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FanDuel NFL DFS Lineup Picks (Week 10): Daily Fantasy Football Advice

Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 10, and a couple of sleepers to consider while building daily rosters.

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 10 of the NFL season. You can also click here to find more DFS analysis articles and tools.

The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.

Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 10! Find me @DFS_Tom if you have any questions.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

FanDuel Quarterbacks - Week 10 DFS Picks

Jared Goff - QB, LAR vs SEA (FD - $8,100)

Goff and the Rams are coming off a very close and exciting loss to the Saints last week and now find themselves at home with an implied total sitting at 30, which is second highest on the slate. You should fully expect the Rams to put up a good showing at home against a divisional rival, where with a win, they could all but lock up the NFC West. Goff has posted multiple touchdowns in three straight games while throwing the ball 35 times or more in two straight games. We all know how dominant their run game can be with Todd Gurley, but when they played the Seahawks he was limited to only 77 yards on the ground. Goff passed for 321 yards the first time he played Seattle this season and we should be in for more of that this week.

Andrew Luck - QB, IND vs JAC (FD - $7,800)

Luck is more of a tournament play this week and is in a very interesting spot at home against the Jaguars. First off, this Jacksonville pass defense has given up multiple passing touchdowns in two of their last three games and doesn't seem to be as scary as the past two seasons. This could be a spot to attack since Luck has posted three or more touchdowns in five straight weeks and is currently has the second most passing touchdowns in the league. Luck is doing this all very quietly since the Colts don't have the best record, but he still brings plenty of fantasy value.

FanDuel Running Backs - Week 10 DFS Picks

Melvin Gordon III - RB, LAC @ OAK (FD - $8,900)

MG3 is going to be one of the chalkiest running backs on the slate and you should be looking to lock him into your cash games this week. He has one of the best matchups on the slate since he is going up against the Raiders, who have the 25th DVOA versus the rush and the 32nd DVOA versus running backs in the passing game. Also, love the fact that MG3 is nearly $2K cheaper compared to Gurley and has shown to have nearly as much upside as he does. Chargers come in on the road as 10 point favorites with an implied team total sitting at 30, which is tied for second highest on the slate. He has red zone equity, he has the pass-catching ability, he can do it all.

Dion Lewis - RB, TEN vs NE (FD - $5,800)

Lewis played on 84% of the snaps last week, showing he is the lead back for the Titans and brings the most fantasy upside. We have a revenge game here for Lewis going against the Patriots, so if you want to take a stroll down narrative street, then this is the spot for you. Last week he had 24 total touches with one touchdown in the passing game, which should line up nicely for him since the Patriots have the 25th DVOA versus running backs in the passing game. The Titans should be playing from behind in this game, so less rushing plays and more passing plays to catch up, means more work for Lewis over Henry.

FanDuel Wide Receivers - Week 10 DFS Picks

Marquez Valdes-Scantling - WR, GB vs MIA (FD - $5,400)

Love the savings that MVS brings and now with Geronimo Allison on IR, he should be in a spot to see more volume in the passing game. MVS has five or more targets in four straight weeks and is still under $6K, which makes him a solid salary saver for cash games this week. He will be facing off against the Dolphins who come in with the 23rd DVOA against the pass. He will see a good amount of coverage from Bobby McCain, who is giving up 0.33 fantasy points per route run this season.

Tyreek Hill - WR, KC vs ARI (FD - $7,600)

Everyone knows about Hill's big-play ability and if you have the salary, you should be trying to get a bit of exposure to him on a weekly basis. The news as of now is that Sammy Watkins is questionable for Sunday's game, so if he is out, we should see a condensed market share of targets, putting Hill in a good spot to capitalize. The Chiefs come in as 16 point home favorites and an implied team total sitting at 33, so the offense will be in full effect Sunday, as we have seen all season.

FanDuel Tight End - Week 10 DFS Pick

Benjamin Watson - TE, NO @ CIN (FD - $5,900)

Watson has 10 targets and nine receptions over the past two weeks, which he has translated into over 100 yards and two touchdowns. Truly solid production out of the veteran, who should be in a spot to continue this recent trend on the road against the Bengals, who have the 11th DVOA versus tight ends. Ideally, the Bengals will be focused on Kamara and Thomas, so Watson will see a bit of an opening in their defense and reach value yet again.

FanDuel Defense - Week 10 DFS Pick

New York Jets vs Buffalo Bills, Defense (FD - $4,900)

Normally, I prefer to spend down at defense, since their production can be so variable on a week to week basis. This week we have a bit of a different situation, where you should be looking to spend up if possible. The Jets are at home and going against a Nathan Peterman led Bills team, which means massive turnover potential. The Jets have six sacks over the past two weeks and sacks can lead to turnover and scoring, which is exactly what you want from them.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

Cristopher Sánchez

Cristopher Sanchez Makes History With Seven More Shutout Innings Against Padres
Teoscar Hernández

Teoscar Hernandez Lifted From Wednesday's Game Early With Hamstring Strain
Younghoe Koo

Jets Sign Kicker Younghoe Koo on Wednesday
Quinn Ewers

Looks Good in Wednesday's OTA Practice
Kenley Jansen

Exits Relief Appearance on Wednesday With Groin Injury
Ty Johnson

Taking Part in OTAs
Ja'Tavion Sanders

Cutting Laterally at OTAs
Tre' Harris

has Been a Top-Three Receiver During Offseason Program
Makai Lemon

Already Working With Starters in OTAs
AJ Barner

Undergoes Offseason Procedures, Not Taking Part in OTAs
Zach Charbonnet

Might Not Return Until Midseason
Von Miller

"For Sure" Plans to Play in 2026
Alvin Kamara

Not at OTAs But Preparing for the 2026 Season
Lamar Jackson

"Absolutely" Wants to Stay With Ravens Long-Term
Mason Plumlee

NBA Upgrades Mason Plumlee's Foul to a Flagrant 1
Victor Wembanyama

Receives Warning From NBA
Atlanta Hawks

Hawks Promote Onsi Saleh to President of Basketball Operations
Jalen Williams

Listed as Questionable for Game 6
Ajay Mitchell

Ruled Out for Game 6
Michael Penix Jr.

Not Cleared for 11-on-11 Work
Jacoby Brissett

Still Absent From OTAs This Week
George Kittle

Still Hoping to be Ready for Week 1
Micah Parsons

Expected to Open Training Camp on the PUP List
Tucker Kraft

Packers Hopeful Tucker Kraft Will Participate in Training Camp
Jacory Croskey-Merritt

Held Out of OTAs on Wednesday
Jayden Daniels

Participating in Commanders OTAs
Chris Bell

No Timetable for Chris Bell's Return from Knee Surgery
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Limited in OTAs Due to Recovery From Shoulder Injury
MarShawn Lloyd

Participating in Packers OTAs
Eury Pérez

Eury Perez Pulled Early on Wednesday With Hamstring Issue
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Drew Mestemaker a Top Big 12 Quarterback Right Away?
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Sungjae Im Remains Boom-or-Bust at Colonial
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Michael Thorbjornsen Trending in Wrong Direction Entering Colonial
De'Aaron Fox

Limited to Nine Points in Game 5 Loss
Russell Henley

a Top Option at Colonial
Harry Hall

Hoping Putter Carries Him at Colonial
Julian Champagnie

Notches 22 Points With Four Triples Tuesday
Stephon Castle

Leads Spurs in Scoring Tuesday Night
Rickie Fowler

Looks to Regain Momentum at Colonial
Victor Wembanyama

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Alex Caruso

a Difference-Maker Again in Game 5
Pierceson Coody

Looking to Stay Hot at Colonial
Jared McCain

Produces 20 Points in First Playoff Start
Shai Gilgeous-Alexander

Scores Game-High 32 Points in Game 5 Win
Martin Necas

Collects an Assist in Game 4 Loss to Golden Knights
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Scores Only Avalanche Goal in Season-Ending Loss
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Finishes Series-Clincher With 20 Saves
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Scores Series-Clincher Tuesday Night
Mark Stone

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Ludvig Aberg

Looking to Exchange Momentum for a Victory in Fort Worth
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Max Homa

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Tony Finau

Faces Different Test at the Colonial
Robert MacIntyre

Seeks Better Beginning in Fort Worth
Tom Hoge

Ups and Downs Could Continue at Colonial
Brian Harman

Not Having the Best Golf Season in 2026
Austin Eckroat

Struggling Too Often Heading to Charles Schwab Challenge
Zach Bauchou

Tries to Keep Momentum Rolling at Colonial
Keegan Bradley

Looking to Rebound at Colonial
Jared McCain

Moves into Starting Five
Boston Celtics

Joe Mazzulla Wins Coach of the Year
Jalen Williams

is Ruled Out for Game 5 on Tuesday
Zion Williamson

to See More Versatile Role
Cleveland Cavaliers

Kenny Atkinson to Remain Cavaliers Head Coach Next Season
Claude Giroux

Planning to Return for 20th NHL Campaign
Carter Hart

Aiming for Sixth Consecutive Win Tuesday
Evgeni Malkin

Inks New One-Year Deal With Penguins
Mackenzie Blackwood

in Net for Game 4 Against Golden Knights
Valeri Nichushkin

a Game-Time Call Tuesday
Nathan MacKinnon

Will Suit Up Tuesday
Ben Griffin

Looking to Repeat This Week at Colonial
Rasmus Hojgaard

a Player to Avoid at Charles Schwab Challenge
Hideki Matsuyama

Needs Solid Driving Week at Charles Schwab Challenge
Justin Thomas

Trending Well Ahead of Charles Schwab Challenge
Akshay Bhatia

Lacking Driving Prowess Needed at Colonial Country Club
CFB

DJ Lagway Looking to Rebound at Baylor
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Josh Hoover Tasked With Leading Indiana Back to the Playoffs
CFB

Braylon Staley the Next 1,000-Yard Tennessee Receiver?
CFB

Ahmad Hardy's Return Timeline Remains Unclear
Evan Mobley

Finishes Season-Ending Loss With 15 Points
James Harden

Wants to Stay in Cleveland
Donovan Mitchell

Remains Committed to Cavaliers
Mikal Bridges

Cools Off in Game 4 Against Cavaliers
Ivan Demidov

Contributes an Assist in Losing Effort
Lane Hutson

Records Power-Play Goal in Game 3 Loss
Frederik Andersen

Enjoys Another Easy Night at the Office in Game 3
Shayne Gostisbehere

Scores First Postseason Goal
Taylor Hall

Ends Four-Game Goal Drought
Andrei Svechnikov

Scores Game 3 Winner in Overtime
Gage Jump

Athletics to Promote Top Pitching Prospect Gage Jump to Major Leagues
Tatsuya Imai

Two Relievers Combine to No-Hit the Rangers on Monday
Valeri Nichushkin

Nathan MacKinnon, Valeri Nichushkin Uncertain for Game 4
Oliver Kapanen

Sitting as Healthy Scratch Monday
Max Domi

Out Indefinitely Due to Offseason Surgery Complications
Dylan Cease

Heading to Injured List With Hamstring Injury
Daniel Suarez

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Christopher Bell

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Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

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Chase Elliott

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Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
MLB

Orioles-Tigers Game Postponed on Saturday
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Rays-Yankees Postponed on Saturday
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
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Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
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Jadan Baugh Primed to Lead Florida Offense in 2026
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LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
RANKINGS
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1B
2B
3B
SS
OF
SP
RP

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QB
RB
WR
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K
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