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FanPicks NFL DFS Lineup Picks for Week 2

RotoBallers, welcome to the show. This year we're partnering with our friends from FanPicks. We'll be running all sorts of promos and fun DFS contests, including weekly freerolls, so stay tuned.

In this column, you will find my recommended FanPicks DFS Lineup Picks to target for Week 2 of the NFL season. The goal is to identify players to start on FanPicks this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanPicks price.

Let's find some DFS lineup sleepers, and win on FanPicks. Good luck in Week 2!

Be sure to check all of our fantasy football rankings for 2025:

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FanPicks Quarterbacks - Week 2 DFS Picks

Jimmy Garoppolo - vs DET ($5,400)

Garoppolo struggled in his first game, but there is a big difference between the Detroit Lions secondary and the Minnesota Vikings in Minnesota. Sam Darnold completed 16 of 21 attempts for 198 yards, two touchdowns, and one interception on Monday night. That game was out of hand quickly, or he likely could have continued to find success. The San Francisco 49ers are also -6 point favorites in a game set at 48 points, giving them an implied total of 27 points.

 

FanPicks Running Backs - Week 2 DFS Picks

James Conner - vs KC ($5,800)

Conner has taken over for Le'Veon Bell, who is expected to miss the game this week, as well. Conner saw 36 touches last week, totaling 192 yards and two touchdowns. He should see another massive role in this game, which will be extremely high scoring. Kansas City gave up plenty of fantasy points to Melvin Gordon and Austin Ekeler last week, and Conner could find similar success. He'll feature a ton of ownership, and for good reason.

Carlos Hyde - at NO ($4,900)

Hyde struggled in his game last week, but he saw 22 carries in that game. He was the lead running back in Cleveland, and that should be the case again this week. He gets a solid matchup against the New Orleans Saints in a game that should feature a ton of scoring. Hyde has a nose for the end zone, and he's one of Cleveland's greatest threats near the goal line. He's surprisingly cheap, making him a great option in all leagues.

 

FanPicks Wide Receivers - Week 2 DFS Picks

Odell Beckham Jr. - at DAL ($6,500)

Beckham had one of the hardest matchups on the slate against Jalen Ramsey, but he still recorded 11 receptions for 111 yards on 15 targets. He's a massive part of the Giants offense, and he'll get a significantly easier matchup this week. Beckham is the cheapest of the elite options on the slate. He'll continue to get better as he returns to game form, and OBJ can safely be used in all leagues.

Kenny Golladay - at SF ($4,500)

Golladay's role in the offense is a bit unknown at this point. It looks like he'll continue to play in two receiver sets, and he was a major part of the offense last week. In his first game of the season, Golladay posted a 7/114 line on 12 targets. He's a red zone threat because of his size, and Gollday is a great option that is seemingly flying under the radar.

 

FanPicks Tight End - Week 2 DFS Pick

Jared Cook - at DEN ($3,300)

Cook was a featured player in the Oakland offense last week, catching nine passes for 180 yards on 12 targets. He gets a matchup against the Denver Broncos, who have struggled at times against tight ends. Cook could see a slight downtick in targets as the season progresses, but he could potentially see double digit targets once again. He's a cheap option with a high floor and even higher ceiling.

 

FanPicks Defense - Week 2 DFS Pick

Los Angeles Chargers - at BUF ($3,400)

The Buffalo Bills feature the worst offense in the NFL. They scored only three points in the opener, and they will now get a matchup against the Los Angeles Chargers, who feature arguably the best secondary in the NFL. Josh Allen will draw the start, and he's a bit known for being careless with the football. The Bills own an implied total of only 17.5 points, which is the second lowest on the slate. Los Angeles is a safe play at defense.

 

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REAL-TIME FANTASY NEWS

Daniel Gafford

Resting Against Clippers
Jalen Duren

Won't Play Versus Miami
Warren Foegele

Not Ready to Return Saturday
Simon Benoit

Won't Play Saturday
Henri Jokiharju

Lands on Injured Reserve
Anthony Davis

Ruled Out on Saturday
Zack Wheeler

Likely to Return in May
Pavel Zacha

a Game-Time Call Saturday
Ryan Helsley

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Out for Second Consecutive Game
William Nylander

Available Saturday
Shedeur Sanders

Could Start for Browns for the Rest of the Season
Kyle Palmieri

Out for 6-8 Months With Torn ACL
Darren Waller

Activated from Injured Reserve, Will Play in Week 13
Amon-Ra St. Brown

"Day-to-Day" With Ankle Injury, Status for Week 14 Unclear
Neemias Queta

Uncertain for Saturday's Game in Minnesota
Derrick White

Expected to Suit Up Versus Timberwolves
Jaylen Brown

Might Miss Saturday's Game
Tyler Warren

Added to Injury Report, Questionable With Illness
Baker Mayfield

Expected to Play in Week 13
Jake Walman

Sidelined for Third Consecutive Game
Jack Roslovic

to Miss Two Weeks
Ryan Nugent-Hopkins

to Return Saturday
Mattias Samuelsson

in Concussion Protocol
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Sustains Lower-Body Injury
Lukas Dostal

Ruled Out for 2-3 Weeks
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Available, Will be on a Minutes Restriction
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A.J. Brown

Goes Over 100 Yards Again, Scores Twice on Friday
Kyshawn George

Returns to Lineup After One-Game Absence
Paul George

Set To Start Friday Against Nets
Kevin Huerter

Set to Return Against Charlotte
Jarrett Allen

Back in Action on Friday
Coby White

Cleared for Action on Friday
Nikola Vučević

Nikola Vucevic Suiting Up Against Charlotte
Trey Murphy III

Uncertain For Saturday's Matchup
Giannis Antetokounmpo

Returning Versus Knicks
Jaden Ivey

Set To Play Against Orlando
Adem Bona

Back on Friday Night
Andrew Nembhard

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De'Anthony Melton

Eyeing Road-Trip Return
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Sidelined on Friday Night
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Good to Go for Week 13
Jonathan Kuminga

Questionable Ahead Of Pelicans Matchup
Brian Thomas Jr.

Good to Go Sunday
Marvin Harrison Jr.

Questionable for Week 13
Bucky Irving

Fully Practices Friday, Listed as Questionable for Week 13
Omarion Hampton

Ruled Out for Week 13
Baker Mayfield

Practices in Full Friday, Listed as Questionable for Week 13
Kirill Marchenko

Misses Third Straight Game
Drake London

Officially Ruled Out for Week 13
Jaden Schwartz

to Miss Six Weeks
Chris Olave

Officially Questionable to Play in Week 13 Due to Back Injury
Andre Burakovsky

Set to End Three-Game Absence
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Will Not Play in Week 13
William Nylander

Out Friday With Illness
J.J. McCarthy

Officially Ruled Out for Week 13
Ryan Hartman

Returns to Action Friday
Brady Tkachuk

Officially Available Friday
Ja'Marr Chase

Helps Bengals Snap Four-Game Skid on Thanksgiving
Mike Matheson

Signs Five-Year Extension
C.J. Stroud

Will Play on Sunday
Brady Tkachuk

Aims to Return Friday
Dylan Cease

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Anthony Rendon

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Josh Hader

Says his Shoulder is "Back to Normal"
Ketel Marte

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J.T. Realmuto

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Jeremiah Smith, Makai Lemon, Skyler Bell Named Biletnikoff Award Finalists
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Warren Schaeffer to Stick Around as Rockies Manager in 2026
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Chris Bell Out for Rivalry Matchup Against Kentucky
Ryan Helsley

Tigers Eyeing Ryan Helsley as a Starter

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