
Matt's must-add fantasy football waiver wire defenses (D/ST) to stream and start for Week 2 of the 2025 season. His fantasy defense start 'em, sit 'em picks.
RotoBaller analyst Matt Donnelly drops his fantasy football must-start defenses (D/ST) for Week 2 of the 2025 season. Get these dynamic defenses in your lineups now!
The 2025 NFL season is underway, which means fantasy football decisions are coming at you hot and heavy! We are here to help with your Week 2 D/ST streamers and set those winning lineups.
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Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
- Running back (RB) fantasy football rankings
- Wide receiver (WR) fantasy football rankings
- Tight end (TE) fantasy football rankings
- Quarterback (QB) fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Kicker (K) fantasy football rankings
- Dynasty fantasy football rankings
2025 Fantasy Football: Week 2 Defenses To Start (D/ST)
Matt Donnelly drops his top Defenses for Week 2 of the 2025 fantasy football season:
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Who Should I Start Tool
Not sure who to start? Check out the Who Should I Start tool:
Compare up to four players and we'll tell you who to start...

Who Should I Start? Who Should I Sit? Some common Week 2 fantasy football lineup decisions are regarding defenses like the Los Angeles Rams DST, Baltimore Ravens DST, San Francisco 49ers DST, Dallas Cowboys DST, Minnesota Vikings DST, Green Bay Packers DST. But not to worry, we are here to help make these decisions and build winning lineups in Week 2. Set your optimal fantasy football lineups for Week 2 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Week 2 Player Decisions. Today's focus is on specific defenses like Los Angeles Rams DST, Baltimore Ravens DST, San Francisco 49ers DST, Dallas Cowboys DST, Minnesota Vikings DST, Green Bay Packers DST. These are some of the most common searches for fantasy football lineups in Week 2.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed, our Who Should I Start? tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, enhanced search results with data to compare, and a slick new interface. We hope you enjoy!
How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 2 Searches. Curious to see some tough lineup decisions for Week 2 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 2 Searches - Start/Sit Player Comparisons
Below are some popular Week 2 searches and comparisons from our 'Who To Start' tool for the Los Angeles Rams DST, Baltimore Ravens DST, San Francisco 49ers DST, Dallas Cowboys DST, Minnesota Vikings DST, Green Bay Packers DST compared to others:
More Fantasy Football Analysis
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