👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

Free MLB Betting Picks - Today's Best Bets, Expert Predictions, Odds (9/21/22)

Miles Mikolas - Fantasy Baseball Rankings, Draft Sleepers, MLB Injury News

John Brubaker's top MLB betting picks and best bets for today's MLB games on 9/21/22. His free picks against the spread, teasers, parlays, and MLB player props.

Happy Wednesday, RotoBallers, we're back for another week of MLB betting picks! Make sure you're following my Twitter, as I can't guarantee that I'll always be able to get the added plays written here in the article, but I will typically add whatever else I'm playing throughout the day. The entire RotoBaller team has been working around the clock to make sure we can get you guys the best betting picks, props, and lineups throughout the season. We're happy you're here with us and are looking forward to an extremely profitable 2022 season!

Attention fellow sports bettors! We have some exciting news to share as we are now officially partnered with various sportsbooks and have some sweet sports betting promo offers! Get your deposit bonus, as well as a year of free RotoBaller Premium access, when you sign up with a new account today! After you're signed up, use our picks in this article for spreads, totals, and props to win big.

If you're new, or just a refresher to those who read my articles last season, I'm John Brubaker. I've been betting MLB baseball games for four years now, and this is my second MLB season working with the great folks at RotoBaller. I've created my own betting model to help me create and identify value on run lines, totals, and money lines. In this article, I'll be providing my favorite betting picks for the MLB games on Wednesday, September 21, 2022.

Featured Promo: New Novig users get a $25 purchase match (50% discount up to $25) on your first Novig deposit, and 6 free months of RotoBaller's "Big-4" Premium Pass (NFL, NBA, MLB, NHL) which includes exclusive tools for Betting, Props, DFS and more! CLAIM IT NOW

 

LucidMedia's 2022 MLB Betting Picks

  • Season to Date: 74-72-2, -15.43 units
  • Sides: 34-35-1, -12.72 units
  • Totals: 37-36-1, -4.41 units
  • Props: 1-0 +1.70 units

 

Today's MLB Betting Picks - Pirates @ Yankees

O/U: 8 | Moneyline: NYY -310

PIT: Roansy Contreras | NYY: Luis Severino

We finished 1-1 yesterday, as Kenley Jansen just couldn't stay out of trouble, allowing a run and effectively killing the Braves run line. That game ended up being a strange one and I'm sending positive vibes to Patrick Corbin, who left the game in the first inning.

We'll start the day off today with a first-inning under play in New York. The visiting Pirates will be sending Roansy Contreras (5-4, 3.24 ERA) to the mound. Contreras has been one of my favorites this year, considering he's been nothing short of perfect in the first inning this season. He's gone through each of his 15 starts, seven of which were on the road, without allowing a first-inning tally this season.

The Yankees will be sending Luis Severino (5-3, 3.45 ERA) to the mound. Severino has been solid both overall and the first inning this season, allowing a run in just two of nine starts in Yankee Stadium, and in just three of 13 starts overall. He should have no issue getting through a Pirates lineup that's been held scoreless in the opening frame in 82.3% of games overall, 84.2% on the road, and in eight of their last 10.

While FanDuel Sportsbook has the first inning under at -120, my model gives the under implied odds of 65.18%, good for "true" odds of -187. There's always the threat of an Aaron Judge home run in the bottom of the first, but I'll back Contreras to stay perfect under the bright lights of Yankee Stadium tonight.

Pick: Under 0.5 First Inning Runs (-120) FanDuel Sportsbook, 1 unit

 

Sports Betting Promo Offers

Featured Promo: Get any Betting Premium Pass for 30% off using code NEW. Win more with exclusive betting picks from proven winners across 9 sports! Find optimal bets with our Betting Picks Tool and Bet Weighting Tool and follow along in our VIP chat rooms! Go Premium, Win More!

 

Today's MLB Betting Picks - Cardinals @ Padres

O/U: 7.5 | Moneyline: SD -123

STL: Miles Mikolas | SD: Blake Snell

We'll head out West to San Diego for another first inning under. We'll back Cardinals right-hander Miles Mikolas (11-12, 3.46 ERA). It's kind of shocking that Mikolas has accrued so many losses this season, given how well he's pitching and how well the Cardinals have played. Nevertheless, he's allowed a first-inning run in just two of 16 starts on the road as well as six of 30 starts overall. 

He'll match up with San Diego southpaw Blake Snell (7-9, 3.85 ERA). Snell has had a pretty solid bounce-back season for the Padres this year and has been excellent in the first inning. First-inning tallies have been few and far between with Snell on the mound, as he's allowed one in just two of 12 starts at Petco Park and in just three of 21 starts overall.

Despite both of these offenses (likely) leading their respective clubs to the playoffs, they haven't jumped on opposing pitchers in the first inning too often. The Cardinals have scored in roughly 32.4% of first innings overall, but that number drops to just 25.7% when on the road. The Padres on the other hand have scored in 24% of first innings overall and in 26.1% of first innings at home. The Cardinals have been held scoreless in nine of their last 10 while the Padres have been held scoreless in eight of their last 10.

FanDuel Sportsbook has the first inning under at -138, which is a surprising number given the low game total of 7.5. We'll take this value though, considering my model gives the under a 63.73% chance of hitting, good for "true" odds of -176. Let's avenge the unfortunate Braves loss last evening and go 2-0 today.

Pick: Under 0.5 First Inning Runs (-138) FanDuel Sportsbook, 1 unit

Good luck, RotoBallers, and make sure to follow my Twitter for more plays. Talk to you tomorrow!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!



More Fantasy Baseball Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Brock Bowers

Still a Top-15 Player in Dynasty Leagues Despite Injury-Plagued Season
Gavin Sheets

Goes Yard Twice, Including Walk-Off Round-Tripper
Washington Commanders

Commanders Host Omar Cooper Jr. for a Pre-Draft Visit
NFL

Makai Lemon to be a Top-20 Draft Pick This Year?
Corbin Carroll

Expected to Start on Saturday
Wyatt Langford

Forced From Friday's Game With Quad Tightness
Bijan Robinson

Falcons Pick Up Bijan Robinson's Fifth-Year Option
Kris Bubic

Dominates White Sox With 11 Strikeouts on Friday
Royce Lewis

Headed for Injured List
Mack Hollins

Can Mack Hollins Maintain a Starting Role in New England in 2026?
Clay Holmes

Removed With Hamstring Tightness
Malik Washington

Has Breakout Potential After Offseason Movement in Miami
Mike Gesicki

Is Mike Gesicki a Buy-Low Candidate After Down 2025?
Cristian Javier

Placed on 15-Day Injured List
Jayden Reed

Poised for Larger Role in Green Bay Following Offseason Movement
Matthew Golden

Does Matthew Golden Have a Clear Path to a Starting Role in His Sophomore Season?
Jaylon Tyson

Rejoins Cavaliers Lineup as Starter
Klay Thompson

Misses Friday's Game Due to Illness
Kevin Huerter

Back in Action Friday
Sam Hauser

Cleared to Play Friday
Neemias Queta

Ready to Take on Pelicans
Derrick White

Good to Go Friday
Jaylen Brown

Active on Friday
Josh Giddey

Still Out Friday
Miles McBride

Exits Knicks Lineup Friday
Mitchell Robinson

Sidelined on Friday
Norman Powell

Won't Play Against Wizards
Tyler Herro

Out on Friday
Saddiq Bey

Herbert Jones Resting Friday
Immanuel Quickley

Unavailable Friday
Julius Randle

Misses Second Straight Game
Jayson Tatum

Won't Play Friday
Jackson Chourio

Still Not Cleared to Hit
Dontayvion Wicks

Eagles Acquiring Dontayvion Wicks From the Packers
Brent Rooker

A's Place Brent Rooker on 10-Day Injured List With Oblique Strain
J.T. Realmuto

Back in Friday's Lineup
Parker Meadows

Goes on 10-Day Injured List With Broken Arm, Concussion
Seiya Suzuki

Back From the Injured List
Carlos Ulberg

A Slight Underdog
Jiří Procházka

Jiri Prochazka Can Become UFC Champion Again
Paulo Costa

Makes his Light-Heavyweight Debut
Azamat Murzakanov

Looks To Remain Unbeaten
Josh Hokit

Looks To Remain Undefeated
Curtis Blaydes

A Favorite At UFC 327
DJ Giddens

an Easily Replaceable Insurance Back
Kenny Moore II

and Colts Seeking a Trade
Hunter Henry

Could Be Impacted by NFL Draft
AJ Barner

a Mispriced Dynasty Asset
Cedric Tillman

Nearing Cut Candidacy in Dynasty Leagues
Josh Jacobs

Has a Health-Related Production Dip Left Josh Jacobs Undervalued?
Sam Carrick

to Miss Start of Playoffs
Alex Lyon

Questionable for Start of Postseason
Dakota Joshua

Unlikely to Return This Season
John Gibson

Exits Thursday's Game Due to Neck Problem
Miro Heiskanen

Uncertain for Playoffs
Brandon Hagel

Expected to Return Before End of Regular Season
Roman Josi

Nursing Upper-Body Injury
Trey Murphy III

Unavailable Against Celtics
Dejounte Murray

Remains Out Friday
Zion Williamson

Won't Suit Up Friday
Jalen Williams

Out on Friday
Jarrett Allen

Won't Play Against Hawks
Moritz Seider

has Five-Point Game on Thursday
Xavier Legette

Trending Down Ahead of Year 3
Rashod Bateman

a Cut Candidate in All Dynasty Leagues?
Ja'Tavion Sanders

Can Ja'Tavion Sanders Break Through in the Panthers' Offense?
Cole Caufield

Reaches 50 Goals
Jayden Reed

Can Jayden Reed Bounce Back as a WR3/Flex in 2026?
Travis Hunter

to be Full-Time Cornerback, Part-Time Wide Receiver in 2026
Blake Coleman

Unavailable Thursday
Quinton Byfield

Cleared to Play Thursday
Thomas Chabot

Makes Surprise Return Thursday
Luke Hughes

to Miss Rest of Season
Stuart Skinner

Faces Devils Thursday
Nazem Kadri

to "Miss Some Games" With Finger Injury
Seth Jones

to Miss Rest of Season Due to Broken Foot
Corbin Carroll

Dealing With Hip Injury, Not Expected to Miss Much Time
Brent Rooker

Exits Early on Thursday Due to Apparent Injury
Zach Benson

Scores Twice in Comeback Victory
Logan Thompson

Shuts Out the Leafs
Zach Eflin

Undergoes Successful Elbow Surgery, Will Miss Remainder of 2026
Andrei Kuzmenko

to Be Re-Evaluated in 7-8 Days
Mason Appleton

Won't Play Thursday
Tony DeAngelo

Expected to Return Thursday
Cole Ragans

"Should be Good" for Next Start
Reynaldo López

Reynaldo Lopez Handed Seven-Game Suspension
Jorge Soler

Suspended Seven Games, Will Appeal
Cole Ragans

Diagnosed With Thumb Contusion
Cole Ragans

Leaves Early on Wednesday After Being Hit in the Hand
Jacob deGrom

Expects to Make his Next Start
Tyrrell Hatton

a Steady Option at The Masters
Justin Thomas

a High-Risk, High-Reward Option at The Masters
PGA

Sungjae Im a Volatile Option at the Masters
Nicolai Hojgaard

Carrying Momentum Into The Masters
Si Woo Kim

in Strong Form Heading to The Masters
Chris Gotterup

Ready to Make His Masters Debut
Patrick Reed

Brings Momentum to The Masters
Jon Rahm

Looks Poised for His Second Green Jacket
Adam Scott

Form Points to Him Competing at Masters
Jordan Spieth

Finding Consistency Heading to Masters
Hideki Matsuyama

Trending In Right Direction For Masters
Tommy Fleetwood

a Contender if his Putter Cooperates at The Masters
Collin Morikawa

Vegas has Lost Confidence in Collin Morikawa Ahead of Masters Tournament
Ludvig Aberg

One of the Top Plays For This Week's Masters Tournament
Rory McIlroy

Set to Defend his Long-Awaited Masters Victory
Bryson DeChambeau

Looks to Finally Claim a Green Jacket
Patrick Cantlay

Needs Plenty to Go Right at Augusta
Harris English

Playing Solid Golf Heading to Masters
Sam Burns

Bouncing Back Nicely After Slow Start to 2026 Season
Corey Conners

Quietly Putting Together A Strong 2026 Season
Russell Henley

Looks to Bounce Back At Masters
Chris Duncan

Suffers Second-Round Submission Loss
Renato Moicano

Gets Back In The Win Column
Tabatha Ricci

Gets Outgrappled
Virna Jandiroba

Bounces Back
Brendson Ribeiro

Suffers First-Round Submission Loss
Abdul-Rakhman Yakhyaev

Earns First-Round Submission Win
Rafael Estevam

Suffers His First Loss
Ethyn Ewing

Dominates At UFC Vegas 115
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF