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PrizePicks MLB DFS Picks for Fantasy Baseball - Wednesday September 21st

Lance McCullers - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Kipp's MLB DFS prop picks for PrizePicks daily fantasy baseball on Wednesday, September 21st. Use his MLB prop picks recommendations to win money on PrizePicks.

Hello everybody and welcome! The 2022 MLB season is heading towards the home stretch and we here at RotoBaller have you covered with some terrific plays from our friends over at PrizePicks.

PrizePicks is a great DFS fantasy picks site where you can choose to select plays in terms of fantasy points or single stats. The goal is to build a 2-player, 3-player, 4-player, or 5-player entry and then select whether or not you want to play for the power play or the flex play. On the power play, you will need to be correct on each of your selections to win, and on the flex play, you will have a little more wiggle room for a chance to win some money back.

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PrizePicks has two types of games. The first type of game is known as Fantasy Score, which consists of selecting various players and trying to determine if they will go over or under their projected fantasy points in a game. The second game is known as Single Stat. For MLB, Single Stat consists of pitcher strikeout props in which you determine if the pitcher in question will go over or under their projected strikeout total. You can mix and match players from each type of game in your entry or select all of your plays from the same type of game. Once you have selected your players and props, you can choose the aforementioned flex play or power play option. Let's see what the board offers today!

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MLB DFS Picks for 9/21/22

Daniel Lynch more than 4.5 strikeouts- Lynch is not the first guy I thought I would be writing up today, but the matchup is ripe. He will be facing the Twins, who have posted a 29.7% K rate vs. southpaws over the previous two weeks, which is ranked fourth-worst in the league. Lynch is also fresh off an eight-strikeout performance against these Twins in his most recent start

Robbie Ray more than 6.5 strikeouts - Ray has a solid matchup in this one against the Athletics, who have posted a K rate of 31% vs. lefties over the previous two weeks, which is ranked second-worst in baseball over that span. They have also posted just a 4.8% walk rate and an 81 wRC+ mark over that same span, so Ray should be able to stay out of trouble in this one. He has faced Oakland three times this season and has eclipsed this total in two of those three starts.

Lance McCullers Jr. more than 5.0 strikeouts - McCullers has looked sharp since his return from the IL and now has five or more strikeouts in all but one start in that timeframe. He will be facing the Rays, who have posted just a 20% K rate vs. righties over the previous two weeks, but have not faced many starters with the strikeout upside of McCullers over that span.

Other Recommendations - 

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REAL-TIME FANTASY NEWS

Davante Adams

Doubtful to Play Thursday Night
LaMelo Ball

Questionable to Play Thursday
Trae Young

Upgraded to Questionable on Injury Report
Ja Morant

Downgraded to Doubtful Wednesday
Matthew Tkachuk

Status Uncertain for Winter Classic
Tyson Foerster

Ruled Out for Five Months
Quinton Byfield

Back From One-Game Absence Wednesday
Gustav Forsling

Available Against Kings
Pavel Dorofeyev

Good to Go Wednesday
Shea Theodore

Out Against Devils
Jack Eichel

Misses First Game of the Season Wednesday
Brett Pesce

Back in Action Wednesday
Devin Neal

Ruled Out for Sunday
Christian Watson

"Should be Good" to Face the Bears on Saturday
Geno Smith

has "a Good Chance" to Return in Week 16
Saquon Barkley

Back at Practice on Wednesday
Brady Cook

Will Start Again in Week 16
Patrick Mahomes

Rehabbing ACL, LCL Tears
Rashee Rice

Won't Practice Due to Concussion
Marvin Harrison Jr.

to Take Part in Wednesday's Walkthrough Practice
Drake London

Day-to-Day, Will Practice on Wednesday
CFB

Jeremiyah Love Officially Heading to NFL Draft
Quinn Ewers

Making First Career Start in Week 16
Tua Tagovailoa

Being Benched by Dolphins
CFB

Jake Merklinger Leaving Tennessee for Transfer Portal
Jeremy Ruckert

Jets, Jeremy Ruckert Agree to a Two-Year Extension
Thatcher Demko

Shuts Out Rangers With 23 Saves
Macklin Celebrini

Notches Four Points in Tuesday's Win
Leon Draisaitl

Reaches Special Milestone During Four-Point Night
Shea Theodore

Questionable for Wednesday Night
Jack Eichel

Battling Illness
Darcy Kuemper

Placed on Injured Reserve
Brandon Montour

Hurt on Tuesday
Sam Merrill

Remains on Shelf Wednesday
Max Strus

Still Out Wednesday
Ayo Dosunmu

May Miss Another Game Wednesday
Brandon Clarke

Upgraded to Questionable on Injury Report
Cam Spencer

Unavailable Wednesday
Mike Conley

Remains Sidelined Wednesday
Zach LaVine

to Be Re-Evaluated in One Week
Mike Trout

Angels Open to Mike Trout Playing Center Field in 2026
Victor Wembanyama

Coming off the Bench on Tuesday Night
Rudy Gobert

Not on the Injury Report for Wednesday
Anthony Edwards

on the Injury Report Again for Wednesday Night
Ja Morant

Questionable for Wednesday's Meeting With Timberwolves
Saquon Barkley

Misses Practice With Stinger
RJ Harvey

Dealing With Rib Injury
Josh Jacobs

Intends to Play Against Bears on Saturday
Zach Bogosian

Misses Tuesday's Game
Marcus Johansson

Unavailable Tuesday
Artyom Levshunov

Scratched for Tuesday
Mathew Barzal

a Game-Time Call Tuesday
Joseph Woll

Returns to Action Tuesday
Mike Matheson

Won't Play on Tuesday
Bam Knight

Cardinals Place Bam Knight on Injured Reserve
CFB

Kansas State's Jayce Brown Intends to Transfer
CFB

Nation's Leading Passer Drew Mestemaker to Enter Transfer Portal
Justin Crawford

Phillies Planning to Start Justin Crawford in Center Field
CFB

Jayden Maiava Signs New Deal to Return to USC
CFB

Aidan Mizell Won't Return to Florida, Entering Transfer Portal
CFB

East Carolina Targeting Jordan Davis as Next Offensive Coordinator
Patrick Mahomes

Targeting Week 1 Return in 2026
CFB

Michigan QB Jadyn Davis Set to Enter Transfer Portal
CFB

Travis Williams Joining Texas A&M Defensive Staff
Cooper Flagg

Becomes Youngest 40-Point Scorer in NBA History
Victor Wembanyama

May Come Off the Bench Again Tuesday
Nikola Jović

Nikola Jovic to Undergo MRI Tuesday
Sam Hauser

Tweaks Left Ankle Monday
Peyton Watson

Not Expected to Be Out Long-Term
Ja Morant

Injures Ankle in Monday's Win
Darren Waller

Hauls in Two Touchdowns in Monday Night Loss
Brandon Clarke

Still Out Monday
Rome Odunze

Considered Week-to-Week With Foot Injury
Davante Adams

Considered Week-to-Week With Hamstring Injury
CFB

Dylan Raiola Entering His Name into Transfer Portal
CFB

Cincinnati's Brendan Sorsby Plans to Transfer When Portal Opens
Adolis García

Adolis Garcia, Phillies Finalizing One-Year Deal on Monday
Brandon Royval

Suffers First-Round TKO Loss
CFB

Baylor, LSU, Miami Among Potential Suitors for DJ Lagway
CFB

Aidan Chiles Will Enter Transfer Portal
Manel Kape

Shines At UFC Vegas 112
Kevin Vallejos

Gets Second-Round Knockout Win
Giga Chikadze

Suffers His First Career Knockout Loss
CFB

Quarterback DJ Lagway Entering Transfer Portal
Cesar Almeida

Gets Dominated
Cezary Oleksiejczuk

Wins Sixth Fight In A Row
Morgan Charrière

Morgan Charriere Suffers First-Round Knockout Loss
Melquizael Costa

Gets First-Round Knockout Win
Marcus Buchecha

Still Winless In The UFC
Kennedy Nzechukwu

And Marcus Buchecha Fight To Draw
Lance Gibson jr

Lance Gibson Jr. Drops Decision In His UFC Debut
King Green

Gets Back In The Win Column
Kenley Jansen

Agrees to One-Year Deal With Tigers
Merrill Kelly

Returns to Diamondbacks on Two-Year Deal
Jorge Polanco

Agrees to Two-Year Deal With Mets
CFB

LaNorris Sellers to Return to South Carolina in 2026
CFB

Washington State Expected to Hire Kirby Moore as Next Head Coach
CFB

Kyle Whittingham Stepping Down as Utah Head Coach
Manel Kape

Set For UFC Vegas 112 Main Event
Brandon Royval

An Underdog At UFC Vegas 112
Kevin Vallejos

Set For His Third UFC Fight
Giga Chikadze

In Dire Need Of Victory
Cesar Almeida

Set To Welcome Cezary Oleksiejczuk To The UFC
Cezary Oleksiejczuk

Set To Make His UFC Debut
Maikel Garcia

Royals Agree on Five-Year Extension
Melquizael Costa

Looks To Extend His Win Streak
Morgan Charrière

Morgan Charriere Looks to Win Second Consecutive Fights
Marcus Buchecha

Looks To Bounce Back
CFB

Sherrone Moore Charged with Home Invasion, Among Other Charges
CFB

Freddie Kitchens Fired from North Carolina Coaching Staff

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