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FantasyDraft Lineup Picks (Week 10) - NFL DFS Advice

It is finally time for NFL Week 10! If you're a FantasyDraft DFS player, then this article is for you.

Each week, I will be providing you with my daily fantasy football lineup picks for FantasyDraft. The lineup picks will range from some of the elite players to mid-priced options and value plays.

If you have any questions or comments, feel free to hit me up on Twitter @BalesSJustin.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

FantasyDraft - DFS Quarterback Pick

Dak Prescott at ATL ($13,300)

Prescott has been playing at an elite level recently. He was not needed in a rainy game against the Redskins, but he has played well in each of his five games aside from that outlier. In those five games, Prescott is averaging 26.8 fantasy points per game. He gets a good matchup against Atlanta, who have been an average defense against the quarterback this season. This game is also expected to stay close, and Prescott can be used in all leagues.

 

FantasyDraft - DFS Running Back Picks

Le'Veon Bell at IND ($17,800)

Bell has been playing at an elite level this season. He's averaging 122.4 total yards and 0.6 touchdowns on 28.6 touches per game. He is the focal point of the Steelers offense, and he gets an elite matchup against the Indianapolis Colts, who have struggled against the run and pass this season. The Steelers are -10 point favorites in this game, suggesting they could run out the clock for the majority of the second half. Bell will see the majority of those touches, making him an elite option.

Lamar Miller at LAR ($9,500)

Miller has struggled at times this season, but he has recorded at least 15 touches in seven of his eight games this season. He gets an elite matchup against the Los Angeles Rams, who are allowing 121.6 rushing yards per game this season. They have also allowed eight rushing touchdowns. Miller is not an elite running back in the NFL, but he comes with a reasonable price tag, and he makes an elite tournament option this week.

 

FantasyDraft - DFS Wide Receiver Picks

Antonio Brown at IND ($17,900)

Brown has struggled with efficiency this season, as his catch rate and touchdown rate are lower than his career averages. Still, Brown is averaging a 7.1/103.4/0.4 line on 11.8 targets per game. The Colts have opted to cut Vontae Davis this week, meaning they will have a replacement level talent cornerback trying to keep up with Brown. He is an elite option in all leagues, even with the high price tag.

Demaryius Thomas vs NE ($10,700)

Thomas is an interesting option this week. The New England Patriots have been one of the worst defenses in the NFL this season. Thomas is one of the biggest beneficiaries of the Denver quarterback change, recording 12 targets in his only game with Brock Osweiler. He should be peppered with targets once again this week, making him a great option for his current price tag.

 

FantasyDraft - DFS Tight End Pick

Garrett Celek vs NYG ($5,000)

Celek is expected to draw the start for George Kittle this week. Last week, Celek saw four targets in limited playing time. He gets an elite matchup against the New York Giants, who rank 32nd in the NFL against the tight end. They have been allowing touchdowns to tight ends at an elite rate this season. Celek comes with an extremely low price tag, and he is an elite option in all leagues.

 

FantasyDraft - DFS Defense Pick

Chicago Bears D/ST vs GB ($5,100)

The Bears defense has quietly been playing extremely well this season. They are averaging 1.4 turnovers and 2.9 sacks per game this season. They have also scored three defensive touchdowns this season, as well. They get a great matchup against the Green Bay Packers, who have been struggling without Aaron Rodgers. The Bears are also -5.5 point favorites in a game set at only 38, giving Green Bay a low implied team total of 16.3 points. Chicago's defense could fly under the radar this week, but they can be used in all leagues.

 

More Week 10 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Eury Pérez

Eury Perez Pulled Early on Wednesday With Hamstring Issue
Indianapolis Colts

Daniel Jones Present at OTA Practice on Wednesday
CFB

Drew Mestemaker a Top Big 12 Quarterback Right Away?
Minnesota Vikings

T.J. Hockenson's Dynasty Stock Continues to Trend Down
Minnesota Vikings

Is Jordan Addison a Clear Buy-Low Candidate Ahead of 2026?
Tampa Bay Buccaneers

Cade Otton Continues to Offer Depth in Dynasty Leagues
PGA

Sungjae Im Remains Boom-or-Bust at Colonial
Detroit Lions

Jared Goff Continues to Have Dynasty Appeal at 31 Years Old
Tampa Bay Buccaneers

No Clear Path to Fantasy Relevance for Tez Johnson in Tampa Bay?
PGA

Michael Thorbjornsen Trending in Wrong Direction Entering Colonial
Zach Ertz

Could Still Contribute in Dynasty Leagues
De'Aaron Fox

Limited to Nine Points in Game 5 Loss
Russell Henley

a Top Option at Colonial
Dyami Brown

Holds Little Dynasty Value in His Return to Washington
Harry Hall

Hoping Putter Carries Him at Colonial
Julian Champagnie

Notches 22 Points With Four Triples Tuesday
Trevor Etienne

Could Still Find Dynasty Relevance After Quiet Rookie Season
Stephon Castle

Leads Spurs in Scoring Tuesday Night
Rickie Fowler

Looks to Regain Momentum at Colonial
Victor Wembanyama

Struggles in Game 5 Loss to Thunder
Bam Knight

Dynasty Value Has Run Dry in Crowded Running Back Room
Alex Caruso

a Difference-Maker Again in Game 5
Pierceson Coody

Looking to Stay Hot at Colonial
Jared McCain

Produces 20 Points in First Playoff Start
Mac Jones

and 49ers Agree to a Revised Contract
Shai Gilgeous-Alexander

Scores Game-High 32 Points in Game 5 Win
Martin Necas

Collects an Assist in Game 4 Loss to Golden Knights
Gabriel Landeskog

Scores Only Avalanche Goal in Season-Ending Loss
Carter Hart

Finishes Series-Clincher With 20 Saves
Dylan Coghlan

Continues Unlikely Success Story
Cole Smith

Scores Series-Clincher Tuesday Night
Mark Stone

Nets Another Goal as Golden Knights Finish Off Avalanche
Ludvig Aberg

Looking to Exchange Momentum for a Victory in Fort Worth
Stephan Jaeger

Trending Upward as PGA Heads to Fort Worth
Max Homa

Comes Off Awful Putting Performance at PGA Championship
Tony Finau

Faces Different Test at the Colonial
Robert MacIntyre

Seeks Better Beginning in Fort Worth
Tom Hoge

Ups and Downs Could Continue at Colonial
Brian Harman

Not Having the Best Golf Season in 2026
Austin Eckroat

Struggling Too Often Heading to Charles Schwab Challenge
Zach Bauchou

Tries to Keep Momentum Rolling at Colonial
Keegan Bradley

Looking to Rebound at Colonial
Tory Horton

Could Do Some Stuff "Toward the End of Spring"
Patrick Mahomes

Takes Part in First OTA Practice on Tuesday
Los Angeles Chargers

Derwin James Jr. Becomes Highest-Paid Safety for the Second Time in his Career
Chris Brooks

Emerging as Top Handcuff to Stash?
MarShawn Lloyd

Sees Short-Term Value Soar
Jared McCain

Moves into Starting Five
Boston Celtics

Joe Mazzulla Wins Coach of the Year
Jalen Williams

is Ruled Out for Game 5 on Tuesday
Bucky Irving

is Expected to be Ready for Training Camp
Zion Williamson

to See More Versatile Role
Parker Washington

Jaguars Think Parker Washington Can Replicate Second-Half Production
Cleveland Cavaliers

Kenny Atkinson to Remain Cavaliers Head Coach Next Season
Josh Jacobs

Arrested on Five Charges, Booked Into Jail
Claude Giroux

Planning to Return for 20th NHL Campaign
Josh Sweat

Cardinals Receiving Trade Calls on Josh Sweat
Carter Hart

Aiming for Sixth Consecutive Win Tuesday
Tetairoa McMillan

Working With the Training Staff on Tuesday
Evgeni Malkin

Inks New One-Year Deal With Penguins
Mackenzie Blackwood

in Net for Game 4 Against Golden Knights
Valeri Nichushkin

a Game-Time Call Tuesday
Nathan MacKinnon

Will Suit Up Tuesday
Ben Griffin

Looking to Repeat This Week at Colonial
Rasmus Hojgaard

a Player to Avoid at Charles Schwab Challenge
Hideki Matsuyama

Needs Solid Driving Week at Charles Schwab Challenge
Justin Thomas

Trending Well Ahead of Charles Schwab Challenge
Akshay Bhatia

Lacking Driving Prowess Needed at Colonial Country Club
CFB

DJ Lagway Looking to Rebound at Baylor
CFB

Josh Hoover Tasked With Leading Indiana Back to the Playoffs
CFB

Braylon Staley the Next 1,000-Yard Tennessee Receiver?
CFB

Ahmad Hardy's Return Timeline Remains Unclear
Evan Mobley

Finishes Season-Ending Loss With 15 Points
James Harden

Wants to Stay in Cleveland
Donovan Mitchell

Remains Committed to Cavaliers
Mikal Bridges

Cools Off in Game 4 Against Cavaliers
OG Anunoby

Active on Both Ends in Blowout Win
Karl-Anthony Towns

Leads Knicks in Scoring During Series-Clincher
Jalen Brunson

Named Eastern Conference Finals MVP
Ivan Demidov

Contributes an Assist in Losing Effort
Lane Hutson

Records Power-Play Goal in Game 3 Loss
Frederik Andersen

Enjoys Another Easy Night at the Office in Game 3
Shayne Gostisbehere

Scores First Postseason Goal
Taylor Hall

Ends Four-Game Goal Drought
Andrei Svechnikov

Scores Game 3 Winner in Overtime
Gage Jump

Athletics to Promote Top Pitching Prospect Gage Jump to Major Leagues
Tatsuya Imai

Two Relievers Combine to No-Hit the Rangers on Monday
Dennis Schröder

Dennis Schroder is Ruled Out for Game 4 on Monday
Michael Porter Jr.

Nets Could Trade Michael Porter Jr.
Valeri Nichushkin

Nathan MacKinnon, Valeri Nichushkin Uncertain for Game 4
Oliver Kapanen

Sitting as Healthy Scratch Monday
Max Domi

Out Indefinitely Due to Offseason Surgery Complications
Dylan Cease

Heading to Injured List With Hamstring Injury
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
MLB

Orioles-Tigers Game Postponed on Saturday
MLB

Rays-Yankees Postponed on Saturday
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
RANKINGS
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1B
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3B
SS
OF
SP
RP

RANKINGS

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