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FanDuel NFL DFS Lineup Picks (Week 12): Daily Fantasy Football Advice

Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 12, and a couple of sleepers to consider while building daily rosters.

RotoBallers, welcome to Week 12 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 12 of the NFL season. You can also click here to find more DFS analysis articles and tools.

The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.

Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 12! Find me @DFS_Tom if you have any questions.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

FanDuel Quarterbacks - Week 12 DFS Picks

Andrew Luck - QB, IND vs MIA (FD - $8,400)

It seems the question is becoming not if, but when? That question is, When will Andrew Luck throw his third touchdown of the game, the first half or the second half? This is due to the fact he has posted three or more touchdowns in seven straight games and you better believe he is in a spot to do that again this week. He will be up against the Dolphins who come in with the 22nd DVOA versus the pass and have given up multiple touchdowns in three of their last four games. Luck is also throwing the ball 40 times per game, which is fifth highest in the league, giving him plenty of upside in any matchup due to the overall volume.

Baker Mayfield - QB, CLE @ CIN (FD - $7,500)

Baker should be good for any format this week and is up against the Bengals in a game where the over-under is set at 47.5 points. The Bengals defense comes in with the 18th DVOA versus the pass and the 30th DVOA versus the rush. The Bengals are simply one of the worst defenses in the league and you should be stacking against them when you can. Baker has multiple touchdowns in four straight weeks and is known for some rushing ability which will only boost his floor of points.

 

FanDuel Running Backs - Week 12 DFS Picks

LeSean McCoy - RB, BUF vs JAC (FD - $6,000)

McCoy and the Bills are three-point underdogs at home to the Jaguars, who have all but lost their season. Going to McCoy and correlating him with the Bills defense could be a strong play this week since this game has a lower over-under set at 37 points. Despite the lack of potential upside from scoring, McCoy is starting to see good usage in the offense and has double-digit carries in three straight weeks along with 13 targets in the passing game over those same three games.

Christian McCaffrey - RB, CAR vs SEA (FD - $8,400)

McCaffrey is coming off a bit of a down game where he had 19 total touches, barely reached 100 combined yards and didn't reach the end zone. That might not seem like seem like a down week for some, but McCaffrey had posted four touchdowns in the three weeks prior, which is where he should return to this week. He is up against the Seahawks who are 19th DVOA versus the rush and have the 13th DVOA versus running backs in the passing game. This matchup has some sneaky shootout potential, which would mean even more touches for McCaffrey in the offense.

 

FanDuel Wide Receivers - Week 12 DFS Picks

Tyler Lockett - WR, SEA @ CAR (FD - $6,300)

Lockett has five receptions in each of the past two weeks, which is his highest total out of any two week period this season. He will be up against this Panthers secondary who got roasted last week by Kenny Golladay and two weeks ago by the Steelers' receivers. An ideal matchup for him since he should be covered by Panthers' cornerback Donte Jackson, who is giving up 0.37 fantasy points per route covered this season.

Alshon Jeffery - WR, PHI vs NYG (FD - $7,200)

Jeffrey played on 100% of the offensive snaps last week but was only able to come away with four receptions for 33 yards. That is truly unlike him, but he is in a spot to bounce back this week since the Eagles are up against the Giants who have the 27th DVOA versus the pass. Jeffrey will likely be covered a lot by Janoris Jenkins who is giving up 0.50 fantasy points per route run this season. This is a game the Eagles can win and almost need to if they want any chance of saving their season, meaning Jeffery needs to step up and have a big game.

 

FanDuel Tight End - Week 12 DFS Pick

Vance McDonald - TE, PIT @ DEN (FD - $5,500)

It's nice to see a tight end show some consistency since we often get a wide range of outcomes from that position. McDonald has four or more targets in four of his last five games and has hauled in two touchdowns in that span. Solid production from a player who isn't too expensive and is now up against the Broncos who are 18th DVOA against tight ends this season.

 

FanDuel Defense - Week 12 DFS Pick

Buffalo Bills vs Jacksonville Jaguars (FD - $4,000)

The Bills are in the mid-range when it comes to pricing this week for defenses and is playing in the game with the lowest over-under on the slate, set at 37. They are also up against the Jaguars and the always turnover prone Blake Bortles, which gives them some nice upside. The Jaguars come in with an implied team total sitting at only 20, which is the sixth lowest on the slate, so you should be looking to have a bit of exposure to them. They have generated six sacks and three interceptions in their last three games.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

NHL

Mitch Marner Delivers Two Assists in Comeback Victory
Mark Stone

Returns With Multi-Point Effort
Valeri Nichushkin

Exits Early Sunday
Nathan MacKinnon

Hurt in Game 3 Loss
Isaiah Hartenstein

Provides Steady Production in Defeat
Chet Holmgren

Has a Quiet Offensive Night on Sunday
Shai Gilgeous-Alexander

Held Under 20 Points in Game 4
Stephon Castle

Hands Out Six Assists in Game 4 Win
Devin Vassell

Tallies 13 Points in Game 4 Win
De'Aaron Fox

Records Double-Double as Spurs Even Series
Victor Wembanyama

Sets Tone Early as Spurs Force a Pivotal Game 5
Isaac Guerendo

Could be a Drop Candidate in Dynasty Leagues in 2026
Jayden Higgins

' Dynasty Arrow is Pointing Up With Clear Path to WR2 Role in Houston
Jakobi Meyers

a Sell-High Candidate in Dynasty Formats?
Drake Maye

to Make a Big Leap in 2026 in Second Season With Josh McDaniels?
Jamal Murray

Earns First Career All-NBA Selection
Kevin Durant

Becomes First Player to Make All-NBA Team With Five Franchises
Shai Gilgeous-Alexander

Victor Wembanyama Lead All-NBA First Team
Taylor Hall

Enjoying Life in Carolina
Mark Stone

Returns to Action Sunday
Cale Makar

Rejoins Avalanche Lineup Sunday
Cason Wallace

Joins Starting Unit Sunday
De'Aaron Fox

Doesn't "Feel Great" Entering Game 4
Jalen Williams

Won't Play Sunday
Christian Watson

Is Christian Watson on the Verge of a Legitimate Breakout?
Khalil Shakir

Dynasty Value in Decline
Travis Hunter

Still a Risky Buy, Even at his Sunken Dynasty Cost
Gunnar Helm

a Dynasty Sleeper with Room to Grow
Drake Maye

Is Drake Maye Becoming the Most Valuable Player in Superflex Dynasty Leagues?
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Pat Freiermuth

Steelers Restructure Pat Freiermuth's Contract
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
Jordan Mason

a Short-Term Dynasty Depth Piece
Dontayvion Wicks

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Chuba Hubbard

Dynasty Value Back on the Rise
Juwan Johnson

an Overlooked Buy Candidate for Contending Dynasty Managers
Kimani Vidal

Easily Acquirable as a High-Value Insurance Back
Evan Mobley

Tallies Series-High 24 Points on Saturday
Donovan Mitchell

Struggles at the Line Saturday
Karl-Anthony Towns

Continues Playmaking Surge on Saturday
OG Anunoby

Delivers Clean Shooting Line Saturday
Mikal Bridges

Fills Box Score in Game 3 Win
Jalen Brunson

Pushes Knicks Closer to NBA Finals
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Magic Interview Jeff Van Gundy for Head-Coaching Position
Phillip Danault

Extends Point Streak to Three Games
Josh Anderson

Nets Two Goals in Painful Loss
Jalen Chatfield

Delivers Two Assists in Crucial Win
Mark Jankowski

Contributes Two Assists in Game 2 Victory
Eric Robinson

Scores in Second Consecutive Game
Nikolaj Ehlers

Tallies Two Goals as Hurricanes Bounce Back Saturday
Giannis Antetokounmpo

Magic Reportedly Have Giannis Antetokounmpo on Their Radar
Ja'Tavion Sanders

a Dynasty Dart Throw With Potential Untapped Upside
Geno Smith

a Low-Cost Dynasty Add Who Still Comes with Risk
C.J. Stroud

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Bhayshul Tuten

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Joe Mixon

Is Joe Mixon's NFL Career Over?
MLB

Orioles-Tigers Game Postponed on Saturday
RJ Harvey

to be Relegated to Third-Down Role After Rookie RB Addition?
MLB

Rays-Yankees Postponed on Saturday
Nazem Kadri

Contributes an Assist in Losing Effort
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Mickey Moniak

Heads to Injured List With Ankle Sprain
Frederik Andersen

Hurricanes Keep Faith in Frederik Andersen
Devon Levi

Attracting Interest From Senators
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
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