Week 10 DraftKings NFL DFS Picks - Main Slate (2024): Brock Purdy, Saquon Barkley, Garrett Wilson, and more

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for the Week 10 (November 2024) Main Slate. His top daily fantasy football lineups to target for DraftKings DFS contests.

Hello, RotoBallers! Welcome back to our DraftKings Main Slate article. I completely understand if you're feeling a bit of whiplash after looking at the Week 10 Main Slate. While last week's slate featured loads of juicy value options, this week's salary scale is extremely tight by comparison.

These DraftKings lineup recommendations are based on matchups, projected DK points and ownership, overall upside/talent levels, and opportunity, as well as factors such as Vegas odds, home-field advantage, and more. There are quite a few great plays available on DK for Week 10 and this article includes a couple of my favorite options at each position.

Also, be sure to check out our weekly FanDuel DFS lineup picks and lots of other great NFL DFS articles and NFL DFS tools to help you win MORE in 2024! Good luck with your DraftKings DFS lineups -- let's dominate this slate together!

DraftKings Quarterbacks - Week 10 DFS Picks

Brock Purdy - SF at TB ($6,500)

While all eyes will be focused on Christian McCaffrey's expected 2024 debut this week, I'm actually more interested in Niners' quarterback Brock Purdy from a DFS perspective. The knock on Purdy has always been that he's a "system QB", but does that really matter if the system is consistently elite?

Admittedly, we're usually relying on hyper-efficiency from Purdy due to Kyle Shanahan's preferred method of attack, but the Iowa State product has been getting it done. Despite ranking a middling 17th in the NFL in pass attempts (242), Purdy stands eighth overall in passing yards (2,101) and third in yards per attempt (8.7).

A Week 10 matchup against a hapless Bucs secondary is a dream spot. Tampa Bay has relinquished the NFL's third-most passing yards and TDs this season.

Justin Herbert - TEN at LAC ($5,200)

Chargers quarterback Justin Herbert is similar to the aforementioned Purdy in that a bet on him is a bet on ultra-efficiency. We're all well aware of new L.A. head coach Jim Harbaugh's desire to play physical, smashmouth football. There's just one problem...the Chargers have had more success throwing the football than running it.

The coaching staff has realized that, as they've turned Herbert loose at a much higher rate since their Week 5 bye. Over their last four games, the Bolts rank second in the NFL in pass rate over expectation, a shift in philosophy that has led to steadily increasing DFS output for Herbert. That willingness to throw the ball should only be amplified due to a Week 10 matchup against a Titans defense that's been a true pass-funnel unit this season.

DraftKings Running Backs - Week 10 DFS Picks

Saquon Barkley - PHI at DAL ($8,300)

There are lots of good running backs in good spots on this Week 10 slate, but Saquon Barkley might just be the best back in the best spot. The first-year Eagle is coming off his third game of 36+ DraftKings points this season against Jacksonville and walks into what's an even better matchup this week against the Cowboys.

Dallas' issues are well-documented, but their struggles against the run are worth noting here. Mike Zimmer's unit is the 29th-ranked rush defense in the NFL and has allowed the league's third-most rushing TDs (10) to the RB position this season. Entering the week as seven-point favorites, there's a good chance Philly grabs control of this game and relentlessly feeds Barkley against this pillow-soft Cowboys front.

Aaron Jones - MIN at JAX ($6,700)

The veteran comes in averaging 21 touches and nearly 100 yards per game over the Vikings' last four while playing 72% or more of Minnesota's offensive snaps in their last three. Jones is serving in a true dual-threat role in Kevin O'Connell's offense.

He's tenth among all NFL running backs in targets (29) and fourth in yards per reception (9.4). Jones should continue to see elite volume against a Jacksonville squad that was tuned up for 199 total yards and two TDs by Saquon Barkley last week.

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DraftKings Wide Receivers - Week 10 DFS Picks

Garrett Wilson - NYJ at ARI ($7,200)

After a sluggish start to the season, Wilson has exploded in recent weeks as his rapport with Jets quarterback Aaron Rodgers continues to develop. Since posting no outings of over 100 receiving yards over the first month of the season, Wilson has now gone over 100 in three of New York's last five games.

The addition of Davante Adams was undoubtedly a concern for Wilson's outlook, though it's arguably been a good thing for him to this point. In Adams' three games with the Jets, Wilson has garnered 27 targets which he's converted into 19 catches for 264 yards and two TDs, while his aDOT has actually increased from 9.0 to 12.3. His Week 10 matchup against Arizona has plenty of potential for a high level of output. The Cardinals rank 25th in Pass Defense DVOA and are coughing up 8.60 yards per target to the WR position.

DeAndre Hopkins - DEN at KC ($5,300)

Facing Patrick Surtain and a solid Denver defense isn't an ideal matchup for Hopkins, but Zay Flowers proved this Broncos unit isn't impregnable by dropping a 5/127/2 stat line against them in Week 9 while playing primarily out of the slot, a tactic that Andy Reid will most likely use often this week in an effort to get D-Hop away from Surtain.

At the end of the day, the veteran's $5,300 DK price tag just feels too cheap, and while there will be better matchups for him down the road, we're highly unlikely to see him at this price again anytime soon, as his usage and production will continue to grow with Patrick Mahomes delivering him the football.

DraftKings Tight Ends - Week 10 DFS Picks

George Kittle - SF at TB ($5,800)

We touched on Tampa Bay's shortcomings against the pass when discussing Brock Purdy earlier in this article. Niners tight end George Kittle is a great stacking partner with Purdy and has the potential to feast on a Bucs unit that is bleeding a massive 9.22 yards per target to the TE position.

In a San Fran pass-catching corps that's been shuffled and reshuffled due to injury, Kittle has put forth elite production. He ranks first in the NFL among tight ends in red-zone targets (13) and TDs (six), while standing second in the league in receiving yards (503).

Cade Otton - SF at TB ($5,500)

Let's stick with this game, but flip over to the Tampa Bay side of the ball. With injuries to Chris Godwin and Mike Evans, tight end Cade Otton has evolved into the Bucs' de-facto WR1. Never coming off the field, Otton has earned a ridiculous 31 targets in Tampa's last three.

Though the Niners' defense is normally one we want to avoid for DFS purposes, it's tough to envision a scenario in which Otton isn't peppered with targets, especially with the strong chance that the Bucs are forced to keep pace with San Fran.

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