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FanDuel Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Justin Bales' week six FanDuel lineup picks. Daily fantasy football sleepers, value picks and lineups advice for FanDuel DFS games and tournaments.

Welcome to RotoBaller's daily fantasy football FanDuel lineup picks for Week 6 of the NFL season. In this article, I, Justin Bales, will be taking you, the reader, through the best FanDuel DFS plays of the week for this upcoming Sunday.

These FanDuel lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. Good luck with your FanDuel DFS lineups!

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FanDuel Quarterback - Week 6 DFS Picks

Drew Brees (vs CAR, $8,500)

Drew Brees could go a little under owned this season, as people seem to be focusing more on the Panthers offense than the Saints offense. Brees is always an elite option at home and the Panthers have been an average pass defense this season. Brees has scored 26.94 and 31.42 fantasy points in two home starts, while this game has a 53 point total. The Saints are small underdogs, which means they will be throwing the entire game, and Brees should have no problems hitting value this week.

 

FanDuel Running Backs - Week 6 DFS Picks

Le'Veon Bell (at MIA, $9,300)

Le'Veon Bell is one of the most expensive players on the slate, and for good reason. He's essentially a wide receiver playing running back at this point in the season. He's consistent lining up in the slot, and he has 17 targets through two games. He also has 38 carries in those games, and is truly a workhorse player. He gets a good matchup against the Dolphins where the Steelers are -7 point favorites. They should get an early lead and rely heavily on Le'Veon Bell to run the clock out in the second half. He's an elite option this weekend.

Carlos Hyde (at BUF, $7,300)

Carlos Hyde is a volume runner, and the 49ers have no problem giving him the volume he needs. He's also an elite red zone option, as he has six touchdowns in five weeks this season. He gets somewhat of a tough matchup against the Bills, but they aren't an elite defense by any means. The 49ers are big underdogs, but they are every week, and they have no problem giving Hyde the ball when they are losing. He's also coming off a six reception game, which adds even more value to him as a player. He's a high upside tournament option this week.

 

FanDuel Wide Receivers - Week 6 DFS Picks

Mike Wallace (at NYG, $6,400)

Steve Smith Sr. is dealing with an injury and he likely will not play this week. That will bump Mike Wallace to the top receiver, as can be seen last week when Smith got hurt and Wallace ended the game with 11 targets. The Ravens also fired their offensive coordinator, and replaced him with Marty Mornhinweg. Mornhinweg loves running the ball, but his offenses also always rank in the top of the league in big plays, which is where Wallace is at his best. He'll have a high floor because of his volume, but he also comes with an elite ceiling. He's a great option in all leagues against the Giants secondary.

Cameron Meredith (vs JAC, $5,400)

Meredith will likely be chalk this week, and it would be wise to use him. He's coming off a game in which he had nine receptions for 130 yards and one touchdown on 12 targets. Brian Hoyer recently stated that if teams are going to take away Alshon Jeffery, the Bears will have to beat them in other ways, which suggests Meredith will continue to see the large amount of targets. He's a big player with touchdown potential, and he's too cheap this week. Cash teams should be started with him.

 

FanDuel Tight End - Week 6 DFS Picks

Jimmy Graham (vs ATL, $6,900)

Jimmy Graham struggled early in the season, but he has 12 receptions for 213 yards and one touchdown on 17 targets over his last two games. There was a report that Graham and Russell Wilson have been working out together after practice to establish a rhythm, and it has worked out recently. He gets a good matchup against the Falcons, and the Seahawks should be able to score plenty of points this week. Graham comes with great upside, but he's significantly cheaper than the elite tight ends on the slate. He can safely be used in all leagues.

 

FanDuel Defense - Week 6 DFS Picks

Detroit Lions D/ST (vs LA, $4,500)

The Lions defense and special teams has struggled quite a bit this season, but this is an elite matchup. The Rams have the worst offense in the NFL, and they have struggled to score this season. The Lions haven't looked great, but they are -2.5 favorites in a game set at only 43.5 points. Unfortunately, the Vikings are on bye this week, so we'll have to find a someone else to use. The Lions will allow you to spend more money at other positions, which is never a bad idea when there is a low game total.




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REAL-TIME FANTASY NEWS

Chris Boucher

Active Thursday vs. Kings
Jalen Duren

Won't Return Thursday After Ankle Injury
Ryan Kalkbrenner

Ruled Out Again Friday
Josh Hart

Sidelined for Fourth Straight Game
Kyshawn George

to Miss Fourth Straight Game Friday
Joel Embiid

Cleared to Play Thursday vs. Mavericks
Jonas Valančiūnas

Jonas Valanciunas Ruled Out for At Least Four Weeks
Bo Bichette

Yankees Showing Interest in Bo Bichette
D'Angelo Russell

Ruled Out Thursday With Illness
George Kittle

Listed as Questionable for Week 18
Alperen Sengün

Alperen Sengun Active Versus Nets
Amon-Ra St. Brown

Trending Towards Playing
Clint Capela

Steven Adams and Clint Capela Sidelined Thursday
Miles Wood

Blue Jackets Place Miles Wood on Injured Reserve
Dak Prescott

May Not Play Full Game in Week 18
Conor Garland

to Miss One Week
Egor Demin

Won't Suit Up Against Houston
Marco Rossi

to Miss at Least One Week
Ace Bailey

Still Out on Thursday Night
Tari Eason

Active on Thursday
Yegor Chinakhov

Set for Penguins Debut Thursday
Lauri Markkanen

Ruled Out on Thursday
Tanner McKee

Will Start for Eagles in Week 18
Shayne Gostisbehere

Misses Third Consecutive Game Thursday
Keyonte George

Unavailable on Thursday
Michael Porter Jr.

Out on Thursday
Auston Matthews

Returns From One-Game Absence
Josh Allen

Trending Towards Resting in Week 18
William Nylander

Remains Out Thursday
Lamar Jackson

Will Officially Return in Week 18
Tobias Harris

Won't Suit Up Against Miami
Lauri Markkanen

on the Injury Report for Thursday Night
Keyonte George

Battling an Illness, Might Miss Thursday's Game
Jusuf Nurkić

Jusuf Nurkic Won't Play on Thursday Evening
Houston Astros

Astros Sign Tatsuya Imai to Three-Year Deal
Jordan Love

Clears Concussion Protocol, Won't Start in Week 18
George Kittle

"Absolutely" Expects to Play in Week 18
Clayton Tune

to Start for Packers in Week 18
Chris Olave

Ruled Out for Week 18
Tom Wilson

Wraps Up 2025 With Gordie Howe Hat Trick
Valeri Nichushkin

Nets Second Career Hat Trick
Frank Vatrano

to Miss Six Weeks With Shoulder Injury
Conor Sheary

Noah Laba Exit With Injuries Wednesday
Brayden McNabb

Suffers Upper-Body Injury Wednesday
Miles Wood

Exits Early Wednesday
Gavin Brindley

Sustains Upper-Body Injury
Michael Porter Jr.

Battling Illness, Questionable Thursday
Davante Adams

Not Expected to Play in Week 18
Geno Smith

Won't Play in Week 18
Aaron Rodgers

Considering Playing Beyond 2025?
Sean Monahan

Sits Out Wednesday's Game
Zach Werenski

Misses Fourth Straight Game Wednesday
Dougie Hamilton

Questionable Wednesday
Radko Gudas

Expected to Remain Out Wednesday
Stefon Diggs

Expected to Play in Week 18
Ilya Lyubushkin

Back From One-Game Absence Wednesday
Alex Lyon

to Miss "Bit of Time"
Erik Cernak

Rejoins Lightning Lineup Wednesday
Christian McCaffrey

Trending to Play in Week 18
Jalen Hurts

Eagles Expected to Rest Jalen Hurts, Most Starters in Week 18
George Kittle

49ers Will be "Very Surprised" if George Kittle Doesn't Play on Saturday
Marvin Harrison Jr.

Ruled Out for Regular-Season Finale
CFB

Lane Kiffin Interested in Sam Leavitt, Brendan Sorsby at LSU
CFB

Deuce Knight Officially Entering Transfer Portal
CFB

Kewan Lacy Expected to Be Full-Go Against Georgia
Stefon Diggs

Facing Strangulation, Assault Charges
CFB

Chip Kelly Named Northwestern Offensive Coordinator
Riley Leonard

Will Start Against the Texans
Bijan Robinson

Explodes for 229 Total Yards, Two Touchdowns on Monday Night
CFB

Penn State Working to Hire D'Anton Lynn as Next Defensive Coordinator
CFB

Omar Cooper Expected to be Full-Go for Rose Bowl
CFB

Marcus Freeman Staying with Notre Dame for 2026 Season
CFB

Star Wideout Cam Coleman Entering Transfer Portal
CFB

Jay Hill Expected to be Next Michigan Defensive Coordinator

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