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DraftKings, FanDuel Daily Fantasy Basketball Picks (3/21/22): Today's Top NBA DFS Lineups

The top daily fantasy basketball lineup picks for DraftKings and FanDuel on March 21, 2022. Juan Carlos Blanco provides NBA DFS analysis and sleeper picks for building optimal DFS rosters.

There's a second consecutive robust slate on tap Monday night, as nine games are on the docket. Oddsmakers seem to be predicting a night of competitive games with their lines, as all but one team is favored by seven points or fewer. Factoring in four games are between teams with winning records, and conditions appear to be ripe for a fun night of DFS play.

With 18 teams in action, the player pool can withstand a few injuries with not much disruption. Accordingly, it's not particularly difficult to pinpoint appealing candidates at each position at each level of salary.

This article will provide you with my daily fantasy basketball lineup picks for DraftKings and FanDuel on 3/21/22. Remember to monitor the NBA injury report as the slate can completely change before lineups lock. Good luck, RotoBallers.

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DraftKings and FanDuel Guards - NBA DFS Lineup Picks

Darius Garland - PG/SG, CLE vs. LAL ($9,300 DK; $8,800 FD)

Garland scored 37.8 DK points against the Lakers in his one prior meeting with them this season, and he's coming into Monday having scored over 40 fantasy points in seven straight games on DK as well. The star point guard continues to enjoy an especially elevated role with Jarrett Allen (finger) out of action, posting a 27.0 percent usage rate without his teammate on the floor. Los Angeles should once again make for a good matchup Monday, as the Lakers are allowing the third-highest offensive efficiency to point guards (27.5 percent), as well as 51.3 DK/50.1 FD points per game to the position on the season.

Cade Cunningham - PG/SG, DET vs. POR ($8,400 DK; $7,500 FD)

Cunningham jumped back into action Saturday after dealing with an illness and didn't miss a beat, posting 43.5 DK/41.2 FD points in a narrow loss to the Cavaliers. The star rookie had scored over 50 fantasy points in three of the prior six games as well, affording him upside that outpaces his salaries on both sites by a substantial degree. Cunningham scored 43.8 DK/41.9 FD points against the Trail Blazers the first time he saw them this season as well on Nov. 30, and Portland is currently considerably more short-handed than it was then. The Blazers are also now yielding the seventh-highest offensive efficiency to two-guards (22.6 percent), along with 45.7 DK/45.8 FD points per game to the position in the last seven. What's more, the Blazers are giving up NBA-high 37.0 percent three-point shooting, brightening Cunningham's prospects further.

Marcus Smart - PG/SG, BOS at OKC ($6,300 DK; $6,800 FD)

Smart offers some cost-effective exposure to a red-hot Celtics squad against the struggling Thunder, which have been particularly vulnerable to point guards of late. OKC has surrendered the fifth-most DK (57.3) and FD (54.5) points per game to ones in the last seven games, putting the versatile Smart in a solid position to overdeliver on his very reasonable salaries. Smart is averaging a well-rounded 14.5 points, 7.3 assists, 3.8 rebounds and 1.6 steals in 11 post-All-Star-break games, shooting an impressive 43.6 percent from three-point range and eclipsing 30 fantasy points on eight occasions during that sample as well. Meanwhile, OKC has been particularly vulnerable defending the perimeter lately, conceding 44.9 percent three-point shooting in the last three games.

ALSO CONSIDER: Josh Hart, SG, POR at DET ($8,000 DK; $7,900 FD)

 

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DraftKings and FanDuel Forwards - NBA DFS Lineup Picks

Jayson Tatum - SF/PF, BOS at OKC ($9,800 DK, $9,600 FD)

Tatum makes for another appealing Celtics option in the matchup against the Thunder, as he comes into Monday's interconference clash averaging an elite 32.5 points, 7.5 rebounds and 4.5 assists per game over 11 post-All-Star-break contests. Like his teammate Smart, Tatum has been impressive efficient from distance during that span, draining 40.7 percent of his 9.8 three-point attempts per game. Consequently, he'll also be in position to benefit from the Thunder's aforementioned weakness against three-point shooting, and he already hung 55 DK/52.1 FD points on OKC the first time he faced them this season.

Scottie Barnes - SF/PF, TOR at CHI ($8,100 DK; $8,500 FD)

The Bulls have had some trouble slowing down power forwards, including Barnes on a couple of occasions, this season, and the rookie comes in on a tear that's seen him average 20.3 points (on 55.2 percent shooting), 9.5 rebounds, 4.0 assists and 1.8 steals per game across his last 11. Barnes has scored over 30 fantasy points in two of three prior meetings against the Bulls as well, while Chicago is allowing the sixth-highest offensive efficiency to power forwards (27.6 percent), along with over 47 DK and 45 FD points per game on the season to the position. There's also a chance Fred VanVleet (knee) misses another game for Toronto on Monday night, which would potentially boost Barnes' value.

Jaxson Hayes - PF, NOP at CHA ($5,400 DK; $6,000 FD)

Hayes turned in another strong effort Sunday evening in the win over the Hawks, posting a 12-point, 12-rebound double-double on the way to 31 DK/27.9 FD points. The young big has scored over 30 DK points in three of his last four games overall, and he's posted over 22 in five consecutive on each site. Despite the second game of a back-to-back Monday, Hayes makes for a good value play against a Hornets team that's allowed Eastern Conference-high 28.5 percent offensive efficiency to power forwards, along with over 46 fantasy points per game to the position for the season.

ALSO CONSIDER: DeMar DeRozan, SF/PF, CHI vs. TOR ($8,700 DK, $8,200 FD)  

 

DraftKings and FanDuel Centers - NBA DFS Lineup Picks

Karl-Anthony Towns - MIN at DAL ($10,400 DK; $9,900 FD)

Towns enters the day questionable with a forearm contusion, so his status will have to be carefully monitored. However, if he's announced as available, he once again makes for an excellent play against a Mavericks squad he's already scored 58.5 DK/54.3 FD points against in one of two meetings this season. KAT boasts as much ceiling as virtually any player as he's demonstrated recently with 70- and 80-fantasy-point efforts, and Dallas has allowed over 59 fantasy points per game on either site to centers in the last seven games.

Kristaps Porzingis, WAS at HOU ($7,700 DK; $7,800 FD)

Porzingis comes at very appealing salaries for a player of his upside, and he arrives at Monday's highly favorable matchup having scored over 30 fantasy points on either site in six of his first seven games in Washington. The big man had his best point total yet as a member of the Wizards in his most recent game Saturday, hanging 27 on the Lakers. The Rockets could very facilitate another spectacular outing Monday night, as Houston has allowed NBA-high 37.7 percent offensive efficiency to centers, as well as NBA-high 70.1 DK/70.5 FD points per game to the position in the last 15. Porzingis has delivered at least 40 DK points on 19 occasions and 40 FD points in 17 instances (out of 41 total games) this season, and Monday's game shapes up as another very likely opportunity for him to repeat the feat.

ALSO CONSIDER: Jonas Valanciunas -  NOP at CHA ($8,300 DK; $7,400 FD)



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REAL-TIME FANTASY NEWS

Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
De'Zhaun Stribling

to be 49ers' New "F" Receiver?
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
Drew Allar

Steelers "Uninstalling" Everything Drew Allar Learned in College
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Ja'Kobi Lane

Is Ja'Kobi Lane the Pass-Catching Answer the Ravens Have Been Seeking?
Zachariah Branch

Does Zachariah Branch Have a Path to Immediate Production?
Max Klare

Can Max Klare Separate Himself in Rams' Tight End Room?
Eli Stowers

the Tight End of the Future in Philadelphia?
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Kenyon Sadiq

Is Kenyon Sadiq the Next Great Rookie Tight End?
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Cade Klubnik

Becoming Fan Favorite, in Play to Win Backup QB Job?
Michael Penix Jr.

Throwing During Offseason Program
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Sam Malinski

Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
Luka Dončić

Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
CFB

Isaac Brown Has All-American Upside in 2026
LeBron James

Uncertain About Future After Season-Ending Loss
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF