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Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 10, and a couple of sleepers to consider while building daily rosters.
RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 10 of the NFL season. You can also click here to find more DFS analysis articles and tools.
The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.
Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 10! Find me @DFS_Tom if you have any questions.
Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
- Running back (RB) rankings
- Wide receiver (WR) rankings
- Quarterback (QB) rankings
- Tight end (TE) rankings
- Defense (D/ST) rankings
- Kicker (K) rankings
- FLEX rankings
- Dynasty rankings
FanDuel Quarterbacks - Week 10 DFS Picks
Jared Goff - QB, LAR vs SEA (FD - $8,100)
Goff and the Rams are coming off a very close and exciting loss to the Saints last week and now find themselves at home with an implied total sitting at 30, which is second highest on the slate. You should fully expect the Rams to put up a good showing at home against a divisional rival, where with a win, they could all but lock up the NFC West. Goff has posted multiple touchdowns in three straight games while throwing the ball 35 times or more in two straight games. We all know how dominant their run game can be with Todd Gurley, but when they played the Seahawks he was limited to only 77 yards on the ground. Goff passed for 321 yards the first time he played Seattle this season and we should be in for more of that this week.
Andrew Luck - QB, IND vs JAC (FD - $7,800)
Luck is more of a tournament play this week and is in a very interesting spot at home against the Jaguars. First off, this Jacksonville pass defense has given up multiple passing touchdowns in two of their last three games and doesn't seem to be as scary as the past two seasons. This could be a spot to attack since Luck has posted three or more touchdowns in five straight weeks and is currently has the second most passing touchdowns in the league. Luck is doing this all very quietly since the Colts don't have the best record, but he still brings plenty of fantasy value.
FanDuel Running Backs - Week 10 DFS Picks
Melvin Gordon III - RB, LAC @ OAK (FD - $8,900)
MG3 is going to be one of the chalkiest running backs on the slate and you should be looking to lock him into your cash games this week. He has one of the best matchups on the slate since he is going up against the Raiders, who have the 25th DVOA versus the rush and the 32nd DVOA versus running backs in the passing game. Also, love the fact that MG3 is nearly $2K cheaper compared to Gurley and has shown to have nearly as much upside as he does. Chargers come in on the road as 10 point favorites with an implied team total sitting at 30, which is tied for second highest on the slate. He has red zone equity, he has the pass-catching ability, he can do it all.
Dion Lewis - RB, TEN vs NE (FD - $5,800)
Lewis played on 84% of the snaps last week, showing he is the lead back for the Titans and brings the most fantasy upside. We have a revenge game here for Lewis going against the Patriots, so if you want to take a stroll down narrative street, then this is the spot for you. Last week he had 24 total touches with one touchdown in the passing game, which should line up nicely for him since the Patriots have the 25th DVOA versus running backs in the passing game. The Titans should be playing from behind in this game, so less rushing plays and more passing plays to catch up, means more work for Lewis over Henry.
FanDuel Wide Receivers - Week 10 DFS Picks
Marquez Valdes-Scantling - WR, GB vs MIA (FD - $5,400)
Love the savings that MVS brings and now with Geronimo Allison on IR, he should be in a spot to see more volume in the passing game. MVS has five or more targets in four straight weeks and is still under $6K, which makes him a solid salary saver for cash games this week. He will be facing off against the Dolphins who come in with the 23rd DVOA against the pass. He will see a good amount of coverage from Bobby McCain, who is giving up 0.33 fantasy points per route run this season.
Tyreek Hill - WR, KC vs ARI (FD - $7,600)
Everyone knows about Hill's big-play ability and if you have the salary, you should be trying to get a bit of exposure to him on a weekly basis. The news as of now is that Sammy Watkins is questionable for Sunday's game, so if he is out, we should see a condensed market share of targets, putting Hill in a good spot to capitalize. The Chiefs come in as 16 point home favorites and an implied team total sitting at 33, so the offense will be in full effect Sunday, as we have seen all season.
FanDuel Tight End - Week 10 DFS Pick
Benjamin Watson - TE, NO @ CIN (FD - $5,900)
Watson has 10 targets and nine receptions over the past two weeks, which he has translated into over 100 yards and two touchdowns. Truly solid production out of the veteran, who should be in a spot to continue this recent trend on the road against the Bengals, who have the 11th DVOA versus tight ends. Ideally, the Bengals will be focused on Kamara and Thomas, so Watson will see a bit of an opening in their defense and reach value yet again.
FanDuel Defense - Week 10 DFS Pick
New York Jets vs Buffalo Bills, Defense (FD - $4,900)
Normally, I prefer to spend down at defense, since their production can be so variable on a week to week basis. This week we have a bit of a different situation, where you should be looking to spend up if possible. The Jets are at home and going against a Nathan Peterman led Bills team, which means massive turnover potential. The Jets have six sacks over the past two weeks and sacks can lead to turnover and scoring, which is exactly what you want from them.
