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PrizePicks MLB DFS Picks for Fantasy Baseball - Wednesday September 21st

Lance McCullers - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Kipp's MLB DFS prop picks for PrizePicks daily fantasy baseball on Wednesday, September 21st. Use his MLB prop picks recommendations to win money on PrizePicks.

Hello everybody and welcome! The 2022 MLB season is heading towards the home stretch and we here at RotoBaller have you covered with some terrific plays from our friends over at PrizePicks.

PrizePicks is a great DFS fantasy picks site where you can choose to select plays in terms of fantasy points or single stats. The goal is to build a 2-player, 3-player, 4-player, or 5-player entry and then select whether or not you want to play for the power play or the flex play. On the power play, you will need to be correct on each of your selections to win, and on the flex play, you will have a little more wiggle room for a chance to win some money back.

Our partners at PrizePicks offer some of the best, and easiest to win, MLB DFS games in the industry. There are no large-field tournaments filled with sharks where you have to get lucky just to place. At PrizePicks, you're not playing against other people, you're just playing against the projections, and the guys at PrizePicks have worked hard to give you really attractive opportunities to make some money. With promo code 'BALLER' you can get a 100% match on your deposit up to $100.

PrizePicks has two types of games. The first type of game is known as Fantasy Score, which consists of selecting various players and trying to determine if they will go over or under their projected fantasy points in a game. The second game is known as Single Stat. For MLB, Single Stat consists of pitcher strikeout props in which you determine if the pitcher in question will go over or under their projected strikeout total. You can mix and match players from each type of game in your entry or select all of your plays from the same type of game. Once you have selected your players and props, you can choose the aforementioned flex play or power play option. Let's see what the board offers today!

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MLB DFS Picks for 9/21/22

Daniel Lynch more than 4.5 strikeouts- Lynch is not the first guy I thought I would be writing up today, but the matchup is ripe. He will be facing the Twins, who have posted a 29.7% K rate vs. southpaws over the previous two weeks, which is ranked fourth-worst in the league. Lynch is also fresh off an eight-strikeout performance against these Twins in his most recent start

Robbie Ray more than 6.5 strikeouts - Ray has a solid matchup in this one against the Athletics, who have posted a K rate of 31% vs. lefties over the previous two weeks, which is ranked second-worst in baseball over that span. They have also posted just a 4.8% walk rate and an 81 wRC+ mark over that same span, so Ray should be able to stay out of trouble in this one. He has faced Oakland three times this season and has eclipsed this total in two of those three starts.

Lance McCullers Jr. more than 5.0 strikeouts - McCullers has looked sharp since his return from the IL and now has five or more strikeouts in all but one start in that timeframe. He will be facing the Rays, who have posted just a 20% K rate vs. righties over the previous two weeks, but have not faced many starters with the strikeout upside of McCullers over that span.

Other Recommendations - 

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REAL-TIME FANTASY NEWS

C.J. Stroud

to Miss Another Game
Jonathan Kuminga

Remains Out Tuesday
Keegan Murray

Could Make his Season Debut This Week
Caris LeVert

Liston as Out on Tuesday
Tobias Harris

Could Return Thursday
Ausar Thompson

Questionable Again on Tuesday
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
Cade Cunningham

is Questionable Tuesday in Atlanta
Jaylen Warren

Mike Tomlin Optimistic About Jaylen Warren's Availability for Week 12
C.J. Stroud

Not Expected to Play on Thursday Night
Aaron Rodgers

Won't Need Surgery on Fractured Wrist, Could Play in Week 12?
Davis Mills

Prepping for Third Straight Start in Week 12?
CFB

Sam Leavitt Set to Enter Transfer Portal?
Mason Rudolph

Could Make His First Start of 2025 in Week 12
Brock Wright

Sets Career-High in Targets; Lined Up for More Work?
Stephon Castle

Out Against Grizzlies
Kimani Vidal

Struggles Again and Faces Role Uncertainty After Bye
Dak Prescott

in Full Command Monday Night With Four Touchdown Passes
Quentin Johnston

Posts Zero Catches During Offensive Collapse
George Pickens

Erupts for 144 Yards, Touchdown in Monday Night Win
Jrue Holiday

Unlikely to Play Tuesday
CeeDee Lamb

George Pickens Benched for First Drive
LeBron James

Officially Listed as Questionable for Tuesday
Jose Altuve

Undergoes Foot Surgery
Giannis Antetokounmpo

Exits Monday's Game With Groin Injury
Julian Strawther

Out on Monday
Cameron Johnson

Cleared for Action Monday
Nikola Jokić

Nikola Jokic Available Against Bulls
Zaccharie Risacher

Considered Questionable for Tuesday's Game
Onyeka Okongwu

Iffy for Tuesday
Kristaps Porzingis

May Miss Another Game Tuesday
Jalen Suggs

Listed as Questionable for Tuesday
Paolo Banchero

to Remain Out Tuesday
Ayo Dosunmu

Playing on Minutes Restriction Monday
Tre Jones

Still Out Monday
Saddiq Bey

Won't Play Against OKC
Alex Singleton

Broncos Optimistic Patrick Surtain, Alex Singleton Will Return After the Bye
Trey Hendrickson

Doubtful Again in Week 12
Shedeur Sanders

Expected to Make First Career Start in Week 12
Josh Jacobs

Dealing With Knee Contusion
Mikael Granlund

Unavailable Monday
Alex Bregman

Red Sox Going for Either Alex Bregman or Pete Alonso?
Conor Garland

Misses Monday's Game
Eetu Luostarinen

Out on Monday
Drake London

Considered "Week-to-Week"
Drew Doughty

Listed as Week-to-Week
Ja'Marr Chase

Being Suspended for One Game for Unsportsmanlike Conduct
John Carlson

a Game-Time Call Monday
Viktor Arvidsson

Out Week-to-Week
Charlie McAvoy

Out Against Hurricanes
CFB

James Franklin to be Virginia Tech's Next Head Coach
Brandon Aiyuk

49ers Won't Open Brandon Aiyuk's Practice Window This Week
Joe Burrow

Could Do 11-on-11 Work This Week in Practice
CFB

Fernando Mendoza the Clear Heisman Trophy Favorite?
CFB

Beau Pribula Has Chance to Face Oklahoma on Saturday
Mitchell Marner

Establishes Vegas Record Sunday
Mats Zuccarello

Logs Two Assists in Overtime Victory
Lucas Raymond

Leads Red Wings to Victory at MSG
Quinn Hughes

Delivers Four Assists in Sunday's Win
Conor Garland

Limited to Handful of Minutes Sunday
Ryan Hartman

Suffers Lower-Body Injury
Adrian Kempe

Agrees to $85 Million Extension With Kings
Jack Della Maddalena

Gets Dominated
Islam Makhachev

Claims UFC Welterweight Belt
Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
Scott Mayfield

Available Sunday
NYI

Max Shabanov Returns From 12-Game Absence Sunday
Samuel Honzek

Out Week-to-Week
Kirby Dach

Sidelined for 4-6 Weeks
Thatcher Demko

Considered Week-to-Week
Filip Hronek

Good to Go Sunday
Quinn Hughes

Back in Action Sunday
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
Justin Thomas

Will Miss Start Of 2026 After Undergoing Back Surgery
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Michael Morales

Looks To Remain Undefeated
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Carlos Prates

A Favorite At UFC 322
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again
Raisel Iglesias

Dodgers Interested in Signing Raisel Iglesias
Pete Alonso

Orioles Could be in the Mix to Sign Pete Alonso
Félix Bautista

Felix Bautista Could Return in Second Half in 2026
Kodai Senga

Attracting Trade Interest, Will the Mets Move him?
Yordan Alvarez

Expected to be Ready for Spring Training
Byron Buxton

Could Waive his No-Trade Clause
Paul Skenes

the Unanimous NL Cy Young Winner
Tarik Skubal

Wins AL Cy Young for Second Straight Year

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