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FanDuel Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Justin Bales' week six FanDuel lineup picks. Daily fantasy football sleepers, value picks and lineups advice for FanDuel DFS games and tournaments.

Welcome to RotoBaller's daily fantasy football FanDuel lineup picks for Week 6 of the NFL season. In this article, I, Justin Bales, will be taking you, the reader, through the best FanDuel DFS plays of the week for this upcoming Sunday.

These FanDuel lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. Good luck with your FanDuel DFS lineups!

Editor's Note: If you like FanDuel, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

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FanDuel Quarterback - Week 6 DFS Picks

Drew Brees (vs CAR, $8,500)

Drew Brees could go a little under owned this season, as people seem to be focusing more on the Panthers offense than the Saints offense. Brees is always an elite option at home and the Panthers have been an average pass defense this season. Brees has scored 26.94 and 31.42 fantasy points in two home starts, while this game has a 53 point total. The Saints are small underdogs, which means they will be throwing the entire game, and Brees should have no problems hitting value this week.

 

FanDuel Running Backs - Week 6 DFS Picks

Le'Veon Bell (at MIA, $9,300)

Le'Veon Bell is one of the most expensive players on the slate, and for good reason. He's essentially a wide receiver playing running back at this point in the season. He's consistent lining up in the slot, and he has 17 targets through two games. He also has 38 carries in those games, and is truly a workhorse player. He gets a good matchup against the Dolphins where the Steelers are -7 point favorites. They should get an early lead and rely heavily on Le'Veon Bell to run the clock out in the second half. He's an elite option this weekend.

Carlos Hyde (at BUF, $7,300)

Carlos Hyde is a volume runner, and the 49ers have no problem giving him the volume he needs. He's also an elite red zone option, as he has six touchdowns in five weeks this season. He gets somewhat of a tough matchup against the Bills, but they aren't an elite defense by any means. The 49ers are big underdogs, but they are every week, and they have no problem giving Hyde the ball when they are losing. He's also coming off a six reception game, which adds even more value to him as a player. He's a high upside tournament option this week.

 

FanDuel Wide Receivers - Week 6 DFS Picks

Mike Wallace (at NYG, $6,400)

Steve Smith Sr. is dealing with an injury and he likely will not play this week. That will bump Mike Wallace to the top receiver, as can be seen last week when Smith got hurt and Wallace ended the game with 11 targets. The Ravens also fired their offensive coordinator, and replaced him with Marty Mornhinweg. Mornhinweg loves running the ball, but his offenses also always rank in the top of the league in big plays, which is where Wallace is at his best. He'll have a high floor because of his volume, but he also comes with an elite ceiling. He's a great option in all leagues against the Giants secondary.

Cameron Meredith (vs JAC, $5,400)

Meredith will likely be chalk this week, and it would be wise to use him. He's coming off a game in which he had nine receptions for 130 yards and one touchdown on 12 targets. Brian Hoyer recently stated that if teams are going to take away Alshon Jeffery, the Bears will have to beat them in other ways, which suggests Meredith will continue to see the large amount of targets. He's a big player with touchdown potential, and he's too cheap this week. Cash teams should be started with him.

 

FanDuel Tight End - Week 6 DFS Picks

Jimmy Graham (vs ATL, $6,900)

Jimmy Graham struggled early in the season, but he has 12 receptions for 213 yards and one touchdown on 17 targets over his last two games. There was a report that Graham and Russell Wilson have been working out together after practice to establish a rhythm, and it has worked out recently. He gets a good matchup against the Falcons, and the Seahawks should be able to score plenty of points this week. Graham comes with great upside, but he's significantly cheaper than the elite tight ends on the slate. He can safely be used in all leagues.

 

FanDuel Defense - Week 6 DFS Picks

Detroit Lions D/ST (vs LA, $4,500)

The Lions defense and special teams has struggled quite a bit this season, but this is an elite matchup. The Rams have the worst offense in the NFL, and they have struggled to score this season. The Lions haven't looked great, but they are -2.5 favorites in a game set at only 43.5 points. Unfortunately, the Vikings are on bye this week, so we'll have to find a someone else to use. The Lions will allow you to spend more money at other positions, which is never a bad idea when there is a low game total.




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REAL-TIME FANTASY NEWS

David Perron

to Miss 5-7 Weeks Due to Hernia Surgery
Luke Kornet

Ruled Out Against Jazz
Mikko Rantanen

Unavailable Thursday
Marvin Bagley III

Sidelined on Thursday
Davion Mitchell

Uncertain to Play Thursday Against Portland
Kel'el Ware

Ruled Out Thursday Against the Trail Blazers
Julius Randle

Added to Thursday's Injury Report as Questionable
Franz Wagner

Ruled Out Thursday Against Charlotte
MacKenzie Gore

Rangers Acquire MacKenzie Gore From the Nationals
LaMelo Ball

Questionable for Thursday's Matchup in Orlando
Moussa Cisse

Upgraded to Probable
Daniel Gafford

Downgraded to Doubtful Thursday Against Golden State
Khris Middleton

Upgraded to Available Thursday Against Denver
Bilal Coulibaly

Not Ready to Return Thursday
Josh Giddey

Likely to Play Thursday Against the Timberwolves
Jalen Suggs

Ruled Out Thursday
Evgeni Malkin

Collects Two Points in Win Over Flames
Christian Dvorak

Notches Three Points in Wednesday's Loss
Clayton Keller

Saves Mammoth From Loss Wednesday Night
Lukas Dostal

Overcomes Avalanche With 40 Saves
Dylan Larkin

Leads Red Wings Past Maple Leafs
Oliver Ekman-Larsson

Exits With Lower-Body Injury Wednesday
Josh Doan

Lands Seven-Year Extension From Sabres
Keyonte George

Iffy for Thursday's Tilt
Lauri Markkanen

Remains Unavailable Thursday
Josh Giddey

Holds Questionable Tag Thursday
Jamal Murray

Probable for Juicy Fantasy Matchup Thursday
Paul George

Could Miss Third Straight Game Thursday
Joel Embiid

Considered Probable Thursday
Kawhi Leonard

Questionable Thursday
Kevin Porter Jr.

