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FanDuel Lineup Picks (Week 10) - NFL DFS Advice

FanDuel NFL DFS lineup picks and start 'em, sit' em for Week 10. Daily fantasy football sleepers and lineups cheat sheet for FanDuel DFS GPPs and tournaments.

Welcome to RotoBaller's daily fantasy football FanDuel lineup picks for Week 10 of the NFL season. In this article I will be taking you through the best FanDuel DFS plays of the week for this upcoming Sunday.

These FanDuel lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more.

Good luck with your FanDuel DFS lineups!

Be sure to check all of our fantasy football rankings for 2025:

 

FanDuel Quarterbacks - Week 10 DFS Picks

Ryan Fitzpatrick (vs. NYJ, $6,100)

Ryan Fitzpatrick will be behind center for the Buccaneers this week and for the foreseeable future. The combination of price and matchup (plus a little narrative) make it difficult to pass in this spot despite the fact that Mike Evans won’t be on the field this week. The Jets are ranked 21st in pass DVOA and the price will allow spending up at other spots on the slate.

Matthew Stafford (vs. CLE, $8,200)

If you’re feeling a safer option than Fitzpatrick this week, Stafford is the quarterback to turn to. Stafford has been good lately, passing for multiple touchdowns in two of his past three games and over 300 yards in all three. He should be able to do each of those things against a hapless Browns pass defense that ranks 28th in pass DVOA for the season. The only risk for Stafford is that the Lions pull ahead quickly without those scores coming through the air, but with the ineptitude of their ground game that seems unlikely.

 

FanDuel Running Backs - Week 10 DFS Picks

Carlos Hyde (vs. NYG, $6,700)

Carlos Hyde hasn’t been anything special on the ground this season which is obviously not a great statement in reference to a running back. On the other hand, he has been very involved in the pass game which has kept his floor at a safe level. When the 49ers have lost by 10 points or less this season, Hyde has seen an average of 23 touches per game. The Giants are just as inept as the 49ers, if not more, so this should be a close game between two bad teams and allow Hyde to see a healthy dose of touches.

Bilal Powell (@TB, $6,000)

With Matt Forte officially out this week, we can look to Powell as a bargain running back that paves the way to Antonio Brown, LeVeon Bell, or Gronk. While the narrative has been that the Jets rushing attack has been an unreliable mess in terms of workload, the absence of Forte should open sufficient volume for Powell to take advantage of. The Bucs are far from tough on opposing running backs, allowing big games to Adrian Peterson, LeSean McCoy, and the Saints running back committee of late, opening up some more nice value at the running back position.

 

FanDuel Wide Receivers - Week 10 DFS Picks

A.J. Green (@TEN, $7,900) 

A.J. Green has been a story this week, but not because of his play. He should be motivated to perform as a result and he’s in a decent spot to do so. Though Tennessee has shown improvement on defense, most of that improvement has come against opposing rushing attacks. If the Bengals are smart, that’s a big if, they will pepper A.J. Green with targets as has a six-inch height advantage over otherwise impressive rookie Adoree’ Jackson.

Marvin Jones (vs. CLE, $6,400)

Golden Tate has been a reliable option this season, but the price disparity between he and Marvin Jones on FanDuel doesn’t make much sense. Over the past three games, in which Matt Stafford has gotten on track, Jones has put up 18.6, 15.8, and 26.2 FD points respectively. In an A+ matchup there’s no reason to go away from Jones.

 

FanDuel Tight End - Week 10 DFS Pick

Rob Gronkowski (@DEN, $8,100) 

Gronk is a relatively easy choice this week, assuming the ability or desire to pay up at the position. The Broncos still can’t cover opposing tight ends, as they have allowed 14.47 FD points per game to them on the season. Coming off of a bye week, the Patriots will be prepared to take advantage of that huge edge making Gronk worth the premium.

 

FanDuel Defense - Week 10 DFS Pick

Chicago Bears (vs. CIN, $4,300)

The Bears have been a respectable defense all season, especially at home, and the Packers offense has been non-existent since the loss of Aaron Rodgers. It comes as little surprise that they have an implied total of just 16.25 The Bears will be the chalk defense of the week, but at this price point there is good reason why.

 

More Week 10 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Coby White

Could Make Season Debut Sunday
Josh Giddey

Set to Return Sunday
Zion Williamson

Tagged as Questionable for Sunday
Ja Morant

Exits With Calf Injury Saturday
Alex Caruso

Injures Hand, Won't Return Saturday
Domantas Sabonis

Considered Questionable for Sunday
Paolo Banchero

Out Again on Sunday
Anthony Davis

Listed as Doubtful for Sunday
Aaron Nesmith

Ruled Out for at Least Four Weeks
Victor Wembanyama

Questionable for Sunday
Tari Eason

to Miss 4-6 Weeks
Julian Strawther

Will Play on Saturday Versus the Timberwolves
Marcus Smart

Out With Illness Saturday
Cameron Johnson

Ruled Out on Saturday Evening
Rui Hachimura

Won't Play on Saturday
Giannis Antetokounmpo

Officially Available Versus the Lakers
Jeff Skinner

Placed on Injured Reserve
Nikola Jokić

Nikola Jokic Available on Saturday Night
Matt Duchene

Continues to Sit Saturday
Thomas Harley

a Game-Time Call Saturday
Kaapo Kakko

Out Week-to-Week
Joseph Woll

Starts on Saturday
John Carlson

Out on Saturday
Rasmus Dahlin

Rejoins Sabres Lineup Saturday
Jack Hughes

to Miss Eight Weeks After Finger Surgery
Luguentz Dort

Will Return Versus Charlotte
Darius Garland

Remains Out on Saturday Night
Zach Edey

Cleared to Make 2025 Debut on Saturday
Cedric Coward

Available Against Cleveland
Sam LaPorta

Placed on Injured Reserve
J.K. Dobbins

Will Undergo Season-Ending Surgery to Repair "Significant" Foot Injury
Tyler Bertuzzi

a Game-Time Call Saturday
Andre Burakovsky

Available Saturday
Alex Nedeljkovic

Available for Saturday's Action
Filip Hronek

Pulled by Concussion Spotter Friday
Jesperi Kotkaniemi

Hurts Ankle in Friday's Win
Seth Jarvis

Not Expected to Be Out for Long
CFB

Garrett Nussmeier Doubtful vs. Arkansas On Saturday
Edwin Díaz

Blue Jays Interested in Signing Edwin Diaz?
Jacob deGrom

Named AL Comeback Player of the Year
Ronald Acuña Jr.

Ronald Acuna Jr. Wins NL Comeback Player of the Year Award
Aroldis Chapman

Named AL Reliever of the Year
Edwin Díaz

Edwin Diaz Named NL Reliever of the Year
NFL

Bill Belichick Won't Pursue NFL Head-Coaching Vacancies
Khalil Shakir

in the Clear to Play in Week 11
Bam Knight

Considered Questionable for Week 11
Brian Thomas Jr.

