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PrizePicks MLB DFS Picks for Fantasy Baseball - Wednesday September 21st

Lance McCullers - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

Kipp's MLB DFS prop picks for PrizePicks daily fantasy baseball on Wednesday, September 21st. Use his MLB prop picks recommendations to win money on PrizePicks.

Hello everybody and welcome! The 2022 MLB season is heading towards the home stretch and we here at RotoBaller have you covered with some terrific plays from our friends over at PrizePicks.

PrizePicks is a great DFS fantasy picks site where you can choose to select plays in terms of fantasy points or single stats. The goal is to build a 2-player, 3-player, 4-player, or 5-player entry and then select whether or not you want to play for the power play or the flex play. On the power play, you will need to be correct on each of your selections to win, and on the flex play, you will have a little more wiggle room for a chance to win some money back.

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PrizePicks has two types of games. The first type of game is known as Fantasy Score, which consists of selecting various players and trying to determine if they will go over or under their projected fantasy points in a game. The second game is known as Single Stat. For MLB, Single Stat consists of pitcher strikeout props in which you determine if the pitcher in question will go over or under their projected strikeout total. You can mix and match players from each type of game in your entry or select all of your plays from the same type of game. Once you have selected your players and props, you can choose the aforementioned flex play or power play option. Let's see what the board offers today!

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MLB DFS Picks for 9/21/22

Daniel Lynch more than 4.5 strikeouts- Lynch is not the first guy I thought I would be writing up today, but the matchup is ripe. He will be facing the Twins, who have posted a 29.7% K rate vs. southpaws over the previous two weeks, which is ranked fourth-worst in the league. Lynch is also fresh off an eight-strikeout performance against these Twins in his most recent start

Robbie Ray more than 6.5 strikeouts - Ray has a solid matchup in this one against the Athletics, who have posted a K rate of 31% vs. lefties over the previous two weeks, which is ranked second-worst in baseball over that span. They have also posted just a 4.8% walk rate and an 81 wRC+ mark over that same span, so Ray should be able to stay out of trouble in this one. He has faced Oakland three times this season and has eclipsed this total in two of those three starts.

Lance McCullers Jr. more than 5.0 strikeouts - McCullers has looked sharp since his return from the IL and now has five or more strikeouts in all but one start in that timeframe. He will be facing the Rays, who have posted just a 20% K rate vs. righties over the previous two weeks, but have not faced many starters with the strikeout upside of McCullers over that span.

Other Recommendations - 

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REAL-TIME FANTASY NEWS

Eetu Luostarinen

Out Week-to-Week After Barbecue Accident
Curtis Lazar

to Miss at Least Three Games
Al Horford

Ruled Out For Wednesday Against Miami
Vladimir Tarasenko

Misses Third Consecutive Game
Mikael Granlund

Remains Out Wednesday
Jaden McDaniels

Out Wednesday
Charlie McAvoy

Out Indefinitely After Facial Surgery
Joel Embiid

Unavailable Wednesday Against Raptors
Stephen Curry

Sidelined on Wednesday
Joe Burrow

to Potentially Return in Week 12?
Aaron Rodgers

Out on Wednesday, Hopes to Practice Thursday
Jaylen Warren

Not Seen at Wednesday's Practice
Dak Prescott

Lands on Injury Report Ahead of Week 12 With Hip Injury
Rhamondre Stevenson

Targeting a Return in Week 12?
Isiah Pacheco

Returning to Practice on Wednesday
Brian Thomas Jr.

Jaguars "Optimistic" About Brian Thomas Jr.'s Week 12 Status
Josh Jacobs

Will Not Practice on Wednesday
Sahith Theegala

Looking to Continue Fall Run at RSM Classic
Jayden Daniels

Commanders Considering Shutting Down Jayden Daniels?
Stephan Jaeger

Looking to Bounce Back at RSM Classic
Tom Hoge

Looking to Regain Form at RSM Classic
Joe Highsmith

Searching for Turnaround at RSM Classic
Adam Hadwin

Looking to Build on T11 Finish in Bermuda
Austin Eckroat

Searching for Momentum at RSM Classic
Joel Dahmen

Trying to Find Form at the RSM Classic
Marvin Harrison Jr.

Ruled Out Again in Week 12
Drake London

Falcons Hoping That Drake London Will Return in Week 13
CFB

Garrett Nussmeier Doubtful to Play Against Western Kentucky
Michael Penix Jr.

Needs Reconstructive Surgery on Torn ACL
Jaxson Dart

Expected to Return to Practice on Wednesday
Shedeur Sanders

Will Start Against Raiders
Dalton Kincaid

Ruled Out Against Texans
Connor Bedard

Continues Tear With Hat Trick
Macklin Celebrini

Pots Hat Trick in Tuesday's Win
Jake Guentzel

Records Eighth Career Hat Trick
Sammy Blais

Injured Versus Blues
Alexander Romanov

Injured in Tuesday's Win
Ryan Hartman

Considered Week-to-Week
Michael Thorbjornsen

Hopes to End 2025 Campaign With Another Solid Finish
Saddiq Bey

Uncertain for Meeting With Nuggets
Sam Merrill

Iffy for Wednesday
Andrew Novak

Looks to End 2025 Season on High Note at RSM Classic
Dereck Lively II

Likely to Play Wednesday
Daniel Gafford

on Track to Return Wednesday
Jaden McDaniels

Uncertain for Wednesday
Jalen Smith

Expected to Play Wednesday
Tre Jones

Questionable for Wednesday
Coby White

Back in Bulls Lineup Wednesday
Harry Higgs

Teetering for PGA Tour Card in 2026
Kelly Oubre Jr.

Unavailable Wednesday
Darius Garland

Sits Out Wednesday's Game
PGA

Nico Echavarria has the Potential to Contend at the RSM Classic
Sam Stevens

Finishing Out Year in Georgia
Seamus Power

Playing Better at the Right Time
Beau Hossler

Roller Coaster Comes to Saint Simons Island
Quade Cummins

The Time is Now for Quade Cummins in Georgia
Austin Cook

Needs a Win at the RSM Classic
Cameron Champ

on the PGA Tour Card Bubble
Grayson Rodriguez

Shipped to Angels
Taylor Ward

Orioles Acquire Taylor Ward From Angels
Shota Imanaga

Accepts Cubs Qualifying Offer
Brandon Woodruff

Returning to Milwaukee in 2026
Denny McCarthy

Looking For Another Solid Finish at RSM Classic
Si Woo Kim

Looking To Use Current Momentum to Flip Script at RSM Classic
Zion Williamson

Considered Questionable for Wednesday
Bam Adebayo

Could Return to Action Wednesday
Mackenzie Hughes

a Good Bounce-Back Candidate at RSM Classic
Jalen Brunson

Questionable for Wednesday
Jerami Grant

Picks Up Late Questionable Tag
Kyle Anderson

Cleared for Action Against the Lakers
Harris English

Making 14th Start at This Week's RSM Classic
Jrue Holiday

Ruled Out Tuesday
Taylor Hendricks

Returning on Tuesday
Konnor Griffin

Could Compete for Starting Shortstop Job in 2026
Gleyber Torres

Accepts Tigers Qualifying Offer
Odell Beckham Jr.

Officially Reinstated by NFL Commissioner
Matt Murray

to Miss Six Weeks With Lower-Body Injury
Ilya Lyubushkin

Out on Tuesday
Jamie Benn

Makes Season Debut Tuesday
Evgenii Dadonov

on Track to Return Tuesday
Dougie Hamilton

a Game-Time Call Tuesday
Anthony Cirelli

Expected to Return Against Devils
Victor Hedman

Questionable for Tuesday
Auston Matthews

to Miss at Least Two More Games
C.J. Stroud

Expected to Return in Week 13 Against Colts
C.J. Stroud

to Miss Another Game
Joe Mixon

Uncertainty Remains Around Joe Mixon's Return Timeline
Jaylen Warren

Mike Tomlin Optimistic About Jaylen Warren's Availability for Week 12
C.J. Stroud

Not Expected to Play on Thursday Night
CFB

Sam Leavitt Set to Enter Transfer Portal?
Jose Altuve

Undergoes Foot Surgery
Mikael Granlund

Unavailable Monday
Alex Bregman

Red Sox Going for Either Alex Bregman or Pete Alonso?
Conor Garland

Misses Monday's Game
CFB

James Franklin to be Virginia Tech's Next Head Coach
CFB

Fernando Mendoza the Clear Heisman Trophy Favorite?
CFB

Beau Pribula Has Chance to Face Oklahoma on Saturday
Jack Della Maddalena

Gets Dominated
Islam Makhachev

Claims UFC Welterweight Belt
Zhang Weili

Gets Outclassed
Valentina Shevchenko

Wins Unanimous Decision At UFC 322
Sean Brady

Suffers First-Round TKO Loss
Michael Morales

Remains Unbeaten
Leon Edwards

Suffers Second-Round Knockout Loss
Leon Edwards

Carlos Prates Becomes The First Man To Knock Out Leon Edwards
Beneil Dariush

Suffers Brutal First-Round Knockout Loss
Beneil Dariush

Benoit Saint Denis Knocks Out Beneil Dariush In 16 Seconds
Josh Naylor

Mariners Finalizing Five-Year Contract
CFB

Jeremiah Smith, Carnell Tate Not Dealing With Long-Term Injuries
CFB

Virginia Tech Close To Naming James Franklin As Head Coach
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Michael Morales

Looks To Remain Undefeated
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Carlos Prates

A Favorite At UFC 322
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again
Raisel Iglesias

Dodgers Interested in Signing Raisel Iglesias
Pete Alonso

Orioles Could be in the Mix to Sign Pete Alonso

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