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DraftKings Lineup Picks (Week 13) - NFL DFS Advice

RotoBallers, welcome to Week 13 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 13 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 13!

Be sure to check all of our fantasy football rankings for 2025:

 

DraftKings Quarterbacks - Week 13 DFS Picks

Philip Rivers - LAC vs CLE (DK - $7,000)

Rivers is one of the high priced quarterbacks on the slate this, and it's for good reason. He has been playing very well over the past few weeks, putting up two or more touchdowns in four of his last five weeks and has a very favorable match up. This week he is at home against the Browns, who have the 27th DVOA against the pass. This is a prime spot for Rivers and the Chargers offense, so pairing him with either Keenan Allen or Hunter Henry is a great idea. Rivers could be better suited for tournaments, since he is high priced, and could be tough to get to for cash games.

Jameis Winston - TB @ GB (DK - $5,600)

If you are looking for a cheaper option at quarterback, who also has some upside, take a look at Winston he has been cleared to play and will be taking on the Packers, who have the 22nd DVOA against the pass. The Packers have given up 23 or more points in five of their last six games, as their defense is really struggling this season. Winston has 10 touchdowns through eight games this season, and with Doug Martin out with a concussion, we should see the Buccaneers pass the ball plenty.

 

DraftKings Running Backs - Week 13 DFS Picks

Jamaal Williams - GB vs TB (DK - $4,700)

With the Packers top two running backs hurt, we should see Williams get the start yet again. He has 18 or more carries in three straight weeks, and looks to be one of the chalkier options on the slate, especially for cash games. He has 18 or more carries in three straight weeks, and is now up against the Buccaneers, who have the 20th DVOA against the run, which makes this a very favorable match up. Williams also offers a bit of savings, so the roster construction path becomes a bit easier if you are looking to fit in some higher priced players.

Leonard Fournette - JAX vs IND (DK - $7,800)

Fournette is a 20+ carry back, but hasn't seen the level of production in some recent games. He has 33 or fewer rushing yards in two of his last three games, but is in a great bounce back spot at home. He is up against the Colts, who have the 13th DVOA against the run, and the 23rd DVOA overall. The game script is projecting that the Jaguars will be up, and with how good their defense is, they should have a lead, be read to pound the running game. Fournette hasn't scored a touchdown in three weeks, so he is due for a bit of positive regression.

 

DraftKings Wide Receivers - Week 13 DFS Picks

Johnny Holton - OAK vs NYG (DK - $3,400)

With both Amari Cooper and Michael Crabtree being out for this game, the back ups for the Raiders will see an expanded role. Not only does Holton offer a ton of salary relief, he has big play potential. This season, he has four catches for 161 yards, and two touchdowns. He is averaging about 40 yards per catch, which shows he is being targeted down the field. Now that average isn't sustainable, but is shows he has the explosiveness, and against a Giants team who have the 23rd DVOA against the pass, it is certainly a possibility this week.

Brandin Cooks - NE @ BUF (DK - $7,700)

Cooks has five or more receptions in four straight weeks, and seems to be benefiting with Chris Hogan out due to an injury. His targets have increased, and he is making the best of them. He has touchdowns in two straight games, and has a decent match up this week, against the Bills who have the 11th DVOA against the pass. The Patriots have the highest implied team total on the slate at 28 points, so we know they will be scoring a ton.

 

DraftKings Tight End - Week 13 DFS Pick

Jack Doyle - IND @ JAX (DK - $5,200)

Doyle is one of the more consistent tight ends in the league, but doesn't get the praise, since he plays for a bad team. He has seven or more receptions in seven of his 10 games this season. Great PPR value from him, and with the Colts projected to be down, they will need to throw the ball. Easy check down passes will be the go to for Brissett, so expect plenty of action for Doyle.

 

DraftKings Defense - Week 13 DFS Pick

Oakland Raiders vs New York Giants (DK $3,100)

The Raiders aren't a defense most people look to roster, but they are in a good spot this week given the match up. They are at home against a now, Geno Smith led New York Giants team. The Giants announced they are benching Eli, and we will see the turnover prone Smith take the field. The Raiders have seven sacks over their last three games, and are a seven point favorite at home. Good for any format this week, and they aren't expensive.

 

More Week 13 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Daniel Gafford

Resting Against Clippers
Jalen Duren

Won't Play Versus Miami
Warren Foegele

Not Ready to Return Saturday
Simon Benoit

Won't Play Saturday
Henri Jokiharju

Lands on Injured Reserve
Anthony Davis

Ruled Out on Saturday
Zack Wheeler

Likely to Return in May
Pavel Zacha

a Game-Time Call Saturday
Ryan Helsley

Agrees to Two-Year Deal With Orioles
David Pastrnak

Out for Second Consecutive Game
William Nylander

Available Saturday
Shedeur Sanders

Could Start for Browns for the Rest of the Season
Kyle Palmieri

Out for 6-8 Months With Torn ACL
Darren Waller

Activated from Injured Reserve, Will Play in Week 13
Amon-Ra St. Brown

"Day-to-Day" With Ankle Injury, Status for Week 14 Unclear
Neemias Queta

Uncertain for Saturday's Game in Minnesota
Derrick White

Expected to Suit Up Versus Timberwolves
Jaylen Brown

Might Miss Saturday's Game
Tyler Warren

Added to Injury Report, Questionable With Illness
Baker Mayfield

Expected to Play in Week 13
Jake Walman

Sidelined for Third Consecutive Game
Jack Roslovic

to Miss Two Weeks
Ryan Nugent-Hopkins

to Return Saturday
Mattias Samuelsson

in Concussion Protocol
Kyle Palmieri

Sustains Lower-Body Injury
Lukas Dostal

Ruled Out for 2-3 Weeks
Amon-Ra St. Brown

Test Confirm Low-Ankle Sprain for Amon-Ra St. Brown
Anthony Davis

Available, Will be on a Minutes Restriction
Kyle Monangai

Leads Bears Backfield in Impressive Week 13 Performance
D'Andre Swift

Goes Over 100 Rushing Yards, Finds End Zone in Win Over Eagles
A.J. Brown

Goes Over 100 Yards Again, Scores Twice on Friday
Kyshawn George

Returns to Lineup After One-Game Absence
Paul George

Set To Start Friday Against Nets
Kevin Huerter

Set to Return Against Charlotte
Jarrett Allen

Back in Action on Friday
Coby White

Cleared for Action on Friday
Nikola Vučević

Nikola Vucevic Suiting Up Against Charlotte
Trey Murphy III

Uncertain For Saturday's Matchup
Giannis Antetokounmpo

Returning Versus Knicks
Jaden Ivey

Set To Play Against Orlando
Adem Bona

Back on Friday Night
Andrew Nembhard

Won't Play Versus Washington
De'Anthony Melton

Eyeing Road-Trip Return
Kristaps Porzingis

Sidelined on Friday Night
Kenneth Walker III

Good to Go for Week 13
Jonathan Kuminga

Questionable Ahead Of Pelicans Matchup
Brian Thomas Jr.

Good to Go Sunday
Marvin Harrison Jr.

Questionable for Week 13
Bucky Irving

Fully Practices Friday, Listed as Questionable for Week 13
Omarion Hampton

Ruled Out for Week 13
Baker Mayfield

Practices in Full Friday, Listed as Questionable for Week 13
Kirill Marchenko

Misses Third Straight Game
Drake London

Officially Ruled Out for Week 13
Jaden Schwartz

to Miss Six Weeks
Chris Olave

Officially Questionable to Play in Week 13 Due to Back Injury
Andre Burakovsky

Set to End Three-Game Absence
Alvin Kamara

Will Not Play in Week 13
William Nylander

Out Friday With Illness
J.J. McCarthy

Officially Ruled Out for Week 13
Ryan Hartman

Returns to Action Friday
Brady Tkachuk

Officially Available Friday
Ja'Marr Chase

Helps Bengals Snap Four-Game Skid on Thanksgiving
Mike Matheson

Signs Five-Year Extension
C.J. Stroud

Will Play on Sunday
Brady Tkachuk

Aims to Return Friday
Dylan Cease

Agrees With Blue Jays on Seven-Year, $210 Million Deal
Anthony Rendon

Angels Could Buy Out Final Year of Anthony Rendon's Contract
Josh Hader

Says his Shoulder is "Back to Normal"
Ketel Marte

Diamondbacks "Actively Listening" on Ketel Marte
J.T. Realmuto

Red Sox Showing Interest in J.T. Realmuto
Sonny Gray

Red Sox Acquire Sonny Gray From the Cardinals
CFB

Jeremiah Smith, Makai Lemon, Skyler Bell Named Biletnikoff Award Finalists
Shohei Ohtani

to Play for Team Japan in 2026 World Baseball Classic
Colorado Rockies

Warren Schaeffer to Stick Around as Rockies Manager in 2026
CFB

Chris Bell Out for Rivalry Matchup Against Kentucky
Ryan Helsley

Tigers Eyeing Ryan Helsley as a Starter
Dan Hooker

Suffers Second-Round Submission Loss
Marcus Semien

Shipped to the Mets on Sunday
Arman Tsarukyan

Gets Submission Win
Brandon Nimmo

Traded to Texas
Belal Muhammad

Loses Back-to-Back Fights
Belal Muhammad

Ian Machado Garry Outpoints Belal Muhammad
Alonzo Menifield

Suffers First-Round Knockout Loss
Volkan Oezdemir

Gets Back In The Win Column

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