Tagged as Questionable for Week 11
Calvin Ridley

Listed as Questionable for Week 11
John Gibson

Fine for Saturday
Kaiden Guhle

Ruled Out for 8-10 Weeks
Justin Thomas

Will Miss Start Of 2026 After Undergoing Back Surgery
Alex Newhook

to Miss Four Months With Broken Ankle
Marco Rossi

Out Week-to-Week
J.K. Dobbins

Out in Week 11 and for "Foreseeable Future"
Zach Hyman

Set for Season Debut Saturday
Jack Hughes

Sustains Non-Hockey Hand Injury
Quinn Hughes

a Game-Time Decision Friday
Rashod Bateman

Ruled Out for Week 11
Sam LaPorta

Ruled Out for Week 11 With Back Injury
Isiah Pacheco

Officially Ruled Out for Week 11
Trey Hendrickson

Shemar Stewart Both Out for Week 11
Jaxson Dart

Officially Ruled Out for Week 11 Due to Concussion
Darius Slayton

Ruled Out for Sunday
Davante Adams

Questionable for Sunday but Expected to Play
Drake London

Questionable vs Panthers
Islam Makhachev

Set For UFC 322 Main Event
Jack Della Maddalena

Set For His First Title Defense
Zhang Weili

Can Become The New Women's Flyweight Champion
Valentina Shevchenko

Set For UFC 322 Co-Main Event
Garrett Wilson

Jets Expect Garrett Wilson to Play Again This Season
Michael Morales

Looks To Remain Undefeated
Lamar Jackson

Ready to Roll for Sunday
CFB

Mario Craver a Game-Time Decision for Week 12
Sean Brady

Set For Title Eliminator Bout
Quentin Johnston

Questionable to Play Against Jaguars
Carlos Prates

A Favorite At UFC 322
Jaxson Dart

"on Track" in the Concussion Protocol
Leon Edwards

Looks To Get Back In The Win Column
Benoît Saint Denis

Benoit Saint Denis Set To Open Up UFC 322 Main Card
Beneil Dariush

Looks To Win Back-To-Back Fights
Chris Godwin

Missing Another Game
CFB

Virginia's Chandler Morris Trending Toward Facing Duke on Saturday
Edwin Díaz

Edwin Diaz Says There's a "50-50" Chance he Returns to Mets
Shohei Ohtani

Wins his Fourth MVP Award
Aaron Judge

Wins AL MVP Award Again
Raisel Iglesias

Dodgers Interested in Signing Raisel Iglesias
Pete Alonso

Orioles Could be in the Mix to Sign Pete Alonso
Félix Bautista

Felix Bautista Could Return in Second Half in 2026
Kodai Senga

Attracting Trade Interest, Will the Mets Move him?
Yordan Alvarez

Expected to be Ready for Spring Training
Byron Buxton

Could Waive his No-Trade Clause
Paul Skenes

the Unanimous NL Cy Young Winner
Tarik Skubal

Wins AL Cy Young for Second Straight Year
CFB

Still No Update on Jermod McCoy's Return Timeline
Sami Valimaki

Riding Momentum Into Bermuda
Matthieu Pavon

Struggling Through a Rough Season
Taylor Montgomery

Hopes to Get Back on Track at Port Royal
Ben Martin

a Risky Play at Bermuda Championship
Mark Hubbard

Primed for a Bounce-Back Week in Bermuda
Lee Hodges

Searching for a Spark in Bermuda
Stephen Vogt

Wins Back-to-Back AL Manager of the Year Honors
Milwaukee Brewers

Pat Murphy Named NL Manager of the Year Again
Patrick Fishburn

Looking to Bounce Back in Bermuda
Eric Cole

Carrying Momentum into Bermuda
Tommy Edman

to Have Ankle Surgery Next Week
Ketel Marte

Diamondbacks Unlikely to Trade Ketel Marte
Roman Anthony

to Have a Normal Offseason
Sahith Theegala

Finishes Tied for 27th at Bank of Utah Championship
Sam Stevens

Finishes Tied for 36th at Baycurrent Classic
Patrick Rodgers

Finishes Tied For Sixth at World Wide Technology Championship
Luke List

Finishes 75th at World Wide Technology Championship
Ben Kohles

Finishes Tied for 63rd at World Wide Technology Championship
PGA

Nico Echavarria Finishes Tied for 14th at World Wide Technology Championship
Luke Clanton

Finishes Tied for 46th at World Wide Technology Championship
Blades Brown

Finishes Tied for 18th at Korn Ferry Tour Championship
CFB

Nic Anderson Could Return for LSU this Season

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP