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DraftKings Daily Fantasy Football Picks (Week 15): NFL DFS Lineups

The top daily fantasy football lineup picks for DraftKings in Week 15. Ben Rolfe's NFL DFS analysis and sleepers for building optimal DFS rosters.

Two Saturday games on top of the usual prime time games has really left this slate a little devoid of options. However, more significantly is the loss of the Chiefs, Rams, Chargers and Saints to prime time slots on Thursday, Sunday and Monday. That has left us looking more for defenses to pick against this week than looking at explosive offenses. Some prime examples are the Falcons and Bengals who have struggled to stop teams at all this year and have looked pretty ugly on defense. Below are my DraftKings DFS Lineup Picks for Week 15.

These DraftKings lineup recommendations are based on matchups, performances so far, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home field advantage, and more. There are quite a few great value plays available, so read on to find out which players are the best for Week 15.

Good luck with your DraftKings DFS lineups!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 15 Picks

Tom Brady - NE @ PIT (DK $5,900)

When you look on DraftKings this looks a bad matchup for Brady. The Steelers appear on there as the ninth-toughest matchup for quarterbacks. However, the Steelers home/road splits have been weird this season. At home, the Steelers defense is actually surrendering five more fantasy points to quarterbacks at home (21.1) than on the road (16.1). In addition, it is expected this game will be high scoring with the over/under having moved from its opening line of 49.5 up to 52. In addition, Brady looked great last week and appears to be preparing to peak at the right time.

Derek Carr - OAK @ CIN (DK $5,400)

I am not sure trusting Carr is ever something I want to do but this is a nice spot for him. The Bengals defense has had major issues this season, surrendering 20 fantasy points per game to opposing quarterbacks on the road. They are also coming off a kitchen sink game on the road against the Chargers and against the lowly Raiders could be primed for a let-down. Carr has scored over 22.5 fantasy points each of the last two weeks.

 

DraftKings DFS Running Backs - Week 15 Picks

David Johnson - ARI @ ATL (DK $7,100)

Facing the Falcons feels almost a gimme pick for the opposing running back right now. The Falcons are currently surrendering 25.1 fantasy points to opposing #1 running backs at home. Any fears that with the Cardinals focusing on the future might lead to fewer touches for Johnson should have been assuaged last week when he had 15 carries and 10 targets in the passing game.

Dalvin Cook - MIN vs. MIA (DK $6,500)

I am gambling that we see a shift in attitude in Minnesota this week with a new head coach. Cook is incredibly talented but has been misused this season. The Vikings offensive line is not great but the Dolphins are surrendering an average of 20 fantasy points per game to opposing #1 running backs when they play on the road. Cook has scored double-digit fantasy points in each of his last three goals and appears to have had a very defined role in the passing game in recent weeks.

Gus Edwards - BAL vs. TB (DK $4,400)

I am not ready to give up on Edwards in Baltimore. Kenneth Dixon had the better week against the Chiefs but Edwards is still the number one back. In addition, he is facing a leaky Buccaneers defense who have allowed an average of 25.6 fantasy points to opposing #1 running backs on the road. That defense has been allowing an average of 35 fantasy points to running backs in general on the road. Therefore, even if Edwards does not see the bulk of the carries there should still be value for him in this game.

 

DraftKings DFS Wide Receivers - Week 15 Picks

Julio Jones - ATL vs. ARI (DK $8,400)

In a year of chaos for the Falcons Jones stands tall. Jones found the end zone twice last week as he bounced back from a tough week against the Ravens. He is seeing an average of just under eight targets per game and has scored touchdowns in four of his last six games. His matchup this week is actually pretty favorable with the Cardinals allowing 23 fantasy points per game to opposing #1 wide receivers at home. He has missed practice twice this week but one was precautionary and the other was for flu-like symptoms which are not expected to keep him out this weekend.

Corey Davis - TEN @ NYG (DK $5,600)

Davis has been extremely hit-or-miss this season and the Giants defense has generally been quite good at home against opposing wide receivers. However, they have surrendered an average of 16.1 fantasy points per game to the opposing number one receiver in MetLife stadium. With the Titans in the AFC playoff hunt and severely short-handed when it comes to weapons I expect Davis to see plenty of targets this weekend.

Larry Fitzgerald - ARI @ ATL (DK $4,700)

Fitzgerald and Johnson are the main weapons the Cardinals have and this week both have great matchups. Fitzgerald generally lines up out of the slot and the Falcons have allowed 13.1 fantasy points per game against the slot receiver at home. Jones saw nine targets next week and I think there is a very real chance it sets a season-high in a game which could have more scoring than many expect.

 

DraftKings DFS Tight Ends - Week 15 Picks

Jared Cook - OAK @ CIN (DK $5,600)

This feels like a slam dunk for me if I have cash to spare at the position. Cook has had over 20 fantasy points each of the last two weeks and has a matchup against the 26th worst defense against the tight end. He is the only reliable weapon the Raiders have and I expect them to use him plenty this week.

Vance McDonald - PIT vs. NE (DK $3,900)

With Zach Ertz and Travis Kelce missing from the slate this is a thin week at the tight end position. McDonald seems to have a fairly good floor and there is potential for upside against a slow New England Patriot defense, who are allowing over 10 fantasy points per game to opposing #1 tight ends. I would prefer Cook but if you are tight for money this is a solid pick.

 

DraftKings DFS Defenses - Week 15 Picks

Buffalo Bills vs. Detroit Lions (DK 2,800)

A Lions offense that has not looked very good now has to travel on the road to a stadium that seems to experience all sorts of weather conditions. Add in that the Bills defense has been solid this year and this actually becomes quite an easy pick for me this week.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

Devon Levi

Attracting Interest From Senators
Jacoby Brissett

Cardinals Not Close to a Reworked Deal
Scott Wedgewood

Starting Game 2 Against Golden Knights
Ben Hutton

Scratched for Game 2 Against Avalanche
Mark Stone

Won't Play Friday
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
Cale Makar

Remains Out Friday
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
NFL

Evan Stewart Pushing Oregon Receiving Corps
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
New York Giants

Giants, GM Joe Schoen Agree on a Multi-Year Extension
Andrew Thomas

Giants Managing Multiple Injuries for Andrew Thomas
Cam Ward

Loses 10 Pounds in the Offseason
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Tucker Kraft

a Top Trade Target in Dynasty Leagues?
Cedric Tillman

Falling Out of Favor in Cleveland
Emmett Johnson

the Handcuff to Roster in Kansas City?
Devaughn Vele

Could Dynasty Managers Sell High on Devaughn Vele Early in the Season?
Brenen Thompson

a Perfect Fit for Chargers, Rising in Dynasty Leagues?
Jonathan Taylor

Is Jonathan Taylor Still a High-End Dynasty Option?
Malik Nabers

' Recovery Timeline Still Unclear
Jaxon Smith-Njigba

Comfortably Into His Dynasty Prime
Saquon Barkley

Still a Capable League-Winner at a Sunken Dynasty Cost
Jack Campbell

Signs Four-Year Extension with Lions
Matthew Stafford

Signs One-Year Extension with Rams
Evan Mobley

Fills the Box Score in Game 2 Loss
James Harden

Held to Two Assists Thursday
Donovan Mitchell

Leads Cavaliers in Scoring in Game 2 Defeat
Karl-Anthony Towns

Records Double-Double in Game 2 Win
Sebastian Aho

Picks Up an Assist in Series-Opening Loss
Mikal Bridges

Adds 19 Points as Knicks Grab 2-0 Lead
Jalen Brunson

Hands Out 14 Assists in Game 2 Win
Seth Jarvis

Needs 33 Seconds to Score in Game 1 Loss
Josh Hart

Erupts for Playoff Career-High 26 Points in Game 2
Jaccob Slavin

Struggles in Game 1 Against Canadiens
Jakub Dobes

Sharp in Game 1 Victory
Cole Caufield

Bags Two Points in Impressive Road Win
Juraj Slafkovsky

Opens Conference Finals With Three-Point Performance
Nick Suzuki

Notches Three Assists in Game 1 Win Over Hurricanes
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Jrue Holiday

Wants to Stay in Portland
Ayo Dosunmu

Timberwolves Hope to Bring Back Ayo Dosunmu
Dylan Harper

Considered Questionable for Friday Night
De'Aaron Fox

Listed as Questionable for Game 3
Jalen Williams

Questionable for Game 3 Against Spurs
Alex Tuch

Hopes to Remain in Buffalo
Sidney Crosby

Wants to Play for "as Many Years as Possible"
Troy Terry

Could Miss Start of Next Season Due to Hip Surgery
Arber Xhekaj

Scratched for Game 1 of Eastern Conference Finals
Jakub Dobes

Seeks More Success Against Hurricanes
Frederik Andersen

Looks to Stay Undefeated Thursday
Calvin Ridley

Not Taking Part in OTAs as Value Continues to Plummet
Carnell Tate

Receiving Early Buzz at OTAs
Ashton Jeanty

Bigger Role Could be Coming for Ashton Jeanty in Year 2
Robby Snelling

Will Undergo Tommy John Surgery
Malik Nabers

' Goal is to be Ready for Start of the Season
De'Von Achane

Dealing With Injury at OTAs?
Devin Vassell

Contributes 22 Points in Wednesday's Loss
Stephon Castle

Tallies Team-High 25 Points in Game 2 Loss
Victor Wembanyama

Records Eighth Postseason Double-Double
Isaiah Hartenstein

Bounces Back With Double-Double
Shai Gilgeous-Alexander

Leads Thunder to Game 2 Victory WIth 30 Points
Dylan Harper

Exits Game 2 Early Due to Right-Leg Injury
Jalen Williams

Suffers Another Hamstring Injury
Valeri Nichushkin

Ends Scoring Slump in Game 1 Loss
Nathan MacKinnon

Extends Point Streak With an Assist
Brett Howden

Pots Another Goal in Game 1 Win Against Avalanche
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
Chicago Bulls

Jerry Stackhouse Emerges as Bulls Head-Coach Candidate
Cooper Flagg

Kon Knueppel Headline All-Rookie Team
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Corey Seager

Going on Injured List With Back Injury
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
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OF
SP
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