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FanDuel NFL DFS Lineup Picks (Week 10): Daily Fantasy Football Advice

Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 10, and a couple of sleepers to consider while building daily rosters.

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 10 of the NFL season. You can also click here to find more DFS analysis articles and tools.

The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.

Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 10! Find me @DFS_Tom if you have any questions.

Holiday Special! Save 50% on any Premium Pass using discount code THANKS. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

FanDuel Quarterbacks - Week 10 DFS Picks

Jared Goff - QB, LAR vs SEA (FD - $8,100)

Goff and the Rams are coming off a very close and exciting loss to the Saints last week and now find themselves at home with an implied total sitting at 30, which is second highest on the slate. You should fully expect the Rams to put up a good showing at home against a divisional rival, where with a win, they could all but lock up the NFC West. Goff has posted multiple touchdowns in three straight games while throwing the ball 35 times or more in two straight games. We all know how dominant their run game can be with Todd Gurley, but when they played the Seahawks he was limited to only 77 yards on the ground. Goff passed for 321 yards the first time he played Seattle this season and we should be in for more of that this week.

Andrew Luck - QB, IND vs JAC (FD - $7,800)

Luck is more of a tournament play this week and is in a very interesting spot at home against the Jaguars. First off, this Jacksonville pass defense has given up multiple passing touchdowns in two of their last three games and doesn't seem to be as scary as the past two seasons. This could be a spot to attack since Luck has posted three or more touchdowns in five straight weeks and is currently has the second most passing touchdowns in the league. Luck is doing this all very quietly since the Colts don't have the best record, but he still brings plenty of fantasy value.

FanDuel Running Backs - Week 10 DFS Picks

Melvin Gordon III - RB, LAC @ OAK (FD - $8,900)

MG3 is going to be one of the chalkiest running backs on the slate and you should be looking to lock him into your cash games this week. He has one of the best matchups on the slate since he is going up against the Raiders, who have the 25th DVOA versus the rush and the 32nd DVOA versus running backs in the passing game. Also, love the fact that MG3 is nearly $2K cheaper compared to Gurley and has shown to have nearly as much upside as he does. Chargers come in on the road as 10 point favorites with an implied team total sitting at 30, which is tied for second highest on the slate. He has red zone equity, he has the pass-catching ability, he can do it all.

Dion Lewis - RB, TEN vs NE (FD - $5,800)

Lewis played on 84% of the snaps last week, showing he is the lead back for the Titans and brings the most fantasy upside. We have a revenge game here for Lewis going against the Patriots, so if you want to take a stroll down narrative street, then this is the spot for you. Last week he had 24 total touches with one touchdown in the passing game, which should line up nicely for him since the Patriots have the 25th DVOA versus running backs in the passing game. The Titans should be playing from behind in this game, so less rushing plays and more passing plays to catch up, means more work for Lewis over Henry.

FanDuel Wide Receivers - Week 10 DFS Picks

Marquez Valdes-Scantling - WR, GB vs MIA (FD - $5,400)

Love the savings that MVS brings and now with Geronimo Allison on IR, he should be in a spot to see more volume in the passing game. MVS has five or more targets in four straight weeks and is still under $6K, which makes him a solid salary saver for cash games this week. He will be facing off against the Dolphins who come in with the 23rd DVOA against the pass. He will see a good amount of coverage from Bobby McCain, who is giving up 0.33 fantasy points per route run this season.

Tyreek Hill - WR, KC vs ARI (FD - $7,600)

Everyone knows about Hill's big-play ability and if you have the salary, you should be trying to get a bit of exposure to him on a weekly basis. The news as of now is that Sammy Watkins is questionable for Sunday's game, so if he is out, we should see a condensed market share of targets, putting Hill in a good spot to capitalize. The Chiefs come in as 16 point home favorites and an implied team total sitting at 33, so the offense will be in full effect Sunday, as we have seen all season.

FanDuel Tight End - Week 10 DFS Pick

Benjamin Watson - TE, NO @ CIN (FD - $5,900)

Watson has 10 targets and nine receptions over the past two weeks, which he has translated into over 100 yards and two touchdowns. Truly solid production out of the veteran, who should be in a spot to continue this recent trend on the road against the Bengals, who have the 11th DVOA versus tight ends. Ideally, the Bengals will be focused on Kamara and Thomas, so Watson will see a bit of an opening in their defense and reach value yet again.

FanDuel Defense - Week 10 DFS Pick

New York Jets vs Buffalo Bills, Defense (FD - $4,900)

Normally, I prefer to spend down at defense, since their production can be so variable on a week to week basis. This week we have a bit of a different situation, where you should be looking to spend up if possible. The Jets are at home and going against a Nathan Peterman led Bills team, which means massive turnover potential. The Jets have six sacks over the past two weeks and sacks can lead to turnover and scoring, which is exactly what you want from them.

More Weekly DFS Analysis




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REAL-TIME FANTASY NEWS

Jalen Smith

Expected to Remain in Lineup Sunday
Ayo Dosunmu

Probable for Meeting With Hawks
Jordan Love

Evaluated for Concussion, Questionable to Return
Coby White

Iffy for Sunday
Andrew Wiggins

May Remain Out Sunday
Davion Mitchell

Questionable for Sunday
Tyler Herro

to Miss Fourth Straight Game Sunday
Trae Young

Available for Sunday's Tilt
Doug McDermott

Active on Saturday
Rui Hachimura

Misses Battle of Los Angeles
Jerami Grant

Won't Play Saturday Night, Kris Murray Joins Starting Unit
Jonathan Isaac

Tristan da Silva Out, Jonathan Isaac Returns for Magic Saturday
Jalen Suggs

Out Against Jazz
Lauri Markkanen

Misses Second Consecutive Game
Grayson Allen

Unavailable Against Warriors
Jonathan Kuminga

Misses Saturday's Action Due to Illness
Cam Spencer

Makes Third Career Start Saturday
Cam Whitmore

Jamir Watkins Out Against Grizzlies
Bilal Coulibaly

Departs Lineup Saturday
Khris Middleton

Ready to Face Grizzlies
Pat Connaughton

Tre Mann, Pat Connaughton Active Saturday
D'Andre Swift

Officially Active Against Packers on Saturday
Dontayvion Wicks

Christian Watson and Dontayvion Wicks Active for Week 16
Caris LeVert

Cleared for Action Saturday
Marcus Mariota

Questionable to Return with Hand Injury
Josh Jacobs

Active for Saturday's Game
Ricky Pearsall

Ruled Out for Week 16
Mike Matheson

Returns Against Former Team Saturday
Timothy Liljegren

Misses Saturday's Game
Mackie Samoskevich

Out on Saturday
Anthony Cirelli

Available Against Hurricanes
Brandon Hagel

Added to Injured Reserve
Nikita Kucherov

a Game-Time Call Saturday
J.T. Miller

Injured in Saturday's Win
Christian Watson

Should Be Able to Go Against Bears
Zach Bogosian

Unavailable Saturday
Marcus Johansson

Questionable for Saturday
Bo Horvat

to Miss Fourth Straight Game Saturday
Seth Jarvis

to Be "Out for a While"
Phillip Danault

Rejoins Canadiens for Draft Pick
Mason Marchment

Blue Jackets Acquire Mason Marchment
Brandon Lowe

Pirates Acquire Brandon Lowe in Three-Team Trade
Shane Baz

Orioles Acquire Shane Baz From the Rays
Jonathan Marchessault

Out Day-to-Day
Tristan Jarry

Oilers Place Tristan Jarry on Injured Reserve
Patrick Kane

to Remain Out Saturday
Shea Theodore

Considered Week-to-Week
Jack Eichel

to Miss at Least Two More Games
Davante Adams

Likely Won't Play in Week 17
Jordan Martinook

Misses Friday's Contest
Evan Rodrigues

Available Against Hurricanes
Tyler Seguin

Undergoes Surgery, to Be Re-Evaluated After Olympics
Marvin Harrison Jr.

