X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


DraftKings Lineup Picks (Week 10) - NFL DFS Advice

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 10 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 10!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings Quarterbacks - Week 10 DFS Picks

Matthew Stafford - DET vs CLE (DK $6,800)

Stafford is looking like one of the best options at quarterback this week, and coming off a big game. He played on Monday night, so his price wasn't adjusted for his performance last week. This is somewhat minor, but still and edge to be gained and we want to jump on it. Stafford has put up 300 yards or more in three straight games, and has seven touchdowns in his last four games. Really strong numbers from the highest paid quarterback. With his price and recent performance you could use him in either cash or GPPs, since he has a favorable match up. Speaking of his opponent, let's talk about the Browns! The Browns have the 28th DVOA against the pass, and simply cannot not stop the ball via the air. You want to find them every week, and target against them. Get exposure to them by either the quarterback or the receivers. The Browns are actually very good vs the run, so nearly all of the Lions offense will come from Stafford.

Ryan Fitzpatrick - TB vs NYJ (DK $4,900)

If you are looking for a cheap quarterback that has a solid match up, key in on Fitzpatrick this week. Not only is this a nice revenge game for him, going up against his former team, but the Jets have the 21st DVOA against the pass, and haven't looked strong on defense. For his price, he really only needs to put up 14.7 DraftKings points in order to reach 3x value, which is what you are looking for in cash games. Anything more than that, and will make a good tournament play. Stacking him with someone like DeSean Jackson, makes a good play since he has plenty of touchdown upside.

 

DraftKings Running Backs - Week 10 DFS Picks

LeSean McCoy - BUF vs. NO (DK $8,300)

Seems like few people are talking about McCoy this week, and might be due to the fact he had such a bad showing last Thursday night. If no one is going to be rostering him, he makes a great tournament play, since he has multi touchdown upside, along with seeing plenty of targets out of the backfield. Getting the full point PPR on DraftKings is huge for a running back, and will have plenty of chances to break the 100 yard bonus in either rushing or receiving. He is $400 cheaper than he was in the two previous weeks, and is at home against the Saints who have the 28th DVOA against the rush. The Saints defense has improved a good amount since the beginning of the season, but it was mainly their secondary. They are still weak vs the run, and with this game set to be cold with a bit of weather, the Bills should be running the ball plenty.

Carlos Hyde - SF vs NYG (DK $6,300)

Hyde is looking to be one of the stone locks this week, for multiple reasons, so let's dive in. First off, he is at home against the Giants, who have have the 28th DVOA overall, and the 26th DVOA against the rush. We all know how bad the Giants are, and they simply cannot stop really anyone on defense. They are bad against the run, bad against the pass, and most importantly, bad against running backs in the passing game. Hyde has six or more targets in four straight weeks, including nine or more in the last two. A running back getting that volume is huge, just as I mentioned with McCoy. Hyde has also seen 12 or more rushing attempts in four straight weeks. They are feeding him the ball in all aspects of the game, and with how bad the 49ers quarterback situation is, he should be in for a very busy day.

 

DraftKings Wide Receivers - Week 10 DFS Picks

Cooper Kupp - LAR vs HOU (DK $4,600)

Kupp was a bit unlucky last week with the Rams putting up so many points, yet barley seeing the ball at all. He ended with three catches on five targets for 54 yards and no touchdowns. Yes, Jared Goff, only completed 14 passes, so Kupp didn't have a ton of chances. But this week Kupp has a good match up against the Texans, who have the 16th DVOA against the pass, and the 30th DVOA against WR2. With the inconsistency Sammy Watkins has been showing, Kupp is seeing the second most targets on the team, with 47 targets in the first nine weeks. The Texans defense really isn't as good as people think, and attacking them in this spot is a good call.

A.J. Green - CIN @ TEN (DK $7,700)

Green is simply too cheap this week. A player with his skill, and his potential ceiling of points should not be under $8K. Whenever a player is in a spot like this, you want to jump all over him, since he price won't stay this low. Yes, his ownership could get a bit out of hand in GPPs, but having legit two touchdown upside for under $8K is fantastic. Last week he was ejected from the game for a fight, so his stats are a bit out of wack. Without last game, he has 46 targets in the prior five, and four touchdowns over that span. Pretty straight forward spot, don't over think it because of last week.

 

DraftKings Tight End - Week 10 DFS Pick

Kyle Rudolph - MIN @ WAS (DK $4,600)

Rudolph is one of the more consistent tight ends in the league, and is viable for any format this week. He has seven or more targets in four straight weeks, and has two touchdowns over that span. He has become one of the favorite targets for backup quarterback Case Keenum, and gets the volume any DFS player loves. Rudolph also has a very favorable match up, since he is up against the Redskins, who have the 29th DVOA against tight ends. Really like him in this spot, just getting up to his price may be hard, if you are trying to roster two top end running backs.

 

DraftKings Defense - Week 10 DFS Pick

Chicago Bears vs Green Bay Packers (DK $3,000)

Bears are going to be one of the more popular options at defense this week, and it comes with good reason. They are up against at Brett Hundley led Packers team, who as we all saw on Monday night, are very bad. The Packers are having a ton of trouble moving the ball offensively, and picking on them in fantasy is a good call. The Bears have 14 sacks over the past four weeks, along with four interceptions. They are putting pressure on the quarterback, and forcing bad decisions. They aren't too expensive, and should have a good floor of points.

 

More Week 10 DFS Analysis

 

NFL DFS Premium Tools & Research

Get a free trial of our powerful NFL Premium Tools. Our famous Matchup Rating Projections, DFS Cheat Sheets, and NFL Lineup Optimizer/Generator.

Win more. Try the most advanced lineup optimizer in daily fantasy football.

Sign Up Now!




REAL-TIME FANTASY NEWS

Philadelphia Eagles

Eagles Offense to Borrow From Kyle Shanahan, Sean McVay in 2026?
Taysom Hill

Saints Haven't Offered a Contract to Taysom Hill
Kayshon Boutte

Working Out Away From the Team
Lamar Jackson

Expected to Return to OTAs Soon
Dalton Kincaid

Taking Part in OTAs This Week
Josh Allen

"Good to Go" for Offseason Workouts
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Rashee Rice

to Miss Two Months After Clean-Up Surgery on his Knee
Dean Wade

Returns to Starting Unit Tuesday
OG Anunoby

Starting on Tuesday
Tobias Harris

May Remain in Motown
Jalen Duren

Pistons Eager to Keep Jalen Duren
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Dallas Mavericks

Jason Kidd Fired as Mavericks Head Coach
De'Aaron Fox

Officially Listed as Questionable for Game 2 Against Thunder
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Tank Bigsby

Is Tank Bigsby a Worthy Dynasty Stash Entering 2026?
Hunter Henry

Profiles as a Dynasty Sell-High Candidate Entering 2026
Gerrit Cole

to Make Season Debut on Friday Against Rays
Matthew Golden

Can Matthew Golden Re-Establish His Dynasty Value in 2026?
Jalen Coker

a Prime Buy-Low Dynasty Target
Dak Prescott

Remains a High-Floor Dynasty Quarterback
CeeDee Lamb

Is CeeDee Lamb's Dynasty Value Poised to Rise in 2026?
Keon Coleman

Joe Brady Likes What he's Seen From Keon Coleman
Deshaun Watson

Hitting it Off With Todd Monken?
Jacoby Brissett

Not Present for First OTA Practice
Tua Tagovailoa

Michael Penix Jr. Splitting First-Team Reps at OTAs
Rashee Rice

Tests Positive for Marijuana, Violating his Probation
Cam Skattebo

Says he'll be Ready for Week 1
De'Von Achane

Present for Start of OTAs This Week
Malik Washington

an Affordable Trade Target in Dynasty Leagues
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
Alex Caruso

Erupts for 31 Points in Game 1 Loss to Spurs
CFB

Kemario Taylor a Breakout Candidate at Quarterback
Jalen Williams

Productive in Comeback Game
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
Shai Gilgeous-Alexander

Records First Double-Double of Postseason
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Stephon Castle

Opens Conference Finals With Double-Double
Dylan Harper

Makes Outstanding Two-Way Impact in Game 1 Win
Victor Wembanyama

Dominates Game 1 Against Thunder
Mattias Samuelsson

Picks Up an Assist in Season-Ending Loss
Rasmus Dahlin

Nets Fourth Postseason Goal
Jakub Dobes

Records 37 Saves in Game 7 Win
Lane Hutson

Contributes Power-Play Assist in Game 7 Victory
Nick Suzuki

Extends Road Point Streak
Alex Newhook

Scores Series-Clincher in Overtime
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Larry Nance Jr.

is Questionable for Game 1 on Tuesday
OG Anunoby

is Probable for Tuesday's Game 1
Luke Kornet

is Cleared for Game 1
New Orleans Pelicans

Jamahl Mosley Agrees to Become Pelicans Next Head Coach
De'Aaron Fox

is Ruled Out for Game 1 on Monday
Ukko-Pekka Luukkonen

Set to Start Game 7
Corey Seager

Going on Injured List With Back Injury
Tage Thompson

Can Match Franchise Record With Another Multi-Point Game
Nick Suzuki

Seeks More Road Success Monday
Lane Hutson

Riding a Five-Game Assist Streak Into Game 7
Filip Gustavsson

Needs Offseason Surgery
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Tobias Harris

Goes Cold in Game 7 Loss
Quinn Hughes

Open to Signing Extension This Offseason
Jalen Duren

Finishes Game 7 with Quiet Line
Cade Cunningham

Endures Cold Shooting Night Sunday
Joel Eriksson Ek

Misses Second Round Due to Heel Injury
Sam Merrill

Catches Fire in Game 7 Win
Jonas Brodin

Sits Out Round 2 Due to Toe Injury
Sam Malinski

Practices Fully Sunday
Josh Manson

Rejoins Practice
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF