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Kipp Heisterman presents his expert NFL DFS prop picks for Week 6 of the Fantasy Football season. Use these prop picks to win money on Monkey Knife Fight, our partner for all DFS prop picks games.
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As always, there are a few games we can look to target this week including the Texans at Chiefs, Falcons at Cardinals, and Seahawks at Browns.
Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
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Texans @ Chiefs
Over/Under Contest
Recommended Prop Pick: Two of two: Patrick Mahomes over 329.5 passing yards and Deshawn Watson over 298.5 passing yards.
This game is going to be a shootout in Kansas City. The total is 55, which is the highest on the board and both have very capable offenses going up against subpar defenses. The Texans have allowed 1,463 passing yards to quarterbacks through the first five games, which ranks third-worst in the league on a total yards basis. Only the Dolphins and Lions rank worse on a yards per game basis.
Add in the fact that Mahomes has thrown for over 300 yards in every game this season while averaging 366.2 yards per game and you have a solid play on the over. The Chiefs' pass defense isn't great, either. They are currently allowing 251.4 passing yards per game to the quarterback position and have yet to face a quarterback or offense as talented as Watson and the Texans.
Watson is currently averaging 272.8 passing yards per game and has superb weapons in DeAndre Hopkins and Will Fuller. The Texans are four-point underdogs in this game and may find themselves in comeback mode at several points throughout the game. If this ends up being the case, Watson should have no problem eclipsing the 300-yard mark. 
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Falcons @ Cardinals
Fantasy Challenge Contest
Recommended Prop Pick: Julio Jones, Larry Fitzgerald, and Austin Hooper over 55.5 fantasy points.
For our second contest selection, we go to Arizona where we find the second-highest total on the board of 51.5. Both of these defenses are flat-out awful. Atlanta is currently allowing 31.3 fantasy points per game to wide receivers, which is dead-last in the league. They have allowed 69 receptions for 985 yards and a whopping 10 touchdowns.
Fitzgerald has quickly become Kyler Murray's favorite target as well. He is currently averaging 8.8 targets per game, which he has turned into 71.6 receiving yards per game and two touchdowns. This is the perfect matchup for him and I expect a huge game. The Cardinals are currently giving up over 22 fantasy points per game to the wide receiver position and have allowed six receiving touchdowns to wide receivers. Julio Jones should be able to exploit the Cardinals secondary without Patrick Peterson and help hit the total.
Lastly, the Cardinals are horrific against the tight end position. They have given up 461 receiving yards, six touchdowns, and an average of 16.4 fantasy points per game to tight ends. These all rank dead-last in the league. Austin Hooper is currently averaging nearly seven receptions per game to go along with 72.6 receiving yards per game. He has become a favorite target of Matt Ryan and should see plenty of looks in this game.
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Seahawks @ Browns
Touchdown Dance Contest
Recommended Prop Pick: Chris Carson, Odell Beckham Jr., and Nick Chubb over 1.5 touchdowns.
The total in this game is not as high as I would have expected at 46, but there is still plenty of opportunity for scoring. The Browns have struggled against the run this year, which was highlighted on Monday Night Football against the 49ers. They are currently giving up 112.2 yards per game to running backs, which means Chris Carson should have ample opportunities to break off a run into the endzone.
Carson has been given 49 carries over the last two weeks and certainly will be given the ball frequently in this game with the hopes of exploiting the Browns struggling run defense. The Seahawks, while a bit stronger vs. the run, have given up four rushing touchdowns on the season. Nick Chubb is currently averaging just under 100 rushing yards per game and has four rushing touchdowns on the season. He should be able to punch at least one more in vs. this Seattle defense.
Lastly, the Seahawks Defense has struggled vs. the pass this season, allowing 793 receiving yards and four touchdowns to the wide receiver position. Odell Beckham was largely uninvolved last week vs the 49ers, which leads me to believe he will be a focal point this week. Beckham rarely goes silent for extended periods, so I look for him to rebound in a big way at home this week.
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