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DraftKings Lineup Picks (Week 10) - NFL DFS Advice

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 10 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 10!

 

DraftKings Quarterbacks - Week 10 DFS Picks

Matthew Stafford - DET vs CLE (DK $6,800)

Stafford is looking like one of the best options at quarterback this week, and coming off a big game. He played on Monday night, so his price wasn't adjusted for his performance last week. This is somewhat minor, but still and edge to be gained and we want to jump on it. Stafford has put up 300 yards or more in three straight games, and has seven touchdowns in his last four games. Really strong numbers from the highest paid quarterback. With his price and recent performance you could use him in either cash or GPPs, since he has a favorable match up. Speaking of his opponent, let's talk about the Browns! The Browns have the 28th DVOA against the pass, and simply cannot not stop the ball via the air. You want to find them every week, and target against them. Get exposure to them by either the quarterback or the receivers. The Browns are actually very good vs the run, so nearly all of the Lions offense will come from Stafford.

Ryan Fitzpatrick - TB vs NYJ (DK $4,900)

If you are looking for a cheap quarterback that has a solid match up, key in on Fitzpatrick this week. Not only is this a nice revenge game for him, going up against his former team, but the Jets have the 21st DVOA against the pass, and haven't looked strong on defense. For his price, he really only needs to put up 14.7 DraftKings points in order to reach 3x value, which is what you are looking for in cash games. Anything more than that, and will make a good tournament play. Stacking him with someone like DeSean Jackson, makes a good play since he has plenty of touchdown upside.

 

DraftKings Running Backs - Week 10 DFS Picks

LeSean McCoy - BUF vs. NO (DK $8,300)

Seems like few people are talking about McCoy this week, and might be due to the fact he had such a bad showing last Thursday night. If no one is going to be rostering him, he makes a great tournament play, since he has multi touchdown upside, along with seeing plenty of targets out of the backfield. Getting the full point PPR on DraftKings is huge for a running back, and will have plenty of chances to break the 100 yard bonus in either rushing or receiving. He is $400 cheaper than he was in the two previous weeks, and is at home against the Saints who have the 28th DVOA against the rush. The Saints defense has improved a good amount since the beginning of the season, but it was mainly their secondary. They are still weak vs the run, and with this game set to be cold with a bit of weather, the Bills should be running the ball plenty.

Carlos Hyde - SF vs NYG (DK $6,300)

Hyde is looking to be one of the stone locks this week, for multiple reasons, so let's dive in. First off, he is at home against the Giants, who have have the 28th DVOA overall, and the 26th DVOA against the rush. We all know how bad the Giants are, and they simply cannot stop really anyone on defense. They are bad against the run, bad against the pass, and most importantly, bad against running backs in the passing game. Hyde has six or more targets in four straight weeks, including nine or more in the last two. A running back getting that volume is huge, just as I mentioned with McCoy. Hyde has also seen 12 or more rushing attempts in four straight weeks. They are feeding him the ball in all aspects of the game, and with how bad the 49ers quarterback situation is, he should be in for a very busy day.

 

DraftKings Wide Receivers - Week 10 DFS Picks

Cooper Kupp - LAR vs HOU (DK $4,600)

Kupp was a bit unlucky last week with the Rams putting up so many points, yet barley seeing the ball at all. He ended with three catches on five targets for 54 yards and no touchdowns. Yes, Jared Goff, only completed 14 passes, so Kupp didn't have a ton of chances. But this week Kupp has a good match up against the Texans, who have the 16th DVOA against the pass, and the 30th DVOA against WR2. With the inconsistency Sammy Watkins has been showing, Kupp is seeing the second most targets on the team, with 47 targets in the first nine weeks. The Texans defense really isn't as good as people think, and attacking them in this spot is a good call.

A.J. Green - CIN @ TEN (DK $7,700)

Green is simply too cheap this week. A player with his skill, and his potential ceiling of points should not be under $8K. Whenever a player is in a spot like this, you want to jump all over him, since he price won't stay this low. Yes, his ownership could get a bit out of hand in GPPs, but having legit two touchdown upside for under $8K is fantastic. Last week he was ejected from the game for a fight, so his stats are a bit out of wack. Without last game, he has 46 targets in the prior five, and four touchdowns over that span. Pretty straight forward spot, don't over think it because of last week.

