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DraftKings Lineup Picks (Week 10) - NFL DFS Advice

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 10 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 10!

 

DraftKings Quarterbacks - Week 10 DFS Picks

Matthew Stafford - DET vs CLE (DK $6,800)

Stafford is looking like one of the best options at quarterback this week, and coming off a big game. He played on Monday night, so his price wasn't adjusted for his performance last week. This is somewhat minor, but still and edge to be gained and we want to jump on it. Stafford has put up 300 yards or more in three straight games, and has seven touchdowns in his last four games. Really strong numbers from the highest paid quarterback. With his price and recent performance you could use him in either cash or GPPs, since he has a favorable match up. Speaking of his opponent, let's talk about the Browns! The Browns have the 28th DVOA against the pass, and simply cannot not stop the ball via the air. You want to find them every week, and target against them. Get exposure to them by either the quarterback or the receivers. The Browns are actually very good vs the run, so nearly all of the Lions offense will come from Stafford.

Ryan Fitzpatrick - TB vs NYJ (DK $4,900)

If you are looking for a cheap quarterback that has a solid match up, key in on Fitzpatrick this week. Not only is this a nice revenge game for him, going up against his former team, but the Jets have the 21st DVOA against the pass, and haven't looked strong on defense. For his price, he really only needs to put up 14.7 DraftKings points in order to reach 3x value, which is what you are looking for in cash games. Anything more than that, and will make a good tournament play. Stacking him with someone like DeSean Jackson, makes a good play since he has plenty of touchdown upside.

 

DraftKings Running Backs - Week 10 DFS Picks

LeSean McCoy - BUF vs. NO (DK $8,300)

Seems like few people are talking about McCoy this week, and might be due to the fact he had such a bad showing last Thursday night. If no one is going to be rostering him, he makes a great tournament play, since he has multi touchdown upside, along with seeing plenty of targets out of the backfield. Getting the full point PPR on DraftKings is huge for a running back, and will have plenty of chances to break the 100 yard bonus in either rushing or receiving. He is $400 cheaper than he was in the two previous weeks, and is at home against the Saints who have the 28th DVOA against the rush. The Saints defense has improved a good amount since the beginning of the season, but it was mainly their secondary. They are still weak vs the run, and with this game set to be cold with a bit of weather, the Bills should be running the ball plenty.

Carlos Hyde - SF vs NYG (DK $6,300)

Hyde is looking to be one of the stone locks this week, for multiple reasons, so let's dive in. First off, he is at home against the Giants, who have have the 28th DVOA overall, and the 26th DVOA against the rush. We all know how bad the Giants are, and they simply cannot stop really anyone on defense. They are bad against the run, bad against the pass, and most importantly, bad against running backs in the passing game. Hyde has six or more targets in four straight weeks, including nine or more in the last two. A running back getting that volume is huge, just as I mentioned with McCoy. Hyde has also seen 12 or more rushing attempts in four straight weeks. They are feeding him the ball in all aspects of the game, and with how bad the 49ers quarterback situation is, he should be in for a very busy day.

 

DraftKings Wide Receivers - Week 10 DFS Picks

Cooper Kupp - LAR vs HOU (DK $4,600)

Kupp was a bit unlucky last week with the Rams putting up so many points, yet barley seeing the ball at all. He ended with three catches on five targets for 54 yards and no touchdowns. Yes, Jared Goff, only completed 14 passes, so Kupp didn't have a ton of chances. But this week Kupp has a good match up against the Texans, who have the 16th DVOA against the pass, and the 30th DVOA against WR2. With the inconsistency Sammy Watkins has been showing, Kupp is seeing the second most targets on the team, with 47 targets in the first nine weeks. The Texans defense really isn't as good as people think, and attacking them in this spot is a good call.

A.J. Green - CIN @ TEN (DK $7,700)

Green is simply too cheap this week. A player with his skill, and his potential ceiling of points should not be under $8K. Whenever a player is in a spot like this, you want to jump all over him, since he price won't stay this low. Yes, his ownership could get a bit out of hand in GPPs, but having legit two touchdown upside for under $8K is fantastic. Last week he was ejected from the game for a fight, so his stats are a bit out of wack. Without last game, he has 46 targets in the prior five, and four touchdowns over that span. Pretty straight forward spot, don't over think it because of last week.

 

DraftKings Tight End - Week 10 DFS Pick

Kyle Rudolph - MIN @ WAS (DK $4,600)

Rudolph is one of the more consistent tight ends in the league, and is viable for any format this week. He has seven or more targets in four straight weeks, and has two touchdowns over that span. He has become one of the favorite targets for backup quarterback Case Keenum, and gets the volume any DFS player loves. Rudolph also has a very favorable match up, since he is up against the Redskins, who have the 29th DVOA against tight ends. Really like him in this spot, just getting up to his price may be hard, if you are trying to roster two top end running backs.

 

DraftKings Defense - Week 10 DFS Pick

Chicago Bears vs Green Bay Packers (DK $3,000)

Bears are going to be one of the more popular options at defense this week, and it comes with good reason. They are up against at Brett Hundley led Packers team, who as we all saw on Monday night, are very bad. The Packers are having a ton of trouble moving the ball offensively, and picking on them in fantasy is a good call. The Bears have 14 sacks over the past four weeks, along with four interceptions. They are putting pressure on the quarterback, and forcing bad decisions. They aren't too expensive, and should have a good floor of points.

 

More Week 10 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Macklin Celebrini

Remains Hot Against Ducks
Kentavious Caldwell-Pope

Out Tuesday
Jaxson Hayes

Off the Injury Report Tuesday
Rui Hachimura

Sits Out Tuesday's Game
Caris LeVert

Unlikely to Play Tuesday
Drew Eubanks

Available Tuesday
Keegan Murray

Questionable to Face Clippers
Zach LaVine

Remains Out Tuesday
John Collins

Uncertain for Tuesday
Bijan Robinson

Explodes for 229 Total Yards, Two Touchdowns on Monday Night
Robert Williams III

Active on Monday Night
Kris Murray

Out on Monday
Pelle Larsson

Exits With Ankle Injury Monday
Josh Giddey

to Miss Rest of Monday's Action
Coby White

Ruled Out for Rest Of Monday's Game
Nikola Jokić

Nikola Jokic Won't Return Monday
Brandon Williams

Available Monday Night
Anthony Davis

Out Against Trail Blazers
Coby White

Questionable to Return Monday
Nikola Jokić

Nikola Jokic Suffers Apperant Knee Injury Monday
Miles Bridges

Injures Ankle Monday
Keyonte George

May Exit the Lineup Tuesday
Joel Embiid

Considered Questionable Tuesday
Davante Adams

Officially Out on Monday Night
Drake London

Active Against Rams
Jake DeBrusk

to Miss Monday's Game as Healthy Scratch
Shane Pinto

Available Monday
Pius Suter

to Miss at Least Four Weeks
Pyotr Kochetkov

Likely Done for the Season
Josh Morrissey

Expected to Play Monday
Karel Vejmelka

Moved to Injured Reserve
Rasmus Dahlin

Expected to Rejoin Sabres Lineup Monday
Yegor Chinakhov

Penguins Acquire Yegor Chinakhov From Blue Jackets
Justin Herbert

Won't Face Broncos in Week 18
Marcus Mariota

Considered "a Stretch" to Play in Week 18
Geno Smith

Dealing With Significant Ankle Injury
Dak Prescott

Will Play in Week 18
Lamar Jackson

Week 18 Status "to be Determined"
Joe Mixon

Won't Return This Season
T.J. Watt

a Long Shot to Play in Week 18?
CFB

Penn State Working to Hire D'Anton Lynn as Next Defensive Coordinator
Joe Burrow

Will Play in Week 18 Against the Browns
CFB

Omar Cooper Expected to be Full-Go for Rose Bowl
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Marcus Freeman Staying with Notre Dame for 2026 Season
CFB

Star Wideout Cam Coleman Entering Transfer Portal
Luther Burden III

Set to Undergo Additional Testing on Quad Injury
Kirill Marchenko

Scores Twice in Sunday's Win
Justin Brazeau

Pots First Career Hat Trick Sunday
Juraj Slafkovsky

Collects Season-High Three Points in Sunday's Loss
Eeli Tolvanen

Continues Scoring Surge With Three-Point Effort
Jack Eichel

to Remain Out Monday
Adam Fox

Nearing Return, Considered Day-to-Day
Josh Morrissey

Considered Day-to-Day After Missing Practice
D'Andre Swift

Finds End Zone Twice in Sunday Night Loss
Luther Burden III

Posts Season-High 138 Yards, Touchdown in Loss
Christian McCaffrey

Racks Up 181 Total Yards, Touchdown in Win Over Bears
Brock Purdy

Delivers Second Straight Five-Touchdown Performance
Parker Washington

Leads Jaguars in Targets, Receptions, and Receiving Yards
Wan'Dale Robinson

Posts Season-High 11 Receptions in Week 17
Josh Allen

Seen Limping From X-Ray Room, Says Foot Injury Didn't Affect Him
Geno Smith

Diagnosed With High-Ankle Sprain
Trey McBride

Sets All-Time Tight End Receptions Record
Matthew Tkachuk

Returns to Practice
Linus Ullmark

Takes Leave of Absence
Travis Sanheim

Good to Go Against Kraken
Nick Foligno

Set to Return Sunday
William Nylander

Out Against Red Wings
CFB

Jay Hill Expected to be Next Michigan Defensive Coordinator
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Michigan Targeting Kyle Whittingham as Next Head Coach
CFB

Texas Leading Rusher Quintrevion Wisner Set to Transfer
Pete Fairbanks

Marlins Agree on One-Year Deal
Brooks Koepka

Leaving LIV Golf

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