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FanDuel NFL DFS Lineup Picks (Week 10): Daily Fantasy Football Advice

Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 10, and a couple of sleepers to consider while building daily rosters.

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 10 of the NFL season. You can also click here to find more DFS analysis articles and tools.

The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.

Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 10! Find me @DFS_Tom if you have any questions.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

FanDuel Quarterbacks - Week 10 DFS Picks

Jared Goff - QB, LAR vs SEA (FD - $8,100)

Goff and the Rams are coming off a very close and exciting loss to the Saints last week and now find themselves at home with an implied total sitting at 30, which is second highest on the slate. You should fully expect the Rams to put up a good showing at home against a divisional rival, where with a win, they could all but lock up the NFC West. Goff has posted multiple touchdowns in three straight games while throwing the ball 35 times or more in two straight games. We all know how dominant their run game can be with Todd Gurley, but when they played the Seahawks he was limited to only 77 yards on the ground. Goff passed for 321 yards the first time he played Seattle this season and we should be in for more of that this week.

Andrew Luck - QB, IND vs JAC (FD - $7,800)

Luck is more of a tournament play this week and is in a very interesting spot at home against the Jaguars. First off, this Jacksonville pass defense has given up multiple passing touchdowns in two of their last three games and doesn't seem to be as scary as the past two seasons. This could be a spot to attack since Luck has posted three or more touchdowns in five straight weeks and is currently has the second most passing touchdowns in the league. Luck is doing this all very quietly since the Colts don't have the best record, but he still brings plenty of fantasy value.

FanDuel Running Backs - Week 10 DFS Picks

Melvin Gordon III - RB, LAC @ OAK (FD - $8,900)

MG3 is going to be one of the chalkiest running backs on the slate and you should be looking to lock him into your cash games this week. He has one of the best matchups on the slate since he is going up against the Raiders, who have the 25th DVOA versus the rush and the 32nd DVOA versus running backs in the passing game. Also, love the fact that MG3 is nearly $2K cheaper compared to Gurley and has shown to have nearly as much upside as he does. Chargers come in on the road as 10 point favorites with an implied team total sitting at 30, which is tied for second highest on the slate. He has red zone equity, he has the pass-catching ability, he can do it all.

Dion Lewis - RB, TEN vs NE (FD - $5,800)

Lewis played on 84% of the snaps last week, showing he is the lead back for the Titans and brings the most fantasy upside. We have a revenge game here for Lewis going against the Patriots, so if you want to take a stroll down narrative street, then this is the spot for you. Last week he had 24 total touches with one touchdown in the passing game, which should line up nicely for him since the Patriots have the 25th DVOA versus running backs in the passing game. The Titans should be playing from behind in this game, so less rushing plays and more passing plays to catch up, means more work for Lewis over Henry.

FanDuel Wide Receivers - Week 10 DFS Picks

Marquez Valdes-Scantling - WR, GB vs MIA (FD - $5,400)

Love the savings that MVS brings and now with Geronimo Allison on IR, he should be in a spot to see more volume in the passing game. MVS has five or more targets in four straight weeks and is still under $6K, which makes him a solid salary saver for cash games this week. He will be facing off against the Dolphins who come in with the 23rd DVOA against the pass. He will see a good amount of coverage from Bobby McCain, who is giving up 0.33 fantasy points per route run this season.

Tyreek Hill - WR, KC vs ARI (FD - $7,600)

Everyone knows about Hill's big-play ability and if you have the salary, you should be trying to get a bit of exposure to him on a weekly basis. The news as of now is that Sammy Watkins is questionable for Sunday's game, so if he is out, we should see a condensed market share of targets, putting Hill in a good spot to capitalize. The Chiefs come in as 16 point home favorites and an implied team total sitting at 33, so the offense will be in full effect Sunday, as we have seen all season.

FanDuel Tight End - Week 10 DFS Pick

Benjamin Watson - TE, NO @ CIN (FD - $5,900)

Watson has 10 targets and nine receptions over the past two weeks, which he has translated into over 100 yards and two touchdowns. Truly solid production out of the veteran, who should be in a spot to continue this recent trend on the road against the Bengals, who have the 11th DVOA versus tight ends. Ideally, the Bengals will be focused on Kamara and Thomas, so Watson will see a bit of an opening in their defense and reach value yet again.

FanDuel Defense - Week 10 DFS Pick

New York Jets vs Buffalo Bills, Defense (FD - $4,900)

Normally, I prefer to spend down at defense, since their production can be so variable on a week to week basis. This week we have a bit of a different situation, where you should be looking to spend up if possible. The Jets are at home and going against a Nathan Peterman led Bills team, which means massive turnover potential. The Jets have six sacks over the past two weeks and sacks can lead to turnover and scoring, which is exactly what you want from them.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

Pat Bryant

Working With Training Staff This Offseason
Jacoby Brissett

in Communication With Cardinals Despite Skipping Workouts
Daniel Jones

Could Take Part in 7-on-7 Drills at OTAs
Tyler Glasnow

Dodgers Put Tyler Glasnow on Injured List With Back Spasms
Sam Merrill

Iffy for Game 3 on Saturday
Anthony Edwards

Rejoins Starting Lineup Friday
Kevin Huerter

Likely to Remain Out Saturday
Jarred Vanderbilt

Considered Questionable for Saturday
Jalen Williams

Ruled Out for Game 3 Against Lakers
Ayo Dosunmu

Cleared to Play Friday
Anthony Edwards

Available Friday Night
Joel Embiid

is Returning for Game 3 on Friday
Brandon Ingram

Undergoes Heel Surgery
Josh Hart

is Available to Play in Game 3
OG Anunoby

is Downgraded to Out for Game 3 on Friday
Mitchell Robinson

is Returning for Game 3
Mats Zuccarello

Expected to Play Saturday
Joel Eriksson Ek

to Be a Game-Time Decision Saturday
Jonas Brodin

Still Out Saturday
Josh Manson

Could Return Saturday
Kaedan Korczak

Scratched for Game 3 Against Ducks
Radko Gudas

Likely to Remain Out Friday
Sam Carrick

Won't Play Friday
Isiah Pacheco

Can Isiah Pacheco Re-Establish His Dynasty Value in Detroit?
Rico Dowdle

Dynasty Ceiling Limited By Backfield Committee in Pittsburgh
Rashid Shaheed

a High-Risk, High-Reward Buy-Low Candidate for Dynasty Managers
Marcus Mariota

Is Marcus Mariota Worth Stashing as an Injury Replacement in Dynasty Leagues?
Jacoby Brissett

a Clear Sell-High Candidate for Dynasty Managers
Blake Snell

to Make Season Debut for Dodgers on Saturday
Najee Harris

Can Najee Harris Re-Establish Some Dynasty Value in 2026?
Cole Ragans

Royals Place Cole Ragans on Injured List With Elbow Impingement
Breece Hall

Jets Sign Breece Hall to Three-Year Extension Worth $45.75 Million
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
Nick Lodolo

Officially Activated, Making Season Debut on Friday
Denver Broncos

Broncos Sign GM George Paton to New Five-Year Deal
Brandon McManus

Packers Release Kicker Brandon McManus
New York Jets

Jets Talking to a "Number of Veteran Quarterbacks"
Travis Etienne Jr.

a Reliable Dynasty Starter Entering First Season With Saints
Kenneth Gainwell

Is Kenneth Gainwell's Dynasty Stock Still Rising After Offseason Change of Scenery?
Mac Jones

a Deep-League Dynasty Stash Candidate
Tez Johnson

Facing Uphill Battle for Playing Time in Tampa Bay
Jared Goff

Remains a High-Floor Dynasty QB2 Heading into 2026
De'Von Achane

Remains a High-End Dynasty RB Despite Uncertain Supporting Cast
Xavier Worthy

Chiefs Limited Xavier Worthy's Usage After Injury Last Year
Rashee Rice

Chiefs Not Ready to Discuss Extension With Rashee Rice?
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
Austin Reaves

Scores 31 Points in Game 2 Defeat
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
Chet Holmgren

Anchors Thunder Past Lakers in Game 2
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
Tobias Harris

Stays Hot in Game 2 Victory
Cade Cunningham

Pushes Pistons to 2-0 Series Lead
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
Jarrett Allen

Provides Bright Spot in Cavs' Game 2 Loss to Pistons
CFB

Rasheem Biles an Instant Impact Player for Texas
James Harden

Struggles in Game 2 Loss
Donovan Mitchell

Finishes Game 2 Loss with 31 Points
Gradey Dick

Open to Trade Away From Toronto
Michael Porter Jr.

Wants to Stay in Brooklyn
Dan Vladar

Looks to Return to Winning Ways Thursday
Connor Dewar

Penguins Re-Sign Connor Dewar for Two Years
Mikko Rantanen

Played Through Torn MCL Late in the Season
Rasmus Dahlin

Ready to Go Friday
Alexander Nikishin

Set to Return Thursday
Christian Dvorak

Available Thursday
Owen Tippett

Remains Out Thursday
Roman Anthony

Heading for the Injured List
CFB

Sam Leavitt Expected to Be Full-Go for Fall Camp
Tarik Skubal

Could Return in 4-6 Weeks After Successful Elbow Surgery
Cole Ragans

Royals Hopeful That Cole Ragans Makes his Next Start
Mark Stone

Nets Late Power-Play Goal in Losing Effort
Leo Carlsson

Pots Game-Winner Wednesday Night
Juraj Slafkovsky

Ends Point Drought in Game 1 Loss
Bowen Byram

Ties Franchise Record With Fourth Postseason Goal
Zach Benson

Posts Second Consecutive Multi-Point Game
Rasmus Dahlin

"Seems Fine" After Early Exit on Wednesday
Emilio Pagán

Emilio Pagan has Grade 2 Hamstring Strain, Expected to Miss 4-8 Weeks
Joe Ryan

Listed as Scheduled Starter for Saturday Against Cleveland
Tyler Glasnow

Not Expected to Land on the Injured List
Framber Valdez

Suspension Reduced to Five Games
Nils Hoglander

Will Miss World Championship Due to Injury
Framber Valdez

Suspended Six Games
Tyler Glasnow

Exits Early on Wednesday With Back Pain
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
CFB

Tanook Hines Stepping into WR1 Role for USC
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Brandon Woodruff

has Fluid Drained From his Right Shoulder
Brandon Woodruff

to Resume Throwing on Saturday, Return Imminent?
Carlos Correa

to Have Season-Ending Ankle Surgery
Jacob Misiorowski

Listed as Friday's Probable Starter
Logan Webb

Dealing With Knee Discomfort
Carlos Correa

Expected to Miss Significant Time With Ankle Injury
Collin Morikawa

Withdraws From Truist Championship
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

Secures Third Win of 2026 Season
Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
Adam Scott

Brings Strong Form to Quail Hollow
Robert MacIntyre

a Steady Option at Truist Championship
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
Emilio Pagán

Emilio Pagan Headed for Injured List With Hamstring Injury
Emilio Pagán

Emilio Pagan Carted Off With Apparent Hamstring Injury on Tuesday
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Chris Gotterup

Looking to Bounce Back at Quail Hollow
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
CFB

LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
CFB

Notre Dame Leads College Football in Returning Snaps
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
Chase Elliott

Earns his Second Texas Motor Speedway Victory
Denny Hamlin

Misses Out on Winning at Texas
Alex Bowman

Finishes Third for the Second Week in a Row at Texas
Tyler Reddick

Earns Seventh Top-Five Finish of the Season at Texas
Chris Buescher

Scores his First Career Texas Finish in the Top Five
CFB

Bryce Underwood in Better Situation Entering Sophomore Season
CFB

Nico Iamaleava Emerging as Leader, Playmaker for UCLA
Jack Della Maddalena

Gets Dominated At UFC Perth
Carlos Prates

Shines At UFC Perth
Beneil Dariush

Suffers A First-Round TKO Loss
Quillan Salkilld

Remains Unbeaten In The UFC
Tim Elliott

Drops Decision At UFC Perth
Steve Erceg

Wins Back-To-Back Fights
Ollie Schmid

Suffers First-Round TKO Loss
Marwan Rahiki

Remains Unbeaten
Christopher Bell

Is Christopher Bell Worth Rostering for Texas Lineups?
William Byron

Might have the Speed to Compete for the Win at Texas
Joey Logano

Provides Solid Upside for Texas DFS Lineups
Chase Briscoe

Could Chase Briscoe be A Sneaky Pick for Texas Lineups?
Ty Gibbs

Should DFS Managers Roster Ty Gibbs at Texas?
Daniel Suarez

Is Daniel Suarez Worth Rostering After Career-Best Starting Position at Texas?
Kyle Busch

Is a DFS Risk Starting in the Top 10 at Texas
Tyler Reddick

One of the Favorites to Win at Texas
Chase Elliott

Could Contend for Another Win at Texas
Carson Hocevar

on Pole at Texas
NASCAR

Bubba Wallace Wrecks in Practice at Texas
Chris Buescher

Looking to Continue Strong Run at Texas
Austin Dillon

Blows Engine in Practice at Texas
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