👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

Free MLB Betting Picks - Today's Best Bets, Expert Predictions, Odds (9/21/22)

Miles Mikolas - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

John Brubaker's top MLB betting picks and best bets for today's MLB games on 9/21/22. His free picks against the spread, teasers, parlays, and MLB player props.

Happy Wednesday, RotoBallers, we're back for another week of MLB betting picks! Make sure you're following my Twitter, as I can't guarantee that I'll always be able to get the added plays written here in the article, but I will typically add whatever else I'm playing throughout the day. The entire RotoBaller team has been working around the clock to make sure we can get you guys the best betting picks, props, and lineups throughout the season. We're happy you're here with us and are looking forward to an extremely profitable 2022 season!

Attention fellow sports bettors! We have some exciting news to share as we are now officially partnered with various sportsbooks and have some sweet sports betting promo offers! Get your deposit bonus, as well as a year of free RotoBaller Premium access, when you sign up with a new account today! After you're signed up, use our picks in this article for spreads, totals, and props to win big.

If you're new, or just a refresher to those who read my articles last season, I'm John Brubaker. I've been betting MLB baseball games for four years now, and this is my second MLB season working with the great folks at RotoBaller. I've created my own betting model to help me create and identify value on run lines, totals, and money lines. In this article, I'll be providing my favorite betting picks for the MLB games on Wednesday, September 21, 2022.

Featured Promo: New Novig users get a $25 purchase match (50% discount up to $25) on your first Novig deposit, and 6 free months of RotoBaller's "Big-4" Premium Pass (NFL, NBA, MLB, NHL) which includes exclusive tools for Betting, Props, DFS and more! CLAIM IT NOW

 

LucidMedia's 2022 MLB Betting Picks

  • Season to Date: 74-72-2, -15.43 units
  • Sides: 34-35-1, -12.72 units
  • Totals: 37-36-1, -4.41 units
  • Props: 1-0 +1.70 units

 

Today's MLB Betting Picks - Pirates @ Yankees

O/U: 8 | Moneyline: NYY -310

PIT: Roansy Contreras | NYY: Luis Severino

We finished 1-1 yesterday, as Kenley Jansen just couldn't stay out of trouble, allowing a run and effectively killing the Braves run line. That game ended up being a strange one and I'm sending positive vibes to Patrick Corbin, who left the game in the first inning.

We'll start the day off today with a first-inning under play in New York. The visiting Pirates will be sending Roansy Contreras (5-4, 3.24 ERA) to the mound. Contreras has been one of my favorites this year, considering he's been nothing short of perfect in the first inning this season. He's gone through each of his 15 starts, seven of which were on the road, without allowing a first-inning tally this season.

The Yankees will be sending Luis Severino (5-3, 3.45 ERA) to the mound. Severino has been solid both overall and the first inning this season, allowing a run in just two of nine starts in Yankee Stadium, and in just three of 13 starts overall. He should have no issue getting through a Pirates lineup that's been held scoreless in the opening frame in 82.3% of games overall, 84.2% on the road, and in eight of their last 10.

While FanDuel Sportsbook has the first inning under at -120, my model gives the under implied odds of 65.18%, good for "true" odds of -187. There's always the threat of an Aaron Judge home run in the bottom of the first, but I'll back Contreras to stay perfect under the bright lights of Yankee Stadium tonight.

Pick: Under 0.5 First Inning Runs (-120) FanDuel Sportsbook, 1 unit

 

Sports Betting Promo Offers

Featured Promo: Get any Betting Premium Pass for 30% off using code NEW. Win more with exclusive betting picks from proven winners across 9 sports! Find optimal bets with our Betting Picks Tool and Bet Weighting Tool and follow along in our VIP chat rooms! Go Premium, Win More!

 

Today's MLB Betting Picks - Cardinals @ Padres

O/U: 7.5 | Moneyline: SD -123

STL: Miles Mikolas | SD: Blake Snell

We'll head out West to San Diego for another first inning under. We'll back Cardinals right-hander Miles Mikolas (11-12, 3.46 ERA). It's kind of shocking that Mikolas has accrued so many losses this season, given how well he's pitching and how well the Cardinals have played. Nevertheless, he's allowed a first-inning run in just two of 16 starts on the road as well as six of 30 starts overall. 

He'll match up with San Diego southpaw Blake Snell (7-9, 3.85 ERA). Snell has had a pretty solid bounce-back season for the Padres this year and has been excellent in the first inning. First-inning tallies have been few and far between with Snell on the mound, as he's allowed one in just two of 12 starts at Petco Park and in just three of 21 starts overall.

Despite both of these offenses (likely) leading their respective clubs to the playoffs, they haven't jumped on opposing pitchers in the first inning too often. The Cardinals have scored in roughly 32.4% of first innings overall, but that number drops to just 25.7% when on the road. The Padres on the other hand have scored in 24% of first innings overall and in 26.1% of first innings at home. The Cardinals have been held scoreless in nine of their last 10 while the Padres have been held scoreless in eight of their last 10.

FanDuel Sportsbook has the first inning under at -138, which is a surprising number given the low game total of 7.5. We'll take this value though, considering my model gives the under a 63.73% chance of hitting, good for "true" odds of -176. Let's avenge the unfortunate Braves loss last evening and go 2-0 today.

Pick: Under 0.5 First Inning Runs (-138) FanDuel Sportsbook, 1 unit

Good luck, RotoBallers, and make sure to follow my Twitter for more plays. Talk to you tomorrow!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!



More Fantasy Baseball Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Patrick Cantlay

Needs Plenty to Go Right at Augusta
Harris English

Playing Solid Golf Heading to Masters
Sam Burns

Bouncing Back Nicely After Slow Start to 2026 Season
Corey Conners

Quietly Putting Together A Strong 2026 Season
Russell Henley

Looks to Bounce Back At Masters
Robert MacIntyre

Hopes to Rebound After Missed Cut at Masters Last Year
Justin Rose

Ready to Put Heartbreaking Playoff Loss Behind Him
Matt Fitzpatrick

Heads to Masters After Winning Valspar Championship
Xander Schauffele

Continues Scorching Start to 2026 Season
Scottie Scheffler

Returns to Action For Masters
Maverick McNealy

Might Perform Well Early at Masters Tournament
Gary Woodland

Riding the Wave Heading into Augusta National
Greg Dulcich

Will Have an Opportunity for a Big Role in 2026
Jacksonville Jaguars

Jaguars Love Their Running Back Room
Lamar Jackson

Present for Start of Offseason Program
Rasmus Hojgaard

Seeks to Continue Momentum from Houston
Shane Lowry

Attempting to Turn Back Time at the Masters
Sepp Straka

Trying to Get Under Par At Augusta
Viktor Hovland

Seeks a Hot Start at the Masters Tournament
Dean Wade

Jaylon Tyson and Dean Wade Set to Sit Out Again on Monday
Thomas Bryant

Unavailable on Monday
Andrew Mangiapane

Available for Monday's Tilt
Max Strus

Ruled Out Against Grizzlies
Shane Wright

Expected to Miss Another Game
Jarrett Allen

Available on Monday
Vladislav Namestnikov

Available Monday
Anthony Cirelli

Out Against Sabres
Evan Mobley

Active Against Memphis
Nino Niederreiter

Rejoins Jets Lineup
Brandon Hagel

Sits Out Third Consecutive Game
DAL

Nathan Bastian to Miss 3-4 Weeks
Mike Trout

Held Out of Series Opener Against Braves
Sam Merrill

Set to Suit Up on Monday
Donovan Mitchell

Ruled Out Monday
Alejandro Kirk

to Undergo Thumb Surgery on Tuesday
James Harden

Out Monday
Juan Soto

Mets Place Juan Soto on 10-Day Injured List
Matthew Boyd

Cubs Putting Matthew Boyd on 15-Day Injured List With Biceps Strain
Mickey Moniak

Goes Yard Twice Against his Old Team
Brent Rooker

Homers Twice, Drives in Six in Win Over Astros
Mike Trout

Considered Day-to-Day With Hand Contusion
New York Giants

Dexter Lawrence Requests a Trade, Won't Take Part in Offseason Program
Brooks Koepka

Needs his Putter to Work at Augusta National
Cameron Young

Playing Incredibly Well Heading into 2026 Masters
Kyle Williams

Is Kyle Williams the Latest Patriots Draft Bust at Wide Receiver?
Elic Ayomanor

Should Benefit from Improved Quarterback Play
Isaac TeSlaa

Unlikely to Repeat Touchdown Efficiency
Deebo Samuel Sr.

Remains Unsigned
Darius Slayton

Where Does Darius Slayton Fit Among a Crowd of Giants Pass-Catchers?
Vít Krejčí

Vit Krejci Still Sidelined Monday
Bruce Brown

Likely Available vs. Portland
Spencer Jones

Remains Sidelined Monday
Isaiah Stewart

Remains Out Monday vs. Orlando
Dillon Brooks

Risks Suspension After 18th Technical Foul
Daniel Gafford

Leaves Game Early with Shoulder Injury
Luka Dončić

Luka Doncic to Undergo Hamstring Treatment in Europe
Will Cuylle

Grabs First Career Hat Trick in Blowout Win
Jacob Markstrom

Records First Shutout of the Season
Brady Tkachuk

Scores Twice Against Hurricanes
Sidney Crosby

Registers Three Points in Sunday's Win
Robert Thomas

Pots First Career Hat Trick
Valeri Nichushkin

Labeled Day-to-Day
Chris Duncan

Suffers Second-Round Submission Loss
Renato Moicano

Gets Back In The Win Column
Tabatha Ricci

Gets Outgrappled
Virna Jandiroba

Bounces Back
Brendson Ribeiro

Suffers First-Round Submission Loss
Abdul-Rakhman Yakhyaev

Earns First-Round Submission Win
Rafael Estevam

Suffers His First Loss
Ethyn Ewing

Dominates At UFC Vegas 115
Pat Bryant

Year 2 Breakout No Longer in the Cards?
Troy Franklin

Set to Take a Step Backward in 2026?
Sam Howell

Joe Milton III to Compete for Backup Role
Cameron Ward

Working in the Building, Making Good Progress
Will Levis

Titans to Trade Will Levis Before the Draft?
Jacob Markstrom

Shuts Out the Canadiens
Brady Tkachuk

Scores Twice on Sunday
Cameron Payne

Out at Least Two Weeks
Duncan Robinson

Iffy for Monday
Jerami Grant

Out Again Monday
Tobias Harris

Questionable Vs. Magic
Karl-Anthony Towns

Back Against Atlanta
Joel Embiid

Available Monday Vs. Spurs
Mike Trout

Exits Early After Getting Hit by Pitch
Kirill Kaprizov

Bags Sixth Career Hat Trick Sunday
Stuart Skinner

Nursing Upper-Body Injury
Charlie Lindgren

Gets the Nod Sunday
Pavel Buchnevich

Ready to Play Sunday Night
Jordan Staal

Jordan Martinook Unavailable Sunday
Frederik Andersen

Takes on Senators Sunday
Trevor Lawrence

Can a Dynamic Surrounding Cast Lead Trevor Lawrence to Another Career Year?
Malik Willis

Dolphins Want to Build Around Malik Willis
Courtland Sutton

Has Courtland Sutton's Dropping Dynasty Value Made Him a Buy-Low Candidate?
David Njoku

One of the Top Remaining Free Agents
Tyler Warren

has Room to Grow in Year 2
Pete Fairbanks

Serving as Opener Before Going on Paternity List
George Klassen

Called Up to Start on Sunday
Stephon Gilmore

Announces his Retirement
Hunter Brown

Placed on 15-Day Injured List with Right-Shoulder Strain
Matthew Stafford

Rams to Put Matthew Stafford on Pitch Count Ahead of 2026 Season?
Jesús Luzardo

Jesus Luzardo Dominates Rockies on Saturday
Byron Buxton

Back in Sunday's Lineup
Mookie Betts

Heading to the Injured List With Oblique Strain
Cade Horton

Cubs Place Cade Horton on 15-Day Injured List With Forearm Strain
Mookie Betts

Considered Day-to-Day, Heading for an MRI on Saturday
Juan Soto

Day-to-Day With Minor Groin Strain, No Decision on IL Yet
MLB

Cubs-Guardians Game Postponed on Saturday
Mookie Betts

Leaves Early With Back Injury
Alejandro Kirk

Placed on 10-Day Injured List With Thumb Fracture
Juan Soto

Mets Concerned About Juan Soto's Calf Injury
Chris Duncan

Set For UFC Vegas 115 Main Event
Renato Moicano

An Underdog At UFC Vegas 115
Tabatha Ricci

Set For UFC Vegas 115 Co-Main Event
Virna Jandiroba

Looks To Bounce Back
Brendson Ribeiro

In Desperate Need Of Win
Abdul-Rakhman Yakhyaev

Looks To Remain Unbeaten
Ethyn Ewing

Set For His Second UFC Bout
Rafael Estevam

Looks To Remain Undefeated
CFB

Gunner Stockton Looking "Great" After Offseason Injury
CFB

Sam Leavitt Showing "Encouraging Signs" at LSU Practice
J.J. Spaun

Needs the Putter to Cooperate in San Antonio
Thorbjorn Olesen

Trending Up in San Antonio
Denny McCarthy

Carrying Momentum into San Antonio
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF