NFL DFS Prop Picks for Monkey Knife Fight - Rams vs. 49ers Monday Night Football

Kipp Heisterman presents his expert NFL DFS prop picks for Week 10's Monday Night Football of the Fantasy Football season. Use these prop picks to win money on Monkey Knife Fight, our partner for all DFS prop picks games.

Welcome to Monday Night Football between the Los Angeles Rams and San Francisco 49ers! Tonight's game means our friends at Monkey Knife Fight are offering some fantastic props for us to play.

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As always, there are some solid props we can look to take advantage of in tonight's game, so let's get to the picks!

• 2025 fantasy football rankings
• Running back (RB) rankings
• Wide receiver (WR) rankings
• Quarterback (QB) rankings
• Tight end (TE) rankings
• Defense (D/ST) rankings
• Kicker (K) rankings
• FLEX rankings
• Dynasty rankings

Rams @ 49ers More or Less Contest

Recommended Prop Pick:

Matthew Stafford less than 280.5 passing yards and Jimmy Garoppolo more than 245.5 passing yards

This is a number Stafford is capable of hitting, but he may not have to, nor is the matchup right for a huge game. San Franciso has actually been solid against the pass this season as they have allowed an average of just 179 passing yards per game over the previous four weeks, which is ranked second-best in the league. They also have only allowed one quarterback to reach this total and none have reached it since Week 1 when Jared Goff threw for 338 passing yards. The Niners have also struggled against the run as they have allowed an average of 112 rushing yards per game to running backs across their previous three games, so the Rams will likely look to exploit that.

Jimmy G has hit this number and then some in his previous two games and has also thrown for more than this total in four of his seven games in 2021. The 49ers will likely be up against it as they are currently 4.5-point underdogs in this one and that is a big reason I like him to go for more than the total as he will likely be forced to throw more in order to stay in this game. The Rams have also struggled a bit against quarterbacks this season as all but two teams have eclipsed this total.

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Rams @ 49ers More or Less Contest

Recommended Prop Pick:

Darrell Henderson more than 17.5 fantasy points and George Kittle more than 14.5 fantasy points

This game sets up nicely for Darrell Henderson as the 49ers are allowing 112 rushing yards per game over the previous four weeks. Henderson has seen nearly 16 carries per game and is averaging 70 rushing yards per game over that span. . The Rams are 4.5-point favorites in this as well, which could lead to some extra carries for Henderson late in the game to salt away the clock. Add in the fact that the 49ers are also allowing over one rushing touchdown per game and you have the recipe for a nice play here.

George Kittle came back with a bang last week as he hauled in six of eight targets for 101 receiving yards and a touchdown. He should be a favorite target again this week as the Rams have allowed an average of six receptions and 54 receiving yards per game to tight ends over the previous four weeks. They have also allowed two receiving touchdowns to tight ends over that span.

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