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DraftKings Daily Fantasy Football Picks (Week 15): NFL DFS Lineups

The top daily fantasy football lineup picks for DraftKings in Week 15. Ben Rolfe's NFL DFS analysis and sleepers for building optimal DFS rosters.

Two Saturday games on top of the usual prime time games has really left this slate a little devoid of options. However, more significantly is the loss of the Chiefs, Rams, Chargers and Saints to prime time slots on Thursday, Sunday and Monday. That has left us looking more for defenses to pick against this week than looking at explosive offenses. Some prime examples are the Falcons and Bengals who have struggled to stop teams at all this year and have looked pretty ugly on defense. Below are my DraftKings DFS Lineup Picks for Week 15.

These DraftKings lineup recommendations are based on matchups, performances so far, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home field advantage, and more. There are quite a few great value plays available, so read on to find out which players are the best for Week 15.

Good luck with your DraftKings DFS lineups!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 15 Picks

Tom Brady - NE @ PIT (DK $5,900)

When you look on DraftKings this looks a bad matchup for Brady. The Steelers appear on there as the ninth-toughest matchup for quarterbacks. However, the Steelers home/road splits have been weird this season. At home, the Steelers defense is actually surrendering five more fantasy points to quarterbacks at home (21.1) than on the road (16.1). In addition, it is expected this game will be high scoring with the over/under having moved from its opening line of 49.5 up to 52. In addition, Brady looked great last week and appears to be preparing to peak at the right time.

Derek Carr - OAK @ CIN (DK $5,400)

I am not sure trusting Carr is ever something I want to do but this is a nice spot for him. The Bengals defense has had major issues this season, surrendering 20 fantasy points per game to opposing quarterbacks on the road. They are also coming off a kitchen sink game on the road against the Chargers and against the lowly Raiders could be primed for a let-down. Carr has scored over 22.5 fantasy points each of the last two weeks.

 

DraftKings DFS Running Backs - Week 15 Picks

David Johnson - ARI @ ATL (DK $7,100)

Facing the Falcons feels almost a gimme pick for the opposing running back right now. The Falcons are currently surrendering 25.1 fantasy points to opposing #1 running backs at home. Any fears that with the Cardinals focusing on the future might lead to fewer touches for Johnson should have been assuaged last week when he had 15 carries and 10 targets in the passing game.

Dalvin Cook - MIN vs. MIA (DK $6,500)

I am gambling that we see a shift in attitude in Minnesota this week with a new head coach. Cook is incredibly talented but has been misused this season. The Vikings offensive line is not great but the Dolphins are surrendering an average of 20 fantasy points per game to opposing #1 running backs when they play on the road. Cook has scored double-digit fantasy points in each of his last three goals and appears to have had a very defined role in the passing game in recent weeks.

Gus Edwards - BAL vs. TB (DK $4,400)

I am not ready to give up on Edwards in Baltimore. Kenneth Dixon had the better week against the Chiefs but Edwards is still the number one back. In addition, he is facing a leaky Buccaneers defense who have allowed an average of 25.6 fantasy points to opposing #1 running backs on the road. That defense has been allowing an average of 35 fantasy points to running backs in general on the road. Therefore, even if Edwards does not see the bulk of the carries there should still be value for him in this game.

 

DraftKings DFS Wide Receivers - Week 15 Picks

Julio Jones - ATL vs. ARI (DK $8,400)

In a year of chaos for the Falcons Jones stands tall. Jones found the end zone twice last week as he bounced back from a tough week against the Ravens. He is seeing an average of just under eight targets per game and has scored touchdowns in four of his last six games. His matchup this week is actually pretty favorable with the Cardinals allowing 23 fantasy points per game to opposing #1 wide receivers at home. He has missed practice twice this week but one was precautionary and the other was for flu-like symptoms which are not expected to keep him out this weekend.

Corey Davis - TEN @ NYG (DK $5,600)

Davis has been extremely hit-or-miss this season and the Giants defense has generally been quite good at home against opposing wide receivers. However, they have surrendered an average of 16.1 fantasy points per game to the opposing number one receiver in MetLife stadium. With the Titans in the AFC playoff hunt and severely short-handed when it comes to weapons I expect Davis to see plenty of targets this weekend.

Larry Fitzgerald - ARI @ ATL (DK $4,700)

Fitzgerald and Johnson are the main weapons the Cardinals have and this week both have great matchups. Fitzgerald generally lines up out of the slot and the Falcons have allowed 13.1 fantasy points per game against the slot receiver at home. Jones saw nine targets next week and I think there is a very real chance it sets a season-high in a game which could have more scoring than many expect.

 

DraftKings DFS Tight Ends - Week 15 Picks

Jared Cook - OAK @ CIN (DK $5,600)

This feels like a slam dunk for me if I have cash to spare at the position. Cook has had over 20 fantasy points each of the last two weeks and has a matchup against the 26th worst defense against the tight end. He is the only reliable weapon the Raiders have and I expect them to use him plenty this week.

Vance McDonald - PIT vs. NE (DK $3,900)

With Zach Ertz and Travis Kelce missing from the slate this is a thin week at the tight end position. McDonald seems to have a fairly good floor and there is potential for upside against a slow New England Patriot defense, who are allowing over 10 fantasy points per game to opposing #1 tight ends. I would prefer Cook but if you are tight for money this is a solid pick.

 

DraftKings DFS Defenses - Week 15 Picks

Buffalo Bills vs. Detroit Lions (DK 2,800)

A Lions offense that has not looked very good now has to travel on the road to a stadium that seems to experience all sorts of weather conditions. Add in that the Bills defense has been solid this year and this actually becomes quite an easy pick for me this week.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

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Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Out Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Isaac TeSlaa

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Troy Franklin

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Courtland Sutton

in Line for Reduced Role in Denver?
KC Concepcion

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George Pickens

' Dynasty Outlook Clouded by Uncertain Future in Dallas
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Hits the Injured List With Groin Injury
Brandon Aiyuk

a Huge Question Mark for Dynasty Managers
Deebo Samuel Sr.

Now Only a Gadget Player/Kick Returner?
Elic Ayomanor

Offseason Additions Hurt Elic Ayomanor's Dynasty Outlook
Tyler Warren

a Clear Top-Five Dynasty Tight End
Jonathon Brooks

a Dynasty RB to Target Despite Injury History?
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Likely to Need Elbow Surgery
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Currently in a Dynasty Buy Window Amid Rollercoaster Offseason
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Isaiah Likely

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Duncan Robinson

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Cade Cunningham

Contributes 21 Points in Game 6 Win
Jalen Duren

Bounces Back With Double-Double
Anthony Edwards

Finishes Season-Ending Loss With 24 Points
Victor Wembanyama

Tallies 19 Points in Friday's Win
De'Aaron Fox

Highly Effective in Blowout Win
Stephon Castle

Shines in Series-Clincher
Kyle Schwarber

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Clay Holmes

Suffers Fractured Fibula on Friday Night
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Heads to 15-Day Injured List
Austin Reaves

Could Command $40M Per Year With New Contract
Jalen Duren

Available to Finish Game 6
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Not Expected to Be Ready for Start of Next Season
Jalen Williams

Declares Himself Healthy for Conference Finals
Terrence Shannon Jr.

Will Play Friday Night
Kevin Huerter

is Available for Game 6
Duncan Robinson

is Returning for Game 6
Caris LeVert

is Cleared for Game 6 on Friday
OG Anunoby

Practices in Full on Friday
Terrence Shannon Jr.

is Tagged as Questionable for Friday
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
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College GameDay Set for First Three Weeks
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Jeremiah Smith Aiming For Ohio State Receiving Records
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Jeremiah Cobb Impresses New Auburn Staff
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Alberto Mendoza Very Likely to Start for Georgia Tech
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Charles Woodson Jr. Commits to Michigan
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Kevin Huerter

Tagged as Questionable for Game 6 Against Cavaliers
Caris LeVert

Considered Questionable for Friday
Lane Hutson

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Amasses Three Points in Crucial Victory Thursday
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Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
Jeremy Lauzon

Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
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Kris Knoblauch Fired as Oilers Head Coach
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Quinn Hughes

Finishes Postseason With 15 Points
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
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Pulled Early With Possible Leg Injury
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Exits Wednesday's Game Early with Ankle Injury
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Returns From Injured List
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ACC, Big 12 Support 24-Team College Football Playoff
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Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
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Jordan Spieth

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Brandt Snedeker

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Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

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Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

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Xander Schauffele

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Isaac Brown Has All-American Upside in 2026
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Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
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Jaron-Keawe Sagapolutele Has Eyes on ACC Title
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Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
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Finishes Second for Best Run of the Year At Watkins Glen
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Scores New Career-Best Finish of Third at Watkins Glen
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Earns his First Top-10 Finish of 2026 at Watkins Glen
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Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
RANKINGS
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