TAP FOR 6 MONTHS OF PREMIUM FREE 💰
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

NFL DFS Lineup Picks for FanDuel, DraftKings - 49ers vs Cardinals MNF Showdown

George Kittle - Fantasy Football Rankings, NFL Injury News, Draft Targets

John's top NFL DFS lineup picks for FanDuel, DraftKings - 49ers vs Cardinals showdown slate on 11/21. His Monday Night Football daily fantasy football advice.

Happy Monday, RotoBallers! I hope your Week 11 has gone well. I had a great day yesterday, going 4-1 on bets while cashing in all the DFS slates that I played. I'll look to keep the train rolling tonight as we have a short turnaround into a three-game slate on Thanksgiving Thursday. Tonight, though, we'll take a look at an NFC West Showdown as the San Francisco 49ers (5-4) take on the Arizona Cardinals (4-6) in Mexico City. It'll be an interesting slate considering Kyler Murray is a game-time decision in this one, and while it seems like Colt McCoy will end up being the starter in this one, I'll do my best to update should Murray suit up for this one.

We have been pretty successful so far with these showdown slates and hopefully, that trend continues from last year into this year. Most of us started our fantasy journeys with football, so it's always nice when it comes around and it's always a shame for it to come to an end. Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. Let's make some coin this season gang, and let's get right to it. 

I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the 49ers vs Cardinals NFL DFS showdown slate on November 21st. These NFL DFS lineup picks can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel. If you have any questions, you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts at any time you'd like!

 

MVP/Captain Plays

Christian McCaffrey - RB, $17,100 (DK), $16,500 (FD)

Key Stats

  • 2022 Stats: 125 rushes, 563 rushing yards, 60 targets, 47 receptions, 395 rushing yards, seven touchdowns.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

I'll start off tonight's slate with Christian McCaffery. I'll make it clear that I'm not picking McCaffery with the thought that he's going to light it up on the ground tonight. While the 49ers are 8.5-point favorites, the game script could lead to a breakout spot for him on the ground, and I'd have to assume that he'll end up splitting carries with Elijah Mitchell. With that said, the 49ers do have a projected 41.47% DVOA to running backs in the passing game, so I project CMC to do the majority of his damage in the passing game.

Jimmy Garoppolo - QB, $14,400 (DK), $14,500 (FD)

Key Stats

  • 2022 Stats: 1,931 passing yards, 11 touchdowns, four interceptions.
  • 2022 Offensive Pass DVOA: 23.3% (7th), per Football Outsiders.
  • 2022 Opposing Defense Pass DVOA: 8.2% (19th), per Football Outsiders.

Throwing CMC the ball will be Jimmy Garoppolo. I've mentioned in previous articles that Garoppolo isn't the "ideal" fantasy quarterback. However, the 49ers do have a relative passing funnel tonight -- with a projected pass DVOA of 22.11% and a projected rush DVOA of -10.09%. My model projects Jimmy G to complete 72.24% of his pass attempts tonight for 273.44 yards and 1.99 touchdowns. He's cheaper than your typical QB on a showdown slate, and that's why I have him slated in here.

Other Captains/MVPs: George Kittle, DeAndre Hopkins, 49ers D/ST

 

Want more NFL DFS tools and content? Our NFL Premium package includes our DFS Cheat Sheets, Research Station, Lineup Optimizer, access to our Premium Slack Chatrooms where members can chat with our NFL analysts, and so much more. Check out this big win from RotoBaller's RealTalkRaph using our Premium tools - join in on the winning!

 

DFS Flex Plays

DeAndre Hopkins - WR, $10,400 (DK), $15,000 (FD)

Key Stats

  • 2022 Stats: 46 targets, 36 receptions, 396 receiving yards, two touchdowns.
  • Individual Matchup (vs Deommodore Lenoir): 17% targets per route, 79% catch rate, 0.29 fantasy points per route, per PFF.

On the other side of the field, we have DeAndre Hopkins. I mentioned at the top of the article that Kyler Murray is a game-time decision for this one. Fortunately, Hopkins is seemingly QB-proof. He's logged at least 13 targets in three of his first four games since returning from suspension and hauled in 10 of his 14 targets for 98 yards last Sunday while Colt McCoy was under center. Hopkins is a bit too pricy for me on FanDuel, but I love him in this spot on DraftKings.

George Kittle - TE, $7,000 (DK), $10,000 (FD)

Key Stats

  • 2022 Stats: 41 targets, 29 receptions, 340 receiving yards, two touchdowns.
  • Individual Matchup (vs Isaiah Simmons): 12% targets per route, 89% catch rate, 0.24 fantasy points per route, per PFF.

One player that I absolutely LOVE on both sites tonight is George Kittle. The Cardinals have a projected 41.57% DVOA against tight ends in this matchup, and Kittle has a strong matchup advantage against Isaiah Simmons, according to PFF. My model projects Kittle to grab 6.21 of his 6.95 targets tonight for 70.33 yards and a 59% chance of scoring a touchdown. He's certainly an option in the 1.5x spot and he'll be in most if not all of my lineups.

Other Flex Options: Colt McCoy, Deebo Samuel, Brandon Aiyuk, Rondale Moore

 

DFS Value Plays

San Francisco 49ers - D/ST, $5,000 (DK), $9,500 (FD)

Key Stats

  • 2022 Stats: 17.66 targets, 29 sacks, seven interceptions, three fumble recoveries, two defensive touchdowns.
  • Projected DVOA: -22.22%

If there's any indication by now I'm writing this up, I'll be heavy 49ers on this slate tonight. If you're making a 49ers "stack," you'll want to have the defense in there as well. The 49ers project to an 8.94% sack rate tonight and a projected -26.84% defensive rushing DVOA. With that said, I do like this play a lot more if it's Colt McCoy under center, with the Niners not allowing the Cardinals to lean on the run game while putting consistent pressure on McCoy. I favor them regardless of who plays quarterback for Arizona tonight, but I'll give them a definite boost if it's McCoy.

Kyle Juszczyk - RB, $600 (DK), $5,000 (FD)

Key Stats

  • 2022 Stats: Three rushes, 10 rushing yards, 15 targets, 11 receptions, 153 rushing yards, one touchdown.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

Last but not least, I'll finish things up with Kyle Juszczyk. Certainly a dart throw here, but he's just too cheap considering the upside he brings to the table. I mentioned when talking about CMC that the 49ers have a projected 41.47% passing DVOA when targeting running backs, and all we need is one reception that Juszczyk takes into the end zone for him to break the slate.

Other Value Plays: Elijah Mitchell, A.J. Green, Robbie Gould, Matt Prater

Enjoy your week and good luck everyone!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis

POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

REAL-TIME FANTASY NEWS

George Kittle

Expects to Return "Well Before November"
CFB

Alberto Mendoza Entering Transfer Portal
Mookie Betts

Plans to Retire at the End of his Current Contract
Tennessee Titans

Titans Set to Hire Robert Saleh as Next Head Coach
Josh Giddey

Could Return Tuesday
Zaccharie Risacher

Ruled Out for the Week
Kristaps Porzingis

to Sit Out at Least One More Week
Jalen Williams

to Be Re-Evaluated in Two Weeks
Tyler Herro

Out Indefinitely With Ribs Issue
Jimmy Butler III

Out for Season With ACL Tear
Ludvig Aberg

Making Season Debut at American Express
Ryan Gerard

Heads to PGA West With Momentum After Strong Week in Hawaii
Naz Reid

Holds Questionable Tag for Tuesday
Rudy Gobert

is Cleared for Tuesday's Game
Christian Braun

to Remain Out on Tuesday
Ron Holland II

is Available to Play on Monday
Joel Embiid

Slated to Suit Up Monday
Miami Dolphins

Dolphins Expected to Hire Jeff Hafley as Next Head Coach
Day'Ron Sharpe

Ruled Out on Monday
Jalen Green

to Return on Tuesday
Draymond Green

Ruled Out for Monday's Game
Egor Demin

Ruled Out on Monday
Ondrej Palat

Ready to Face Flames
Devin Booker

Active Against Nets
Chris Kreider

Returns From Two-Game Absence Monday
Corey Perry

Back With Kings
Paul George

Sidelined on Monday
Bobby Brink

Available Monday Night
William Nylander

Misses Second Straight Game Monday
Draymond Green

Downgraded to Questionable on Monday
Kiefer Sherwood

Sharks Pick Up Kiefer Sherwood From Canucks
Matthew Tkachuk

Set for Season Debut Monday
Sepp Straka

Eyes Repeat At The American Express
Si Woo Kim

Poised To Contend At The American Express
Zach Charbonnet

has Torn ACL
Zach Charbonnet

Needs Knee Surgery, Out for Rest of Playoffs
Tennessee Titans

Mike McCarthy a Finalist for Titans Head-Coaching Job?
Colston Loveland

Suffers Concussion in Divisional Round Loss
Kyren Williams

Scores Two Touchdowns in Divisional Round Win
Buffalo Bills

Bills Fire Head Coach Sean McDermott
De'Anthony Melton

Out for Front End of Back-to-Back
Tom Wilson

May Return Monday
Zaccharie Risacher

to Miss Another Game vs. Bucks
Henri Jokiharju

Moved to Non-Roster List
Daniel Gafford

Remains Out Monday Against New York
Frank Nazar

Returns to Practice
Oskar Sundqvist

Suffers Skate Cut Sunday
Kasperi Kapanen

Considered Day-to-Day
Zach Whitecloud

Joins Flames
Rasmus Andersson

Moves to Vegas
Carson Soucy

Expected Back on Monday
Teuvo Teravainen

to Remain Out Monday
Matthew Tkachuk

"Close" to Season Debut
Rodrigo Abols

Flyers Place Rodrigo Abols on Injured Reserve
Alex Lyon

Practices on Sunday
Rhamondre Stevenson

Returns in Sunday's AFC Divisional Round Game
Josh Norris

Out Week-to-Week
Dylan Holloway

Set to Return Sunday
Ha-Seong Kim

has Finger Surgery, Out 4-5 Months
Rhamondre Stevenson

Questionable to Return on Sunday With Eye Injury
Woody Marks

Returns Following Brief Exit on Sunday
Dalton Schultz

Won't Return in Sunday's AFC Divisional Round Game
Aaron Rodgers

Steelers Open to Aaron Rodgers Returning in 2026?
Jarrett Stidham

to Start AFC Championship Game
Zach Charbonnet

Questionable to Return Against 49ers
Atlanta Falcons

Falcons Hiring Kevin Stefanski as Head Coach
Bo Nix

Suffers Broken Bone in Ankle, Done for Playoffs
Green Bay Packers

Packers Sign Head Coach Matt LaFleur to Multi-Year Extension
Ricky Pearsall

Active for Divisional Round
Sam Darnold

Officially Active for Saturday's Divisional Round Game vs. 49ers
CFB

Darian Mensah Entering Transfer Portal
J.T. Realmuto

Signs Three-Year Deal to Return to Phillies
Bo Bichette

Agrees to Three-Year Contract With Mets
CFB

Weber State Signs former Ohio State, Cal Quarterback Devin Brown
Bo Bichette

Phillies the "Overwhelming" Favorite to Sign Bo Bichette
Josh Lowe

Angels Acquire Josh Lowe in Three-Team Trade
Kyle Tucker

Signs Four-Year Contract With Dodgers
Clayton Kershaw

to Pitch for Team USA in World Baseball Classic
CFB

Auburn, Ohio State the Lead Suitors for Kyle Parker
CFB

Oregon QB Transfer Bryson Beaver Linked to Georgia, Kentucky
CFB

Jake Merklinger Commits to UConn
Ben Griffin

Looks To Stay Hot In 2026
Ranger Suárez

Ranger Suarez Agrees to Five-Year Deal With Red Sox
CFB

Dante Moore Not Entering 2026 NFL Draft, Will Return to Oregon