some passing work to James White, Lewis should operate as the Patriots' lead back in Week 16 against a Buffalo run defense that has allowed the most rushing touchdowns and the most fantasy points per game to opposing running backs. While the Patriots haven't used Lewis as a pass-catcher very frequently, he did show the ability to catch passes back in 2015 before he tore his ACL. At just $26, Lewis shapes up as an excellent option who would presumably see all the clock-killing carries when the Patriots inevitably get out to a big lead against Buffalo.

Kenyan Drake, Miami Dolphins @ KC, $21

Drake remains an excellent running back option who you will want to have plenty of exposure to this weekend. The second-year running back has operated as a true bell-cow back since Damien Williams got injured, having played in 93% of his team's offensive snaps over the past two weeks. Even if Williams returns this week, Drake has certainly shown enough to remain locked in as the team's starting running back. Yahoo has been slow to adjust Drake's price, meaning you can get a borderline RB1 at a significant discount. The Chiefs have struggled against the run this season, ranking 31st in run defense DVOA.

 

Wide Receiver Picks for Yahoo DFS

Michael Thomas, New Orleans Saints vs. ATL, $29

Thomas is significantly underpriced on Yahoo, checking in at a full $10 below Keenan Allen, the most expensive receiver on the slate. While we haven't seen a ton of ceiling games from Thomas in this new run-first New Orleans offense, he has been one of the most consistent receivers in the league this season. Thomas has seen at least eight targets in nine straight games while dipping below 70 receiving yards just twice over that span. The Falcons had no answer for him two weeks ago when these two teams met, allowing him to catch 10 passes for 117 yards and a touchdown. Thomas is one of the receivers who I am building cash lineups around this weekend.

Larry Fitzgerald, Arizona Cardinals vs. NYG, $26

Fitzgerald is another rock-solid cash game option who possesses enough upside to use in tournaments as well. Similar to Michael Thomas, Fitzgerald's target share is one of the most consistent in the league. The veteran pass catcher has seen at least seven targets in seven straight games while topping 60 receiving yards in five of those contests. He draws a tasty Week 16 matchup against a Giants defense that mailed it in a long time ago. New York's pass defense is allowing the second-most passing yards per game this season and ranks 25th in DVOA according to Football Outsiders.

 

Tight End Picks for Yahoo DFS

Delanie Walker, Tennessee Titans vs. LAR, $17

Walker brings overall TE1 upside to the table but at a fraction of the cost of Rob Gronkowski or Travis Kelce. While the Titans' pass offense has struggled at times this season, Walker has remained one of the more consistent options at a tight end position that can be tough to find players to trust. The matchup against the Rams isn't an easy one but the Titans will likely have to abandon their "exotic smash mouth" run-first offense early to keep up with an explosive Rams offense.

Cameron Brate, Tampa Bay Buccaneers @ CAR, $11

Brate stands to see a huge increase in target share with rookie tight end O.J. Howard landing on injured reserve earlier in the week. Without Howard around to steal targets from him, Brate should be on the field running pass routes for most of the game against the rival Carolina Panthers. He isn't a sure thing, but we know Jameis Winston likes to target him in the red zone. At just $1 over the minimum salary on Yahoo, Brate opens up plenty of funds to use on studs elsewhere when setting lineups.

 

Defense/Special Teams Pick for Yahoo DFS

Carolina Panthers vs. TB, $17

The Panthers are a strong play this week in a home game against a turnover-prone Jameis Winston. Tampa Bay's offense has been a huge disappointment this season. On the year, the Buccaneers have 21 giveaways, seventh-highest in the league. The Panthers are massive 10-point home favorites against a Buccaneers team that has an implied team total of 18.25 points. They are a strong play in both cash games and tournaments.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

Jiri Kulich

Aims to Return Next Season
Jeremy Lauzon

Not Expected to Play Wednesday
Brock Bowers

Klint Kubiak Calls Brock Bowers a "Football Robot From Heaven"
Mark Stone

Likely to Remain Out Wednesday
Scott Wedgewood

Starting Western Conference Finals for Avalanche
Sam Malinski

Set to Return Wednesday
Artturi Lehkonen

Expected to Play Wednesday Night
Cale Makar

Will Miss Game 1 Against Golden Knights
Malachi Fields

Appears Well-Positioned for Rookie Year Breakout in New York
Aaron Rodgers

Plans to Retire Following 2026 Season
Anthony Richardson Sr.

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DJ Giddens

Does DJ Giddens Carry Dynasty Buy-Low Appeal into 2026?
AJ Barner

Enters 2026 as a Dynasty Sell-High Candidate
Josh Jacobs

Is Josh Jacobs at the Peak of His Dynasty Value?
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Wilson

Cardinals Interested in Inking Michael Wilson to a Long-Term Extension
Kyle Williams

Bulks Up, Ready to Make Year 2 Leap
Deshaun Watson

the First QB Up During OTA Drills on Wednesday
Quinshon Judkins

Taking Part in 11-on-11 Drills
Xavier Legette

Fighting for His Future in Carolina?
Brian Thomas Jr.

Jaguars Not Expected to Trade Brian Thomas Jr.
Rashod Bateman

Future in Baltimore is Bleak
Mark Andrews

Poised to Bounce Back in 2026?
Tyrone Tracy Jr.

Is Tyrone Tracy Jr. a Sneaky Dynasty Buy?
Chimere Dike

Dynasty Managers Compelled to Hold Chimere Dike?
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Jameson Williams

a High-Ceiling Buy for Risk-Tolerant Dynasty Managers
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Chase Brown

a Short-term Dynasty Buy Whose Value Could Extend Beyond 2026
Tony Finau

Looking for Consistency at TPC Craig Ranch
J.K. Dobbins

Becoming an Underpriced Starting Running Back
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Rome Odunze

Has Ambiguity Among Bears WRs Created Buying Opportunity for Rome Odunze?
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
James Harden

Struggles in Eastern Conference Finals Opener
Evan Mobley

Bags Second Consecutive Double-Double
Donovan Mitchell

Produces Top Two-Way Performance in Game 1 Loss
OG Anunoby

Plays Key Role in Comeback Win
Mikal Bridges

Remains Efficient in Game 1 Against Cavaliers
Karl-Anthony Towns

Extends Double-Double Streak to Four Games
Jalen Brunson

Leads Knicks to Historic Comeback Win
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Dean Wade

Returns to Starting Unit Tuesday
OG Anunoby

Starting on Tuesday
Tobias Harris

May Remain in Motown
Jalen Duren

Pistons Eager to Keep Jalen Duren
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Dallas Mavericks

Jason Kidd Fired as Mavericks Head Coach
De'Aaron Fox

Officially Listed as Questionable for Game 2 Against Thunder
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
Alex Caruso

Erupts for 31 Points in Game 1 Loss to Spurs
CFB

Kemario Taylor a Breakout Candidate at Quarterback
Jalen Williams

Productive in Comeback Game
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
Shai Gilgeous-Alexander

Records First Double-Double of Postseason
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Stephon Castle

Opens Conference Finals With Double-Double
Dylan Harper

Makes Outstanding Two-Way Impact in Game 1 Win
Victor Wembanyama

Dominates Game 1 Against Thunder
Mattias Samuelsson

Picks Up an Assist in Season-Ending Loss
Rasmus Dahlin

Nets Fourth Postseason Goal
Jakub Dobes

Records 37 Saves in Game 7 Win
Lane Hutson

Contributes Power-Play Assist in Game 7 Victory
Nick Suzuki

Extends Road Point Streak
Alex Newhook

Scores Series-Clincher in Overtime
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Larry Nance Jr.

is Questionable for Game 1 on Tuesday
OG Anunoby

is Probable for Tuesday's Game 1
Ukko-Pekka Luukkonen

Set to Start Game 7
Corey Seager

Going on Injured List With Back Injury
Tage Thompson

Can Match Franchise Record With Another Multi-Point Game
Nick Suzuki

Seeks More Road Success Monday
Lane Hutson

Riding a Five-Game Assist Streak Into Game 7
Filip Gustavsson

Needs Offseason Surgery
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Quinn Hughes

Open to Signing Extension This Offseason
Joel Eriksson Ek

Misses Second Round Due to Heel Injury
Jonas Brodin

Sits Out Round 2 Due to Toe Injury
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF