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Starts & Sits for MLB Week 22 - All Starting Pitcher Matchups for Fantasy Baseball

Miles Mikolas - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Fantasy baseball starts and sits, advice for all starting pitcher matchups Week 22. Set optimal lineups with Jon's start/sit recommendations.

Welcome back RotoBallers! Big week in fantasy leagues as we approach the end of the season and playoffs! As always, we are here with our starting pitcher starts and sits series to help you set those winning lineups for the week ahead!

For those who are not familiar, RotoBaller puts out a weekly grid of starting pitcher matchups and "start or sit" recommendations, and this is our 10th year now writing this weekly column. For every week of the fantasy baseball season, we are going to analyze every single projected starting pitcher matchup for fantasy baseball and help you set optimal lineups.

Below are the projected starting pitching matchups and starts/sits for Week 22, covering September 5th through September 11th. We will keep this updated as rotations continue to be announced and modified. This column will make continuous adjustments for any postponements or rotation shuffles, reflecting official beat writer speculation for as many unconfirmed rotation slots as possible – so be sure to check back daily. Let's set those winning lineups!

Be sure to check all of our fantasy baseball lineup tools and resources:

 

Start/Sit Data Overview

This weekly piece considers the pitcher’s opponents, their outlook against lefties and righties, some ballpark factors, and historical splits. With all of this information, we then provide our start/sit recommendations for each starting pitcher matchup for the approaching week of fantasy baseball.

Each player will be valued with a Start/Sit recommendation, we are also including a "Score" column this year to display the level of confidence in that pick. Scores go from 0-100 in increments of five. The higher, the better! They are also color-coded, as you'll see.

Legend:

  • Proj GS - the number of starts the starter is projected to make in the week's scoring period.
  • Score - A metric of confidence, from 0-100 in increments of five. The higher, the better for the pitcher.

This chart is updated daily as probable starters are constantly changing with game postponements, injuries, and other events.

 

Week 21 Start/Sit Recommendations

Updated start/sit recommendations for this week's MLB games. If you cannot see the chart below, click here to see the start/sit grid on a separate page:



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POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Al Horford

Back on the Sidelines Monday Night
Ryan Dunn

to Miss Second Straight Game with Knee Injury
Justin Herbert

Won't Face Broncos in Week 18
Jose Alvarado

Serving Suspension on Monday Night
Jerami Grant

Achilles Injury Continues to Sideline Jerami Grant
Jakob Poeltl

Continues to Miss Time with Back Issue
RJ Barrett

Sitting Out Second Night of a Back-to-Back
Marcus Mariota

Considered "a Stretch" to Play in Week 18
Geno Smith

Dealing With Significant Ankle Injury
Mark Williams

Suspended for One Game, Won't Face Washington
Dak Prescott

Will Play in Week 18
Mitchell Robinson

Sidelined Against New Orleans
Jalen Johnson

Under The Weather, Ruled Out on Monday
Lamar Jackson

Week 18 Status "to be Determined"
Khris Middleton

Resting Versus Phoenix
Kyshawn George

Out Again on Monday
Isaiah Hartenstein

Won't Suit Up On Monday
Alperen Sengün

Alperen Sengun Sitting Out Another Game Monday
Trae Young

Ruled Out Monday
Joe Mixon

Won't Return This Season
T.J. Watt

a Long Shot to Play in Week 18?
CFB

Penn State Working to Hire D'Anton Lynn as Next Defensive Coordinator
Joe Burrow

Will Play in Week 18 Against the Browns
CFB

Omar Cooper Expected to be Full-Go for Rose Bowl
CFB

Marcus Freeman Staying with Notre Dame for 2026 Season
CFB

Star Wideout Cam Coleman Entering Transfer Portal
Luther Burden III

Set to Undergo Additional Testing on Quad Injury
Trae Young

Questionable Monday With Quad Contusion
Kirill Marchenko

Scores Twice in Sunday's Win
Josh Giddey

Expected to Suit Up Monday
Alperen Sengün

Alperen Sengun Could Miss Another Game Monday
Justin Brazeau

Pots First Career Hat Trick Sunday
Anthony Davis

Listed as Questionable for Monday
Juraj Slafkovsky

Collects Season-High Three Points in Sunday's Loss
Jalen Suggs

Poised to Miss Seventh Straight Game
Eeli Tolvanen

Continues Scoring Surge With Three-Point Effort
Grayson Allen

Misses Sixth Straight Game Monday
Jack Eichel

to Remain Out Monday
Adam Fox

Nearing Return, Considered Day-to-Day
Josh Morrissey

Considered Day-to-Day After Missing Practice
D'Andre Swift

Finds End Zone Twice in Sunday Night Loss
Luther Burden III

Posts Season-High 138 Yards, Touchdown in Loss
Christian McCaffrey

Racks Up 181 Total Yards, Touchdown in Win Over Bears
Brock Purdy

Delivers Second Straight Five-Touchdown Performance
De'Aaron Fox

Questionable Against the Cavaliers
Parker Washington

Leads Jaguars in Targets, Receptions, and Receiving Yards
Wan'Dale Robinson

Posts Season-High 11 Receptions in Week 17
Josh Allen

Seen Limping From X-Ray Room, Says Foot Injury Didn't Affect Him
Geno Smith

Diagnosed With High-Ankle Sprain
Trey McBride

Sets All-Time Tight End Receptions Record
Geno Smith

Exits Early With Ankle Injury
DJ Moore

Suiting Up Against 49ers on Sunday Night
Ricky Pearsall

Officially Active for Week 17 Against Bears
Matthew Tkachuk

Returns to Practice
Linus Ullmark

Takes Leave of Absence
Travis Sanheim

Good to Go Against Kraken
Nick Foligno

Set to Return Sunday
William Nylander

Out Against Red Wings
Jared McCann

Available Sunday
Vince Dunn

on Track to Return Sunday
Blake Lizotte

Activated From Injured Reserve
CFB

Jay Hill Expected to be Next Michigan Defensive Coordinator
Andrei Svechnikov

Extends Scoring Run With Three-Point Effort
Auston Matthews

Bags Three Points Saturday Night
Alex Laferriere

Records First Career Hat Trick
William Nylander

Sustains Lower-Body Injury Saturday
Zach Werenski

Unlikely to Play Sunday
Jake Evans

to Miss 4-6 Weeks
CFB

Michigan Targeting Kyle Whittingham as Next Head Coach
CFB

Texas Leading Rusher Quintrevion Wisner Set to Transfer
Pete Fairbanks

Marlins Agree on One-Year Deal
Brooks Koepka

Leaving LIV Golf
Ryan O'Hearn

Pirates Agree on Two-Year Deal

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