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Starts & Sits for MLB Week 21 - All Starting Pitcher Matchups for Fantasy Baseball

Shohei Ohtani - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Fantasy baseball starts and sits, advice for all starting pitcher matchups Week 21. Set optimal lineups with Jon's start/sit recommendations.

Welcome back RotoBallers! Big week in fantasy leagues as we approach the end of the season and playoffs! As always, we are here with our starting pitcher starts and sits series to help you set those winning lineups for the week ahead!

For those who are not familiar, RotoBaller puts out a weekly grid of starting pitcher matchups and "start or sit" recommendations, and this is our 10th year now writing this weekly column. For every week of the fantasy baseball season, we are going to analyze every single projected starting pitcher matchup for fantasy baseball and help you set optimal lineups.

Below are the projected starting pitching matchups and starts/sits for Week 21, covering August 29th through September 4th. We will keep this updated as rotations continue to be announced and modified. This column will make continuous adjustments for any postponements or rotation shuffles, reflecting official beat writer speculation for as many unconfirmed rotation slots as possible – so be sure to check back daily. Let's set those winning lineups!

Be sure to check all of our fantasy baseball lineup tools and resources:

 

Start/Sit Data Overview

This weekly piece considers the pitcher’s opponents, their outlook against lefties and righties, some ballpark factors, and historical splits. With all of this information, we then provide our start/sit recommendations for each starting pitcher matchup for the approaching week of fantasy baseball.

Each player will be valued with a Start/Sit recommendation, we are also including a "Score" column this year to display the level of confidence in that pick. Scores go from 0-100 in increments of five. The higher, the better! They are also color-coded, as you'll see.

Legend:

  • Proj GS - the number of starts the starter is projected to make in the week's scoring period.
  • Score - A metric of confidence, from 0-100 in increments of five. The higher, the better for the pitcher.

This chart is updated daily as probable starters are constantly changing with game postponements, injuries, and other events.

 

Week 21 Start/Sit Recommendations

Updated start/sit recommendations for this week's MLB games. If you cannot see the chart below, click here to see the start/sit grid on a separate page:



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POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
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24x7 News and Alerts

REAL-TIME FANTASY NEWS

Denny McCarthy

Looking For Another Solid Finish at RSM Classic
Si Woo Kim

Looking To Use Current Momentum to Flip Script at RSM Classic
Zion Williamson

Considered Questionable for Wednesday
Bam Adebayo

Could Return to Action Wednesday
Mackenzie Hughes

a Good Bounce Back Candidate at RSM Classic
Jalen Brunson

Questionable for Wednesday
Jerami Grant

Picks Up Late Questionable Tag
Kyle Anderson

Cleared for Action Against the Lakers
Harris English

Making 14th Start at This Week's RSM Classic
Jrue Holiday

Ruled Out Tuesday
Taylor Hendricks

Returning on Tuesday
Kyle Filipowski

Won't Suit Up Versus the Lakers
LeBron James

Will Play on Tuesday Night
Luke Clanton

Looking For a Solid Finish in Year's Final Event
Daniel Berger

Making Start in Season Finale at This Week's RSM Classic
Konnor Griffin

Could Compete for Starting Shortstop Job in 2026
Keegan Murray

Expected to Make Season Debut Thursday
Gleyber Torres

Accepts Tigers Qualifying Offer
Alexandre Sarr

Uncertain for Wednesday's Game in Minnesota
Ausar Thompson

Returning Versus Atlanta
Cade Cunningham

Active on Tuesday Night
Jabari Smith Jr.

Questionable with Knee Issue Ahead of Meeting Versus Cleveland
Domantas Sabonis

to Miss Wednesday's Game
Paul George

Won't Play Wednesday Night
Onyeka Okongwu

Available on Tuesday
Joel Embiid

Listed as Doubtful for Wednesday
Jalen Suggs

Available Tuesday
Zaccharie Risacher

Ruled Out With Hip Contusion vs. Pistons
Odell Beckham Jr.

Officially Reinstated by NFL Commissioner
Kristaps Porzingis

Ruled Out on Tuesday Night
Matt Murray

to Miss Six Weeks With Lower-Body Injury
Ilya Lyubushkin

Out on Tuesday
Jamie Benn

Makes Season Debut Tuesday
Evgenii Dadonov

on Track to Return Tuesday
Dougie Hamilton

a Game-Time Call Tuesday
Anthony Cirelli

Expected to Return Against Devils
Victor Hedman

Questionable for Tuesday
Auston Matthews

to Miss at Least Two More Games
C.J. Stroud

Expected to Return in Week 13 Against Colts
C.J. Stroud

to Miss Another Game
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
Jaylen Warren

Mike Tomlin Optimistic About Jaylen Warren's Availability for Week 12
C.J. Stroud

Not Expected to Play on Thursday Night
Aaron Rodgers

Won't Need Surgery on Fractured Wrist, Could Play in Week 12?
Davis Mills

Prepping for Third Straight Start in Week 12?
CFB

Sam Leavitt Set to Enter Transfer Portal?
Mason Rudolph

Could Make His First Start of 2025 in Week 12
Brock Wright

Sets Career-High in Targets; Lined Up for More Work?
Kimani Vidal

Struggles Again and Faces Role Uncertainty After Bye
Dak Prescott

in Full Command Monday Night With Four Touchdown Passes
Quentin Johnston

Posts Zero Catches During Offensive Collapse
George Pickens

Erupts for 144 Yards, Touchdown in Monday Night Win
CeeDee Lamb

George Pickens Benched for First Drive
Jose Altuve

Undergoes Foot Surgery
Alex Singleton

Broncos Optimistic Patrick Surtain, Alex Singleton Will Return After the Bye
Trey Hendrickson

Doubtful Again in Week 12
Shedeur Sanders

Expected to Make First Career Start in Week 12
Josh Jacobs

Dealing With Knee Contusion
Mikael Granlund

Unavailable Monday
Alex Bregman

Red Sox Going for Either Alex Bregman or Pete Alonso?
Conor Garland

Misses Monday's Game
Eetu Luostarinen

Out on Monday
Drake London

Considered "Week-to-Week"
Drew Doughty

Listed as Week-to-Week
Ja'Marr Chase

Being Suspended for One Game for Unsportsmanlike Conduct
John Carlson

a Game-Time Call Monday
Viktor Arvidsson

Out Week-to-Week
Charlie McAvoy

Out Against Hurricanes
CFB

James Franklin to be Virginia Tech's Next Head Coach
CFB

Fernando Mendoza the Clear Heisman Trophy Favorite?
CFB

Beau Pribula Has Chance to Face Oklahoma on Saturday
Mitchell Marner

Establishes Vegas Record Sunday
Mats Zuccarello

Logs Two Assists in Overtime Victory
Lucas Raymond

Leads Red Wings to Victory at MSG
Quinn Hughes

Delivers Four Assists in Sunday's Win
Conor Garland

Limited to Handful of Minutes Sunday
Ryan Hartman

Suffers Lower-Body Injury
Jack Della Maddalena

Gets Dominated
Islam Makhachev

Claims UFC Welterweight Belt
Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
Justin Thomas

Will Miss Start Of 2026 After Undergoing Back Surgery
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Michael Morales

Looks To Remain Undefeated
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Carlos Prates

A Favorite At UFC 322
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again
Raisel Iglesias

Dodgers Interested in Signing Raisel Iglesias
Pete Alonso

Orioles Could be in the Mix to Sign Pete Alonso

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