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Must-Start Defenses (D/ST) for Week 2 Fantasy Football (2025)

Matt's must-add fantasy football waiver wire defenses (D/ST) to stream and start for Week 2 of the 2025 season. His fantasy defense start 'em, sit 'em picks.

RotoBaller analyst Matt Donnelly drops his fantasy football must-start defenses (D/ST) for Week 2 of the 2025 season. Get these dynamic defenses in your lineups now!

The 2025 NFL season is underway, which means fantasy football decisions are coming at you hot and heavy! We are here to help with your Week 2 D/ST streamers and set those winning lineups.

Be sure to tune into RotoBaller Radio on SiriusXM (channel Sirius 210, XM 87) - every weekday morning at 6:00 AM ET. You can also find new weekly shows on YouTubeSpreaker, SpotifyiTunes and on the site under RotoBaller Radio podcasts. Win more in 2025 with RotoBaller!

Be sure to check all of our fantasy football rankings for 2025:

 

2025 Fantasy Football: Week 2 Defenses To Start (D/ST)

Matt Donnelly drops his top Defenses for Week 2 of the 2025 fantasy football season:

Thanks for listening to today's episode! Be sure to tune in throughout the week, and to also follow RotoBaller on Twitter, YouTube, Spotify and iTunes for the latest fantasy news and analysis.

 

Who Should I Start Tool

Not sure who to start? Check out the Who Should I Start tool:

Who Should I Start for 11?

Compare up to four players and we'll tell you who to start...

Who To Start?
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Who Should I Start? Who Should I Sit? Some common Week 2 fantasy football lineup decisions are regarding defenses like the Los Angeles Rams DST, Baltimore Ravens DST, San Francisco 49ers DST, Dallas Cowboys DST, Minnesota Vikings DST, Green Bay Packers DST. But not to worry, we are here to help make these decisions and build winning lineups in Week 2. Set your optimal fantasy football lineups for Week 2 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.

Week 2 Player Decisions. Today's focus is on specific defenses like Los Angeles Rams DST, Baltimore Ravens DST, San Francisco 49ers DST, Dallas Cowboys DST, Minnesota Vikings DST, Green Bay Packers DST. These are some of the most common searches for fantasy football lineups in Week 2.

Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.

Improvements For Who Should I Start? You may have noticed, our Who Should I Start? tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, enhanced search results with data to compare, and a slick new interface. We hope you enjoy!

How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.

Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.

Popular Week 2 Searches. Curious to see some tough lineup decisions for Week 2 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.

 

Popular Week 2 Searches - Start/Sit Player Comparisons

Below are some popular Week 2 searches and comparisons from our 'Who To Start' tool for the Los Angeles Rams DST, Baltimore Ravens DST, San Francisco 49ers DST, Dallas Cowboys DST, Minnesota Vikings DST, Green Bay Packers DST compared to others:

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POPULAR FANTASY TOOLS

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REAL-TIME FANTASY NEWS

Ryan McDonagh

to Sit Out "a Few Games"
Josh Giddey

Is Questionable Wednesday Against the Pistons
Charlie McAvoy

Back in Action Tuesday
Giannis Antetokounmpo

Listed as Questionable for Wednesday
Scott Laughton

Unavailable Tuesday
LaMelo Ball

Ruled Out for Wednesday
Ryan Strome

Won't Play Tuesday
TreVeyon Henderson

Upgrades to Full Practice Participation
Shayne Gostisbehere

Ready to Face Capitals
Taylor Hendricks

Will Miss a Second Straight Game on Tuesday
Thatcher Demko

Returns to Canucks Crease Tuesday
Devin Carter

Ruled Out Tuesday Against Denver
Domantas Sabonis

Will Play Tuesday Night
Justin Tucker

Suspension Lifted, Eligible to Sign With Any Team
Jalen Green

Will Miss 4-6 Weeks
Al Horford

Will Not Play Tuesday
J.K. Dobbins

Could Land on Injured Reserve
Sam Hauser

Will Be Available Tuesday Against the Sixers
Travis Hunter

Undergoes Season-Ending Knee Surgery
Brandon Clarke

Expected to Miss 6-9 More Weeks
Ochai Agbaji

Ruled Out Tuesday Against the Nets
Day'Ron Sharpe

Will Not Play Tuesday
Tarik Skubal

Tigers Unlikely to Trade Tarik Skubal
Joel Embiid

Ruled Out Tuesday Against Boston
Joe Burrow

Week 14 a Realistic Return Date for Joe Burrow?
Framber Valdez

Cubs Could Land Framber Valdez in Free Agency
Jaylen Warren

to See More Touches?
Deshaun Watson

Browns Not Opening Deshaun Watson's 21-Day Practice Window
Al Horford

Questionable for Tuesday
Paul George

Remains Out Tuesday vs. Celtics
Luguentz Dort

Ruled Out With Right Upper-Trap Strain
Aaron Wiggins

Sidelined for Third Straight Game
Sandro Mamukelashvili

Questionable With Neck Stiffness
T.J. McConnell

Questionable Tuesday vs. Jazz
Jake Walman

Plays Key Role in Comeback Victory
Alexis Lafrenière

Alexis Lafreniere Bags Three Points in Monday's Win
Matthew Wood

Scores First Career Hat Trick at MSG
Brad Marchand

Stays Hot in Vegas
William Eklund

Could Be an Option Tuesday
Nick Leddy

Available on Tuesday
Mitchell Robinson

Considered Questionable for Tuesday
Aaron Gordon

Listed as Probable for Tuesday
Romeo Doubs

Questionable to Return in Week 10 Due to Chest Injury
Sandy Alcantara

Marlins Ready to Trade Sandy Alcantara
Ketel Marte

Diamondbacks Motivated to Move Ketel Marte
Hunter Greene

Reds to Listen to Offers on Hunter Greene
Paul Skenes

Pirates Won't Trade Paul Skenes
Joe Burrow

Could Return for Thanksgiving Game
Pete Alonso

Mets Expected to Let Pete Alonso Walk in Free Agency
Kyle Tucker

to Sign With Yankees, Blue Jays, or Dodgers
Drake Baldwin

Named NL Rookie of the Year
Kyle Hendricks

Hanging Up his Cleats After 12 Seasons
Freddy Peralta

Red Sox Linked to Freddy Peralta
Nick Kurtz

Named AL Rookie of the Year
Brandon Aiyuk

49ers Won't Open Brandon Aiyuk's Practice Window This Week
Matthew Golden

Officially Out Against Eagles
TreVeyon Henderson

on Week 11 Injury Report With Knee Injury
Matthew Golden

Not Expected to Play on Monday Night
Casey Mittelstadt

Out Week-to-Week
Garrett Wilson

Expected to Miss 3-4 Weeks With Knee Sprain
Jason Zucker

Dealing With Severe Viral Issue
Jiri Kulich

to "Miss Significant Time" Due to Blood Clot
Zack MacEwen

to Re-Enter Devils Lineup Monday
William Karlsson

Out on Monday
Ryan Nugent-Hopkins

to Miss at Least One Week
Vincent Trocheck

Available Monday
Isiah Pacheco

May Not be Ready to Return in Week 11
Dalton Kincaid

Labeled Week-to-Week With Hamstring Injury
Oronde Gadsden

Diagnosed With Bruised Quad, Considered "Day-to-Day"
Rashod Bateman

Dealing With a Sprained Ankle
Jayden Daniels

Won't Travel to Madrid in Week 11
Terry McLaurin

Won't Play in Week 11
Trey Hendrickson

Doubtful to Play in Week 11
CFB

Nic Anderson Could Return for LSU this Season
Lukas Dostal

Pushes Winning Streak to Career-Best Six Games
Matt Boldy

Has Two-Point Night Sunday
Emmanuel Clase

Indicted on Gambling Charges, Facing 65 Years in Prison
Randy Brown

Suffers Second-Round TKO Loss
Gabriel Bonfim

Extends His Win Streak
Joseph Morales

Gets First-Round Submission Win
Matt Schnell

Suffers First-Round Submission Loss
Muslim Salikhov

Suffers First-Round TKO Loss
Uros Medic

Wins Back-To-Back Fights
Ismael Bonfim

Loses Back-to-Back Fights
Chris Padilla

Remains Unbeaten In The UFC
Marco Tulio

Suffers His First UFC Loss
Christian Leroy Duncan

Scores Second-Round Knockout Victory
Aaron Judge

Headlines AL Silver Slugger Award Winners
Shohei Ohtani

Headlines List of NL Silver Slugger Winners
MLB

Munetaka Murakami Officially Being Posted on Friday
Randy Brown

Set For UFC Vegas 111 Main Event
Gabriel Bonfim

Looks To Extend His Win Streak
Joseph Morales

A Favorite At UFC Vegas 111
Matt Schnell

Set For UFC Vegas 111 Co-Main Event
Uros Medic

Aims To Win Back-To-Back Fights
Muslim Salikhov

Looks For His Fourth Consecutive Win
Chris Padilla

Looks To Remain Unbeaten In The UFC
Ismael Bonfim

Looks To Get Back In The Win Column
Marco Tulio

Looks To Remain Undefeated In The UFC
Christian Leroy Duncan

Set To Open Up UFC Vegas 111 Main Card
Kyle Tucker

Headlines List of 13 Players to Receive Qualifying Offers
Pete Fairbanks

Becomes a Free Agent
CFB

Luke Fickell Will Return as Wisconsin's Head Coach in 2026
Bo Bichette

Blue Jays Extend Qualifying Offer to Bo Bichette
Craig Stammen

Named Padres New Manager
Jorge Polanco

Declines his 2026 Option to Become a Free Agent

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