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DraftKings Lineup Picks (Week 15) - NFL DFS Advice

RotoBallers, welcome to Week 15 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 15 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 14!

 

DraftKings Quarterbacks - Week 15 DFS Picks

Matt Ryan - ATL @ TB (DK - $6,300)

Ryan is coming off a very rough three interception game, but now has a very favorable match up in his favor. He is at division rival Tampa Bay, who has the 31st DVOA against the pass, who when he played them earlier this season, he put up over 300 yards and one touchdown. This is a level of production that he should be able to match, considering the Falcons have an implied team total of 27 points, which is third highest on the slate. This game is on Monday night, so you will have to have to play on one of the expanded slates to get to him. Given the match up, he has multi-touchdown upside and a good play for GPPs.

Derek Carr - OAK vs DAL (DK - $5,700)

Carr has scored 14.5 or more DraftKings points in six of his last seven games, and is facing a weak defensive opponent. At his price, he really only needs about 16 DK points in order to reach 3x value for cash games. He is up against the Cowboys, who have the 22nd DVOA against the pass, and have shown they are very weak in the secondary. Carr will be without Amari Cooper, so pairing him with Michael Crabtree is a good idea for either format. Carr along with the Raiders haven't been consistent this season, so some DFS player might be afraid to roster him, opening the chance for lower ownership.

 

DraftKings Running Backs - Week 15 DFS Picks

Dion Lewis - RB, NE @ PIT (DK - $5,400)

Lewis has double digit rushing attempts in seven of his last last eight games, along with 11 targets in his lat four games. This game vs the Steelers has an over-under of 53 points, making it the highest of the slate, so you will want some exposure to this game. He isn't too expensive, and with the snaps he is seeing, he can pay off his salary quickly. The Steelers have the 29th DVOA against running backs in the passing game, which makes this a fantastic match up, considering his PPR value out of the backfield.

LeSean McCoy - RB, BUF vs MIA (DK - $8,400)

McCoy is in line to see plenty of work this week considering the fact the Bills are in a tough spot at quarterback. Seemingly for the past month, the Bills have a rotating cast at quarterbacks, because of injuries. McCoy had 32 carries last week, which is super high, but that was mainly due to the weather. He won't see that type of volume every week, but with Tyrod Taylor on the injury report, he could see close to it. McCoy is up against the Dolphins who have the 14th DVOA against the run.

 

DraftKings Wide Receivers - Week 15 DFS Picks

Michael Thomas - WR, NO vs NYJ (DK - $7,400)

Thomas is coming off his best game of the season, and is in an even better spot this week. He is up against the Jets who have the 27th DVOA against pass, and the 30th DVOA against WR1. This is a prime spot for him, and has massive PPR value. He has seen eight or more targets in 12 of 13 games this season, and should be able to replicate that production. He is almost a lock for 12 or more DraftKings points, and should be good for any format this week.

Keelan Cole - WR, JAX vs HOU (DK - $3,700)

Cole has 27 targets over his last five games, and for his price, he offers a ton of savings. He is up against the Texans who have the 18th DVOA against the pass, and the 27th DVOA against WR2. Cole also has touchdowns in two straight weeks, and is in a good spot to repeat that. This game may not have the highest over-under, but Cole offers some much needed savings on this full slate.

 

DraftKings Tight End - Week 15 DFS Pick

Evan Engram - TE, NYG vs PHI (DK - $5,600)

Engram has seen six or more targets in 11 of his 13 games this season, and has become the favorite receiver of Eli Manning. He is up against the Eagles, who have the 19th DVOA against tight ends, putting him in a good spot to succeed this week. If you don't want to spend all the way up to get Gronk or Kelce, he makes a good option in the middle. Good for any format this week, as he has PPR value, along with touchdown upside.

 

DraftKings Defense - Week 15 DFS Pick

Minnesota Vikings vs Cincinnati Bengals - (DK - $3,500)

The Vikings are averaging three more DraftKings points at home this season, and are now up against a Bengals team who has been very inconsistent on offense. They have seven sacks over their past four games, and two interceptions over that span. They are one of the more expensive options on the slate, so getting up to them in price price can be hard in cash games, but they are a great tournament option.

 

More Week 15 DFS Analysis

 




REAL-TIME FANTASY NEWS

Jake Walman

to Miss at Least Two More Weeks
Berkly Catton

Out Week-to-Week
Franz Wagner

Likely to Miss 2-4 Weeks
Nils Hoglander

Set for Season Debut Monday
Elias Pettersson

Misses Second Straight Game
Logan Cooley

Out Indefinitely
Brayden Point

Nikita Kucherov, Brayden Point Back for Lightning Monday
CFB

Anthony Hill Jr. Declaring for 2026 NFL Draft
CFB

Ryan Walters a Candidate for Tennessee Defensive Coordinator Job?
Trey Hendrickson

Set for Core-Muscle Surgery, Expected to Miss Around Six Weeks
Drake London

Considered Day-to-Day Going into Thursday Night
Jayden Daniels

No Long-Term Concerns for Jayden Daniels
Zach Ertz

MRI Confirms Season-Ending Torn ACL for Zach Ertz
Tee Higgins

Back in the Concussion Protocol
Riley Leonard

Week 15 Status Uncertain Due to Knee Injury
Mike Evans

Could Return on Thursday Night
De'Von Achane

May Require Rest This Week
Daniel Jones

' Season Over With Torn Achilles
Rory McIlroy

Ends 2025 as the Year's Most Unburdened Player
Aaron Rai

Needs to Figure Out Putting Woes This Offseason
Jordan Spieth

Plays Better on Paper in 2025 Than Results Show
Shedeur Sanders

Will Start for Browns the Rest of the Season
PGA

Chris Gotterup Needs to Find Better Touch and Consistency This Offseason
Hideki Matsuyama

Ends 2025 Season With a Bookend Victory
CFB

Tennessee Fires Defensive Coordinator Tim Banks
Scottie Scheffler

Comes Up Just Shy of Hero World Challenge Victory
Jordan Poole

Remains Sidelined on Monday
Merab Dvalishvili

Drops A Decision At UFC 323
Herbert Jones

Tagged as Questionable Against Spurs
Petr Yan

Reclaims Bantamweight Title
CeeDee Lamb

Progressing Well After Concussion
Stephon Castle

has a Chance to Return on Monday
Alexandre Pantoja

Era Ends With Gruesome Injury
Joshua Van

Becomes Second-Youngest UFC Champion
Dillon Brooks

Iffy for Monday Night
Brandon Moreno

Suffers His First TKO Loss
Brandon Moreno

Tatsuro Taira Becomes First Fighter To Finish Brandon Moreno
Garrett Wilson

No Timetable Yet for Garrett Wilson's Return
Henry Cejudo

Payton Talbott Retires Henry Cejudo
Henry Cejudo

Retires After UFC 323 Loss
Jan Blachowicz

Bogdan Guskov Vs. Jan Blachowicz Ends In A Majority Draw
Jan Blachowicz

And Bogdan Guskov Fight To Majority Draw
Dennis Schröder

Dennis Schroder Could Return on Monday Night
Keegan Murray

Listed as Questionable Vs. Pacers
DK Metcalf

Spends Night in Hospital Due to Stomach Pain
CFB

Texas RB CJ Baxter Entering Transfer Portal
Mark Stone

Records Two Assists in Sunday's Win
Carter Hart

Defeats Rangers Sunday
Cutter Gauthier

Delivers Two Assists Sunday
Leo Carlsson

Nets Two Goals in Blowout Win
Logan Thompson

Posts First Shutout of the Season
Brayden Schenn

Leads Blues to Victory Sunday
Macklin Celebrini

Bags Three Points in Impressive Road Victory
Jaylen Wright

Runs Wild in Week 14 Win
Chase Brown

Scores Two Touchdowns in Week 14 Loss
Nico Collins

Leads Texans in Receiving in Sunday Night Win
San Francisco Giants

Jeff Kent Elected to Baseball Hall of Fame
Ketel Marte

Red Sox Interested in Trading for Ketel Marte
Kyle Schwarber

Pirates Make Four-Year Offer to Kyle Schwarber
Travis Etienne Jr.

Scores Two Touchdowns in Week 14
Christian Watson

Continues to Find the End Zone in Week 14
Blake Corum

Leads Rams Backfield With Phenomenal Week 14 Showing
Michael Wilson

Enjoys Heavy Involvement in Week 14
Puka Nacua

Enjoys Best Game of the Season in Rout of Cardinals
CFB

Mississippi State, Rice Accept Bowl Bids as 5-7 Teams
CFB

Auburn, Florida State, Baylor Among Teams to Decline Bowl Bids
Paul George

Available on Sunday Evening
Joel Embiid

Available Against Lakers
Lauri Markkanen

Ruled Out Versus OKC
Jimmy Butler III

Officially Active on Sunday Night
CFB

Rob Aurich Set to Become Nebraska's Defensive Coordinator
LeBron James

Available Versus Philadelphia
MON

Samuel Montembeault Ruled Out for Sunday
Carter Hart

Available Against Rangers Sunday
Ryan Leonard

to Miss "Extended Period of Time"
John Carlson

a Game-Time Decision Sunday
Jordan Kyrou

Unavailable Against Canadiens
Matt Duchene

Set to Return Against Penguins
Pyotr Kochetkov

Back for Hurricanes Sunday
Evgeni Malkin

Won't Play on Sunday
CFB

Notre Dame Opting Out of Postseason Amid College Football Playoff Exclusion
Karl-Anthony Towns

Ruled Out Against Orlando
Draymond Green

Remains on the Shelf Versus Chicago
Jimmy Butler III

Expected to Return on Sunday
Immanuel Quickley

Now Probable Versus Boston
Shai Gilgeous-Alexander

Will Miss First Game of the Year on Sunday
Joel Embiid

Upgraded to Probable Against Lakers
Ja Morant

Doubtful Against Portland
Robert Williams III

Now Questionable Versus Memphis
Donovan Clingan

Questionable Versus Grizzlies
CFB

Kendal Briles a Candidate for South Carolina Offensive Coordinator Job
CFB

James Madison Playoff-Bound After Duke Wins ACC Title?
CFB

Notre Dame, Miami, Alabama on College Football Playoff Bubble
CFB

Brent Pry Could Return to Virginia Tech as Defensive Coordinator
Jose A. Ferrer

Mariners Acquire Jose A. Ferrer from the Nationals
Harry Ford

Traded to the Nationals
Cody Bellinger

Drawing Interest From the Phillies
MacKenzie Gore

Will the Nationals Trade MacKenzie Gore?
Byron Buxton

Twins Not Planning to Trade Joe Ryan, Byron Buxton
Petr Yan

Looks To Reclaim Bantamweight Belt
Merab Dvalishvili

Set For His Fourth Title Defense
Joshua Van

Can Become The New Flyweight Champion
Alexandre Pantoja

Set For Fifth Title Defense At UFC 323
Tatsuro Taira

Looks To Win Back-To-Back Fights
Brandon Moreno

Searches For His Third Win In A Row
Payton Talbott

A Favorite At UFC 323
Henry Cejudo

Set For His Retirement Fight
Jan Blachowicz

Set To Open Up UFC 323 Main Card
Bogdan Guskov

Looks To Extend His Win Streak
CFB

Emmett Johnson Leaving Nebraska for 2026 NFL Draft
CFB

Jam Miller Unlikely to Play in SEC Title Game
CFB

Penn State Expected to Hire Matt Campbell from Iowa State
CFB

Arkansas Targeting Ron Roberts for Defensive Coordinator Job
Jhostynxon Garcia

Pirates Acquire Jhostynxon Garcia From Red Sox
Cody Bellinger

Yankees Pushing Hard to Re-Sign Cody Bellinger
CFB

Penn State Eyeing Iowa State Coach Matt Campbell For Coaching Vacancy
Alex Bregman

Cubs Have Renewed Interest in Alex Bregman
CFB

Billy Napier Finalizing Deal to Become James Madison's New Head Coach
CFB

Buster Faulkner Set to Become Florida's New Offensive Coordinator
CFB

Joe Sloan Expected to be Kentucky's New Offensive Coordinator
CFB

Lane Kiffin Working to Keep Defensive Coordinator Blake Baker at LSU
Kyle Tucker

Visits With Blue Jays
Emilio Pagán

Reds Bring Back Closer Emilio Pagan on Two-Year Deal
Cedric Mullins

Rays Agree on One-Year Deal
Freddy Peralta

Brewers Considering Trading Freddy Peralta
Kyle Schwarber

Reds Serious About Adding Kyle Schwarber in Free Agency?

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