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FanDuel Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Justin Bales' week six FanDuel lineup picks. Daily fantasy football sleepers, value picks and lineups advice for FanDuel DFS games and tournaments.

Welcome to RotoBaller's daily fantasy football FanDuel lineup picks for Week 6 of the NFL season. In this article, I, Justin Bales, will be taking you, the reader, through the best FanDuel DFS plays of the week for this upcoming Sunday.

These FanDuel lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. Good luck with your FanDuel DFS lineups!

Editor's Note: If you like FanDuel, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

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FanDuel Quarterback - Week 6 DFS Picks

Drew Brees (vs CAR, $8,500)

Drew Brees could go a little under owned this season, as people seem to be focusing more on the Panthers offense than the Saints offense. Brees is always an elite option at home and the Panthers have been an average pass defense this season. Brees has scored 26.94 and 31.42 fantasy points in two home starts, while this game has a 53 point total. The Saints are small underdogs, which means they will be throwing the entire game, and Brees should have no problems hitting value this week.

 

FanDuel Running Backs - Week 6 DFS Picks

Le'Veon Bell (at MIA, $9,300)

Le'Veon Bell is one of the most expensive players on the slate, and for good reason. He's essentially a wide receiver playing running back at this point in the season. He's consistent lining up in the slot, and he has 17 targets through two games. He also has 38 carries in those games, and is truly a workhorse player. He gets a good matchup against the Dolphins where the Steelers are -7 point favorites. They should get an early lead and rely heavily on Le'Veon Bell to run the clock out in the second half. He's an elite option this weekend.

Carlos Hyde (at BUF, $7,300)

Carlos Hyde is a volume runner, and the 49ers have no problem giving him the volume he needs. He's also an elite red zone option, as he has six touchdowns in five weeks this season. He gets somewhat of a tough matchup against the Bills, but they aren't an elite defense by any means. The 49ers are big underdogs, but they are every week, and they have no problem giving Hyde the ball when they are losing. He's also coming off a six reception game, which adds even more value to him as a player. He's a high upside tournament option this week.

 

FanDuel Wide Receivers - Week 6 DFS Picks

Mike Wallace (at NYG, $6,400)

Steve Smith Sr. is dealing with an injury and he likely will not play this week. That will bump Mike Wallace to the top receiver, as can be seen last week when Smith got hurt and Wallace ended the game with 11 targets. The Ravens also fired their offensive coordinator, and replaced him with Marty Mornhinweg. Mornhinweg loves running the ball, but his offenses also always rank in the top of the league in big plays, which is where Wallace is at his best. He'll have a high floor because of his volume, but he also comes with an elite ceiling. He's a great option in all leagues against the Giants secondary.

Cameron Meredith (vs JAC, $5,400)

Meredith will likely be chalk this week, and it would be wise to use him. He's coming off a game in which he had nine receptions for 130 yards and one touchdown on 12 targets. Brian Hoyer recently stated that if teams are going to take away Alshon Jeffery, the Bears will have to beat them in other ways, which suggests Meredith will continue to see the large amount of targets. He's a big player with touchdown potential, and he's too cheap this week. Cash teams should be started with him.

 

FanDuel Tight End - Week 6 DFS Picks

Jimmy Graham (vs ATL, $6,900)

Jimmy Graham struggled early in the season, but he has 12 receptions for 213 yards and one touchdown on 17 targets over his last two games. There was a report that Graham and Russell Wilson have been working out together after practice to establish a rhythm, and it has worked out recently. He gets a good matchup against the Falcons, and the Seahawks should be able to score plenty of points this week. Graham comes with great upside, but he's significantly cheaper than the elite tight ends on the slate. He can safely be used in all leagues.

 

FanDuel Defense - Week 6 DFS Picks

Detroit Lions D/ST (vs LA, $4,500)

The Lions defense and special teams has struggled quite a bit this season, but this is an elite matchup. The Rams have the worst offense in the NFL, and they have struggled to score this season. The Lions haven't looked great, but they are -2.5 favorites in a game set at only 43.5 points. Unfortunately, the Vikings are on bye this week, so we'll have to find a someone else to use. The Lions will allow you to spend more money at other positions, which is never a bad idea when there is a low game total.




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REAL-TIME FANTASY NEWS

Cameron Payne

Out at Least Two Weeks
Duncan Robinson

Iffy for Monday
Jerami Grant

Out Again Monday
Tobias Harris

Questionable Vs. Magic
Karl-Anthony Towns

Back Against Atlanta
Joel Embiid

Available Monday Vs. Spurs
Mike Trout

Exits Early After Getting Hit by Pitch
Brandon Williams

Good to Go Sunday
Marvin Bagley III

Available Sunday Against Lakers
Moussa Diabaté

Moussa Diabate Back in Lineup Sunday
Kirill Kaprizov

Bags Sixth Career Hat Trick Sunday
Stuart Skinner

Nursing Upper-Body Injury
Charlie Lindgren

Gets the Nod Sunday
Pavel Buchnevich

Ready to Play Sunday Night
Jordan Staal

Jordan Martinook Unavailable Sunday
Frederik Andersen

Takes on Senators Sunday
Linus Ullmark

Faces Hurricanes Sunday
Trevor Lawrence

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Malik Willis

Dolphins Want to Build Around Malik Willis
Courtland Sutton

Has Courtland Sutton's Dropping Dynasty Value Made Him a Buy-Low?
Ryan Rollins

Available Against Grizzlies
David Njoku

One of the Top Remaining Free Agents
Leonard Miller

Matas Buzelis Out Sunday, Leonard Miller Joins Starting Lineup
Tyler Warren

Has Room to Grow in Year Two
Nikola Vučević

Nikola Vucevic Back in Action Sunday
Josh Giddey

Won't Play Against Suns
Trey Murphy III

Out Sunday
Dejounte Murray

Misses Second Straight Game
Anthony Edwards

Won't Play Sunday
Pete Fairbanks

Serving as Opener Before Going on Paternity List
George Klassen

Called Up to Start on Sunday
Stephon Gilmore

Announces his Retirement
Hunter Brown

Placed on 15-Day Injured List with Right-Shoulder Strain
Matthew Stafford

Rams to Put Matthew Stafford on Pitch Count Ahead of 2026 Season?
Isaiah Likely

John Harbaugh "Certain" Isaiah Likely Will Break Out
New York Jets

Jets "Leaning Toward" Arvell Reese at No. 2 Overall
Cleveland Browns

Browns Targeting Carnell Tate at No. 6 Overall?
Tennessee Titans

Titans "Love" Their Running Back Room
Jauan Jennings

Asking for Too Much Money?
Brandon Aiyuk

Nothing Imminent With Brandon Aiyuk
Luther Burden III

Bears Want to Continue to Get the Ball to Luther Burden III
Jesús Luzardo

Jesus Luzardo Dominates Rockies on Saturday
Byron Buxton

Back in Sunday's Lineup
Mookie Betts

Heading to the Injured List With Oblique Strain
A.J. Brown

to be Traded to Patriots on June 2?
Cade Horton

Cubs Place Cade Horton on 15-Day Injured List With Forearm Strain
Isaiah Collier

Out Again Sunday
Immanuel Quickley

Still Sidelined Sunday
Nicolas Claxton

Won't Play Sunday
Evan Mobley

Sidelined Sunday
Jarrett Allen

Won't Play Against Indiana
Clayton Keller

Collects Four Points Against Canucks
Jack Eichel

Records Three Assists in Saturday's Win
Gabe Perreault

Nets First Career Hat Trick
Nicolas Hague

Exits Early Against Sharks
MacKenzie Weegar

Listed as Day-to-Day
Jack McBain

Considered Week-to-Week
Justin Faulk

Questionable Sunday
MarShawn Lloyd

a Dynasty Trade Target with Long-Term Upside?
Emanuel Wilson

a Low-Risk Trade Target in Dynasty Leagues?
Jalen Nailor

Seems Likely to Face Competition
Adrian Kempe

Delivers a Four-Point Performance
Dylan Sampson

a Candidate for Standalone Value in 2026?
Jaylin Noel

Still the Texans' WR4 for 2026?
Evgeni Malkin

Collects Four Points on Saturday
Keenan Allen

Remains a Free Agent in Early April
Mookie Betts

Considered Day-to-Day, Heading for an MRI on Saturday
Juan Soto

Day-to-Day With Minor Groin Strain, No Decision on IL Yet
Nick Lardis

Available Against Kraken
Oliver Ekman-Larsson

Won't Play Saturday
MLB

Cubs-Guardians Game Postponed on Saturday
Mookie Betts

Leaves Early With Back Injury
Tyler Kleven

Out Week-to-Week
Mason Marchment

Expected to Return Saturday
Aliaksei Protas

Returns on Saturday
Alejandro Kirk

Placed on 10-Day Injured List With Thumb Fracture
Juan Soto

Mets Concerned About Juan Soto's Calf Injury
Juan Soto

Removed with Calf Tightness
Byron Buxton

is Day-to-Day with Forearm Contusion
Byron Buxton

Leaves on Friday After Being Hit by a Pitch
Cade Horton

Headed for Injured List Stint
Isaac Paredes

Placed on Bereavement List
Jordan Lawlar

Suffers Fractured Wrist, Set to Miss 6-8 Weeks
Alejandro Kirk

Having X-Rays on his Thumb
Chris Duncan

Set For UFC Vegas 115 Main Event
Renato Moicano

An Underdog At UFC Vegas 115
Tabatha Ricci

Set For UFC Vegas 115 Co-Main Event
Virna Jandiroba

Looks To Bounce Back
Brendson Ribeiro

In Desperate Need Of Win
Abdul-Rakhman Yakhyaev

Looks To Remain Unbeaten
Ethyn Ewing

Set For His Second UFC Bout
Rafael Estevam

Looks To Remain Undefeated
CFB

Gunner Stockton Looking "Great" After Offseason Injury
CFB

Sam Leavitt Showing "Encouraging Signs" at LSU Practice
J.J. Spaun

Needs the Putter to Cooperate in San Antonio
Thorbjorn Olesen

Trending Up in San Antonio
Denny McCarthy

Carrying Momentum into San Antonio
Chris Kirk

Has Course History on His Side in San Antonio
Billy Horschel

a Volatile Option at the Valero Texas Open
Joe Highsmith

Still Searching for Form in San Antonio
Christiaan Bezuidenhout

Looks to Find Form at the Valero Texas Open
Jordan Spieth

a Horse for Course History at TPC San Antonio
Robert MacIntyre

Has One Flaw to Overcome at Valero Texas Open to be a Must-Play
Maverick McNealy

In Exceptional Form This Season
Michael Thorbjornsen

Playing Well But Still Searching For A Win
Hideki Matsuyama

Playing Well Heading to the Valero Texas Open
Si Woo Kim

Heads to Valero Texas Open For Final Tune-Up Before Masters
Collin Morikawa

Withdraws From Valero Texas Open
PGA

Stephan Jaegar Still Looking For Consistency at Valero Texas Open
Nicolai Hojgaard

is Red-Hot Coming to TPC San Antonio
Tony Finau

a Risky Proposition at Valero Texas Open
Ludvig Aberg

Looks to Shake Off Collapse at Valero Texas Open
Patrick Rodgers

Needs to Make More Birdies in San Antonio
Sepp Straka

Seeks Opportunity in San Antonio This Weekend
Nick Taylor

Could Again Struggle at the Valero Texas Open
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF