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Starts & Sits for MLB Week 25 - All Starting Pitcher Matchups for Fantasy Baseball

Miles Mikolas - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Fantasy baseball starts and sits, advice for all starting pitcher matchups Week 25. Set optimal lineups with Jon's start/sit recommendations.

We made it to the end. Week 25 is the final 10 days of the season. I am pleased to bring you this chart one more time, and I appreciate all the readership and the feedback (good and bad). I have given a score to 4,860 probable starters this year (with some help from automation). I would be lying if I said I wasn't ready for a break, but I think I'll be back with you next year!

If somehow this is your first time reading (I don't know why you would pick the final week of the season to view this for the first time), RotoBaller puts out a weekly grid of starting pitcher matchups and "start or sit" recommendations, and this is our 10th year now writing this weekly column. For every week of the fantasy baseball season, we are going to analyze every single projected starting pitcher matchup for fantasy baseball and help you set optimal lineups.

Below are the projected starting pitching matchups and starts/sits for Week 25, covering September 26 through the end of the season, October 5th. We will keep this updated as rotations continue to be announced and modified. This column will make continuous adjustments for any postponements or rotation shuffles, reflecting official beat writer speculation for as many unconfirmed rotation slots as possible – so be sure to check back daily. Let's set those winning lineups!

Be sure to check all of our fantasy baseball lineup tools and resources:

 

Start/Sit Data Overview

This weekly piece considers the pitcher’s opponents, their outlook against lefties and righties, some ballpark factors, and historical splits. With all of this information, we then provide our start/sit recommendations for each starting pitcher matchup for the approaching week of fantasy baseball.

Each player will be valued with a Start/Sit recommendation, we are also including a "Score" column this year to display the level of confidence in that pick. Scores go from 0-100 in increments of five. The higher, the better! They are also color-coded, as you'll see.

Legend:

  • Proj GS - the number of starts the starter is projected to make in the week's scoring period.
  • Score - A metric of confidence, from 0-100 in increments of five. The higher, the better for the pitcher.

This chart is updated daily as probable starters are constantly changing with game postponements, injuries, and other events.

 

Week 25 Start/Sit Recommendations

Updated start/sit recommendations for this week's MLB games. If you cannot see the chart below, click here to see the start/sit grid on a separate page:



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POPULAR FANTASY TOOLS

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REAL-TIME FANTASY NEWS

Elly De La Cruz

Played Through Partially Torn Quad to End 2025
C.J. Stroud

in Good Position to Return in Week 13
Darius Garland

Might Play on Friday Night
Jaren Jackson Jr.

Out Against Sacramento, Santi Aldama Starting
Tyrese Maxey

Available Versus Milwaukee
Zaccharie Risacher

Cleared to Face Spurs
Kristaps Porzingis

Back in Action on Thursday
Chris Godwin

Could Play in Week 12 After Return to Full Practice
Keon Coleman

to be a Healthy Scratch Again on Thursday Night
Tarik Skubal

Tigers "Doubtful" to Trade Tarik Skubal
Jarrett Allen

Questionable for Friday
Simon Holmstrom

Ready for Action Thursday
Lars Eller

Available Thursday
Domantas Sabonis

Will Miss at Least 3-4 Weeks
Ridly Greig

Out Against Ducks
Nikola Jović

Nikola Jovic Out Against Bulls on Friday
Jake Neighbours

Back for Blues Thursday
Alexandre Sarr

Listed as Questionable for Friday Against the Raptors
TB

Nicholas Paul Available Thursday
Paul George

Set to Suit Up Thursday
Victor Hedman

Out for "Couple of Weeks"
Tyler Bertuzzi

Set to Return Thursday
Gary Harris

Added to the Injury Report as Questionable for Thursday
Daniel Jones

Added to Colts' Injury Report With Calf Issue
Andrew Wiggins

Unavailable For Friday's Matchup With Chicago
Indiana Pacers

Garrison Mathews Will Join the Pacers
Joe Burrow

Logs Second Straight Full Practice on Thursday
Dante Exum

Will Miss the Rest of the Season
Keegan Murray

Is Available For His Season Debut Thursday
Tyrese Maxey

Listed as Probable for Thursday
Domantas Sabonis

Will Not Play Thursday Against Memphis
Joel Embiid

Listed as Out for Thursday
Aaron Rodgers

Seen at Practice on Thursday
Jaylen Warren

Moving Around Well on Thursday
Bucky Irving

Will be on a Snap Count When he Returns
Jaxson Dart

Could Clear Concussion Protocol Thursday
Lamar Jackson

Returns to Thursday's Practice
Josh Jacobs

to Do Individual Drills on Thursday
Joe Mixon

Not Expected to Play This Season
Chris Godwin

Attending Thursday's Practice
Bucky Irving

Continues Practice Attendance
Rasmus Andersson

Bags Three Points Wednesday Night
Morgan Geekie

Nets Two Power-Play Goals Wednesday
Joe Burrow

Bengals Haven't Ruled Out Joe Burrow for Week 12
Connor McMichael

Posts Three Assists in Wednesday's Win
Alexander Romanov

Islanders Place Alexander Romanov on Injured Reserve
Lars Eller

to Miss Thursday's Action
Nic Dowd

Out on Thursday
Adam Lowry

Inks Extension With Jets
Jaren Jackson Jr.

Likely Out on Thursday
Zaccharie Risacher

Questionable for Thursday
Kristaps Porzingis

at Risk of Missing Another Game
Brian Thomas Jr.

Limited in Practice on Wednesday
Raisel Iglesias

Returning to the Braves on One-Year Deal
Lamar Jackson

Absent Due to Ankle Injury
Conor Garland

to Return on Thursday
Thomas Harley

to Miss Road Trip
Eetu Luostarinen

Out Week-to-Week After Barbecue Accident
Curtis Lazar

to Miss at Least Three Games
Vladimir Tarasenko

Misses Third Consecutive Game
Mikael Granlund

Remains Out Wednesday
Charlie McAvoy

Out Indefinitely After Facial Surgery
Joe Burrow

to Potentially Return in Week 12?
Aaron Rodgers

Out on Wednesday, Hopes to Practice Thursday
Jaylen Warren

Not Seen at Wednesday's Practice
Dak Prescott

Lands on Injury Report Ahead of Week 12 With Hip Injury
Sahith Theegala

Looking to Continue Fall Run at RSM Classic
Stephan Jaeger

Looking to Bounce Back at RSM Classic
Tom Hoge

Looking to Regain Form at RSM Classic
Joe Highsmith

Searching for Turnaround at RSM Classic
Adam Hadwin

Looking to Build on T11 Finish in Bermuda
Austin Eckroat

Searching for Momentum at RSM Classic
Joel Dahmen

Trying to Find Form at the RSM Classic
CFB

Garrett Nussmeier Doubtful to Play Against Western Kentucky
Michael Thorbjornsen

Hopes to End 2025 Campaign With Another Solid Finish
Andrew Novak

Looks to End 2025 Season on High Note at RSM Classic
Harry Higgs

Teetering for PGA Tour Card in 2026
PGA

Nico Echavarria has the Potential to Contend at the RSM Classic
Sam Stevens

Finishing Out Year in Georgia
Seamus Power

Playing Better at the Right Time
Beau Hossler

Roller Coaster Comes to Saint Simons Island
Quade Cummins

The Time is Now for Quade Cummins in Georgia
Austin Cook

Needs a Win at the RSM Classic
Cameron Champ

on the PGA Tour Card Bubble
Grayson Rodriguez

Shipped to Angels
Taylor Ward

Orioles Acquire Taylor Ward From Angels
Shota Imanaga

Accepts Cubs Qualifying Offer
Brandon Woodruff

Returning to Milwaukee in 2026
Denny McCarthy

Looking For Another Solid Finish at RSM Classic
Si Woo Kim

Looking To Use Current Momentum to Flip Script at RSM Classic
Mackenzie Hughes

a Good Bounce-Back Candidate at RSM Classic
Harris English

Making 14th Start at This Week's RSM Classic
Konnor Griffin

Could Compete for Starting Shortstop Job in 2026
Gleyber Torres

Accepts Tigers Qualifying Offer
CFB

Sam Leavitt Set to Enter Transfer Portal?
Jose Altuve

Undergoes Foot Surgery
Alex Bregman

Red Sox Going for Either Alex Bregman or Pete Alonso?
CFB

James Franklin to be Virginia Tech's Next Head Coach
CFB

Fernando Mendoza the Clear Heisman Trophy Favorite?
CFB

Beau Pribula Has Chance to Face Oklahoma on Saturday
Jack Della Maddalena

Gets Dominated
Islam Makhachev

Claims UFC Welterweight Belt
Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday

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