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FanDuel Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Justin Bales' week six FanDuel lineup picks. Daily fantasy football sleepers, value picks and lineups advice for FanDuel DFS games and tournaments.

Welcome to RotoBaller's daily fantasy football FanDuel lineup picks for Week 6 of the NFL season. In this article, I, Justin Bales, will be taking you, the reader, through the best FanDuel DFS plays of the week for this upcoming Sunday.

These FanDuel lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. Good luck with your FanDuel DFS lineups!

Editor's Note: If you like FanDuel, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

Editor's Note: Find sleeper picks, undervalued ADPs, and draft targets to help you dominate your fantasy football drafts. Try our free who to draft tool for personalized recommendations.

 

FanDuel Quarterback - Week 6 DFS Picks

Drew Brees (vs CAR, $8,500)

Drew Brees could go a little under owned this season, as people seem to be focusing more on the Panthers offense than the Saints offense. Brees is always an elite option at home and the Panthers have been an average pass defense this season. Brees has scored 26.94 and 31.42 fantasy points in two home starts, while this game has a 53 point total. The Saints are small underdogs, which means they will be throwing the entire game, and Brees should have no problems hitting value this week.

 

FanDuel Running Backs - Week 6 DFS Picks

Le'Veon Bell (at MIA, $9,300)

Le'Veon Bell is one of the most expensive players on the slate, and for good reason. He's essentially a wide receiver playing running back at this point in the season. He's consistent lining up in the slot, and he has 17 targets through two games. He also has 38 carries in those games, and is truly a workhorse player. He gets a good matchup against the Dolphins where the Steelers are -7 point favorites. They should get an early lead and rely heavily on Le'Veon Bell to run the clock out in the second half. He's an elite option this weekend.

Carlos Hyde (at BUF, $7,300)

Carlos Hyde is a volume runner, and the 49ers have no problem giving him the volume he needs. He's also an elite red zone option, as he has six touchdowns in five weeks this season. He gets somewhat of a tough matchup against the Bills, but they aren't an elite defense by any means. The 49ers are big underdogs, but they are every week, and they have no problem giving Hyde the ball when they are losing. He's also coming off a six reception game, which adds even more value to him as a player. He's a high upside tournament option this week.

 

FanDuel Wide Receivers - Week 6 DFS Picks

Mike Wallace (at NYG, $6,400)

Steve Smith Sr. is dealing with an injury and he likely will not play this week. That will bump Mike Wallace to the top receiver, as can be seen last week when Smith got hurt and Wallace ended the game with 11 targets. The Ravens also fired their offensive coordinator, and replaced him with Marty Mornhinweg. Mornhinweg loves running the ball, but his offenses also always rank in the top of the league in big plays, which is where Wallace is at his best. He'll have a high floor because of his volume, but he also comes with an elite ceiling. He's a great option in all leagues against the Giants secondary.

Cameron Meredith (vs JAC, $5,400)

Meredith will likely be chalk this week, and it would be wise to use him. He's coming off a game in which he had nine receptions for 130 yards and one touchdown on 12 targets. Brian Hoyer recently stated that if teams are going to take away Alshon Jeffery, the Bears will have to beat them in other ways, which suggests Meredith will continue to see the large amount of targets. He's a big player with touchdown potential, and he's too cheap this week. Cash teams should be started with him.

 

FanDuel Tight End - Week 6 DFS Picks

Jimmy Graham (vs ATL, $6,900)

Jimmy Graham struggled early in the season, but he has 12 receptions for 213 yards and one touchdown on 17 targets over his last two games. There was a report that Graham and Russell Wilson have been working out together after practice to establish a rhythm, and it has worked out recently. He gets a good matchup against the Falcons, and the Seahawks should be able to score plenty of points this week. Graham comes with great upside, but he's significantly cheaper than the elite tight ends on the slate. He can safely be used in all leagues.

 

FanDuel Defense - Week 6 DFS Picks

Detroit Lions D/ST (vs LA, $4,500)

The Lions defense and special teams has struggled quite a bit this season, but this is an elite matchup. The Rams have the worst offense in the NFL, and they have struggled to score this season. The Lions haven't looked great, but they are -2.5 favorites in a game set at only 43.5 points. Unfortunately, the Vikings are on bye this week, so we'll have to find a someone else to use. The Lions will allow you to spend more money at other positions, which is never a bad idea when there is a low game total.




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REAL-TIME FANTASY NEWS

Zach Bogosian

Unavailable Saturday
Marcus Johansson

Questionable for Saturday
Bo Horvat

to Miss Fourth Straight Game Saturday
Seth Jarvis

to Be "Out for a While"
Phillip Danault

Rejoins Canadiens for Draft Pick
Mason Marchment

Blue Jackets Acquire Mason Marchment
Ja Morant

to Miss Second Straight Game Saturday
Brandon Lowe

Pirates Acquire Brandon Lowe in Three-Team Trade
RJ Barrett

to Remain Out Saturday
Jakob Poeltl

Facing Another Potential Absence Saturday
Jerami Grant

Picks Up Questionable Tag
Deandre Ayton

to Miss Matchup Against Clippers Saturday
Lauri Markkanen

Unlikely to Play Saturday
Klay Thompson

Iffy for Saturday
Anthony Davis

Expected to Play Saturday
James Harden

Available Saturday
Domantas Sabonis

to Miss 4-5 More Weeks
Anthony Edwards

Returns Without Minutes Restriction Friday
Zach Collins

Upgraded to Available Friday
Tre Jones

Available With Minutes Restriction
Ayo Dosunmu

Returns From Three-Game Absence
Kasparas Jakucionis

Makes First Career Start Friday
Davion Mitchell

Ruled Out Friday
Craig Porter Jr.

Skips Friday's Game
Sam Hauser

Available Versus Heat
Shane Baz

Orioles Acquire Shane Baz From the Rays
Andrew Wiggins

Misses Friday's Action
Donovan Mitchell

Unavailable Friday Due to Illness
Jonathan Marchessault

Out Day-to-Day
Tristan Jarry

Oilers Place Tristan Jarry on Injured Reserve
Patrick Kane

to Remain Out Saturday
Shea Theodore

Considered Week-to-Week
Karl-Anthony Towns

& Josh Hart Active Friday Night
Jack Eichel

to Miss at Least Two More Games
Davante Adams

Likely Won't Play in Week 17
Jordan Martinook

Misses Friday's Contest
Evan Rodrigues

Available Against Hurricanes
Tyler Seguin

Undergoes Surgery, to Be Re-Evaluated After Olympics
Marvin Harrison Jr.

Listed as Questionable for Week 16
Drake London

Expected to Play Sunday
Tee Higgins

Questionable to Play in Week 16
Michael Carter

Will Start at RB in Week 16
Dalton Kincaid

Will Practice on Friday, Expected to Play on Sunday
Garrett Wilson

Shelved for Remainder of 2025
CFB

Darian Mensah Returning to Duke Next Season
CFB

Josh Hoover Linked to Indiana in Transfer Portal
CFB

Arch Manning Agrees to Reduced Compensation for 2026 Season
Zach Werenski

Enjoys Second Consecutive Multi-Goal Game
Logan Thompson

Collects Second Shutout of the Season
Linus Ullmark

Blanks Penguins Thursday
Tyson Kozak

Hurt Against Flyers
Conor Timmins

to Miss 6-8 Weeks With Broken Leg
Tristan Jarry

Sustains Lower-Body Injury Versus Bruins
Anthony Cirelli

Injured in Thursday's Loss
Kenneth Walker III

Breaks Off Long Touchdown in Comeback Win vs. Rams
Matthew Stafford

Racks Up Highest Yardage Total in Over a Decade
Puka Nacua

Delivers Career-Best Performance on Thursday Night Football
Michael King

Padres Bring Michael King Back on Three-Year Deal
Logan Webb

Will Pitch for Team USA in World Baseball Classic
Tarik Skubal

Joins Team USA for World Baseball Classic
Jakobi Meyers

Jaguars Agree to Three-Year Extension With Jakobi Meyers
Davante Adams

Officially Out on Thursday Night
Devin Neal

Placed on Injured Reserve, Will Not Return in 2025
CFB

Will Muschamp Becoming Next Texas Defensive Coordinator
Christian Watson

Questionable for Week 16
Josh Jacobs

Listed as Questionable for Saturday Night
T.J. Watt

Unlikely to Play in Week 16
D'Andre Swift

Questionable to Face the Packers
Rome Odunze

Ruled Out for Week 16
Jawhar Jordan

Could be in for Significant Workload Against Raiders
Rome Odunze

Expected to Miss Third Straight Game
CFB

Beau Pribula Set to Enter Transfer Portal
Josh Jacobs

Expected to Play in Week 16
Bo Bichette

Willing to Make the Move to Second Base
CFB

Jeremiyah Love Officially Heading to NFL Draft
CFB

Jake Merklinger Leaving Tennessee for Transfer Portal
Mike Trout

Angels Open to Mike Trout Playing Center Field in 2026
CFB

Kansas State's Jayce Brown Intends to Transfer
CFB

Nation's Leading Passer Drew Mestemaker to Enter Transfer Portal
Justin Crawford

Phillies Planning to Start Justin Crawford in Center Field
CFB

Jayden Maiava Signs New Deal to Return to USC
CFB

Aidan Mizell Won't Return to Florida, Entering Transfer Portal
CFB

East Carolina Targeting Jordan Davis as Next Offensive Coordinator
CFB

Michigan QB Jadyn Davis Set to Enter Transfer Portal
CFB

Travis Williams Joining Texas A&M Defensive Staff
CFB

Dylan Raiola Entering His Name into Transfer Portal
CFB

Cincinnati's Brendan Sorsby Plans to Transfer When Portal Opens
Adolis García

Adolis Garcia, Phillies Finalizing One-Year Deal on Monday
Brandon Royval

Suffers First-Round TKO Loss
CFB

Baylor, LSU, Miami Among Potential Suitors for DJ Lagway
CFB

Aidan Chiles Will Enter Transfer Portal
Manel Kape

Shines At UFC Vegas 112
Kevin Vallejos

Gets Second-Round Knockout Win
Giga Chikadze

Suffers His First Career Knockout Loss
CFB

Quarterback DJ Lagway Entering Transfer Portal
Cesar Almeida

Gets Dominated
Cezary Oleksiejczuk

Wins Sixth Fight In A Row
Morgan Charrière

Morgan Charriere Suffers First-Round Knockout Loss
Melquizael Costa

Gets First-Round Knockout Win
Marcus Buchecha

Still Winless In The UFC
Kennedy Nzechukwu

And Marcus Buchecha Fight To Draw
Lance Gibson jr

Lance Gibson Jr. Drops Decision In His UFC Debut
King Green

Gets Back In The Win Column
Kenley Jansen

Agrees to One-Year Deal With Tigers
Merrill Kelly

Returns to Diamondbacks on Two-Year Deal

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP