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PrizePicks MLB DFS Picks for Fantasy Baseball - Wednesday September 21st

Lance McCullers - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Kipp's MLB DFS prop picks for PrizePicks daily fantasy baseball on Wednesday, September 21st. Use his MLB prop picks recommendations to win money on PrizePicks.

Hello everybody and welcome! The 2022 MLB season is heading towards the home stretch and we here at RotoBaller have you covered with some terrific plays from our friends over at PrizePicks.

PrizePicks is a great DFS fantasy picks site where you can choose to select plays in terms of fantasy points or single stats. The goal is to build a 2-player, 3-player, 4-player, or 5-player entry and then select whether or not you want to play for the power play or the flex play. On the power play, you will need to be correct on each of your selections to win, and on the flex play, you will have a little more wiggle room for a chance to win some money back.

Our partners at PrizePicks offer some of the best, and easiest to win, MLB DFS games in the industry. There are no large-field tournaments filled with sharks where you have to get lucky just to place. At PrizePicks, you're not playing against other people, you're just playing against the projections, and the guys at PrizePicks have worked hard to give you really attractive opportunities to make some money. With promo code 'BALLER' you can get a 100% match on your deposit up to $100.

PrizePicks has two types of games. The first type of game is known as Fantasy Score, which consists of selecting various players and trying to determine if they will go over or under their projected fantasy points in a game. The second game is known as Single Stat. For MLB, Single Stat consists of pitcher strikeout props in which you determine if the pitcher in question will go over or under their projected strikeout total. You can mix and match players from each type of game in your entry or select all of your plays from the same type of game. Once you have selected your players and props, you can choose the aforementioned flex play or power play option. Let's see what the board offers today!

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MLB DFS Picks for 9/21/22

Daniel Lynch more than 4.5 strikeouts- Lynch is not the first guy I thought I would be writing up today, but the matchup is ripe. He will be facing the Twins, who have posted a 29.7% K rate vs. southpaws over the previous two weeks, which is ranked fourth-worst in the league. Lynch is also fresh off an eight-strikeout performance against these Twins in his most recent start

Robbie Ray more than 6.5 strikeouts - Ray has a solid matchup in this one against the Athletics, who have posted a K rate of 31% vs. lefties over the previous two weeks, which is ranked second-worst in baseball over that span. They have also posted just a 4.8% walk rate and an 81 wRC+ mark over that same span, so Ray should be able to stay out of trouble in this one. He has faced Oakland three times this season and has eclipsed this total in two of those three starts.

Lance McCullers Jr. more than 5.0 strikeouts - McCullers has looked sharp since his return from the IL and now has five or more strikeouts in all but one start in that timeframe. He will be facing the Rays, who have posted just a 20% K rate vs. righties over the previous two weeks, but have not faced many starters with the strikeout upside of McCullers over that span.

Other Recommendations - 

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REAL-TIME FANTASY NEWS

VJ Edgecombe

Misses Second Consecutive Game Tuesday
Paul George

Expected to Play Tuesday
Tyrese Maxey

Considered Probable Tuesday
Joel Embiid

Could Return Tuesday
Isiah Pacheco

Targeting a Return on Thursday
Shohei Ohtani

to Play for Team Japan in 2026 World Baseball Classic
Patrick Williams

Available Monday vs. Pelicans
Jaren Jackson Jr.

Cleared to Play Against Denver
Kevin Huerter

Ruled Out With Pelvis Soreness
Nicolas Claxton

Cleared to Face New York
Dean Wade

Sidelined Monday
Nikola Vučević

Nikola Vucevic Unavailable Against Pelicans
Landry Shamet

Sidelined Against Nets
Tyler Herro

Making 2025 Debut on Monday
Caris LeVert

Jaden Ivey, Caris LeVert Available Versus Indiana
Kevin Love

Out Monday Versus Warriors
Grayson Allen

and Ryan Dunn Sidelined vs. Rockets
Lamar Jackson

Now Dealing With a Toe Injury
Anthony Davis

Downgraded on Monday Night
Lonzo Ball

Set to Suit Up Versus Toronto
Jake Walman

to Remain Out Tuesday
Draymond Green

Ruled Out With Foot Sprain
Sam Merrill

and Craig Porter Jr. Out Monday
RJ Barrett

Sidelined Versus Cleveland
Ridly Greig

Still Out Monday
De'Andre Hunter

Out Versus Raptors
Baker Mayfield

Dealing With Low-Grade Shoulder Sprain
Thomas Chabot

Misses Monday's Matchup
Kirill Marchenko

Out Monday
J.T. Miller

Unavailable Monday
Brayden Point

Out Against Flyers
Nikita Kucherov

Good to Go Monday
Chris Godwin

Buccaneers Plan to "Ramp Up" Chris Godwin's Usage
Colorado Rockies

Warren Schaeffer to Stick Around as Rockies Manager in 2026
Ashton Jeanty

Ankle Injury isn't Severe
Jayden Daniels

to Practice This Week, Considered a Long Shot for Week 13
C.J. Stroud

Remains in Concussion Protocol
Mike Evans

Could Return Before End of Regular Season
J.J. McCarthy

in Concussion Protocol
Tyrod Taylor

to Remain the Jets' Starting QB
Shedeur Sanders

to Make Another Start for Browns in Week 13
Tee Higgins

Won't Play on Thanksgiving
Joe Burrow

Bengals Expect Joe Burrow to Play on Thursday
Baker Mayfield

Not Being Ruled Out for Week 13
CFB

Chris Bell Out for Rivalry Matchup Against Kentucky
New York Giants

Giants Fire Defensive Coordinator Shane Bowen
Tee Higgins

in the Concussion Protocol
Scott Wedgewood

Gives Avalanche Second Consecutive Shutout
Macklin Celebrini

Makes History During Multi-Point Performance
Joey Daccord

Posts Shutout in Losing Effort
David Rittich

Keeps Kraken Quiet
Jesper Wallstedt

Picks Up Third Shutout of the Season
Rasmus Andersson

Extends Point Streak With Three Assists
Davante Adams

Catches Two Touchdowns in Sunday Night Win
Baker Mayfield

has Sprained Shoulder, Will Undergo MRI Monday
Las Vegas Raiders

Raiders Fire Offensive Coordinator Chip Kelly
Ryan Helsley

Tigers Eyeing Ryan Helsley as a Starter
Quinshon Judkins

Salvages his Day With Two Trips to the End Zone
Alvin Kamara

Dealing With MCL Sprain, Timetable Unclear
Dan Hooker

Suffers Second-Round Submission Loss
Marcus Semien

Shipped to the Mets on Sunday
Arman Tsarukyan

Gets Submission Win
Brandon Nimmo

Traded to Texas
Belal Muhammad

Loses Back-to-Back Fights
Belal Muhammad

Ian Machado Garry Outpoints Belal Muhammad
Alonzo Menifield

Suffers First-Round Knockout Loss
Volkan Oezdemir

Gets Back In The Win Column
Jack Hermansson

Gets Knocked Out
Jack Hermansson

Myktybek Orolbai Knocks Out Jack Hermansson
Shamil Gaziev

Suffers First-Round Knockout Loss
Waldo Cortes-Acosta

Shines At UFC Qatar
Tagir Ulanbekov

Suffers Third-Round Submission Loss
Kyoji Horiguchi

Makes Triumphant UFC Return
MON

Alexandre Texier Joins Canadiens
Jason Dickinson

Returns to Action Sunday
Elias Lindholm

Activated From Injured Reserve
Mikko Rantanen

Suspended for One Game
Neal Pionk

Sustains Lower-Body Injury Sunday
Jean-Gabriel Pageau

Out Week-to-Week
Alexander Romanov

Out 5-6 Months Due to Shoulder Surgery
Sidney Crosby

Records 500th Multi-Point Game
Adolis García

Rangers Non-Tender Adolis Garcia on Friday
CFB

Beau Pribula Expected to Start Against Oklahoma
Dan Hooker

An Underdog At UFC Qatar
Arman Tsarukyan

Looks To Extend His Win Streak
Ian Machado Garry

A Favorite At UFC Qatar
Belal Muhammad

Looks To Bounce Back
Alonzo Menifield

Looks For His Third Consecutive Win
Volkan Oezdemir

Looks To Get Back In The Win Column
Myktybek Orolbai

Looks To Win Back-To-Back Fights
Jack Hermansson

Makes His Welterweight Debut
Kyoji Horiguchi

Returns To The UFC
Elly De La Cruz

Played Through Partially Torn Quad to End 2025
Tarik Skubal

Tigers "Doubtful" to Trade Tarik Skubal
Raisel Iglesias

Returning to the Braves on One-Year Deal
Sahith Theegala

Looking to Continue Fall Run at RSM Classic
Stephan Jaeger

Looking to Bounce Back at RSM Classic
Tom Hoge

Looking to Regain Form at RSM Classic
Joe Highsmith

Searching for Turnaround at RSM Classic
Adam Hadwin

Looking to Build on T11 Finish in Bermuda
Austin Eckroat

Searching for Momentum at RSM Classic
Joel Dahmen

Trying to Find Form at the RSM Classic
CFB

Garrett Nussmeier Doubtful to Play Against Western Kentucky
Michael Thorbjornsen

Hopes to End 2025 Campaign With Another Solid Finish
Andrew Novak

Looks to End 2025 Season on High Note at RSM Classic
Harry Higgs

Teetering for PGA Tour Card in 2026
PGA

Nico Echavarria has the Potential to Contend at the RSM Classic

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