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TNF NFL DFS Lineup Picks for FanDuel, DraftKings - 49ers vs Titans Showdown

John's top NFL DFS lineup picks for FanDuel, DraftKings and Thursday Night Football - the 49ers vs Titans showdown slate. His Week 16 TNF daily fantasy football advice.

Happy Thursday, RotoBallers! Week 16 is here! This season has been going by super quickly, and I can't believe that this is the last Thursday Night game of the season. We have a rather interesting contest tonight as the 49ers (8-6) head to Nashville to take on the Titans (9-5). This is a battle that should put a dent in the AFC West divisional race regardless of the result, and it should be an exciting one. Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. 

In this article I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the Thursday Night Football slate on December 23rd. These lineups can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel.

If you have any questions you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts any time you'd like. Let's make some coin this season gang, and let's get right to it!

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DFS Captains/MVPs for DraftKings, FanDuel

Ryan Tannehill ($15,000 DK, $15,000 FD)

Key Stats:

  • 2021 Stats: 3,118 passing yards, 14 touchdowns, 14 interceptions. 
  • Offensive Pass DVOA: -2.9% (26th)
  • Opposing Defense Pass DVOA: 7.1% (21st)

Tannehill hasn't necessarily had "the magic" as we saw from him last year, which we can partly blame on the loss of Derrick Henry mid-season. However, Tannehill is still very much "fantasy-viable" if you need a guy who has a solid floor. While his ceiling isn't too high, I can expect Tennessee to throw the ball quite a bit tonight, and getting A.J. Brown back in the lineup should provide the boost that Tannehill needs to have a solid game.

Recommendation: Cash/GPP (DK/FD)

Best Correlations: A.J. Brown, Deebo Samuel

 

Jeff Wilson Jr. ($7,800 DK, $11,000 FD)

Key Stats:

  • 2021 Stats: 65 attempts, 249 yards, one touchdown, five targets, four receptions, 19 yards. 
  • 2021 Data: 31.71% attempt rate, 30.43% red-zone attempt rate, 33.33% rate within the 5yd line, 3.68% target rate, 9.09% red-zone target rate, one end zone target.
  • Offensive Rush DVOA: 7.1% (4th)
  • Opposing Defense Rush DVOA: -9.5% (17th)

Jeff Wilson Jr. finally broke out last week to the cheers of DFS players everywhere. If I had to guess, he'll be one of if not the most expensive captains on the slate on DraftKings. His price is too cheap and he does have a solid matchup against a middle-of-the-road rushing defense. While I do have some concerns over Deebo Samuel taking 14 carries over the last two weeks, I would expect Kyle Shanahan to stick to his game plan of running the football so Wilson getting 10-12 touches seems inevitable. This creates a solid value opportunity, especially on DK, for Wilson to be in your captain spot.

Recommendation: Cash/GPP (FD/DK)

Best Correlations: Ryan Tannehill, George Kittle

Other Captain/MVP Plays: Deebo Samuel, A.J. Brown

 

DFS Flex Plays for DraftKings, FanDuel

Jimmy Garoppolo ($10,400 DK, $14,000 FD)

Key Stats:

  • 2021 Stats: 3,172 passing yards, 18 touchdowns, 8 interceptions.
  • Offensive Pass DVOA: 33.2% (4th)
  • Opposing Defense Pass DVOA: 4.8% (15th)

Every time I look at this year's DVOA and see the 49ers sitting at fourth it surprises me. All credit to them, but I certainly wouldn't rate them as the fourth-best passing offense in football. Regardless, Jimmy G has been throwing the pill around well of late. I don't really like going double QB on DraftKings and I prefer Tannehill to Garoppolo, but I will most likely be running Jimmy G in most of my FanDuel lineups.

Recommendation: Cash/GPP (FD/DK)

Best Correlations: George Kittle, Deebo Samuel, Ryan Tannehill

 

George Kittle ($11,200 DK, $13,000 FD)

Key Stats:

  • 2021 Stats: 82 targets, 63 receptions, 850 receiving yards, six touchdowns.
  • 2021 Data: 25.31% target rate, 17.95% red-zone target rate, five end zone targets.  
  • Individual Matchup (vs Jayon Brown): 11% target per route covered, 88% catch rate, 0.23 fantasy points per route. 

While to some there was never a doubt regarding Kittle's quality as a tight end, Kittle has certainly silenced any and all doubters over the last three weeks. He's logged 28 catches for 425 yards and three touchdowns in that span and has a very intriguing matchup against the Titans' defense (and Jayon Brown specifically) tonight. His price is steep, but for a guy who's been consistently putting up numbers of late, I want him in my lineups. I should note that I prefer him slightly over Deebo Samuel tonight but should have plenty of them both.

Recommendation: GPP (DK), Cash/GPP (FD)

Best Correlations: Jimmy Garoppolo, Ryan Tannehill

Other Flex Plays: A.J. Brown, Julio Jones, D'Onta Foreman

 

DFS Value Plays for DraftKings, FanDuel

49ers D/ST ($3,800 DK)

Key Stats:

  • 2021 Stats: 6 interceptions, 11 fumble recoveries, 36 sacks, two defensive touchdowns. 

There is a chance tonight that even with the return of A.J. Brown, the Titans' offense stalls and can't really get anything going tonight against a relatively hot SF defense. I'll most likely be using them in stacks with Jeff Wilson Jr. as well as some San Francisco onslaught stacks, but backing the Niners here is a solid way to create some space if you want both Kittle and Deebo in your lineups.

Recommendation: Cash/GPP (FD/DK)

Best Correlations: Jimmy Garopollo, Jeff Wilson Jr.

Robbie Gould ($4,400 DK, $9,000 FD)

While he hasn't been "as good as Gould" this season, he's still been pretty dang solid. He's knocked down 14 of 17 field goals and has missed just one extra point all season. He's logged at least seven fantasy points in each of the last four games, and that should continue tonight. I feel that regardless of how the game script goes, Gould should be optimal. Remember: kickers are always optimal.

Recommendation: Cash/GPP (FD/DK)

Best Correlations: Jimmy Garoppolo, Jeff Wilson Jr.

Other Value Plays: Nick Westbrook-Ikhine, Anthony Firkser

 

Overall Slate Note

This should be a fun slate with two offenses that seem rather consolidated and want their big boys to do most of the work for them. I'll have a ton of ownership among both teams' top skill-position guys, and just slightly more Tannehill than Jimmy G on both sites in tournaments. I don't have much to say as far as lineup restrictions go, other than the suggestion of not playing both Foreman and Hilliard in the same lineups. Outside of that, I'd like to thank you for reading my Thursday Night articles in this goofy but fun 2021 season. I also want to wish you a Merry Christmas, Happy Holidays, and wish you health and happiness for the rest of 2021 and throughout 2022. I'll catch you all on Sunday!

Have a good Thursday everyone, see you soon!



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REAL-TIME FANTASY NEWS

P.J. Washington

is Ruled Out for Thursday's Contest
Jaime Jaquez Jr.

is Returning on Thursday
Daniel Jones

Colts Plan to Re-Sign Daniel Jones
Darius Garland

to Play on Thursday
Anthony Edwards

Active Thursday
Coby White

to Play with Minutes Limit on Thursday
Ace Bailey

Sidelined on Thursday
Kevin Huerter

Won't Play on Thursday
Andrew Nembhard

Won't Play on Thursday
Brandon Miller

is Cleared for Thursday's Game
LaMelo Ball

Upgraded to Available on Thursday
Kevin Love

Available For Thursday
Kawhi Leonard

Suffers Ankle Injury, Considered Questionable for Friday
Jamie Drysdale

Unavailable Against Maple Leafs
Bobby Brink

Sits Out Thursday
Simon Nemec

Back for Devils Thursday
Jusuf Nurkić

Jusuf Nurkic Questionable For Thursday Against Mavs
Troy Terry

Misses Thursday's Game
Alexis Lafrenière

Alexis Lafreniere Good to Go Against Sabres
Brad Marchand

Out Thursday
Ace Bailey

Considered Questionable Versus Dallas
Evgeni Malkin

Set to Return Thursday
Anthony Edwards

Questionable for Thursday
Davante Adams

Off the Injury Report, Will Play Against Carolina
Bo Bichette

Phillies to Meet With Bo Bichette
Rome Odunze

Will Return for Wild-Card Game on Saturday
CFB

DJ Lagway Commits to Baylor
Miami Dolphins

Dolphins Fire Head Coach Mike McDaniel
Matvei Michkov

Expected to Play Thursday
Alex Lyon

to Miss at Least One More Week
Mason Marchment

Placed on Injured Reserve, Out Week-to-Week
Alexis Lafrenière

Alexis Lafreniere Battling Illness, Iffy for Thursday
J.T. Miller

Likely to Return Thursday
Adam Henrique

Out Through Olympic Break
Dean Wade

Ruled Out Thursday
Brandon Williams

Questionable for Thursday
P.J. Washington

Doubtful Thursday
Jaime Jaquez Jr.

Questionable Thursday
Donovan Mitchell

Available Thursday
Corey Kispert

Hawks Land Corey Kispert
Sam LaPorta

Plans to be Back for Training Camp
Owen Caissie

Shipped to Miami as Centerpiece of Trade
Edward Cabrera

Cubs Officially Acquire Edward Cabrera From Marlins
Nathan Walker

Ready to End 16-Game Absence
Rutger McGroarty

Out Indefinitely With Concussion
Kevin Stenlund

a Game-Time Call Wednesday
Ty Dellandrea

Ruled Out Wednesday
Adam Erne

Misses Wednesday's Action
Tom Wilson

Aliaksei Protas Won't Play Wednesday
Anze Kopitar

Out Wednesday
Rome Odunze

Plans to Play on Saturday
Edward Cabrera

Cubs Finalizing Deal to Acquire Edward Cabrera From Marlins
New York Giants

Giants "All-In" on Hiring John Harbaugh
CFB

Jackson Arnold Signs with UNLV
CFB

Sam Leavitt Scheduled to Visit Tennessee
Devon Toews

to Miss at Least Two Weeks
New York Giants

John Harbaugh Expected to be Favorite to Become New Giants Head Coach
Baltimore Ravens

John Harbaugh Won't Return as Ravens Head Coach
Bo Bichette

Unlikely to Return to Toronto?
Jordan Love

Ready to Start in Wild-Card Game Against Bears
CFB

Jadan Baugh Staying with Florida for Junior Season
Washington Commanders

Commanders "Mutually" Parting Ways With OC Kliff Kingsbury
CFB

Byrum Brown Officially Commits to Auburn
CFB

Austin Simmons Signing with Missouri
CFB

Ty Simpson Undecided on 2026 Plans
CFB

Quarterback AJ Hill Following Ryan Silverfield to Arkansas
Atlanta Falcons

Falcons Have Requested an Interview With Klint Kubiak
Deshaun Watson

Browns Expect Deshaun Watson to be on the Team Next Year
Wan'Dale Robinson

Dealing With Fractured Ribs
Cam Skattebo

Hopes to be Back by Training Camp
Cameron Ward

Won't Need Surgery on his Shoulder
Davante Adams

Rams Expect Davante Adams to Return in Wild-Card Round
Arizona Cardinals

Cardinals Fire Head Coach Jonathan Gannon
Las Vegas Raiders

Raiders Fire Head Coach Pete Carroll
Malik Nabers

Unsure if He Will Be Ready for Week 1 of 2026 Season
CFB

Trinidad Chambliss Will Return to Ole Miss If Granted Sixth Year of Eligibility
Cincinnati Bengals

Zac Taylor Will Return as Bengals Head Coach in 2026
Bo Bichette

Phillies Have Interest in Bo Bichette
Kansas City Royals

Matt Quatraro Signs Three-Year Extension With Royals
CFB

Transfer QB Billy Edwards Commits to North Carolina
CFB

Sam Leavitt Visiting Texas Tech on Saturday
CFB

DJ Lagway Expected To Visit Florida State
Kyle Tucker

Blue Jays "Remain the Favorite" to Sign Kyle Tucker

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