Listed as Questionable for Week 16
Drake London

Expected to Play Sunday
Tee Higgins

Questionable to Play in Week 16
Michael Carter

Will Start at RB in Week 16
Dalton Kincaid

Will Practice on Friday, Expected to Play on Sunday
Garrett Wilson

Shelved for Remainder of 2025
CFB

Darian Mensah Returning to Duke Next Season
CFB

Josh Hoover Linked to Indiana in Transfer Portal
CFB

Arch Manning Agrees to Reduced Compensation for 2026 Season
Kenneth Walker III

Breaks Off Long Touchdown in Comeback Win vs. Rams
Matthew Stafford

Racks Up Highest Yardage Total in Over a Decade
Puka Nacua

Delivers Career-Best Performance on Thursday Night Football
Michael King

Padres Bring Michael King Back on Three-Year Deal
Logan Webb

Will Pitch for Team USA in World Baseball Classic
Tarik Skubal

Joins Team USA for World Baseball Classic
Jakobi Meyers

Jaguars Agree to Three-Year Extension With Jakobi Meyers
Davante Adams

Officially Out on Thursday Night
Devin Neal

Placed on Injured Reserve, Will Not Return in 2025
CFB

Will Muschamp Becoming Next Texas Defensive Coordinator
Christian Watson

Questionable for Week 16
CFB

Beau Pribula Set to Enter Transfer Portal
Bo Bichette

Willing to Make the Move to Second Base
CFB

Jeremiyah Love Officially Heading to NFL Draft
CFB

Jake Merklinger Leaving Tennessee for Transfer Portal
Mike Trout

Angels Open to Mike Trout Playing Center Field in 2026
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Kansas State's Jayce Brown Intends to Transfer
CFB

Nation's Leading Passer Drew Mestemaker to Enter Transfer Portal
Justin Crawford

Phillies Planning to Start Justin Crawford in Center Field
CFB

Jayden Maiava Signs New Deal to Return to USC
CFB

Aidan Mizell Won't Return to Florida, Entering Transfer Portal
CFB

East Carolina Targeting Jordan Davis as Next Offensive Coordinator
CFB

Michigan QB Jadyn Davis Set to Enter Transfer Portal
CFB

Travis Williams Joining Texas A&M Defensive Staff
CFB

Dylan Raiola Entering His Name into Transfer Portal
CFB

Cincinnati's Brendan Sorsby Plans to Transfer When Portal Opens
Adolis García

Adolis Garcia, Phillies Finalizing One-Year Deal on Monday
Brandon Royval

Suffers First-Round TKO Loss
CFB

Baylor, LSU, Miami Among Potential Suitors for DJ Lagway
CFB

Aidan Chiles Will Enter Transfer Portal
Manel Kape

Shines At UFC Vegas 112
Kevin Vallejos

Gets Second-Round Knockout Win
Giga Chikadze

Suffers His First Career Knockout Loss
CFB

Quarterback DJ Lagway Entering Transfer Portal
Cesar Almeida

Gets Dominated
Cezary Oleksiejczuk

Wins Sixth Fight In A Row
Morgan Charrière

Morgan Charriere Suffers First-Round Knockout Loss
Melquizael Costa

Gets First-Round Knockout Win
Marcus Buchecha

Still Winless In The UFC
Kennedy Nzechukwu

And Marcus Buchecha Fight To Draw
Lance Gibson jr

Lance Gibson Jr. Drops Decision In His UFC Debut
King Green

Gets Back In The Win Column
Kenley Jansen

Agrees to One-Year Deal With Tigers
Merrill Kelly

Returns to Diamondbacks on Two-Year Deal

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K
DEF
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