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Starts & Sits for MLB Week 21 - All Starting Pitcher Matchups for Fantasy Baseball

Shohei Ohtani - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Fantasy baseball starts and sits, advice for all starting pitcher matchups Week 21. Set optimal lineups with Jon's start/sit recommendations.

Welcome back RotoBallers! Big week in fantasy leagues as we approach the end of the season and playoffs! As always, we are here with our starting pitcher starts and sits series to help you set those winning lineups for the week ahead!

For those who are not familiar, RotoBaller puts out a weekly grid of starting pitcher matchups and "start or sit" recommendations, and this is our 10th year now writing this weekly column. For every week of the fantasy baseball season, we are going to analyze every single projected starting pitcher matchup for fantasy baseball and help you set optimal lineups.

Below are the projected starting pitching matchups and starts/sits for Week 21, covering August 29th through September 4th. We will keep this updated as rotations continue to be announced and modified. This column will make continuous adjustments for any postponements or rotation shuffles, reflecting official beat writer speculation for as many unconfirmed rotation slots as possible – so be sure to check back daily. Let's set those winning lineups!

Be sure to check all of our fantasy baseball lineup tools and resources:

 

Start/Sit Data Overview

This weekly piece considers the pitcher’s opponents, their outlook against lefties and righties, some ballpark factors, and historical splits. With all of this information, we then provide our start/sit recommendations for each starting pitcher matchup for the approaching week of fantasy baseball.

Each player will be valued with a Start/Sit recommendation, we are also including a "Score" column this year to display the level of confidence in that pick. Scores go from 0-100 in increments of five. The higher, the better! They are also color-coded, as you'll see.

Legend:

  • Proj GS - the number of starts the starter is projected to make in the week's scoring period.
  • Score - A metric of confidence, from 0-100 in increments of five. The higher, the better for the pitcher.

This chart is updated daily as probable starters are constantly changing with game postponements, injuries, and other events.

 

Week 21 Start/Sit Recommendations

Updated start/sit recommendations for this week's MLB games. If you cannot see the chart below, click here to see the start/sit grid on a separate page:



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POPULAR FANTASY TOOLS

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Import Your Leagues
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Compare Any Players
Compare Any Players
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REAL-TIME FANTASY NEWS

Sam LaPorta

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Josh Jacobs

"Feeling Pretty Good," Practicing Again on Friday
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Could Suit Up in Week 12
Jaxson Dart

Won't Play Vs. Detroit
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Completes Another Week of Practice
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Ruled Out Friday Against Wizards
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Looks To Get Back In The Win Column
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Tagged as Questionable on Friday
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Won't Play on Friday Vs. Pacers
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May Be Out Longer Than Expected?
Tagir Ulanbekov

Set To Open Up UFC Qatar Main Card
Marvin Bagley III

Doubtful as Wizards Frontcourt Thins
Draymond Green

Set to Rejoin Lineup vs. Blazers
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Probable for Friday's Home Game
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Expected Back in the Lineup on Friday
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Uncertain Against Heat
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Questionable Ahead of Heat Matchup
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Exits With Injury Thursday
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Played Through Partially Torn Quad to End 2025
C.J. Stroud

in Good Position to Return in Week 13
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Might Play on Friday Night
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Available Versus Milwaukee
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Cleared to Face Spurs
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Could Play in Week 12 After Return to Full Practice
Keon Coleman

to be a Healthy Scratch Again on Thursday Night
Tarik Skubal

Tigers "Doubtful" to Trade Tarik Skubal
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Questionable for Friday
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Ready for Action Thursday
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Available Thursday
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Will Miss at Least 3-4 Weeks
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Out Against Ducks
Nikola Jović

Nikola Jovic Out Against Bulls on Friday
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Back for Blues Thursday
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Listed as Questionable for Friday Against the Raptors
TB

Nicholas Paul Available Thursday
Paul George

Set to Suit Up Thursday
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Out for "Couple of Weeks"
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Set to Return Thursday
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Added to the Injury Report as Questionable for Thursday
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Added to Colts' Injury Report With Calf Issue
Andrew Wiggins

Unavailable For Friday's Matchup With Chicago
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Logs Second Straight Full Practice on Thursday
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Seen at Practice on Thursday
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Moving Around Well on Thursday
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Will be on a Snap Count When he Returns
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Could Clear Concussion Protocol Thursday
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Returns to Thursday's Practice
Josh Jacobs

to Do Individual Drills on Thursday
Joe Mixon

Not Expected to Play This Season
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Attending Thursday's Practice
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Bags Three Points Wednesday Night
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Nets Two Power-Play Goals Wednesday
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Searching for Momentum at RSM Classic
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Trying to Find Form at the RSM Classic
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Garrett Nussmeier Doubtful to Play Against Western Kentucky
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Hopes to End 2025 Campaign With Another Solid Finish
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Looks to End 2025 Season on High Note at RSM Classic
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PGA

Nico Echavarria has the Potential to Contend at the RSM Classic
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Playing Better at the Right Time
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The Time is Now for Quade Cummins in Georgia
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Taylor Ward

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Accepts Cubs Qualifying Offer
Brandon Woodruff

Returning to Milwaukee in 2026
Denny McCarthy

Looking For Another Solid Finish at RSM Classic
Si Woo Kim

Looking To Use Current Momentum to Flip Script at RSM Classic
Mackenzie Hughes

a Good Bounce-Back Candidate at RSM Classic
Harris English

Making 14th Start at This Week's RSM Classic
Konnor Griffin

Could Compete for Starting Shortstop Job in 2026
Gleyber Torres

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Jose Altuve

Undergoes Foot Surgery
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James Franklin to be Virginia Tech's Next Head Coach
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Valentina Shevchenko

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Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
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Virginia Tech Close To Naming James Franklin As Head Coach

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