Who Should I Pickup for Fantasy Football Week 5? Chris Godwin, Adonai Mitchell, Jeremy McNichols, Kyle Pitts Sr., Isaiah Bond, Tyler Allgeier, Dalton Schultz, Jake Tonges, Dontayvion Wicks, Jalen Tolbert

Tampa Bay Buccaneers wide receiver Chris Godwin wasn't exactly eased back into the offense in his season debut in the Week 4 loss to the Philadelphia Eagles on Sunday, as he was targeted a team-high-tying 10 times.

Godwin came down with only three catches for 26 yards, but it was a good sign to see him play 81% of the offensive snaps in his first game since dislocating his ankle in Week 7 of last year. It helped that top wideout Mike Evans (hamstring) was inactive in this game, but the main takeaway is that Godwin is a full-go moving forward and should have WR2 upside for a Week 5 tilt against the hosting Seattle Seahawks this Sunday.

Evans is expected to miss multiple games, so Godwin should be heavily targeted once again as he gets his legs under him in a pass-happy offense.

Indianapolis Colts head coach Shane Steichen said that wide receiver Adonai Mitchell is "going to have to earn" more opportunities going forward after his costly fumble in the team's Week 4 loss to the Los Angeles Rams.

Mitchell recorded three catches for 96 yards on four targets against Los Angeles, but dropped the ball just before crossing the goal line on what should have been a 70-plus-yard touchdown. The 22-year-old has logged seven catches for 137 yards on 12 targets through four games this season.

He saw increased playing time in Week 4 with Colts wideout Alec Pierce (concussion) sidelined. If Pierce returns for the team's Week 5 matchup against the Las Vegas Raiders, Mitchell could have a hard time getting on the field.

Atlanta Falcons tight end Kyle Pitts Sr. had his best week of the season to date in Sunday's 34-27 win over the Commanders, reeling in all five of his targets for 70 yards and a touchdown, his first of the year. That now makes four straight weeks with at least five targets and at least four catches to begin the 2025 campaign, currently ranking as the ninth-highest scoring tight end in half-point PPR leagues.

The former first-round draft pick's target share (18.5 percent) ranks second on the team behind only Drake London, and that is even the case if you only look at Weeks 2-4 when Darnell Mooney was on the field. It's almost a five percent increase in target share compared to his involvement last season, too.

The Falcons have a bye in Week 5, and Pitts returns to a tough matchup in Week 6 against the Bills, a team that has allowed the second-fewest fantasy points to TEs this year, so it will be a good test to see if Michael Penix Jr. can keep him involved on an every-week basis.

Cleveland Browns rookie wide receiver Isaiah Bond has seen his targets and receiving yards increase in each of his four games this season. With Cedric Tillman (hamstring) now sidelined for multiple weeks, Bond could be leaned on more heavily as part of the Browns' passing attack.

Tillman left Sunday's game against the Lions in the second quarter, and Bond ended the day as the team's leading receiver, bringing in three of his six targets for 58 yards. With five NFL teams on a Week 5 bye, now is the time in the schedule for fantasy managers to get creative, and Bond at least offers big-play upside for those in a roster bind.

With the Browns traveling to London to play the Vikings in Week 5, any Cleveland players will need to be inserted into lineups early, stymying flexibility and making Bond a player to monitor rather than play for at least one more week.

San Francisco 49ers tight end Jake Tonges (shoulder) caught his second touchdown of the season in the team's 26-21 loss to the Jaguars on Sunday. Tonges left the game just six plays in due to a possible shoulder injury but returned near the end of the first quarter.

He finished the game with three catches on five targets and had 58 receiving yards, good for second-most on the team in Week 4. Tonges has emerged as the preferred pass-catching tight end in George Kittle's (hamstring) absence.

Both Ricky Pearsall (knee) and Jauan Jennings (ribs/ankle/shoulder) suffered injuries on Sunday, and on a short week (the 49ers face the Rams on Thursday), their status is up in the air. If either or both are limited or absent, then Tonges could see a greater target share than usual.