TAP FOR 6 MONTHS OF PREMIUM FREE 💰
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

NFL DFS Lineup Picks for FanDuel, DraftKings - 49ers vs Cardinals MNF Showdown

George Kittle - Fantasy Football Rankings, NFL Injury News, Draft Targets

John's top NFL DFS lineup picks for FanDuel, DraftKings - 49ers vs Cardinals showdown slate on 11/21. His Monday Night Football daily fantasy football advice.

Happy Monday, RotoBallers! I hope your Week 11 has gone well. I had a great day yesterday, going 4-1 on bets while cashing in all the DFS slates that I played. I'll look to keep the train rolling tonight as we have a short turnaround into a three-game slate on Thanksgiving Thursday. Tonight, though, we'll take a look at an NFC West Showdown as the San Francisco 49ers (5-4) take on the Arizona Cardinals (4-6) in Mexico City. It'll be an interesting slate considering Kyler Murray is a game-time decision in this one, and while it seems like Colt McCoy will end up being the starter in this one, I'll do my best to update should Murray suit up for this one.

We have been pretty successful so far with these showdown slates and hopefully, that trend continues from last year into this year. Most of us started our fantasy journeys with football, so it's always nice when it comes around and it's always a shame for it to come to an end. Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. Let's make some coin this season gang, and let's get right to it. 

I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the 49ers vs Cardinals NFL DFS showdown slate on November 21st. These NFL DFS lineup picks can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel. If you have any questions, you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts at any time you'd like!

Featured Promo: Looking for some more fantasy football action? Adopt a dynasty orphan team over at FFPC. Sign up today and get $25 off any FFPC league. Sign Up Now!

 

MVP/Captain Plays

Christian McCaffrey - RB, $17,100 (DK), $16,500 (FD)

Key Stats

  • 2022 Stats: 125 rushes, 563 rushing yards, 60 targets, 47 receptions, 395 rushing yards, seven touchdowns.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

I'll start off tonight's slate with Christian McCaffery. I'll make it clear that I'm not picking McCaffery with the thought that he's going to light it up on the ground tonight. While the 49ers are 8.5-point favorites, the game script could lead to a breakout spot for him on the ground, and I'd have to assume that he'll end up splitting carries with Elijah Mitchell. With that said, the 49ers do have a projected 41.47% DVOA to running backs in the passing game, so I project CMC to do the majority of his damage in the passing game.

Jimmy Garoppolo - QB, $14,400 (DK), $14,500 (FD)

Key Stats

  • 2022 Stats: 1,931 passing yards, 11 touchdowns, four interceptions.
  • 2022 Offensive Pass DVOA: 23.3% (7th), per Football Outsiders.
  • 2022 Opposing Defense Pass DVOA: 8.2% (19th), per Football Outsiders.

Throwing CMC the ball will be Jimmy Garoppolo. I've mentioned in previous articles that Garoppolo isn't the "ideal" fantasy quarterback. However, the 49ers do have a relative passing funnel tonight -- with a projected pass DVOA of 22.11% and a projected rush DVOA of -10.09%. My model projects Jimmy G to complete 72.24% of his pass attempts tonight for 273.44 yards and 1.99 touchdowns. He's cheaper than your typical QB on a showdown slate, and that's why I have him slated in here.

Other Captains/MVPs: George Kittle, DeAndre Hopkins, 49ers D/ST

 

Want more NFL DFS tools and content? Our NFL Premium package includes our DFS Cheat Sheets, Research Station, Lineup Optimizer, access to our Premium Slack Chatrooms where members can chat with our NFL analysts, and so much more. Check out this big win from RotoBaller's RealTalkRaph using our Premium tools - join in on the winning!

 

DFS Flex Plays

DeAndre Hopkins - WR, $10,400 (DK), $15,000 (FD)

Key Stats

  • 2022 Stats: 46 targets, 36 receptions, 396 receiving yards, two touchdowns.
  • Individual Matchup (vs Deommodore Lenoir): 17% targets per route, 79% catch rate, 0.29 fantasy points per route, per PFF.

On the other side of the field, we have DeAndre Hopkins. I mentioned at the top of the article that Kyler Murray is a game-time decision for this one. Fortunately, Hopkins is seemingly QB-proof. He's logged at least 13 targets in three of his first four games since returning from suspension and hauled in 10 of his 14 targets for 98 yards last Sunday while Colt McCoy was under center. Hopkins is a bit too pricy for me on FanDuel, but I love him in this spot on DraftKings.

George Kittle - TE, $7,000 (DK), $10,000 (FD)

Key Stats

  • 2022 Stats: 41 targets, 29 receptions, 340 receiving yards, two touchdowns.
  • Individual Matchup (vs Isaiah Simmons): 12% targets per route, 89% catch rate, 0.24 fantasy points per route, per PFF.

One player that I absolutely LOVE on both sites tonight is George Kittle. The Cardinals have a projected 41.57% DVOA against tight ends in this matchup, and Kittle has a strong matchup advantage against Isaiah Simmons, according to PFF. My model projects Kittle to grab 6.21 of his 6.95 targets tonight for 70.33 yards and a 59% chance of scoring a touchdown. He's certainly an option in the 1.5x spot and he'll be in most if not all of my lineups.

Other Flex Options: Colt McCoy, Deebo Samuel, Brandon Aiyuk, Rondale Moore

 

DFS Value Plays

San Francisco 49ers - D/ST, $5,000 (DK), $9,500 (FD)

Key Stats

  • 2022 Stats: 17.66 targets, 29 sacks, seven interceptions, three fumble recoveries, two defensive touchdowns.
  • Projected DVOA: -22.22%

If there's any indication by now I'm writing this up, I'll be heavy 49ers on this slate tonight. If you're making a 49ers "stack," you'll want to have the defense in there as well. The 49ers project to an 8.94% sack rate tonight and a projected -26.84% defensive rushing DVOA. With that said, I do like this play a lot more if it's Colt McCoy under center, with the Niners not allowing the Cardinals to lean on the run game while putting consistent pressure on McCoy. I favor them regardless of who plays quarterback for Arizona tonight, but I'll give them a definite boost if it's McCoy.

Kyle Juszczyk - RB, $600 (DK), $5,000 (FD)

Key Stats

  • 2022 Stats: Three rushes, 10 rushing yards, 15 targets, 11 receptions, 153 rushing yards, one touchdown.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

Last but not least, I'll finish things up with Kyle Juszczyk. Certainly a dart throw here, but he's just too cheap considering the upside he brings to the table. I mentioned when talking about CMC that the 49ers have a projected 41.47% passing DVOA when targeting running backs, and all we need is one reception that Juszczyk takes into the end zone for him to break the slate.

Other Value Plays: Elijah Mitchell, A.J. Green, Robbie Gould, Matt Prater

Enjoy your week and good luck everyone!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis

POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

RANKINGS

QB
RB
WR
TE
K
DEF

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

Mac Jones

' Price on Trade Market Described as "Astronomical"
Daniel Jones

Colts, Daniel Jones Making Progress on Long-Term Deal
Romeo Doubs

Patriots Signing Former Packers Wideout Romeo Doubs
Geno Smith

Jets Trade for Geno Smith
Jaylen Warren

Likely to be in Third-Down, Change-of-Pace Role in 2026
Geno Smith

to Reunite With the Jets?
Alec Pierce

Projected for "8-10" Targets Per Game
Zane Gonzalez

Agrees to One-Year Deal With Dolphins
Ka'imi Fairbairn

Texans Sign Ka'imi Fairbairn to Two-Year Deal
Isiah Pacheco

Lions Signing Isiah Pacheco on Tuesday
Kalif Raymond

Heading to Bears on One-Year Deal
Rachaad White

a Fallback Option for Seahawks?
Kyle Stowers

to Make Grapefruit League Debut on Saturday
Dawson Knox

Bills, Dawson Knox Agree to New Three-Year Contract
Hunter Greene

to be Sidelined Through July
Michael Pittman Jr.

a Good Fit With Steelers?
Nate Hobbs

Packers Release Nate Hobbs
New York Giants

Giants Expected to Sign Greg Newsome to a One-Year Deal
Tyler Bass

Bills Revise Tyler Bass' Contract
Chuba Hubbard

a Fantasy Winner to Start Free Agency
RJ Harvey

Stuck in a Timeshare in Year 2?
Kyle Anderson

May Miss Second Straight Game
Jordan Goodwin

Nearing Return From Calf Injury
Bhayshul Tuten

a Day 1 Free-Agency Winner
James Reimer

Posts Shutout With Seventh Franchise
Jalen Smith

Likely Available Tuesday Against Golden State
Devin Lloyd

Signing With Panthers on Three-Year Deal
Tim Stützle

Tim Stutzle Stretches Point Streak to 13 Games
T.J. McConnell

Sidelined Tuesday Against Kings
Justin Sourdif

Amasses Three Points In Monday's Win
Jarace Walker

Likely to Play Tuesday Against Kings
Connor Bedard

Sets Up Two Goals in Overtime Win
Ivica Zubac

Still Sidelined as Pacers Face Kings
Erik Gudbranson

to Miss Three-Game Road Trip
Kel'el Ware

in Danger of Missing Tuesday's Game
Evander Kane

Dealing With Upper-Body Injury
Max Greyserman

Gradually Improving Each Week in Florida
Oliver Moore

Expected to Miss "Significant Time"
PGA

The Nico Echavarria Roller Coaster Heads to The Players Championship
Andrew Wiggins

Misses Third Straight Game
Ludvig Aberg

a Threat to Contend at The Players Championship
Norman Powell

Remains Out Tuesday
Collin Sexton

Considered Questionable Tuesday
Matas Buzelis

Expected to Play Tuesday
Josh Giddey

Probable Tuesday
Coby White

Sits Out First Game of Back-to-Back
Andrew Nembhard

Doubtful Tuesday
Pascal Siakam

Won't Suit Up Tuesday
Anton Forsberg

Escapes With Overtime Victory
Artemi Panarin

Collects Two Points Against Former Team
Adrian Kempe

Scores Two Goals in Victory
Igor Shesterkin

Stifles the Flyers on Monday
Mika Zibanejad

Scores Twice Versus Philadelphia
Harris English

Hopes to Find Any Sort of Success at TPC Sawgrass
Pierceson Coody

Looks to Get Back on Track in First Players Appearance
Daniel Berger

Presses On at The Players Championship
Min Woo Lee

an Intriguing Option at the Players
Sahith Theegala

Looks to Continue Strong Form at the Players
Jonathan Kuminga

in Danger of Missing Third Consecutive Game
John Collins

Won't Play This Week
Quinten Post

Starting Monday Night
DeMar DeRozan

Overcomes Illness, Available Tuesday
LeBron James

Listed as Questionable for Tuesday
Payton Pritchard

Iffy to Face Spurs Tuesday
Jason Day

Needs to Find Form Again at Players Championship
Patrick Cantlay

Hasn't Found Consistency This Season
Jesús Luzardo

Jesus Luzardo, Phillies Agree on Five-Year Extension
Corbin Carroll

Could Make Spring Debut This Week
James Reimer

Starting Monday Night
Joel Hanley

Returns to Action Against Capitals
Evander Kane

Brock Boeser, Evander Kane Iffy Monday
Spencer Knight

Out Against Mammoth
Jaden Schwartz

Out Indefinitely
Brad Marchand

to Miss "Weeks"
Jake Sanderson

Considered Week-to-Week
Max Holloway

Drops Decision At UFC 326
Charles Oliveira

Becomes The New BMF Champion
Caio Borralho

Bounces Back
Reinier de Ridder

Reinier De Ridder Loses Back-To-Back Fights
Rob Font

Gets Dominated
Raul Rosas Jr.

Extends His Win Streak
Michael Johnson

Suffers Second-Round Knockout Loss
Drew Dober

Knocks Out Michael Johnson
Rafael Devers

Back in Cactus League Lineup on Monday
Ryan Blaney

Earns his Second Consecutive Phoenix Cup Series Win
Christopher Bell

Falls Short of Victory Despite Dominating at Phoenix
Kyle Larson

Earns Hard-Fought Finish of Third at Phoenix
Denny Hamlin

Quietly Gains Another Top-Five Finish at Phoenix
Joey Logano

Crashes out at Phoenix Despite Strong Run
Nick Seeler

Could Return Monday
Travis Konecny

a Game-Time Call Monday
Tarik Skubal

Could Make Another Start in World Baseball Classic
Jackson Chourio

Should Return to WBC Lineup on Monday
Byron Buxton

"Fine" After Being Hit by Pitch
Ryan Blaney

is Always A Top Favorite to Compete for the Win At Phoenix
Denny Hamlin

Is Denny Hamlin Worth Rostering for Phoenix?
Christopher Bell

is Likely to have Another Solid Phoenix Run
Chase Briscoe

has Plenty of Upside for DFS Lineups at Phoenix
Joey Logano

Could Dominate at Phoenix This Weekend
Chase Elliott

has Plenty of Upside for Sunday's Race at Phoenix
Chris Buescher

Is Chris Buescher Worth Rostering For Phoenix DFS Lineups?
Ross Chastain

Has Found Speed Again at Phoenix
Josh Berry

a Solid Sleeper at Phoenix
Brad Keselowski

Skips Qualifying After Practice Crash at Phoenix
Tyler Reddick

Spins in Practice at Phoenix
William Byron

Should Be a Contender at Phoenix
Kyle Larson

Is Always a Threat at Phoenix
NASCAR

Could Bubba Wallace Be Playable for Phoenix DFS Lineups?
Anthony Alfredo

Is A Favorable DFS Option In A Substitution Role At Phoenix
Brandon Woodruff

Making Cactus League Debut on Saturday
Byron Buxton

Leaves WBC Game After Being Hit by a Pitch on his Elbow
Jackson Chourio

"Fine" After Suffering Hand Contusion
Max Holloway

A Favorite At UFC 326
Charles Oliveira

Set For BMF Title Fight
Reinier de Ridder

Reinier De Ridder Looks To Bounce Back
Caio Borralho

Set For UFC 326 Co-Main Event
Rob Font

Looks To Get Back In The Win Column
Raul Rosas Jr.

Looks For His Fifth Consecutive Win
Drew Dober

Returns At UFC 326
Michael Johnson

Looks To Extend His Win Streak
Rafael Devers

Could Return to Game Action Next Week
Jeremy Peña

Jeremy Pena Hopes to be Ready for Opening Day
Jackson Chourio

Won't Play in WBC on Friday
Carlos Correa

Scratched With Neck Injury
Jeremy Peña

Jeremy Pena has Finger Fracture, to be Re-Evaluated in Two Weeks
Jeremy Peña

Jeremy Pena Suffers Small Fracture in his Finger