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FanDuel NFL DFS Lineup Picks (Week 10): Daily Fantasy Football Advice

Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 10, and a couple of sleepers to consider while building daily rosters.

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 10 of the NFL season. You can also click here to find more DFS analysis articles and tools.

The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.

Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 10! Find me @DFS_Tom if you have any questions.

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FanDuel Quarterbacks - Week 10 DFS Picks

Jared Goff - QB, LAR vs SEA (FD - $8,100)

Goff and the Rams are coming off a very close and exciting loss to the Saints last week and now find themselves at home with an implied total sitting at 30, which is second highest on the slate. You should fully expect the Rams to put up a good showing at home against a divisional rival, where with a win, they could all but lock up the NFC West. Goff has posted multiple touchdowns in three straight games while throwing the ball 35 times or more in two straight games. We all know how dominant their run game can be with Todd Gurley, but when they played the Seahawks he was limited to only 77 yards on the ground. Goff passed for 321 yards the first time he played Seattle this season and we should be in for more of that this week.

Andrew Luck - QB, IND vs JAC (FD - $7,800)

Luck is more of a tournament play this week and is in a very interesting spot at home against the Jaguars. First off, this Jacksonville pass defense has given up multiple passing touchdowns in two of their last three games and doesn't seem to be as scary as the past two seasons. This could be a spot to attack since Luck has posted three or more touchdowns in five straight weeks and is currently has the second most passing touchdowns in the league. Luck is doing this all very quietly since the Colts don't have the best record, but he still brings plenty of fantasy value.

FanDuel Running Backs - Week 10 DFS Picks

Melvin Gordon III - RB, LAC @ OAK (FD - $8,900)

MG3 is going to be one of the chalkiest running backs on the slate and you should be looking to lock him into your cash games this week. He has one of the best matchups on the slate since he is going up against the Raiders, who have the 25th DVOA versus the rush and the 32nd DVOA versus running backs in the passing game. Also, love the fact that MG3 is nearly $2K cheaper compared to Gurley and has shown to have nearly as much upside as he does. Chargers come in on the road as 10 point favorites with an implied team total sitting at 30, which is tied for second highest on the slate. He has red zone equity, he has the pass-catching ability, he can do it all.

Dion Lewis - RB, TEN vs NE (FD - $5,800)

Lewis played on 84% of the snaps last week, showing he is the lead back for the Titans and brings the most fantasy upside. We have a revenge game here for Lewis going against the Patriots, so if you want to take a stroll down narrative street, then this is the spot for you. Last week he had 24 total touches with one touchdown in the passing game, which should line up nicely for him since the Patriots have the 25th DVOA versus running backs in the passing game. The Titans should be playing from behind in this game, so less rushing plays and more passing plays to catch up, means more work for Lewis over Henry.

FanDuel Wide Receivers - Week 10 DFS Picks

Marquez Valdes-Scantling - WR, GB vs MIA (FD - $5,400)

Love the savings that MVS brings and now with Geronimo Allison on IR, he should be in a spot to see more volume in the passing game. MVS has five or more targets in four straight weeks and is still under $6K, which makes him a solid salary saver for cash games this week. He will be facing off against the Dolphins who come in with the 23rd DVOA against the pass. He will see a good amount of coverage from Bobby McCain, who is giving up 0.33 fantasy points per route run this season.

Tyreek Hill - WR, KC vs ARI (FD - $7,600)

Everyone knows about Hill's big-play ability and if you have the salary, you should be trying to get a bit of exposure to him on a weekly basis. The news as of now is that Sammy Watkins is questionable for Sunday's game, so if he is out, we should see a condensed market share of targets, putting Hill in a good spot to capitalize. The Chiefs come in as 16 point home favorites and an implied team total sitting at 33, so the offense will be in full effect Sunday, as we have seen all season.

FanDuel Tight End - Week 10 DFS Pick

Benjamin Watson - TE, NO @ CIN (FD - $5,900)

Watson has 10 targets and nine receptions over the past two weeks, which he has translated into over 100 yards and two touchdowns. Truly solid production out of the veteran, who should be in a spot to continue this recent trend on the road against the Bengals, who have the 11th DVOA versus tight ends. Ideally, the Bengals will be focused on Kamara and Thomas, so Watson will see a bit of an opening in their defense and reach value yet again.

FanDuel Defense - Week 10 DFS Pick

New York Jets vs Buffalo Bills, Defense (FD - $4,900)

Normally, I prefer to spend down at defense, since their production can be so variable on a week to week basis. This week we have a bit of a different situation, where you should be looking to spend up if possible. The Jets are at home and going against a Nathan Peterman led Bills team, which means massive turnover potential. The Jets have six sacks over the past two weeks and sacks can lead to turnover and scoring, which is exactly what you want from them.

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REAL-TIME FANTASY NEWS

San Francisco 49ers

49ers Select Kaelon Black With 90th Overall Pick
Chicago Bears

Zavion Thomas Selected 89th Overall by Bears
Giancarlo Stanton

Exits With Leg Tightness on Friday
Miami Dolphins

Dolphins Select Will Kacmarek With 87th Overall Pick
Tampa Bay Buccaneers

Buccaneers Draft Ted Hurst 84th Overall in NFL Draft
Isaiah Joe

Likely to Miss Game 3 Against Suns
Carolina Panthers

Panthers Select Chris Brazzell II in the Third Round
Baltimore Ravens

Ja'Kobi Lane Heading to the Ravens With 80th Overall Pick
Peyton Watson

to Remain Sidelined Saturday
Pittsburgh Steelers

Drew Allar Selected 76th Overall by Steelers
Atlanta Falcons

Falcons Select Speedy Receiver Zachariah Branch At 79 Overall
Aaron Gordon

Questionable for Saturday's Game 4
Miami Dolphins

Dolphins Select Caleb Douglas With 75th Overall Pick
Jordan Goodwin

on Track to Return Saturday
New York Giants

Giants Trade Up to Pick 74, Select Malachi Fields
NFL

Saints Select Oscar Delp With 73rd Overall Pick
Grayson Allen

Listed as Questionable for Saturday
Mark Williams

Won't Play Saturday
Washington Commanders

Commanders Use 71st Overall Pick on Antonio Williams
Chicago Bears

Bears Select Sam Roush With 69th Pick
Victor Wembanyama

Will Miss Game 3 Against Trail Blazers
Carson Beck

Selected 65th Overall by Cardinals
Los Angeles Rams

Rams Select Max Klare With 61st Overall Pick
Houston Texans

Texans Select Marlin Klein With 59th Overall Pick
Jonathan Greenard

Eagles Acquire Jonathan Greenard, Sign him to Four-Year Extension
Jacksonville Jaguars

Jaguars Select Nate Boerkircher With 56th Overall Pick
Philadelphia Eagles

Eagles Select Eli Stowers at No. 54 Overall
Pittsburgh Steelers

Steelers Trade Up, Select Germie Bernard With 47th Overall Pick
Dee Winters

Cowboys Acquire Dee Winters in Trade With the 49ers
Tari Eason

Reed Sheppard Move into Starting Five on Friday
Nickeil Alexander-Walker

Wins Most Improved Player Award
Immanuel Quickley

to Miss Rest of First-Round Series
Kevin Durant

is Ruled Out for Game 3 on Friday
Joel Embiid

Officially Ruled Out for Game 3
Eugenio Suárez

Eugenio Suarez Scratched on Friday With Mid-Back Pain
Troy Terry

Available for Game 3 Against Oilers
Radko Gudas

Misses Second Straight Game Friday
Charle-Edouard D'Astous

Unavailable Friday
Dan Vladar

Considered a Game-Time Call for Saturday
Jake Sanderson

Ruled Out for Game 4 Due to Concussion
Yakov Trenin

Won't Play in Game 4 Against Stars
Mats Zuccarello

a Game-Time Decision Saturday
Jackson Holliday

Receives Positive Test Results, Will be Shut Down for a Week
Jeff Hoffman

Out as Blue Jays Closer
Youssef Zalal

Set For UFC Vegas 116 Main Event
Aljamain Sterling

An Underdog At UFC Vegas 116
Joselyne Edwards

Set For UFC Vegas 116 Co-Main Event
Norma Dumont

Looks To Extend Her Win Streak
Alexander Hernandez

A Favorite At UFC Vegas 116
Rafa Garcia

Looks For His Third Consecutive Win
Adrian Luna Martinetti

Set For His UFC Debut
Davey Grant

Looks To Get Back In The Win Column
Jaden McDaniels

Records Double-Double in Game 3
Ayo Dosunmu

Paces Wolves in Game 3 Victory
Jalen Johnson

Flirts with Triple-Double in Game 3 Win
Mikal Bridges

Goes Scoreless in Game 3 Loss
Anthony Edwards

Limited to 24 Minutes in Game 3
Jalen Brunson

Pours in 26 Points in Game 3 Defeat
CJ McCollum

Delivers Clutch Shot in Game 3 Win
Jordan Kyrou

Recovering From Minor Knee Procedure
Roope Hintz

"Ways Away" From Returning
Jason Dickinson

Could Be an Option for Game 3
Adam Henrique

Misses Trip to Anaheim
Jake Sanderson

Dealing With Head Injury
Josh Manson

Evaluated for Upper-Body Injury
Alex Lyon

Comes in and Shuts Down Boston
Jake Sanderson

Suffers Hand Injury While Blocking Shot
Jake LaRavia

Available for Game 3 Friday
Austin Reaves

Upgraded to Questionable on Injury Report
Francisco Lindor

Expected to Miss "Significant Time"
Tyler Kleven

Available for Senators Versus Hurricanes
Josh Norris

Out With Undisclosed Injury for Thursday Night
Noah Ostlund

Will Return for Game 3 Against Boston
Francisco Lindor

Mets Officially Place Francisco Lindor on Injured List With Calf Strain
Michael Harris II

Removed Early With Quad Tightness
Francisco Lindor

Likely Headed to the Injured List
Jason Robertson

Scores in Sixth Straight Playoff Game
Matt Duchene

Records Second Consecutive Multi-Point Game
Sean Couturier

Contributes Two Assists in Game 3 Win
Michael Harris II

Continues to Heat Up With Two-Homer Game on Wednesday
Francisco Lindor

Leaves Wednesday's Game Early With Calf Tightness
JR Ritchie

Earns Promotion, Will Make MLB Debut on Thursday
Wyatt Langford

Expected to Go on Injured List With Flexor Strain
Maikel Garcia

Leaves Early on Wednesday With Elbow Soreness
Roman Anthony

Day-to-Day With Sore Back
Juan Soto

Officially Back in Mets Lineup on Wednesday
J.T. Realmuto

Phillies Place J.T. Realmuto on Injured List With Back Injury
Lucas Giolito

Signs With Padres, Worth a Waiver-Wire Pickup?
Ryan Helsley

Orioles Put Ryan Helsley on Bereavement List on Wednesday
CFB

Beau Pribula Leading Virginia Quarterback Competition
Marco Penge

Trending Down Entering Zurich Classic
Sahith Theegala

Eyes Another Strong Week at Zurich Classic
Brooks Koepka

Shane Lowry Teams Up with Brooks Koepka at Zurich Classic
Si Woo Kim

Adds Another Strong Finish at RBC Heritage
Elly De La Cruz

Early-Season Breakout Continues on Tuesday
Wyatt Langford

Pulled Early on Tuesday With Forearm Tightness
Luke Clanton

Hoping to Find Form in New Orleans
Jackson Holliday

Leaves Rehab Game With Hand Discomfort
Scottie Scheffler

is Starting to Hit His Stride
Brooks Koepka

Looking for Progress in PGA Return With Partner at Zurich Classic
Matt Fitzpatrick

Looks to Share Recent Form at Zurich Classic
CFB

Ashton Daniels Named Florida State's Starting Quarterback
Tyler Reddick

Earns His Fifth Win of the 2026 Season at Kansas
Kyle Larson

Finishes as the Runner-Up at Kansas
Chase Briscoe

Rallies for A New Career-Best Finish at Kansas
Denny Hamlin

Leads the Most Laps at Kansas but Misses Out on Victory
Christopher Bell

Falls Out of Contention for Kansas Victory on Final Restart
Mike Malott

Scores Third-Round TKO Win
Gilbert Burns

Retires After UFC Winnipeg Loss
Charles Jourdain

Extends Winning Streak
Kyler Phillips

Drops Decision At UFC Winnipeg
Mandel Nallo

Suffers First-Round TKO Loss In His UFC Debut
Jai Herbert

Scores First-Round TKO Win
Karine Silva

Gets Dominated at UFC Winnipeg
Jasmine Jasudavicius

Dominates Karine Silva
Kyle Larson

Should not be Underestimated for the Win at Kansas
Denny Hamlin

Can Denny Hamlin Dominate at Kansas Again?
NASCAR

Christoper Bell Should Contend for First Win at Kansas
Tyler Reddick

Fastest in Practice and Qualifying for Kansas Race
Ryan Blaney

Could Score another Top-10 Finish at Kansas
Ty Gibbs

Poised to Continue Hot Streak at Kansas
Chris Buescher

Always Consistent, Has Speed Heading Into Kansas
William Byron

is A Solid DFS Option for Kansas Lineups
Carson Hocevar

Poised for Career-Best Run at Kansas
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Kansas?
Chase Elliott

Is A Favorable DFS Option for Kansas Lineups
Joey Logano

Could Joey Logano be Considered Playable In DFS This Week at Kansas?
NASCAR

Bubba Wallace is A Favorable Driver to Consider for Kansas Lineups
Ross Chastain

Is Ross Chastain A Worthy DFS Option for Kansas?
Brad Keselowski

Could Brad Keselowski be A Sneaky DFS Option for Kansas?
Daniel Suarez

Should DFS Managers Roster Daniel Suarez at Kansas?
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