👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

MNF NFL DFS Lineup Picks for FanDuel, DraftKings - Rams vs 49ers Showdown

John's top NFL DFS lineup picks for FanDuel, and DraftKings for Monday Night Football - Rams vs 49ers showdown slate. His Week 10 MNF daily fantasy football advice.

Happy Monday, RotoBallers! I hope your Week 10 has been profitable so far. I personally had a great day in cash yesterday, cleaning the house on all four of the major slates. I hope to carry this momentum into tonight in what should be an exciting matchup as the Rams (7-2) try to bounce back from last week's performance as they head to San Francisco for another prime-time matchup against the 49ers (3-5). Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. Let's break it down. 

In this article I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the Monday Night Football slate on November 15th. These lineups can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel.

If you have any questions you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts any time you'd like. Let's make some coin this season gang, and let's get right to it!

Featured Promo: Looking for some more fantasy football action? Adopt a dynasty orphan team over at FFPC. Sign up today and get $25 off any FFPC league. Sign Up Now!

 

NFL DFS Captain Plays

Matthew Stafford ($16,200 DK, $17,000 FD)

Key Stats:

  • 2021 Stats: 2,771 passing yards, 23 touchdowns, six interceptions.
  • Offensive Pass DVOA: 44.8% (3rd)
  • Opposing Defense Pass DVOA: 19.1% (25th)

Luckily we get a slight discount on Stafford tonight, with Cooper Kupp being the highest-priced player on DraftKings. It's unfortunate that the Rams lost Robert Woods this week, but they made a solid addition in Odell Beckham Jr. I don't think OBJ makes a massive difference in this game tonight, but with the matchup being what it is I think it's tough to fade Stafford. He's an absolute must in optimal lineups on FD, and I'll have a decent percentage of him on DK.

Recommendation: Cash (DK/FD)

Best Correlations: Cooper Kupp, Van Jefferson, Deebo Samuel

 

George Kittle ($11,700 DK, $10,500 FD)

Key Stats:

  • 2021 Stats: 36 targets, 25 receptions, 328 yards, one touchdown.
  • 2021 Data: 92.42% target rate, 21.3% target rate, 6.25% red-zone target rate, 2 end-zone targets
  • Opposing DVOA vs TE: -21.4% (8th)
  • Individual Matchup (vs Ernest Jones): 12% target per route, 90% catch rate, 0.25 fantasy points per route.

It's been an injury-ridden year for Kittle, but boy did he come back last week with a vengeance. After he missed four consecutive weeks, he logged six receptions on eight targets for 101 yards and a touchdown against Arizona last Sunday. Out of all the Niners' pass-catchers, Kittle has the best matchup of the week. He's shown recent success against the Rams, catching 20 of 26 targets for 191 yards and two touchdowns in his last three games against them.

Recommendation: Cash (DK), GPP (FD)

Best Correlations: Jimmy Garoppolo, Matthew Stafford, Cooper Kupp

Other Captains: Cooper Kupp, Brandon Aiyuk

 

NFL DFS Flex Plays

Jimmy Garoppolo ($10,000 DK, $14,000 FD)

Key Stats:

  • 2021 Stats: 1,754 passing yards, eight touchdowns, five interceptions.
  • Offensive Pass DVOA: 26% (8th)
  • Opposing Defense Pass DVOA: -6.7% (5th)

This is more of a FanDuel play for me, as I really don't think Jimmy G will be optimal on DraftKings tonight. I feel like the 49ers' 26% pass DVOA is a bit misleading, considering the 49ers really try to establish and use the run to move down the field. The matchup isn't particularly great either, but it's worth noting that Garoppolo threw for 268 yards and three touchdowns against the Rams last October. Overall though, I'd rather spread my ownership around the 49ers pass catchers and use the extra salary elsewhere on DraftKings.

Recommendation: Cash (FD), GPP (DK)

Best Correlations: George Kittle, Deebo Samuel, Cooper Kupp

 

Elijah Mitchell ($6,400 DK, $11,500 FD)

Key Stats:

  • 2021 Stats: 89 attempts, 469 rushing yards, three rushing touchdowns, nine targets, nine receptions, 73 receiving yards.
  • 2021 Data: 64.82% snap rate, 57.42% attempt rate, 47.62% red-zone attempt rate, 25% attempt rate withing the 5yd line.
  • Offensive Rush DVOA: 3.5% (3rd)
  • Opposing Defense Pass DVOA: -13.5% (14th)
  • Opposing DVOA vs RB (receiving): -4.1% (18th)

I'm a bit confused as to why Mitchell is so cheap on DraftKings, but we'll take it nonetheless. He showed his versatility last week, catching five of five targets for 43 yards, but this week I would have to assume Kyle Shanahan's game plan will be to use Mitchell and the running game to control the clock and keep the ball out of Matthew Stafford's hands. We could get dumped if the game becomes too out of hand too quickly, but the upside is certainly worth the risk.

Recommendation: Cash (DK, FD), GPP (CPT, DK)

Best Correlations: Matthew Stafford, George Kittle, Robbie Gould

Other Flex Plays: Deebo Samuel, Tyler Higbee, O'dell Beckham Jr.,

 

NFL DFS Value Plays

Van Jefferson Jr. ($5,400 DK, $8,000 FD)

Key Stats:

  • 2021 Stats: 46 targets, 27 receptions, 433 yards, three touchdowns.
  • 2021 Data: 78.19% snap rate, 14.33% target rate, 11.94% red-zone target rate, five end-zone targets.
  • Defensive DVOA vs 'Other WR': 10.3% (25th)
  • Individual Matchup (vs Emmanuel Moseley): 19% target per route, 54% catch rate, 0.21 fantasy points per route.

I understand why Jefferson is a bit cheaper, as the news about Robert Woods's ACL injury didn't come out until Friday. Again, we'll take the value we can get on this slate, especially because I truly don't believe that OBJ will have a huge factor in this game. Robert Woods took up 21.5% of the target share, so it's not crazy to assume guys like Jefferson and Higbee will have some positive regression in the target department. While his matchup is average, it shouldn't be hard for Jefferson to hit value tonight, and he's a must-play in cash lineups on DK.

Recommendation: Cash (DK/FD)

Best Correlations: Matthew Stafford, Jimmy Garoppolo

 

Rams D/ST ($4,600 DK)

Key Stats:

  • 2021 Stats: 28 sacks, 12 interceptions, two fumble recoveries.
  • Defensive DVOA: -9.4% (9th)
  • Opposing Offense DVOA: 13.1% (7th)

I consider this more of a GPP play tonight, as I'm about 50/50 on which way this game could go. You really never know what you're going to get from San Francisco's offense, but I do think there's a very real chance that Jimmy is a dud tonight and the Rams absolutely dominate. They've been ball-hawking all season and should get some decent pressure on Garoppolo and force him to make mistakes. It's also worth that in the last two games against the Rams they've allowed 23 and 24 points.

Recommendation: GPP (DK)

Best Correlations: Darrell Henderson Jr., Matthew Stafford, Robbie Gould

Other Value Plays: Robbie Gould, Matt Gay

 

NFL DFS: Overall Slate Notes

I think this is a super interesting, yet unpredictable matchup. I think the Rams snap their four-game losing streak against San Francisco, but I also think that this should be a game that could go down the wire. All outcomes feel possible, so I'll be spreading my lineups out accordingly. Unlike last night, though, I do think this game can be a "cash" slate as well, as both offenses seem rather consolidated. I know it's somewhat "going against the grain" to play cash games in a showdown slate, but I've found myself having success over the last few years.

Have a good week everyone, good luck, and I'll talk to you again on Thursday. 



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

NFL

Eric McAlister's Dynasty Value in Question Coming Off Pre-Draft Injury
Jhoan Duran

Placed on 15-Day Injured List With Oblique Strain
Brian Thomas Jr.

Can Brian Thomas Jr. Rebound After Down Year in 2025?
Patrick Mahomes

Dynasty Value in Question After Injury?
Tre' Harris

Offers Buy-Low Upside for Dynasty Managers
Braelon Allen

Still Offers Dynasty Upside Despite Lost Season in 2025
Kyle Stowers

Will be Activated on Sunday
Aaron Rodgers

Remains a Free Agent Ahead of the NFL Draft
Josh Allen

Healthy and Armed with New Top Receiver
Kyler Murray

a Zero-Risk Dynasty Target?
Rachaad White

Is Rachaad White an Offseason Trade Target in Dynasty Leagues?
Jesper Wallstedt

to Start in Goal for Minnesota on Saturday
Stefon Diggs

Still a Free Agent Ahead of the NFL Draft
Trey Benson

Stuck in a Crowded Backfield
Jacory Croskey-Merritt

Year 2 Value Tied to Pick No. 7 in the NFL Draft
Sean Tucker

Dynasty Value Still Comes Primarily as an Injury Replacement
Jake Tonges

a Capable Fill-in for as Long as He Needs to Be
NFL

Ja'Kobi Lane Could Need Time to Develop for Fantasy Managers
Chig Okonkwo

Could Still Be Undervalued Despite Calls for a Breakout
LaMelo Ball

Scores 23 Points in Season-Ending Loss
Jordan Goodwin

Fills Stat Sheet in Play-In Win
Paolo Banchero

Powers Magic Into Playoffs
Jalen Green

Drops 36 Points to Clinch Playoff Spot
Amen Thompson

Off Injury Report for Playoff Opener
Jabari Smith Jr.

Cleared After Resting in Season Finale
Alperen Sengün

Alperen Sengun Cleared for Game 1 Against Lakers
Logan Stankoven

Presumed Ready for Game 1
NFL

First Round of NFL Draft Could Feature Plenty of Trades
Max Muncy

has Another Multi-Homer Game at Coors Field
Lourdes Gurriel Jr.

Expected to Make Season Debut on Saturday
Austin Riley

Hits Two Home Runs in Shutout Win Over Phillies
Daulton Varsho

Removed Early on Friday With Knee Discomfort
Rashawn Slater

Joe Alt Expected to Participate in Offseason Program
Aaron Gordon

Available for Game 1 Against Timberwolves
Julius Randle

Cleared for Playoffs
Jaxson Hayes

Available Saturday Night
Grayson Allen

Will Play Against Warriors
Kristaps Porzingis

Cleared for Friday's Game
Kevin Durant

Iffy for Saturday's Game 1
Mark Williams

Won't Play Friday Night
Spencer Jones

is Questionable for Game 1 on Saturday
Peyton Watson

is Ruled Out for Game 1 on Saturday
Edwin Uceta

Having More Shoulder Issues, "Shut Down for a Few Days"
Moussa Diabaté

Moussa Diabate is Available on Friday
Ayo Dosunmu

is Available for Saturday's Game
Anthony Edwards

Questionable for Saturday's Action
Jonathan Isaac

Remains Out Friday
NFL

Jeremiyah Love Considered the Top Overall Talent in 2026 NFL Draft?
Jarrett Allen

Removed From Injury Report Ahead of Playoffs
Aaron Jones Sr.

Role in Minnesota Could Continue to Decrease in 2026
Romeo Doubs

Appears Poised for Larger Role in New England
Josh Hader

Moved to 60-Day Injured List
Willson Contreras

Returns to Red Sox Lineup on Friday
Daniel Palencia

Goes on 15-Day Injured List With Oblique Strain
Juan Soto

Still on Track to Return Next Week
Los Angeles Angels

Garret Anderson Dies at 53 Years Old
Mike Malott

A Favorite At UFC Winnipeg
Gilbert Burns

Set For UFC Winnipeg Main Event
Kyler Phillips

Set UFC Winnipeg Co-Main Event
Charles Jourdain

Looks To Extend His Win Streak
Jai Herbert

An Underdog At UFC Winnipeg
Mandel Nallo

Set For His UFC Debut
Karine Silva

Looks To Get Back In The Win Column
Jasmine Jasudavicius

Looks To Bounce Back
Robert Thomas

Wraps Up Season With a Hat Trick
Macklin Celebrini

Establishes Sharks' New Scoring Record
Scott Wedgewood

Keeps Kraken From Scoring Thursday
Nathan MacKinnon

Wins Rocket Richard Trophy With 53 Goals
Connor McDavid

Secures Sixth Art Ross Trophy With Four-Assist Performance
Connor Dewar

Ready for Game 1
Nikita Grebenkin

Unavailable at Start of Playoffs
Parker Messick

Flirts With No-Hitter in Latest Gem Against Orioles
Mike Trout

Hits Five Homers in Series Versus Yankees
CGY

Arsenii Sergeev to Make NHL Debut Thursday
Aleksander Barkov

Cleared for World Championship
Pierre-Luc Dubois

Dealing With Fractured Hand
Zach Whitecloud

Ready to Rock Thursday
Matt Coronato

Available Against Kings
Josh Manson

Expected to Return for Postseason
Nathan MacKinnon

Martin Necas Sit Out Regular-Season Finale
Spencer Arrighetti

Fans 10 in Season Debut, to Remain a Focal Point in Rotation?
Nick Pivetta

Dealing With Flexor Strain, Could Miss Months
Nico Hoerner

Homers, Drive in Five in Win Over Phillies
Shota Imanaga

Strikes Out 11 in First Win of the Season
Sal Stewart

Continues to Hit, Goes Deep Twice on Wednesday
Shohei Ohtani

Strikes Out 10 in Win Over Mets
Connor Bedard

Has Two Assists in Season Finale
Claude Giroux

Sends Out Two Assists in Battle of Ontario Win
Tye Kartye

Registers First Career Three-Point Game
Owen Power

Records Two Assists Wednesday
Esa Lindell

Tallies Two Points in Regular-Season Finale
Shohei Ohtani

Will Pitch on Wednesday, But Won't DH
CFB

Michigan Lands Commitment From Quarterback Kamden Lopati
Sahith Theegala

Brings Strong Form Into Harbour Town
Wyndham Clark

Needs Putter to Show Up at RBC Heritage
Jacob Bridgeman

Looks to Return to Elite Form at Harbour Town
J.J. Spaun

a Volatile Option at RBC Heritage
PGA

Sungjae Im Offers High-Upside Value at RBC Heritage
Matt Fitzpatrick

Set for Another Strong Showing at RBC Heritage
Jason Day

Eyes Bounce-Back After Sunday Struggles at the Masters
Akshay Bhatia

Looking to Rebound at Harbour Town
Cameron Young

Hoping to Secure Second Win of Season at RBC Heritage
Scottie Scheffler

Looks to Win Again at RBC Heritage
Shane Lowry

Has Disappointing Final Round at Masters
Viktor Hovland

Hoping to Build on Final Round at Masters
Brian Harman

Struggling For Consistency Heading to RBC Heritage
Chris Gotterup

Putting Together Outstanding 2026 Season
Justin Thomas

Looks to Defend in Hilton Head
Jordan Spieth

in Search of Improved Putting at RBC Heritage
Marco Penge

May Continue Up-and-Down Ride at the RBC Heritage
Xander Schauffele

Could Get The Job Done at RBC Heritage
Jake Knapp

Keeps Building Strong Results in 2026
Kurt Kitayama

Trying to Regain Form From Florida
Collin Morikawa

Continues to be a Scary DFS Play at RBC Heritage
CFB

Tramell Jones Jr. Outperforms Aaron Philo During Florida's Spring Scrimmage
CFB

Keelon Russell Flashes in Alabama's Spring Game
Ty Gibbs

Holds off the Field for His First Cup Series Victory at Bristol
Ryan Blaney

Earns His First Runner-Up Finish at Bristol
Kyle Larson

Dominant Performance At Bristol Falls Short of Victory
Tyler Reddick

Matches his Career-Best Finish at Bristol
Alex Bowman

Crashes Early at Bristol in Return From Injury
Carlos Ulberg

Is The New Light Heavyweight Champion
Jiří Procházka

Jiri Prochazka Suffers First-Round Knockout Loss
Azamat Murzakanov

Suffers His First Loss
Paulo Costa

Wins Back-to-Back Fights
Curtis Blaydes

Drops Decision At UFC 327
Josh Hokit

Remains Unbeaten
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF