Matt Terelle's Week 10 daily fantasy football advice and sleepers. NFL DFS lineup picks and value plays for Fantasy Aces at RB, WR, QB, TE, and DEF.

Hey there RotoBallers! In this article I will be taking a look at some of my favorite FantasyAces DFS lineups plays for Week 10 of the NFL slate.

These picks are based on a multitude of factors including matchup, talent, recent performance, and pricing on Fantasy Aces. Let's get to the picks!

Editor's Note: New users that sign up on FantasyAces, make a $20 deposit, and enter any game will receive our full season NFL (or NBA) Premium Pass for free, a $59.99 value. Just email [email protected] with your new FantasyAces username - and boom, that's it! We will email you with your Premium pass.

• 2025 fantasy football rankings
• Running back (RB) rankings
• Wide receiver (WR) rankings
• Quarterback (QB) rankings
• Tight end (TE) rankings
• Defense (D/ST) rankings
• Kicker (K) rankings
• FLEX rankings
• Dynasty rankings

Quarterback Plays for Fantasy Aces

Eli Manning (vs. CIN, $6,450)

Manning is coming off one of his best games of the season, throwing for 257 yards, four touchdowns, and two interceptions against the Eagles. While the interceptions weren't ideal, Manning was extremely efficient against an Eagles pass defense that has been stingy against opposing quarterbacks for most of the season. Now he gets to take on a Bengals pass defense that has been one of the best matchups for opposing signal callers on the year. Cincinnati has been getting dismantled through the air this season, allowing 20.04 fantasy points per game to quarterbacks, seventh-highest in the league. I've found the scoring system on Aces favorable for those who search for values at the quarterback position and Eli is one of the top values on the slate. 

Dak Prescott (@ PIT, $6,200)

Prescott's price somehow dropped $250 from last week on Aces, even following his three-touchdown performance against the Browns in Week 9. His upside is just as high this week, but the Cowboys could struggle to play ball-control football against a Pittsburgh offense that can be explosive at home. With Ben Roethlisberger a week healthier, look for the Steelers offense to look much better than it did last week against the Ravens. Prescott, as mentioned above, remains very reasonably priced and sets up as a perfect QB2 on Fantasy Aces for this weekend.

Running Back Plays for Fantasy Aces

David Johnson (vs. SF, $6,400)

Johnson is the most expensive back on the slate, but he also has a mouth-watering matchup against a 49ers run defense that has been an absolute disaster this season. San Francisco is fresh off of allowing the Mark Ingram/Tim Hightower duo to combine for 245 rushing yards and three touchdowns in Week 9. Johnson's extensive work in the passing game makes him basically matchup-proof anyway, but it is going to be really hard to keep him out of lineups with the 49ers on the other side of the field. It is doubtful the Cardinals will have to throw very often and Johnson could be deployed in clock-killing mode as early as the third quarter on Sunday. Fade DJ at your own risk this weekend. 

Darren Sproles (vs. ATL, $4,650)

Sproles has emerged as the lead back in Philadelphia, handling 13 of 21 running back carries in Week 9, while also pulling in three receptions. This game should be high-scoring, with the over/under set at a robust 50 points. Furthermore, the Falcons have really struggled to contain opposing pass-catching backs as their pass defense DVOA against running backs ranks just 26th in the league according to Football Outsiders. Sproles' role in the passing game insulates him from becoming a poor game script casualty and keeps his floor high for this matchup which should produce plenty of fantasy goodness for daily players this weekend. 

Wide Receiver Plays for Fantasy Aces

Mike Evans (vs. CHI, $5,900)

Evans is coming off a massive Thursday night game which saw him turn 17 targets into 11 catches for 150 yards and two touchdowns, including this beauty for his second score of the night. Evans did enter the concussion protocol after the game, but he's been able to practice thus far and at this point of the week it would be a minor shock if he wasn't able to play in Week 10. The Bears secondary is allowing the sixth-most fantasy points per game to opposing wide receivers on the season. Evans should be in line for another high target volume against Chicago this weekend. 

Alshon Jeffery (@ TB, $4,850)

Jeffery's price is still suppressed, even though he found the end zone for the first time all season in Week 8, the last time Chicago took the field. Jeffery is just the 18th-most expensive wide receiver on Aces this weekend, even though he has the potential to finish as a top-five wideout when all is said and done. The Buccaneers secondary has struggled this season, ranking 20th in DVOA. Rookie cornerback Vernon Hargreaves is expected to spend the majority of his time attempting to slow Jeffery. There is a huge price discrepancy between the two as Hargreaves is 5'10" while Jeffery stands 6'3". This shapes up as a huge mismatch for a star wide receiver who should be peppered with targets from quarterback Jay Cutler. 

Tight End Play for Fantasy Aces

Travis Kelce (@ CAR, $4,700)

Kelce, while he didn't enjoy the officiating last week, did post five catches for 58 yards before getting ejected during the fourth quarter of the Chiefs' win over the Jaguars. Jeremy Maclin, Kansas City's top target, is not expected to play this week after suffering a groin injury during last week's game. That should give Kelce some extra work as he gets set to take on a Panthers defense that is allowing the third-most fantasy points per game to tight ends this season. Add in the fact that Carolina is stout against opposing run games and we should see the Chiefs throwing more often than they usually prefer to.  

Defense/Special Teams Play for Fantasy Aces

Washington Redskins (vs. MIN, $2,700)

The Redskins defense could be a sneaky start this weekend as they have a nice shot at performing and could be lightly owned in the Week 10 slate. Minnesota's offense has been struggling, to say the least, over their three-game losing streak, scoring just 36 points over that span. Washington's defense has struggled against opposing run games, but Minnesota's weak offensive line has rendered their run game practically useless, so it is doubtful the Vikings will be able to take advantage of the Redskins' weakness in that facet of the game. Washington is a -2.5 point favorite at home, against a bad offense, in a game that should be low-scoring, making them a prime target for daily leagues.