 

DraftKings Tight End - Week 10 DFS Pick

Kyle Rudolph - MIN @ WAS (DK $4,600)

Rudolph is one of the more consistent tight ends in the league, and is viable for any format this week. He has seven or more targets in four straight weeks, and has two touchdowns over that span. He has become one of the favorite targets for backup quarterback Case Keenum, and gets the volume any DFS player loves. Rudolph also has a very favorable match up, since he is up against the Redskins, who have the 29th DVOA against tight ends. Really like him in this spot, just getting up to his price may be hard, if you are trying to roster two top end running backs.

 

DraftKings Defense - Week 10 DFS Pick

Chicago Bears vs Green Bay Packers (DK $3,000)

Bears are going to be one of the more popular options at defense this week, and it comes with good reason. They are up against at Brett Hundley led Packers team, who as we all saw on Monday night, are very bad. The Packers are having a ton of trouble moving the ball offensively, and picking on them in fantasy is a good call. The Bears have 14 sacks over the past four weeks, along with four interceptions. They are putting pressure on the quarterback, and forcing bad decisions. They aren't too expensive, and should have a good floor of points.

 

More Week 10 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Malik Willis

Gets Three New Receivers in the Draft
Antonio Williams

to See Starting Role on Day 1 in Weak Wide Receiver Room?
Terrance Ferguson

No Longer the Unquestioned Future TE1 in Los Angeles?
Brenton Strange

Does Brenton Strange Still Need to Prove Himself in Jacksonville?
KC Concepcion

Already Facing Competition for Targets in Cleveland
Jacory Croskey-Merritt

Remains the Top Option in Washington Backfield?
MLB

Red Sox Fire Manager Alex Cora and Other Coaches
A.J. Lawson

Questionable for Sunday Due to Back Spasms
Kevin Huerter

Injures Left Hip Saturday
Green Bay Packers

Packers Take Kicker Trey Smack with Pick No. 216
Kelly Oubre Jr.

Iffy for Sunday
Victor Wembanyama

Still Questionable on Injury Report
Denver Broncos

Broncos Select Dallen Bentley with 256th Pick
Kevin Durant

Uncertain for Sunday's Action
Austin Reaves

Listed as Questionable for Sunday's Game 4
Aaron Gordon

Active on Saturday
Indianapolis Colts

Colts Select Deion Burks with Pick No. 254
Joel Embiid

Remains Doubtful Ahead of Game 4
New England Patriots

Patriots Select Jam Miller with 245th Pick
Indianapolis Colts

Colts Select Seth McGowan with Pick No. 237
New England Patriots

Patriots Take Quarterback Behren Morton with Pick No. 234
Kansas City Chiefs

Chiefs Draft Garrett Nussmeier With 249th Overall Pick
Cleveland Browns

Browns Draft Carsen Ryan in the Seventh Round
Tennessee Titans

Titans Select Jaren Kanak with Pick No. 225
Washington Commanders

Commanders Take Quarterback Athan Kaliakmanis with Pick No. 223
Houston Texans

Texans Select Lewis Bond with Pick No. 204
Pittsburgh Steelers

Navy's Eli Heidenreich to the Steelers at No. 230 Overall
Jacksonville Jaguars

Jaguars Double Dip at Wide Receiver with C.J. Williams at Pick No. 203
Josh Manson

Not Expected to Play Sunday
Los Angeles Rams

Rams Select CJ Daniels with 197th Pick
Mason Lohrei

Set to Miss Game 4 as Healthy Scratch
Cincinnati Bengals

Bengals Select Jack Endries at No. 221 Overall
Emil Andrae

Won't Play Saturday
Arturs Silovs

Starting Game 4 Against Flyers
Dan Vladar

Cleared for Game 4
Mats Zuccarello

Remains Out Saturday
Nikolaj Ehlers

Dealing With Lower-Body Injury
Steven Kwan

Scratched With Neck Stiffness
Trey Yesavage

Returning From Injured List on Tuesday
Eugenio Suárez

Eugenio Suarez Heading to the Injured List With Oblique Strain
Kirby Dach

Battles and Scores Two Points in Friday Triumph
Connor McDavid

Delivers Mixed-Bag Performance Friday
MLB

Saturday's Mets-Rockies Game Postponed Due to Weather
Karel Vejmelka

Saves Utah With Huge Effort Friday
Lane Hutson

Scores Crucial Overtime Goal in Montreal Win
Lawson Crouse

Cashes in With Two Goals for Utah
Mikael Granlund

Serves Up Trio of Assists in Anaheim Big Win
Giancarlo Stanton

Exits With Leg Tightness on Friday
Isaiah Joe

Likely to Miss Game 3 Against Suns
Peyton Watson

to Remain Sidelined Saturday
Aaron Gordon

Questionable for Saturday's Game 4
Jordan Goodwin

on Track to Return Saturday
Grayson Allen

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Mark Williams

Won't Play Saturday
Victor Wembanyama

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Tari Eason

Reed Sheppard Move into Starting Five on Friday
Nickeil Alexander-Walker

Wins Most Improved Player Award
Immanuel Quickley

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Kevin Durant

is Ruled Out for Game 3 on Friday
Joel Embiid

Officially Ruled Out for Game 3
Eugenio Suárez

Eugenio Suarez Scratched on Friday With Mid-Back Pain
Troy Terry

Available for Game 3 Against Oilers
Radko Gudas

Misses Second Straight Game Friday
Charle-Edouard D'Astous

Unavailable Friday
Dan Vladar

Considered a Game-Time Call for Saturday
Jake Sanderson

Ruled Out for Game 4 Due to Concussion
Yakov Trenin

Won't Play in Game 4 Against Stars
Mats Zuccarello

a Game-Time Decision Saturday
Jackson Holliday

Receives Positive Test Results, Will be Shut Down for a Week
Jeff Hoffman

Out as Blue Jays Closer
Youssef Zalal

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Aljamain Sterling

An Underdog At UFC Vegas 116
Joselyne Edwards

Set For UFC Vegas 116 Co-Main Event
Norma Dumont

Looks To Extend Her Win Streak
Alexander Hernandez

A Favorite At UFC Vegas 116
Rafa Garcia

Looks For His Third Consecutive Win
Adrian Luna Martinetti

Set For His UFC Debut
Davey Grant

Looks To Get Back In The Win Column
Jaden McDaniels

Records Double-Double in Game 3
Jordan Kyrou

Recovering From Minor Knee Procedure
Francisco Lindor

Expected to Miss "Significant Time"
Francisco Lindor

Mets Officially Place Francisco Lindor on Injured List With Calf Strain
Michael Harris II

Removed Early With Quad Tightness
Francisco Lindor

Likely Headed to the Injured List
Michael Harris II

Continues to Heat Up With Two-Homer Game on Wednesday
Francisco Lindor

Leaves Wednesday's Game Early With Calf Tightness
JR Ritchie

Earns Promotion, Will Make MLB Debut on Thursday
Wyatt Langford

Expected to Go on Injured List With Flexor Strain
Maikel Garcia

Leaves Early on Wednesday With Elbow Soreness
Roman Anthony

Day-to-Day With Sore Back
Juan Soto

Officially Back in Mets Lineup on Wednesday
J.T. Realmuto

Phillies Place J.T. Realmuto on Injured List With Back Injury
CFB

Beau Pribula Leading Virginia Quarterback Competition
Marco Penge

Trending Down Entering Zurich Classic
Sahith Theegala

Eyes Another Strong Week at Zurich Classic
Brooks Koepka

Shane Lowry Teams Up with Brooks Koepka at Zurich Classic
Si Woo Kim

Adds Another Strong Finish at RBC Heritage
Luke Clanton

Hoping to Find Form in New Orleans
Scottie Scheffler

is Starting to Hit His Stride
Brooks Koepka

Looking for Progress in PGA Return With Partner at Zurich Classic
Matt Fitzpatrick

Looks to Share Recent Form at Zurich Classic
CFB

Ashton Daniels Named Florida State's Starting Quarterback
Tyler Reddick

Earns His Fifth Win of the 2026 Season at Kansas
Kyle Larson

Finishes as the Runner-Up at Kansas
Chase Briscoe

Rallies for A New Career-Best Finish at Kansas
Denny Hamlin

Leads the Most Laps at Kansas but Misses Out on Victory
Christopher Bell

Falls Out of Contention for Kansas Victory on Final Restart
Mike Malott

Scores Third-Round TKO Win
Gilbert Burns

Retires After UFC Winnipeg Loss
Charles Jourdain

Extends Winning Streak
Kyler Phillips

Drops Decision At UFC Winnipeg
Mandel Nallo

Suffers First-Round TKO Loss In His UFC Debut
Jai Herbert

Scores First-Round TKO Win
Karine Silva

Gets Dominated at UFC Winnipeg
Jasmine Jasudavicius

Dominates Karine Silva
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