🖥 CYBER WEEK - TAP TO SAVE 50% WITH CODE CYBER
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

NFL DFS Lineup Picks for FanDuel, DraftKings - 49ers vs Cardinals MNF Showdown

George Kittle - Fantasy Football Rankings, NFL Injury News, Draft Targets

John's top NFL DFS lineup picks for FanDuel, DraftKings - 49ers vs Cardinals showdown slate on 11/21. His Monday Night Football daily fantasy football advice.

Happy Monday, RotoBallers! I hope your Week 11 has gone well. I had a great day yesterday, going 4-1 on bets while cashing in all the DFS slates that I played. I'll look to keep the train rolling tonight as we have a short turnaround into a three-game slate on Thanksgiving Thursday. Tonight, though, we'll take a look at an NFC West Showdown as the San Francisco 49ers (5-4) take on the Arizona Cardinals (4-6) in Mexico City. It'll be an interesting slate considering Kyler Murray is a game-time decision in this one, and while it seems like Colt McCoy will end up being the starter in this one, I'll do my best to update should Murray suit up for this one.

We have been pretty successful so far with these showdown slates and hopefully, that trend continues from last year into this year. Most of us started our fantasy journeys with football, so it's always nice when it comes around and it's always a shame for it to come to an end. Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. Let's make some coin this season gang, and let's get right to it. 

I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the 49ers vs Cardinals NFL DFS showdown slate on November 21st. These NFL DFS lineup picks can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel. If you have any questions, you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts at any time you'd like!

Cyber Week Special! Save 50% on any Premium Pass using discount code CYBER. Win more with our DFS, Betting and Season-Long Premium Pass, get expert tools and advice for NBA, NFL, MLB, NHL from proven winners! Dan Palyo leads the team with exclusive picks for DFS picks, Props, betting. Enhance your game with industry-leading tools like our Lineup Optimizers, Team Sync Platform, DFS Cheat Sheets and more. GAIN ACCESS

 

MVP/Captain Plays

Christian McCaffrey - RB, $17,100 (DK), $16,500 (FD)

Key Stats

  • 2022 Stats: 125 rushes, 563 rushing yards, 60 targets, 47 receptions, 395 rushing yards, seven touchdowns.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

I'll start off tonight's slate with Christian McCaffery. I'll make it clear that I'm not picking McCaffery with the thought that he's going to light it up on the ground tonight. While the 49ers are 8.5-point favorites, the game script could lead to a breakout spot for him on the ground, and I'd have to assume that he'll end up splitting carries with Elijah Mitchell. With that said, the 49ers do have a projected 41.47% DVOA to running backs in the passing game, so I project CMC to do the majority of his damage in the passing game.

Jimmy Garoppolo - QB, $14,400 (DK), $14,500 (FD)

Key Stats

  • 2022 Stats: 1,931 passing yards, 11 touchdowns, four interceptions.
  • 2022 Offensive Pass DVOA: 23.3% (7th), per Football Outsiders.
  • 2022 Opposing Defense Pass DVOA: 8.2% (19th), per Football Outsiders.

Throwing CMC the ball will be Jimmy Garoppolo. I've mentioned in previous articles that Garoppolo isn't the "ideal" fantasy quarterback. However, the 49ers do have a relative passing funnel tonight -- with a projected pass DVOA of 22.11% and a projected rush DVOA of -10.09%. My model projects Jimmy G to complete 72.24% of his pass attempts tonight for 273.44 yards and 1.99 touchdowns. He's cheaper than your typical QB on a showdown slate, and that's why I have him slated in here.

Other Captains/MVPs: George Kittle, DeAndre Hopkins, 49ers D/ST

 

Want more NFL DFS tools and content? Our NFL Premium package includes our DFS Cheat Sheets, Research Station, Lineup Optimizer, access to our Premium Slack Chatrooms where members can chat with our NFL analysts, and so much more. Check out this big win from RotoBaller's RealTalkRaph using our Premium tools - join in on the winning!

 

DFS Flex Plays

DeAndre Hopkins - WR, $10,400 (DK), $15,000 (FD)

Key Stats

  • 2022 Stats: 46 targets, 36 receptions, 396 receiving yards, two touchdowns.
  • Individual Matchup (vs Deommodore Lenoir): 17% targets per route, 79% catch rate, 0.29 fantasy points per route, per PFF.

On the other side of the field, we have DeAndre Hopkins. I mentioned at the top of the article that Kyler Murray is a game-time decision for this one. Fortunately, Hopkins is seemingly QB-proof. He's logged at least 13 targets in three of his first four games since returning from suspension and hauled in 10 of his 14 targets for 98 yards last Sunday while Colt McCoy was under center. Hopkins is a bit too pricy for me on FanDuel, but I love him in this spot on DraftKings.

George Kittle - TE, $7,000 (DK), $10,000 (FD)

Key Stats

  • 2022 Stats: 41 targets, 29 receptions, 340 receiving yards, two touchdowns.
  • Individual Matchup (vs Isaiah Simmons): 12% targets per route, 89% catch rate, 0.24 fantasy points per route, per PFF.

One player that I absolutely LOVE on both sites tonight is George Kittle. The Cardinals have a projected 41.57% DVOA against tight ends in this matchup, and Kittle has a strong matchup advantage against Isaiah Simmons, according to PFF. My model projects Kittle to grab 6.21 of his 6.95 targets tonight for 70.33 yards and a 59% chance of scoring a touchdown. He's certainly an option in the 1.5x spot and he'll be in most if not all of my lineups.

Other Flex Options: Colt McCoy, Deebo Samuel, Brandon Aiyuk, Rondale Moore

 

DFS Value Plays

San Francisco 49ers - D/ST, $5,000 (DK), $9,500 (FD)

Key Stats

  • 2022 Stats: 17.66 targets, 29 sacks, seven interceptions, three fumble recoveries, two defensive touchdowns.
  • Projected DVOA: -22.22%

If there's any indication by now I'm writing this up, I'll be heavy 49ers on this slate tonight. If you're making a 49ers "stack," you'll want to have the defense in there as well. The 49ers project to an 8.94% sack rate tonight and a projected -26.84% defensive rushing DVOA. With that said, I do like this play a lot more if it's Colt McCoy under center, with the Niners not allowing the Cardinals to lean on the run game while putting consistent pressure on McCoy. I favor them regardless of who plays quarterback for Arizona tonight, but I'll give them a definite boost if it's McCoy.

Kyle Juszczyk - RB, $600 (DK), $5,000 (FD)

Key Stats

  • 2022 Stats: Three rushes, 10 rushing yards, 15 targets, 11 receptions, 153 rushing yards, one touchdown.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

Last but not least, I'll finish things up with Kyle Juszczyk. Certainly a dart throw here, but he's just too cheap considering the upside he brings to the table. I mentioned when talking about CMC that the 49ers have a projected 41.47% passing DVOA when targeting running backs, and all we need is one reception that Juszczyk takes into the end zone for him to break the slate.

Other Value Plays: Elijah Mitchell, A.J. Green, Robbie Gould, Matt Prater

Enjoy your week and good luck everyone!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis

POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

REAL-TIME FANTASY NEWS

Marcus Smart

The Fantasy Basketball Cut List - Who to Drop or Hold After Week 6
NHL

NHL DFS Picks and Heat Map (Premium Content) - December 4, 2025
Nazem Kadri

NHL DFS Lineup Picks for DraftKings: Goalies, Value Plays, Stacks, and Power Plays Picks (12/4/25)
Kevin Huerter

Sidelined One Week
Daniel Gafford

Aggravates Right-Ankle Injury on Wednesday
Collin Sexton

Injured in Loss to Knicks
Giannis Antetokounmpo

Suffers Calf Injury on Wednesday Night
Kyren Williams

Expected to Play in Week 14
Davante Adams

Expected to Play Despite Missing Wednesday's Practice
Kyle Tucker

Visits With Blue Jays
Woody Marks

Texans Say Woody Marks Will be Fine
Rasmus Ristolainen

to Miss at Least One More Week
Drew Doughty

Logs Full Practice Wednesday
Emilio Pagán

Reds Bring Back Closer Emilio Pagan on Two-Year Deal
Jeff Skinner

Remains Sidelined Wednesday
Petr Mrazek

Out 2-3 Weeks
Pelle Larsson

Set to Suit Up Versus Dallas
Tyler Seguin

Likely Done for the Season
P.J. Washington

Ruled Out Against Miami
Neal Pionk

Returns to Jets Lineup
Jalen Smith

to Miss Third Straight Game
Duncan Robinson

Sidelined Again Wednesday
J.J. McCarthy

Practices in Full, on Track to Return in Week 14
Daniel Gafford

Set To Play Against Heat
Tre Jones

Ruled Out for Wednesday's Game
LaMelo Ball

Good to Go on Wednesday
Cedric Mullins

Rays Agree on One-Year Deal
Steven Adams

Cleared To Play Against Kings
Deni Avdija

is Available to Play on Wednesday
Kevin Porter Jr.

Available on Wednesday
Bobby Portis

Available to Play on Wednesday
Lonzo Ball

Upgraded To Available Against Portland
Giannis Antetokounmpo

Cleared for Wednesday's Game
Jamal Murray

Cleared To Play Against Indiana
Nikola Jokić

Nikola Jokic Available on Wednesday Night
Luka Dončić

Luka Doncic Ruled Out on Thursday Due to a Personal Matter
Mark Andrews

Agrees to Three-Year Extension With Ravens
Freddy Peralta

Brewers Considering Trading Freddy Peralta
Kyle Schwarber

Reds Serious About Adding Kyle Schwarber in Free Agency?
Amon-Ra St. Brown

Officially Questionable for Thursday Night
Omarion Hampton

"on Track and Looking Good" for Week 14
CFB

Brent Key Signing Five-Year Deal to Remain at Georgia Tech
Joey Bosa

Week-to-Week With Hamstring Injury
Bryce Young

Panthers Expected to Pick Up Bryce Young's Fifth-Year Option
Deshaun Watson

Browns Opening Practice Window for Deshaun Watson
CFB

Brian Hartline Expected to Land USF Head-Coaching Job
CFB

Collin Klein Expected to be Top Target for Kansas State if Head-Coach Job Opens
CFB

Chris Klieman Considering Stepping Down at Kansas State
Aaron Rodgers

Appears to be Healthier Heading into Week 14
Jalen McMillan

Expected to Have his 21-day Practice Window Opened
Mike Evans

' Practice Window Opened, Returning to Practice on Wednesday
Alexander Wennberg

a Game-Time Call Wednesday
Michael Callahan

Sustains Lower-Body Injury Tuesday
Michael Rasmussen

Makes Early Exit Tuesday
Scott Wedgewood

Exits Early With Back Problem
Evander Kane

Expected to Be Fine After Skate Cut
Tyler Seguin

Injured Versus Rangers
Sean Monahan

Expected to Play Thursday
NHL

NHL DFS Picks and Heat Map (Premium Content) - December 3, 2025
Nathan Walker

Out for Eight Weeks
Lian Bichsel

to Sit Out 6-8 Weeks
Viktor Arvidsson

Activated From Injured Reserve
Warren Foegele

Remains Out Tuesday
Valeri Nichushkin

Available After Eight-Game Absence
CFB

D.J. Durkin Staying at Auburn Under Alex Golesh
CFB

Charlie Weis Jr. Permitted to Coach Ole Miss Offense in College Football Playoff
Tyrone Tracy Jr.

Says he's Fine After Suffering Hip Contusion
Omarion Hampton

Likely to Return in Week 14
CFB

Five-Star Quarterback Jared Curtis Flips Commitment From Georgia to Vanderbilt
CFB

Florida Hiring Brad White as Defensive Coordinator
Kyle Schwarber

Giants Have Checked in on Kyle Schwarber
Willson Contreras

Willing to Waive his Full No-Trade Clause?
Brandon Aiyuk

49ers "Hopeful" Brandon Aiyuk Will Play in 2025
Tyrone Tracy Jr.

Carted Off With Hip Injury on Monday Night
Edwin Díaz

Mets Still Interested in Re-Signing Edwin Diaz
Devin Williams

Agrees to Three-Year Deal With Mets
Cole Ragans

Red Sox Targeting Cole Ragans in a Trade?
CFB

Kentucky Hires Oregon Offensive Coordinator Will Stein As Head Coach
Davante Adams

Not Dealing With a Serious Injury
Kyler Murray

Surgery Not on the Table for Kyler Murray
Marvin Harrison Jr.

in Danger of Missing Week 14?
CFB

Kalani Sitake the Top Target for Penn State Coaching Job
Justin Herbert

Having Hand Surgery on Monday
CFB

Josh Heupel Says He's Not a Candidate for Penn State Head Coach Job
CFB

Will Stein, Brian Hartline the Top Candidates for Kentucky Job?
CFB

Nebraska Fires Defensive Coordinator John Butler After One Season
CFB

UCLA Expected to Hire Bob Chesney as Next Head Coach
CFB

Lane Kiffin to Make $13 Million Salary, Ties Kirby Smart
CFB

Buster Faulkner, Joey Halzle Candidates for Florida Offensive Coordinator Job?
CFB

Kentucky Officially Fires Mark Stoops
CFB

Lane Kiffin to be Introduced as LSU's Next Head Coach on Monday
CFB

Florida Poised to Land Jon Sumrall as Next Head Coach
CFB

Alex Golesh Taking Over Auburn Head-Coaching Job
CFB

Arkansas Expected to Hire Ryan Silverfield as Next Head Coach
Zack Wheeler

Likely to Return in May
Ryan Helsley

Agrees to Two-Year Deal With Orioles