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Starts & Sits for MLB Week 22 - All Starting Pitcher Matchups for Fantasy Baseball

Miles Mikolas - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Fantasy baseball starts and sits, advice for all starting pitcher matchups Week 22. Set optimal lineups with Jon's start/sit recommendations.

Welcome back RotoBallers! Big week in fantasy leagues as we approach the end of the season and playoffs! As always, we are here with our starting pitcher starts and sits series to help you set those winning lineups for the week ahead!

For those who are not familiar, RotoBaller puts out a weekly grid of starting pitcher matchups and "start or sit" recommendations, and this is our 10th year now writing this weekly column. For every week of the fantasy baseball season, we are going to analyze every single projected starting pitcher matchup for fantasy baseball and help you set optimal lineups.

Below are the projected starting pitching matchups and starts/sits for Week 22, covering September 5th through September 11th. We will keep this updated as rotations continue to be announced and modified. This column will make continuous adjustments for any postponements or rotation shuffles, reflecting official beat writer speculation for as many unconfirmed rotation slots as possible – so be sure to check back daily. Let's set those winning lineups!

Be sure to check all of our fantasy baseball lineup tools and resources:

 

Start/Sit Data Overview

This weekly piece considers the pitcher’s opponents, their outlook against lefties and righties, some ballpark factors, and historical splits. With all of this information, we then provide our start/sit recommendations for each starting pitcher matchup for the approaching week of fantasy baseball.

Each player will be valued with a Start/Sit recommendation, we are also including a "Score" column this year to display the level of confidence in that pick. Scores go from 0-100 in increments of five. The higher, the better! They are also color-coded, as you'll see.

Legend:

  • Proj GS - the number of starts the starter is projected to make in the week's scoring period.
  • Score - A metric of confidence, from 0-100 in increments of five. The higher, the better for the pitcher.

This chart is updated daily as probable starters are constantly changing with game postponements, injuries, and other events.

 

Week 21 Start/Sit Recommendations

Updated start/sit recommendations for this week's MLB games. If you cannot see the chart below, click here to see the start/sit grid on a separate page:



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POPULAR FANTASY TOOLS

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Import Your Leagues
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Compare Any Players
Compare Any Players
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24x7 News and Alerts

REAL-TIME FANTASY NEWS

Jauan Jennings

Won't be Suspended
Draymond Green

Will be Questionable for Wednesday Against the Rockets
Goga Bitadze

Downgraded to Questionable
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Will Miss At Least 7-10 Days
Paul George

Will Not Play Tuesday against the Magic
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Will Play Tuesday Against the Magic
Omarion Hampton

Chargers Open Omarion Hampton's Practice Window
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Ruled Out Against Orlando
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Returns to Practice
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D.K. Metcalf Will Be Limited Early in the Week
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Set to Return on Thursday
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Red Sox Showing Interest in J.T. Realmuto
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Red Sox Acquire Sonny Gray From the Cardinals
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Expected to Make his Return in Week 13
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Jeremiah Smith, Makai Lemon, Skyler Bell Named Biletnikoff Award Finalists
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has Been Throwing, Return Timeline Unclear
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As Many as Three NFL Teams Could Have Interest in Hiring Bill Belichick
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Out Indefinitely With Hip-Flexor Strain
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Active Tuesday in Philadelphia
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Cleared To Play Against 76ers
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Ready to Return Tuesday in Philadelphia
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Uncertain For Tuesday's Game Against Wizards
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Will Not Play Tuesday Against the Magic
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Erupts for Five Points in Monday's Win
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Sustains Upper-Body Injury Monday
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Hurt Against Capitals
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Remains Out Tuesday
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Won't Play Tuesday
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Misses Second Consecutive Game Tuesday
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Expected to Play Tuesday
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Considered Probable Tuesday
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Could Return Tuesday
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Targeting a Return on Thursday
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to Play for Team Japan in 2026 World Baseball Classic
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Available Monday vs. Pelicans
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Now Dealing With a Toe Injury
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to Remain Out Tuesday
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Still Out Monday
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Dealing With Low-Grade Shoulder Sprain
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Misses Monday's Matchup
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Out Monday
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Unavailable Monday
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Out Against Flyers
Nikita Kucherov

Good to Go Monday
Chris Godwin

Buccaneers Plan to "Ramp Up" Chris Godwin's Usage
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Warren Schaeffer to Stick Around as Rockies Manager in 2026
Ashton Jeanty

Ankle Injury isn't Severe
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to Practice This Week, Considered a Long Shot for Week 13
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Remains in Concussion Protocol
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Could Return Before End of Regular Season
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in Concussion Protocol
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to Remain the Jets' Starting QB
Shedeur Sanders

to Make Another Start for Browns in Week 13
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Won't Play on Thanksgiving
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Chris Bell Out for Rivalry Matchup Against Kentucky
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Gives Avalanche Second Consecutive Shutout
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Makes History During Multi-Point Performance
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Posts Shutout in Losing Effort
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Keeps Kraken Quiet
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Picks Up Third Shutout of the Season
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Extends Point Streak With Three Assists
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Shipped to the Mets on Sunday
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Gets Submission Win
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Traded to Texas
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Loses Back-to-Back Fights
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Ian Machado Garry Outpoints Belal Muhammad
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Suffers First-Round Knockout Loss
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Gets Back In The Win Column
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Gets Knocked Out
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Myktybek Orolbai Knocks Out Jack Hermansson
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Suffers First-Round Knockout Loss
Waldo Cortes-Acosta

Shines At UFC Qatar
Tagir Ulanbekov

Suffers Third-Round Submission Loss
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Makes Triumphant UFC Return
MON

Alexandre Texier Joins Canadiens
Adolis García

Rangers Non-Tender Adolis Garcia on Friday
CFB

Beau Pribula Expected to Start Against Oklahoma
Dan Hooker

An Underdog At UFC Qatar
Arman Tsarukyan

Looks To Extend His Win Streak
Ian Machado Garry

A Favorite At UFC Qatar
Belal Muhammad

Looks To Bounce Back
Alonzo Menifield

Looks For His Third Consecutive Win
Volkan Oezdemir

Looks To Get Back In The Win Column
Myktybek Orolbai

Looks To Win Back-To-Back Fights
Jack Hermansson

Makes His Welterweight Debut
Kyoji Horiguchi

Returns To The UFC
Elly De La Cruz

Played Through Partially Torn Quad to End 2025
Tarik Skubal

Tigers "Doubtful" to Trade Tarik Skubal
Raisel Iglesias

Returning to the Braves on One-Year Deal

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