TAP FOR 6 MONTHS OF PREMIUM FREE 💰
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

Free MLB Betting Picks - Today's Best Bets, Expert Predictions, Odds (9/21/22)

Miles Mikolas - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

John Brubaker's top MLB betting picks and best bets for today's MLB games on 9/21/22. His free picks against the spread, teasers, parlays, and MLB player props.

Happy Wednesday, RotoBallers, we're back for another week of MLB betting picks! Make sure you're following my Twitter, as I can't guarantee that I'll always be able to get the added plays written here in the article, but I will typically add whatever else I'm playing throughout the day. The entire RotoBaller team has been working around the clock to make sure we can get you guys the best betting picks, props, and lineups throughout the season. We're happy you're here with us and are looking forward to an extremely profitable 2022 season!

Attention fellow sports bettors! We have some exciting news to share as we are now officially partnered with various sportsbooks and have some sweet sports betting promo offers! Get your deposit bonus, as well as a year of free RotoBaller Premium access, when you sign up with a new account today! After you're signed up, use our picks in this article for spreads, totals, and props to win big.

If you're new, or just a refresher to those who read my articles last season, I'm John Brubaker. I've been betting MLB baseball games for four years now, and this is my second MLB season working with the great folks at RotoBaller. I've created my own betting model to help me create and identify value on run lines, totals, and money lines. In this article, I'll be providing my favorite betting picks for the MLB games on Wednesday, September 21, 2022.

Featured Promo: New Novig users get a $25 purchase match (50% discount up to $25) on your first Novig deposit, and 6 free months of RotoBaller's "Big-4" Premium Pass (NFL, NBA, MLB, NHL) which includes exclusive tools for Betting, Props, DFS and more! CLAIM IT NOW

 

LucidMedia's 2022 MLB Betting Picks

  • Season to Date: 74-72-2, -15.43 units
  • Sides: 34-35-1, -12.72 units
  • Totals: 37-36-1, -4.41 units
  • Props: 1-0 +1.70 units

 

Today's MLB Betting Picks - Pirates @ Yankees

O/U: 8 | Moneyline: NYY -310

PIT: Roansy Contreras | NYY: Luis Severino

We finished 1-1 yesterday, as Kenley Jansen just couldn't stay out of trouble, allowing a run and effectively killing the Braves run line. That game ended up being a strange one and I'm sending positive vibes to Patrick Corbin, who left the game in the first inning.

We'll start the day off today with a first-inning under play in New York. The visiting Pirates will be sending Roansy Contreras (5-4, 3.24 ERA) to the mound. Contreras has been one of my favorites this year, considering he's been nothing short of perfect in the first inning this season. He's gone through each of his 15 starts, seven of which were on the road, without allowing a first-inning tally this season.

The Yankees will be sending Luis Severino (5-3, 3.45 ERA) to the mound. Severino has been solid both overall and the first inning this season, allowing a run in just two of nine starts in Yankee Stadium, and in just three of 13 starts overall. He should have no issue getting through a Pirates lineup that's been held scoreless in the opening frame in 82.3% of games overall, 84.2% on the road, and in eight of their last 10.

While FanDuel Sportsbook has the first inning under at -120, my model gives the under implied odds of 65.18%, good for "true" odds of -187. There's always the threat of an Aaron Judge home run in the bottom of the first, but I'll back Contreras to stay perfect under the bright lights of Yankee Stadium tonight.

Pick: Under 0.5 First Inning Runs (-120) FanDuel Sportsbook, 1 unit

 

Sports Betting Promo Offers

Featured Promo: Get any Betting Premium Pass for 30% off using code NEW. Win more with exclusive betting picks from proven winners across 9 sports! Find optimal bets with our Betting Picks Tool and Bet Weighting Tool and follow along in our VIP chat rooms! Go Premium, Win More!

 

Today's MLB Betting Picks - Cardinals @ Padres

O/U: 7.5 | Moneyline: SD -123

STL: Miles Mikolas | SD: Blake Snell

We'll head out West to San Diego for another first inning under. We'll back Cardinals right-hander Miles Mikolas (11-12, 3.46 ERA). It's kind of shocking that Mikolas has accrued so many losses this season, given how well he's pitching and how well the Cardinals have played. Nevertheless, he's allowed a first-inning run in just two of 16 starts on the road as well as six of 30 starts overall. 

He'll match up with San Diego southpaw Blake Snell (7-9, 3.85 ERA). Snell has had a pretty solid bounce-back season for the Padres this year and has been excellent in the first inning. First-inning tallies have been few and far between with Snell on the mound, as he's allowed one in just two of 12 starts at Petco Park and in just three of 21 starts overall.

Despite both of these offenses (likely) leading their respective clubs to the playoffs, they haven't jumped on opposing pitchers in the first inning too often. The Cardinals have scored in roughly 32.4% of first innings overall, but that number drops to just 25.7% when on the road. The Padres on the other hand have scored in 24% of first innings overall and in 26.1% of first innings at home. The Cardinals have been held scoreless in nine of their last 10 while the Padres have been held scoreless in eight of their last 10.

FanDuel Sportsbook has the first inning under at -138, which is a surprising number given the low game total of 7.5. We'll take this value though, considering my model gives the under a 63.73% chance of hitting, good for "true" odds of -176. Let's avenge the unfortunate Braves loss last evening and go 2-0 today.

Pick: Under 0.5 First Inning Runs (-138) FanDuel Sportsbook, 1 unit

Good luck, RotoBallers, and make sure to follow my Twitter for more plays. Talk to you tomorrow!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!



More Fantasy Baseball Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Daily Stats & Leaders
All Pitcher Matchups
Compare Any Players
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Michael Penix Jr.

Says he's Ahead of Schedule After Knee Surgery
Ryan Brasier

Finalizing Deal With Rangers
Connor Norby

to be in Platoon Role?
Graham Pauley

Defense Gives him an Advantage at 3B
Braxton Garrett

on Track to be a Full-Go in Camp
Max Meyer

Expected to be Full-Go for Spring Training
Cleveland Browns

Jim Schwartz Resigns as Browns Defensive Coordinator
Malik Nabers

Says his Rehab has Been "Phenomenal"
CFB

Oklahoma Hiring Former NFL Defensive Lineman DeShawn Williams to Analyst Role
San Diego Padres

Padres Sign Leandro Cedeno to Minor-League Contract
A.J. Ewing

a Name to Watch in Mets Pipeline
Cooper Ingle

to Contend for Early MLB Debut?
Luis Pena

Expected to Begin Season at High-A?
Dominick Barlow

Lands Standard Contract With 76ers
Carlos Lagrange

Earns Ticket to MLB Spring Training
Jalen Suggs

Records First Career Triple-Double vs. Nets
Sean Sullivan

to Attend Big-League Camp
Isaiah Jackson

Not Available Friday vs. Kings
CFB

Jahmal Edrine Charged with Sexual Assault, No Longer Enrolled at Virginia
Jared Thomas

Earns Invite to Spring Training
Jakob Chychrun

Makes Big Impact in Thursday's Win
Kristaps Porzingis

Unlikely to Debut Saturday vs. Lakers
Ivica Zubac

Not Ready for Indiana Debut on Friday
Brandon Bussi

Shuts Out Rangers With 16 Saves
Grayson Allen

Exits Early vs. Warriors
Carlos Estévez

Carlos Estevez Poised for Regression After Career Season
Anze Kopitar

Reaches 1,300 Career Points
Luka Dončić

Luka Doncic Exits Early with Hamstring Soreness
Matt Olson

Carries High Floor at First Base
Mark Stone

Becomes First Vegas Player With 100 Multi-Point Games
David Bednar

Poised to Remain Elite Closer in New York
Daniil Tarasov

Injured in Battle of Florida
Brent Suter

Angels Closing in on Contract with Brent Suter
Andrei Kuzmenko

Hurt Versus Vegas
Ty France

Linked to Three Suitors Ahead of Spring Training
John Carlson

Suffers Lower-Body Injury
Kyle Finnegan

Not Expected to See Many Save Opportunities?
Arizona Diamondbacks

Diamondbacks Acquire Infielder Jose Mejia From Baltimore
Arizona Diamondbacks

Wellington Aracena Traded to Diamondbacks
Javier Báez

Javier Baez Suspended From WBC After Positive Marijuana Test
Matthew Stafford

Named 2025 NFL MVP, Will Return in 2026
Jaxon Smith-Njigba

Takes Home Offensive Player of the Year Honors
Christian McCaffrey

Named Comeback Player of the Year
Bobby Portis

Questionable to Play Friday
Tetairoa McMillan

Named Offensive Rookie of the Year
Myles Garrett

Unanimously Wins Defensive Player of the Year Award
Nikola Vučević

Nikola Vucevic Set for Celtics Debut Friday
Joel Embiid

Good to Go Against Lakers
Andrew Nembhard

Ready to Return Friday
Pascal Siakam

Available Friday
Ty Jerome

to Sit Out Friday's Action
Deni Avdija

Considered Questionable for Friday's Matchup
De'Anthony Melton

Will Play Against Suns
Jalen Duren

Exits Early Thursday
Darius Garland

Unavailable Friday Night
Domantas Sabonis

Iffy for Friday
Josh Okogie

Tari Eason Out Thursday
Kelly Olynyk

Luke Kornet Out, Kelly Olynyk In Thursday
Julius Randle

Still Dealing With Thumb Issue, Questionable for Friday
Brad Marchand

Evan Rodrigues Among Panthers Absentees Thursday
Calum Ritchie

Rejoins Islanders Lineup as Second-Line Center
Zach Benson

Sits Out Second Straight Game
Pierre-Luc Dubois

Available Against Predators
Rickard Rakell

Out Thursday
Brayden Point

Won't Play in Olympics
Jonathan Huberdeau

to Have Season-Ending Hip Surgery
CFB

Houston, Vanderbilt, Tennessee Land Top-Three QBs in 2026 Class
Joe Mixon

Committed to Playing in 2026
CFB

Michigan Signs Top-15 Recruiting Class Despite Coaching Change
CFB

USC Finishes with No. 1 Signing Class in 2026
Valeri Nichushkin

Sets Up Three Goals Wednesday
CFB

Trinidad Chambliss Denied Medical Redshirt Waiver By NCAA
Ryan O'Reilly

Delivers Three Assists in Overtime Loss
Matt Boldy

Records Historically Fast Hat Trick Wednesday
Jet Greaves

Gives Blue Jackets Second Straight Shutout
Wyatt Kaiser

Hurt Against Blue Jackets
Sandis Vilmanis

Injured in Wednesday's Win
Jack Hughes

Out Thursday
CFB

Sam Leavitt to be Limited In Spring Practice
Jordan Love

Avoids Offseason Surgery
Matt Fitzpatrick

Back in Action at WM Phoenix Open
Sahith Theegala

Riding Hot Start Into WM Phoenix Open
J.J. Spaun

Looks to Regain Form at WM Phoenix Open
Viktor Hovland

a Volatile Option at WM Phoenix Open
Rasmus Hojgaard

Aims to Build on Solid Start to 2026
Brian Harman

Looks to Find Form at WM Phoenix Open
Daniel Berger

Has the Tools to Go One Step Higher at Scottsdale
Max Greyserman

Searching for Consistency at WM Phoenix Open
Jake Knapp

Wants Revenge at WM Phoenix Open
CFB

Joey Aguilar Granted Temporary Restraining Order Against NCAA
Joel Dahmen

Carrying Momentum Into WM Phoenix Open
Corey Conners

Unlikely to Contend at Scottsdale
Sepp Straka

Seeks a Rebound After The American Express
Jordan Spieth

Healthy Heading to WM Phoenix Open
Keith Mitchell

Building Momentum for Event in Scottsdale
Tom Hoge

The Tom Hoge Roller Coaster Heads to Scottsdale for WM Phoenix Open
Rickie Fowler

Worth a Look at WM Phoenix Open
Xander Schauffele

Making Second Appearance at Phoenix Open
Collin Morikawa

Needs a Bounce-Back at Waste Management Phoenix Open
Hideki Matsuyama

Has a Shot to Challenge at the Waste Management Phoenix Open
Max Homa

Playing Well Heading to Waste Management Phoenix Open
Ben Griffin

Will Need to Find Approach Game to Compete in Phoenix
Michael Penix Jr.

Matt Ryan Not Committing to Michael Penix Jr. as the Starting QB
NASCAR

Billy Horschel Unlikely to Right the Ship in Phoenix
Matthew Stafford

Doesn't Need Offseason Back Surgery
CFB

Joey Aguilar Files New Lawsuit Against NCAA Seeking Sixth Year of Eligibility
Davante Adams

Expected to Return to Rams in 2026
Los Angeles Rams

Rams Sign Sean McVay, Les Snead to Contract Extensions
Diego Lopes

Outclassed At UFC 325
Alexander Volkanovski

Dominates Diego Lopes
Dan Hooker

Stopped In The Second Round
Benoît Saint Denis

Benoit Saint Denis Extends His Win Streak
Rafael Fiziev

Suffers Second-Round TKO Loss
MMA

Maurício Ruffy Gets Back In The Win Column
San Francisco 49ers

49ers Set to Name Raheem Morris Their Defensive Coordinator
Las Vegas Raiders

Raiders Close to Naming Klint Kubiak the Next Head Coach
Arizona Cardinals

Cardinals Finalizing Deal to Make Mike LaFleur the Next Head Coach
CFB

Gus Malzahn Retiring from Coaching
Breece Hall

Jets Want to Re-Sign Breece Hall, Could Use Franchise Tag
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF