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DraftKings Lineup Picks (Week 10) - NFL DFS Advice

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 10 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 10!

 

DraftKings Quarterbacks - Week 10 DFS Picks

Matthew Stafford - DET vs CLE (DK $6,800)

Stafford is looking like one of the best options at quarterback this week, and coming off a big game. He played on Monday night, so his price wasn't adjusted for his performance last week. This is somewhat minor, but still and edge to be gained and we want to jump on it. Stafford has put up 300 yards or more in three straight games, and has seven touchdowns in his last four games. Really strong numbers from the highest paid quarterback. With his price and recent performance you could use him in either cash or GPPs, since he has a favorable match up. Speaking of his opponent, let's talk about the Browns! The Browns have the 28th DVOA against the pass, and simply cannot not stop the ball via the air. You want to find them every week, and target against them. Get exposure to them by either the quarterback or the receivers. The Browns are actually very good vs the run, so nearly all of the Lions offense will come from Stafford.

Ryan Fitzpatrick - TB vs NYJ (DK $4,900)

If you are looking for a cheap quarterback that has a solid match up, key in on Fitzpatrick this week. Not only is this a nice revenge game for him, going up against his former team, but the Jets have the 21st DVOA against the pass, and haven't looked strong on defense. For his price, he really only needs to put up 14.7 DraftKings points in order to reach 3x value, which is what you are looking for in cash games. Anything more than that, and will make a good tournament play. Stacking him with someone like DeSean Jackson, makes a good play since he has plenty of touchdown upside.

 

DraftKings Running Backs - Week 10 DFS Picks

LeSean McCoy - BUF vs. NO (DK $8,300)

Seems like few people are talking about McCoy this week, and might be due to the fact he had such a bad showing last Thursday night. If no one is going to be rostering him, he makes a great tournament play, since he has multi touchdown upside, along with seeing plenty of targets out of the backfield. Getting the full point PPR on DraftKings is huge for a running back, and will have plenty of chances to break the 100 yard bonus in either rushing or receiving. He is $400 cheaper than he was in the two previous weeks, and is at home against the Saints who have the 28th DVOA against the rush. The Saints defense has improved a good amount since the beginning of the season, but it was mainly their secondary. They are still weak vs the run, and with this game set to be cold with a bit of weather, the Bills should be running the ball plenty.

Carlos Hyde - SF vs NYG (DK $6,300)

Hyde is looking to be one of the stone locks this week, for multiple reasons, so let's dive in. First off, he is at home against the Giants, who have have the 28th DVOA overall, and the 26th DVOA against the rush. We all know how bad the Giants are, and they simply cannot stop really anyone on defense. They are bad against the run, bad against the pass, and most importantly, bad against running backs in the passing game. Hyde has six or more targets in four straight weeks, including nine or more in the last two. A running back getting that volume is huge, just as I mentioned with McCoy. Hyde has also seen 12 or more rushing attempts in four straight weeks. They are feeding him the ball in all aspects of the game, and with how bad the 49ers quarterback situation is, he should be in for a very busy day.

 

DraftKings Wide Receivers - Week 10 DFS Picks

Cooper Kupp - LAR vs HOU (DK $4,600)

Kupp was a bit unlucky last week with the Rams putting up so many points, yet barley seeing the ball at all. He ended with three catches on five targets for 54 yards and no touchdowns. Yes, Jared Goff, only completed 14 passes, so Kupp didn't have a ton of chances. But this week Kupp has a good match up against the Texans, who have the 16th DVOA against the pass, and the 30th DVOA against WR2. With the inconsistency Sammy Watkins has been showing, Kupp is seeing the second most targets on the team, with 47 targets in the first nine weeks. The Texans defense really isn't as good as people think, and attacking them in this spot is a good call.

A.J. Green - CIN @ TEN (DK $7,700)

Green is simply too cheap this week. A player with his skill, and his potential ceiling of points should not be under $8K. Whenever a player is in a spot like this, you want to jump all over him, since he price won't stay this low. Yes, his ownership could get a bit out of hand in GPPs, but having legit two touchdown upside for under $8K is fantastic. Last week he was ejected from the game for a fight, so his stats are a bit out of wack. Without last game, he has 46 targets in the prior five, and four touchdowns over that span. Pretty straight forward spot, don't over think it because of last week.

 

DraftKings Tight End - Week 10 DFS Pick

Kyle Rudolph - MIN @ WAS (DK $4,600)

Rudolph is one of the more consistent tight ends in the league, and is viable for any format this week. He has seven or more targets in four straight weeks, and has two touchdowns over that span. He has become one of the favorite targets for backup quarterback Case Keenum, and gets the volume any DFS player loves. Rudolph also has a very favorable match up, since he is up against the Redskins, who have the 29th DVOA against tight ends. Really like him in this spot, just getting up to his price may be hard, if you are trying to roster two top end running backs.

 

DraftKings Defense - Week 10 DFS Pick

Chicago Bears vs Green Bay Packers (DK $3,000)

Bears are going to be one of the more popular options at defense this week, and it comes with good reason. They are up against at Brett Hundley led Packers team, who as we all saw on Monday night, are very bad. The Packers are having a ton of trouble moving the ball offensively, and picking on them in fantasy is a good call. The Bears have 14 sacks over the past four weeks, along with four interceptions. They are putting pressure on the quarterback, and forcing bad decisions. They aren't too expensive, and should have a good floor of points.

 

More Week 10 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Maxx Crosby

Trending Toward Playing Against Broncos
Chris Olave

Set to Play Vs. Bucs
LaMelo Ball

Won't Suit Up Against Denver
Immanuel Quickley

Questionable for Sunday Afternoon
Deshaun Watson

Expected to Stay With Browns Next Year
Klay Thompson

Downgraded Versus Houston
Alperen Sengün

Alperen Sengun Out Again on Saturday Evening
Tyler Herro

Will Miss Another Game on Saturday
Jimmy Butler III

Out Again on Saturday Night
Draymond Green

Ruled Out Versus Cleveland
Jose A. Ferrer

Mariners Acquire Jose A. Ferrer from the Nationals
Mason Marchment

Expected to Return Saturday
Danila Yurov

Returns From Two-Game Absence Saturday
Jesperi Kotkaniemi

Available Saturday
Harry Ford

Traded to the Nationals
Shane Pinto

to Miss Two Weeks
David Pastrnak

Misses Fifth Consecutive Game Saturday
Andrei Vasilevskiy

Remains Out Saturday
Nikita Kucherov

Out on Saturday
Jayden Reed

Activated Off Injured Reserve, Will Play in Week 14
Omarion Hampton

Activated From IR, Faces Uncertain Workload Monday Night
Cody Bellinger

Drawing Interest From the Phillies
MacKenzie Gore

Will the Nationals Trade MacKenzie Gore?
Justin Herbert

Officially Listed as Questionable for Monday Night Football
Justin Herbert

Chargers "Expecting" Justin Herbert to Play in Week 14
Yves Missi

Trending Toward Game-Time Decision
Khris Middleton

Questionable With Knee Soreness Against Hawks
Noah Clowney

On Track To Suit Up Against Pelicans
De'Anthony Melton

Questionable With Knee Management
Draymond Green

Questionable With Mid-Foot Sprain
Jimmy Butler III

Day-To-Day As Warriors Prepare For Cleveland
Mikko Rantanen

Picks Up Three Points Against Sharks
Kyle Connor

Scores in Fourth Consecutive Game
Beckett Sennecke

Notches Two Points in Friday's Win
Ryan Leonard

Suffers Upper-Body Injury Friday
Carter Hart

Day-to-Day With Lower-Body Injury
Brayden Point

Questionable for Saturday
Victor Hedman

Expected to Return Saturday
Byron Buxton

Twins Not Planning to Trade Joe Ryan, Byron Buxton
Patrick Williams

Dalen Terry Available Versus Pacers
Coby White

Returns With Minutes Restriction Friday
Ayo Dosunmu

Out Friday Against Pacers
Zach Collins

Available for Season Debut Friday
Robert Williams III

Donovan Clingan Out, Robert Williams III in for Portland Friday
Evan Mobley

Ready to Play Friday
Kristaps Porzingis

Coming Off the Bench Friday
Spencer Jones

Available Against Hawks
Ozzy Wiesblatt

to Miss 8-10 Weeks With Upper-Body Injury
Pierre-Olivier Joseph

Out With Illness Friday
Evander Kane

Doubtful for Friday
Conor Garland

Back From Two-Game Absence Friday
Thomas Harley

Could Be an Option Next Week
Mikael Granlund

Returning From 10-Game Absence Friday
John Carlson

Misses Second Consecutive Game Friday
Rome Odunze

has Fractured Foot, Labeled Week-to-Week
Sauce Gardner

Ruled Out for Sunday
Petr Yan

Looks To Reclaim Bantamweight Belt
Merab Dvalishvili

Set For His Fourth Title Defense
Joshua Van

Can Become The New Flyweight Champion
Aaron Jones Sr.

Cleared to Play in Week 14
Chris Olave

Listed as Questionable for Week 14
Alexandre Pantoja

Set For Fifth Title Defense At UFC 323
Tatsuro Taira

Looks To Win Back-To-Back Fights
Alvin Kamara

Ruled Out for Sunday
Brandon Moreno

Searches For His Third Win In A Row
Rome Odunze

Ruled Out for Week 14
Payton Talbott

A Favorite At UFC 323
Henry Cejudo

Set For His Retirement Fight
Drake London

Ruled Out vs Seattle
Jan Blachowicz

Set To Open Up UFC 323 Main Card
Lamar Jackson

Will Play on Sunday
Bogdan Guskov

Looks To Extend His Win Streak
CFB

Emmett Johnson Leaving Nebraska for 2026 NFL Draft
Dalton Kincaid

to be Questionable for Week 14
Tee Higgins

Clears Concussion Protocol, is a Full-Go for Sunday
CFB

Jam Miller Unlikely to Play in SEC Title Game
CFB

Penn State Expected to Hire Matt Campbell from Iowa State
Mike Evans

Not Quite Ready to Return This Week
Jayden Daniels

Will Start Against Vikings
Lamar Jackson

Returns to Practice, on Track to Play on Sunday
Kyler Murray

Won't Return This Year, Cardinals Non-Committal on his Future
CFB

Arkansas Targeting Ron Roberts for Defensive Coordinator Job
Jhostynxon Garcia

Pirates Acquire Jhostynxon Garcia From Red Sox
Cody Bellinger

Yankees Pushing Hard to Re-Sign Cody Bellinger
CFB

Penn State Eyeing Iowa State Coach Matt Campbell For Coaching Vacancy
Alex Bregman

Cubs Have Renewed Interest in Alex Bregman
CFB

Billy Napier Finalizing Deal to Become James Madison's New Head Coach
CFB

Buster Faulkner Set to Become Florida's New Offensive Coordinator
CFB

Joe Sloan Expected to be Kentucky's New Offensive Coordinator
CFB

Lane Kiffin Working to Keep Defensive Coordinator Blake Baker at LSU
CFB

Brian Daboll a Candidate for Penn State Head-Coaching Job?
Kyle Tucker

Visits With Blue Jays
Emilio Pagán

Reds Bring Back Closer Emilio Pagan on Two-Year Deal
Cedric Mullins

Rays Agree on One-Year Deal
Freddy Peralta

Brewers Considering Trading Freddy Peralta
Kyle Schwarber

Reds Serious About Adding Kyle Schwarber in Free Agency?
CFB

Brent Key Signing Five-Year Deal to Remain at Georgia Tech
CFB

Brian Hartline Expected to Land USF Head-Coaching Job
CFB

Collin Klein Expected to be Top Target for Kansas State if Head-Coach Job Opens
CFB

Chris Klieman Considering Stepping Down at Kansas State
CFB

D.J. Durkin Staying at Auburn Under Alex Golesh
CFB

Charlie Weis Jr. Permitted to Coach Ole Miss Offense in College Football Playoff
CFB

Five-Star Quarterback Jared Curtis Flips Commitment From Georgia to Vanderbilt
CFB

Florida Hiring Brad White as Defensive Coordinator
Kyle Schwarber

Giants Have Checked in on Kyle Schwarber
Willson Contreras

Willing to Waive his Full No-Trade Clause?
Edwin Díaz

Mets Still Interested in Re-Signing Edwin Diaz
Devin Williams

Agrees to Three-Year Deal With Mets
Cole Ragans

Red Sox Targeting Cole Ragans in a Trade?
CFB

Kentucky Hires Oregon Offensive Coordinator Will Stein As Head Coach
CFB

Kalani Sitake the Top Target for Penn State Coaching Job
CFB

Josh Heupel Says He's Not a Candidate for Penn State Head Coach Job

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