Out Indefinitely With Oblique Strain
Brandon Sproat

Dealt to Brewers in Four-Player Trade
Jett Williams

Brewers Acquire Jett Williams From Mets
Freddy Peralta

Mets Acquire Freddy Peralta From Brewers
Seth Jones

to Miss Olympics
Martin Pospisil

Makes Season Debut Wednesday
Teddy Blueger

Available Wednesday Night
Tom Wilson

Comes Off Injured Reserve
Luke Hughes

Devils Place Luke Hughes on Long-Term Injured Reserve
Valeri Nichushkin

Returns to Action Wednesday
Kris Letang

a Game-Time Call Wednesday
Kyle Tucker

Expected to Bat Second or Third in Dodgers' Lineup
Brandon Aiyuk

has "Played his Last Snap as a Niner"
Cody Bellinger

Signs Five-Year, $162.5 Million Contract With Yankees
Adam Scott

Looks to Overcome Putting Woes at American Express
Billy Horschel

Looking to Rebound at The American Express
Josh Allen

Might Need Foot Surgery
Russell Henley

Looks to Build on Strong Start at The American Express
Jason Day

Looking to Start 2026 Strong at The American Express
Wyndham Clark

Looking to Regain Form at The American Express
Sam Burns

Looks to Continue Success at The American Express
Akshay Bhatia

Looking to Flip the Script at The American Express
Christiaan Bezuidenhout

Looking to Build on Strong Fall in Season Debut
Kurt Kitayama

Hopes To Continue Strong Start to 2026 Season at American Express
CFB

Princewill Umanmielen Expected to Sign with LSU
Scottie Scheffler

Returns To American Express After Missing Last Year's Edition
Robert MacIntyre

Keeps Momentum Rolling Heading Into American Express
Brian Harman

Can Challenge at American Express if His Putter Stays Hot
Ben Griffin

Outstanding Form Continues Heading Into American Express
Matt Fitzpatrick

Continues Playing Well Following Outstanding Finish to 2025 Season
Patrick Cantlay

Looks to Get a Jump Start on His 2026 Season
Blades Brown

Set to Make First PGA Tour Appearance of 2026
Kevin Roy

Has Some Confidence Heading to Southern California
Josh Morrissey

Has Three-Point Night Against Blues
Min Woo Lee

Poised to Make Bigger Impact in 2026
Miro Heiskanen

Records Three Helpers Tuesday
Brandon Hagel

Stays Hot Tuesday Night
Ryan O'Reilly

Extends Scoring Streak With Three-Point Effort
Max Homa

Needs a Better Start for 2026
Konsta Helenius

Bags Three Points In Tuesday's Win
Tony Finau

Trying to Reverse Disturbing Trend
Cam Davis

Aims for More Accuracy at American Express
Luisangel Acuña

Luisangel Acuna Sent to White Sox in Trade
Luis Robert Jr.

Mets Acquire Luis Robert Jr. from White Sox
Los Angeles Chargers

Mike McDaniel Expected to Become Chargers Offensive Coordinator
Carlos Beltran

Andruw Jones Elected to Baseball Hall of Fame
CFB

Alberto Mendoza Expected to Land at Georgia Tech
Malik Nabers

Giants Hope Malik Nabers Will be Back for Start of Training Camp
CFB

Duke Suing Quarterback Darian Mensah
Cam Skattebo

Should be Ready by OTAs
George Kittle

Expects to Return "Well Before November"
CFB

Alberto Mendoza Entering Transfer Portal
Mookie Betts

Plans to Retire at the End of his Current Contract
Tennessee Titans

Titans Set to Hire Robert Saleh as Next Head Coach
Miami Dolphins

Dolphins Expected to Hire Jeff Hafley as Next Head Coach
Zach Charbonnet

has Torn ACL
Zach Charbonnet

Needs Knee Surgery, Out for Rest of Playoffs
Tennessee Titans

Mike McCarthy a Finalist for Titans Head-Coaching Job?
Colston Loveland

Suffers Concussion in Divisional Round Loss
Kyren Williams

Scores Two Touchdowns in Divisional Round Win
Buffalo Bills

Bills Fire Head Coach Sean McDermott
Rhamondre Stevenson

Returns in Sunday's AFC Divisional Round Game
Ha-Seong Kim

has Finger Surgery, Out 4-5 Months
Rhamondre Stevenson

Questionable to Return on Sunday With Eye Injury
Woody Marks

Returns Following Brief Exit on Sunday
Dalton Schultz

Won't Return in Sunday's AFC Divisional Round Game
Aaron Rodgers

Steelers Open to Aaron Rodgers Returning in 2026?
Jarrett Stidham

to Start AFC Championship Game
Zach Charbonnet

Questionable to Return Against 49ers

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