👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

MNF NFL DFS Lineup Picks for FanDuel, DraftKings - Rams vs 49ers Showdown

John's top NFL DFS lineup picks for FanDuel, and DraftKings for Monday Night Football - Rams vs 49ers showdown slate. His Week 10 MNF daily fantasy football advice.

Happy Monday, RotoBallers! I hope your Week 10 has been profitable so far. I personally had a great day in cash yesterday, cleaning the house on all four of the major slates. I hope to carry this momentum into tonight in what should be an exciting matchup as the Rams (7-2) try to bounce back from last week's performance as they head to San Francisco for another prime-time matchup against the 49ers (3-5). Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. Let's break it down. 

In this article I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the Monday Night Football slate on November 15th. These lineups can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel.

If you have any questions you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts any time you'd like. Let's make some coin this season gang, and let's get right to it!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

NFL DFS Captain Plays

Matthew Stafford ($16,200 DK, $17,000 FD)

Key Stats:

  • 2021 Stats: 2,771 passing yards, 23 touchdowns, six interceptions.
  • Offensive Pass DVOA: 44.8% (3rd)
  • Opposing Defense Pass DVOA: 19.1% (25th)

Luckily we get a slight discount on Stafford tonight, with Cooper Kupp being the highest-priced player on DraftKings. It's unfortunate that the Rams lost Robert Woods this week, but they made a solid addition in Odell Beckham Jr. I don't think OBJ makes a massive difference in this game tonight, but with the matchup being what it is I think it's tough to fade Stafford. He's an absolute must in optimal lineups on FD, and I'll have a decent percentage of him on DK.

Recommendation: Cash (DK/FD)

Best Correlations: Cooper Kupp, Van Jefferson, Deebo Samuel

 

George Kittle ($11,700 DK, $10,500 FD)

Key Stats:

  • 2021 Stats: 36 targets, 25 receptions, 328 yards, one touchdown.
  • 2021 Data: 92.42% target rate, 21.3% target rate, 6.25% red-zone target rate, 2 end-zone targets
  • Opposing DVOA vs TE: -21.4% (8th)
  • Individual Matchup (vs Ernest Jones): 12% target per route, 90% catch rate, 0.25 fantasy points per route.

It's been an injury-ridden year for Kittle, but boy did he come back last week with a vengeance. After he missed four consecutive weeks, he logged six receptions on eight targets for 101 yards and a touchdown against Arizona last Sunday. Out of all the Niners' pass-catchers, Kittle has the best matchup of the week. He's shown recent success against the Rams, catching 20 of 26 targets for 191 yards and two touchdowns in his last three games against them.

Recommendation: Cash (DK), GPP (FD)

Best Correlations: Jimmy Garoppolo, Matthew Stafford, Cooper Kupp

Other Captains: Cooper Kupp, Brandon Aiyuk

 

NFL DFS Flex Plays

Jimmy Garoppolo ($10,000 DK, $14,000 FD)

Key Stats:

  • 2021 Stats: 1,754 passing yards, eight touchdowns, five interceptions.
  • Offensive Pass DVOA: 26% (8th)
  • Opposing Defense Pass DVOA: -6.7% (5th)

This is more of a FanDuel play for me, as I really don't think Jimmy G will be optimal on DraftKings tonight. I feel like the 49ers' 26% pass DVOA is a bit misleading, considering the 49ers really try to establish and use the run to move down the field. The matchup isn't particularly great either, but it's worth noting that Garoppolo threw for 268 yards and three touchdowns against the Rams last October. Overall though, I'd rather spread my ownership around the 49ers pass catchers and use the extra salary elsewhere on DraftKings.

Recommendation: Cash (FD), GPP (DK)

Best Correlations: George Kittle, Deebo Samuel, Cooper Kupp

 

Elijah Mitchell ($6,400 DK, $11,500 FD)

Key Stats:

  • 2021 Stats: 89 attempts, 469 rushing yards, three rushing touchdowns, nine targets, nine receptions, 73 receiving yards.
  • 2021 Data: 64.82% snap rate, 57.42% attempt rate, 47.62% red-zone attempt rate, 25% attempt rate withing the 5yd line.
  • Offensive Rush DVOA: 3.5% (3rd)
  • Opposing Defense Pass DVOA: -13.5% (14th)
  • Opposing DVOA vs RB (receiving): -4.1% (18th)

I'm a bit confused as to why Mitchell is so cheap on DraftKings, but we'll take it nonetheless. He showed his versatility last week, catching five of five targets for 43 yards, but this week I would have to assume Kyle Shanahan's game plan will be to use Mitchell and the running game to control the clock and keep the ball out of Matthew Stafford's hands. We could get dumped if the game becomes too out of hand too quickly, but the upside is certainly worth the risk.

Recommendation: Cash (DK, FD), GPP (CPT, DK)

Best Correlations: Matthew Stafford, George Kittle, Robbie Gould

Other Flex Plays: Deebo Samuel, Tyler Higbee, O'dell Beckham Jr.,

 

NFL DFS Value Plays

Van Jefferson Jr. ($5,400 DK, $8,000 FD)

Key Stats:

  • 2021 Stats: 46 targets, 27 receptions, 433 yards, three touchdowns.
  • 2021 Data: 78.19% snap rate, 14.33% target rate, 11.94% red-zone target rate, five end-zone targets.
  • Defensive DVOA vs 'Other WR': 10.3% (25th)
  • Individual Matchup (vs Emmanuel Moseley): 19% target per route, 54% catch rate, 0.21 fantasy points per route.

I understand why Jefferson is a bit cheaper, as the news about Robert Woods's ACL injury didn't come out until Friday. Again, we'll take the value we can get on this slate, especially because I truly don't believe that OBJ will have a huge factor in this game. Robert Woods took up 21.5% of the target share, so it's not crazy to assume guys like Jefferson and Higbee will have some positive regression in the target department. While his matchup is average, it shouldn't be hard for Jefferson to hit value tonight, and he's a must-play in cash lineups on DK.

Recommendation: Cash (DK/FD)

Best Correlations: Matthew Stafford, Jimmy Garoppolo

 

Rams D/ST ($4,600 DK)

Key Stats:

  • 2021 Stats: 28 sacks, 12 interceptions, two fumble recoveries.
  • Defensive DVOA: -9.4% (9th)
  • Opposing Offense DVOA: 13.1% (7th)

I consider this more of a GPP play tonight, as I'm about 50/50 on which way this game could go. You really never know what you're going to get from San Francisco's offense, but I do think there's a very real chance that Jimmy is a dud tonight and the Rams absolutely dominate. They've been ball-hawking all season and should get some decent pressure on Garoppolo and force him to make mistakes. It's also worth that in the last two games against the Rams they've allowed 23 and 24 points.

Recommendation: GPP (DK)

Best Correlations: Darrell Henderson Jr., Matthew Stafford, Robbie Gould

Other Value Plays: Robbie Gould, Matt Gay

 

NFL DFS: Overall Slate Notes

I think this is a super interesting, yet unpredictable matchup. I think the Rams snap their four-game losing streak against San Francisco, but I also think that this should be a game that could go down the wire. All outcomes feel possible, so I'll be spreading my lineups out accordingly. Unlike last night, though, I do think this game can be a "cash" slate as well, as both offenses seem rather consolidated. I know it's somewhat "going against the grain" to play cash games in a showdown slate, but I've found myself having success over the last few years.

Have a good week everyone, good luck, and I'll talk to you again on Thursday. 



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Zavion Thomas

Is Zavion Thomas' Dynasty Value Being Overinflated by Unexpected Draft Capital?
Justice Hill

Role in Question After NFL Draft
Alperen Sengün

Alperen Sengun Finishes Series with Double-Double Effort
Audric Estimé

Audric Estime Buried on Saints' Depth Chart
LeBron James

Leads Lakers Past Rockets in Game 6
Scottie Barnes

Anchors Both Ends in Game 6 Victory
Jarquez Hunter

Unlikely to See a Significant Usage Spike in Second Season
Evan Mobley

Shines Despite Game 6 Overtime Loss
Kyren Williams

and Blake Corum Could See a 50/50 Split in 2026
RJ Barrett

Hits Clutch Three to Force Game 7
Paolo Banchero

Struggles with Shot in Game 6 Loss
Cade Cunningham

Carries Pistons to Decisive Game 7
CJ McCollum

Hawks Plan to Bring Back CJ McCollum
Yandy Díaz

Yandy Diaz Leaves With Side Tightness, Considered Day-to-Day
Jacob Misiorowski

Leaves Start Early on Friday With Hamstring Cramp
Austin Reaves

Starting Friday Night
Brandon Nimmo

Aggravates Hamstring, Pulled Early on Friday
Luke Kennard

Lakers Hope to Retain Luke Kennard in Free Agency
Dillon Brooks

Suns Want to Keep Dillon Brooks Long-Term
Jamal Shead

Joins Starting Lineup Friday
Jayson Tatum

OK for Game 7 Against 76ers
Joel Embiid

Probable for Game 7 Against Celtics
Jonathan Isaac

Downgraded to Out
Kevin Huerter

Misses Second Consecutive Game Friday
Brandon Ingram

Out on Friday
Tobias Harris

Cleared to Play Friday
Kevin Durant

Officially Out for Game 6
Ryan Helsley

Placed on Injured List With Elbow Inflammation
Dylan Holloway

Signs Five-Year Extension With Blues
Barrett Hayton

Jack McBain Iffy for Friday
Logan Stanley

a Game-Time Decision Friday
Viktor Arvidsson

Ruled Out Friday
TB

Nicholas Paul Set to Return Friday
Charle-Edouard D'Astous

Ready for Action Friday
Victor Hedman

to Be an Option "Really Soon"
Ja'Marr Chase

Is Ja'Marr Chase the Obvious Dynasty WR1 Entering 2026?
Javonte Williams

Can Javonte Williams Replicate 2025 Success in 2026?
Terry McLaurin

is Well-Positioned to Rebound in 2026
Justin Herbert

Dynasty Value Rising Following Offseason Overhaul in Los Angeles
Tee Higgins

Is Tee Higgins a Top-24 Dynasty Wide Receiver?
Ryan Pepiot

to Miss the Rest of the Season, Scheduled for Hip Surgery
Kansas City Chiefs

Chiefs Looking to Establish a Running Game in 2026
James Conner

Buried on Cardinals' Depth Chart Heading into 2026
DK Metcalf

Won't be Charged for Incident With Lions Fan
Brandon Woodruff

Goes on Injured List With Shoulder Inflammation
Nico Hoerner

Leaves Friday's Game Early With Neck Tightness
Broderick Jones

Steelers Decline the Fifth-Year Option for Broderick Jones
Russell Wilson

Ready to Hang Up his Cleats for TV Gig?
Chase Claypool

to Try Out for the Packers
Jack Della Maddalena

Returns At UFC Perth
Carlos Prates

Set For UFC Perth Main Event
Quillan Salkilld

Set For Co-Main Event
Beneil Dariush

An Underdog At UFC Perth
Steve Erceg

Looks To Win Back-To-Back Fights
Tim Elliott

Looks For His Third Consecutive Win
Ollie Schmid

Set For His UFC Debut
Marwan Rahiki

Looks To Remain Undefeated
Cam Skattebo

Role Survives the NFL Draft
Malik Nabers

Has Top-Tier Upside When Healthy
Evan Engram

Still Atop Depth Chart After NFL Draft
TreVeyon Henderson

Run-Heavy Apparoach Set to Benefit TreVeyon Henderson?
Wyatt Langford

Suffers Setback With Forearm Injury
Caleb Williams

Continues to Trend Upward in Ben Johnson's System
Terrence Shannon Jr.

Steps Up in Series Clincher
Jaden McDaniels

Leads Timberwolves to Round 2
Brandon Woodruff

to Get Some Time Off
Nikita Chibrikov

Recovering From Core-Muscle Surgery
WPG

Elias Salomonsson Out 5-6 Months After Shoulder Surgery
Radko Gudas

Remains Out Thursday
Tyler Myers

Scratched on Thursday
Michael Bunting

Arttu Hyry Unavailable Thursday, Michael Bunting Makes Postseason Debut
Bobby Brink

to Sit Out Thursday's Game 6
Jonas Brodin

Will Miss Game 6 Against Stars
Michael Harris II

Could be Forced to the Injured List
Luis Robert Jr.

Officially Placed on Injured List
Clayton Keller

Sets Up Two Goals Wednesday Night
Pavel Dorofeyev

Nets Special Hat Trick in Game 5 Win
Dan Vladar

Backstops Flyers to Series-Clinching Win
Leon Draisaitl

Oilers to Use Connor McDavid and Leon Draisaitl on Same Line Thursday
Brady Tkachuk

Remains Committed to Senators
Arttu Hyry

Could Be Available Thursday
Brandon Nimmo

Leaves Wednesday's Game With Hamstring Tightness
MLB

Phillies-Giants Postponed on Wednesday Due to Rain
Nils Lundkvist

to Remain Out Thursday
MLB

Orioles-Astros Game Postponed Due to Inclement Weather on Wednesday
Gary Woodland

Riding Momentum Into Cadillac Championship
Jordan Spieth

Brings Boom-or-Bust Potential to Cadillac Championship
Adam Scott

Looks Poised for Another Strong Finish at Doral
Maverick McNealy

Needs Approach Game to Click at Doral
George Springer

Being Activated From Injured List, Won't Start on Wednesday
Wyatt Langford

Expected to be Activated on Saturday
Garrett Crochet

Goes on Injured List With Shoulder Inflammation
CFB

Jameson Williams Files Lawsuit Against NCAA, SEC, Big Ten
Junior Caminero

Back in Wednesday's Lineup After Injury Scare
Harry Hall

Volatility Continues at Cadillac Championship
Tommy Fleetwood

Looks to Rebound at Trump National Doral
Pierceson Coody

a Risky Value Play at Cadillac Championship
Akshay Bhatia

Offers Upside with Risk at Cadillac Championship
Justin Thomas

a Scary Proposition at Cadillac Championship
Scottie Scheffler

The Leading Favorite at Cadillac Championship
Collin Morikawa

Still a Smash Play at Cadillac Championship
Viktor Hovland

Showed at Augusta He Can Finish Well
Sepp Straka

Attempting to Finish Better in Miami
PGA

J.J Spaun Enduring Roller Coaster Start to 2026
Min Woo Lee

Seeks to Make Adjustments at Cadillac Championship
Max Homa

May Struggle at Old Doral This Weekend
Ben Griffin

Rebounds From Rough Stretch as Miami Looms
Shane Lowry

Searching For Answers at Cadillac Championship
Russell Henley

Daunting Test at Doral Likely Not a Place For Russell Henley
Justin Rose

Returns to Action After Finishing Third at Masters Tournament
Hideki Matsuyama

Has The Approach Game to Win at Cadillac Championship
Junior Caminero

Suffers Jaw Contusion on Tuesday, Considered Day-to-Day
Pete Fairbanks

Going on Injured List With Nerve Irritation
Spencer Strider

to Make Season Debut This Weekend
CFB

Brendan Sorsby Facing Potential Permanent Loss of Eligibility
Carson Hocevar

Scores his First Career NASCAR Cup Series Victory at Talladega
Chris Buescher

Misses out on Winning at Talladega by Finishing Second
Alex Bowman

Earns First Top-Five Finish at Talladega Since Returning From Injury
Chase Elliott

Scores A Fourth-Place Finish at Talladega
Zane Smith

Nabs First Top-Five Finish of the 2026 Season at Talladega
CFB

Texas Tech Quarterback Brendan Sorsby Enters Rehab
Youssef Zalal

Suffers Unanimous-Decision Loss
Aljamain Sterling

Wins Back-To-Back Fights
Norma Dumont

Drops Decision At UFC Vegas 116
Joselyne Edwards

Scores Upset Win
Alexander Hernandez

Gets Dominated
Alexander Hernandez

Rafa Garcia Dominates Alexander Hernandez
Adrian Luna Martinetti

Unsuccessful In His UFC Debut
Davey Grant

Gets Back In The Win Column
Denny Hamlin

Is Denny Hamlin Worth Rostering for Talladega?
NASCAR

Is Bubba Wallace Playable in Talladega DFS Lineups?
Tyler Reddick

Stay Away From Tyler Reddick at Talladega
Ryan Blaney

Can Ryan Blaney Shake Off The Bad Luck at Talladega?
Austin Cindric

Could Contend For Another Talladega Win
Kyle Busch

an Easy DFS Pick at Talladega
Ricky Stenhouse Jr

. a High-Risk, High-Reward Pick at Talladega
Todd Gilliland

a Sleeper to Watch at Talladega
Brad Keselowski

Is Brad Keselowski Worth Rostering for Talladega Lineups?
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF