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DraftKings Daily Fantasy Football Lineup Picks (Week 4): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 4 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 4. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

Be sure to check all of our fantasy football rankings for 2025:

 

DraftKings Quarterbacks - Week 4 DFS Picks

Philip Rivers (vs NO, $6,900)

Philip Rivers is the best quarterback option on the board this week. He gets a fantastic matchup against the New Orleans Saints, a team that had a horrible defense to start the season and is currently dealing with multiple injuries in their secondary. The San Diego Chargers are going to pick them apart with their ariel attack. Rivers has been throwing the ball around 40 times per game, and if the Saints turn this game into a shootout, which is likely, he should throw the ball at least 40-45 times. This will be a very high-scoring affair, forcing Rivers to hit value. He may be limited as far as his offensive toys go, but the Chargers' quarterback will find a way to get it done.

 

DraftKings Running Backs - Week 4 DFS Picks

Le'Veon Bell (vs KC, $7,500)

The Pittsburgh Steelers are going to shove the ball down Le'Veon Bell's throat this week. Whether he likes it or not, he is going to touch the ball upwards of 30-40 times. At least, he should. The Kansas City Chiefs have not been great at stopping the run, and the Steelers' offense needs a little bit of stability after last week's terrible loss to the Philadelphia Eagles. Bell has yet to play this season, but everyone knows that he is the best running back in the league. He has something to prove tonight, and that is exactly what he will do. Pay up for his high price tag. There are plenty of value plays to make it work.

Carlos Hyde (vs DAL, $4,200)

Even with Le'Veon Bell back in action this week, Carlos Hyde is the most valuable running back on the board. He gets a solid matchup against the Dallas Cowboys, a team that struggles defensively, and he has been great all season so far. In two of his first three games, he has over 20 fantasy points. Finding the end zone four times, Hyde is a high-upside, low-priced fantasy steal this week. He is part of Chip Kelly's fast-paced offense now, and it looks like he is going to excel. There is no reason to avoid him. Roster him in both 50/50 and touranment lineups without hesitation.

 

DraftKings Wide Receivers - Week 4 DFS Picks

Tyrell Williams (vs NO, $4,400)

It is always a great idea to pair a wide receiver with a quarterback in daily fantasy football. It increases the upside of the lineup. Even before Keenan Allen went down with an injury, Williams was targeted five times. That was week one. In week three, he was targeted nine times, and he is quickly becoming a bigger part of the San Diego Chargers' offense. He is going to start finding the end zone more frequently, as long as his targets stay up. In his last two starts, he has 12.9 and 15.1 fantasy points, making him a great play in both 50/50 contests and tournaments. He is very likely to hit value.

Quincy Enunwa (vs SEA, $4,400)

Quincy Enunwa is having a great season so far, as far as fantasy is concerned. With 25 targets in three weeks, he is averaging over 13 fantasy points per game. For his price tag, that is solid. Eric Decker is out this week with a partially torn rotator cuff, so Enunwa is going to continue to see more targets. In week three, he had 11, which was one more than Brandon Marshall. Marshall is going to get shadowed and likely double-covered by the Seattle Seahawks' best members of the secondary, leaving Enunwa room to work. As long as he makes the most of his targets, Enunwa will at least hit value.

 

DraftKings Tight Ends - Week 4 DFS Picks

Zach Miller (vs DET, $2,700)

This is the easiest recommendation of the week. Zach Miller is entirely too cheap on DraftKings right now. He gets a great matchup against the Detroit Lions, and the Chicago Bears have to start Brian Hoyer with Jay Cutler currently dealing with an injury. Hoyer loves to check down to the tight end, evidenced by his nine targets, eight receptions, and two touchdowns last week against the Dallas Cowboys. He posted over 25 fantasy points. His price tag last week was higher than his price tag this week. Miller is poised to have a great season, especially if Cutler remains injured. He will save quite a bit of salary cap space, as well. Use him in both 50/50 contests and tournaments.

 




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REAL-TIME FANTASY NEWS

Drake Baldwin

Named NL Rookie of the Year
Patrick Williams

Active Versus San Antonio
Kyle Hendricks

Hanging Up his Cleats After 12 Seasons
Giannis Antetokounmpo

Available Versus Dallas
Dereck Lively II

Still Sidelined on Monday
Freddy Peralta

Red Sox Linked to Freddy Peralta
Josh Giddey

Ruled Out Against Spurs
Nick Kurtz

Named AL Rookie of the Year
Daniel Gafford

Available Versus Milwaukee
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Out Again on Monday
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Matthew Golden

Officially Out Against Eagles
TreVeyon Henderson

on Week 11 Injury Report With Knee Injury
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Not Expected to Play on Monday Night
Casey Mittelstadt

Out Week-to-Week
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Expected to Miss 3-4 Weeks With Knee Sprain
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Dealing With Severe Viral Issue
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to "Miss Significant Time" Due to Blood Clot
Zack MacEwen

to Re-Enter Devils Lineup Monday
William Karlsson

Out on Monday
Ryan Nugent-Hopkins

to Miss at Least One Week
Vincent Trocheck

Available Monday
Isiah Pacheco

May Not be Ready to Return in Week 11
Dalton Kincaid

Labeled Week-to-Week With Hamstring Injury
Oronde Gadsden

Diagnosed With Bruised Quad, Considered "Day-to-Day"
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Dealing With a Sprained Ankle
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Won't Travel to Madrid in Week 11
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Won't Play in Week 11
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Upgraded Ahead of Monday's Matchup
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Doubtful to Play in Week 11
Taylor Hendricks

Questionable for Matchup with Timberwolves
Luke Kornet

Questionable for Matchup With Bulls
Jalen Suggs

to Rest Monday Vs. Portland
Taurean Prince

Out With Herniated Disc in his Neck
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Returning to Practice This Week
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Giants Fire Head Coach Brian Daboll
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No Timetable for Chris Godwin's Return
Bucky Irving

Could Miss Week 11
C.J. Stroud

Remains in the Concussion Protocol
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Nic Anderson Could Return for LSU this Season
Dante Exum

Remains Out vs. Bucks
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Exits With Hamstring Tightness vs. Knicks
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Pushes Winning Streak to Career-Best Six Games
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Has Two-Point Night Sunday
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Controls Flames
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Registers Two Assists Sunday
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Extends Scoring Streak With Three-Point Effort
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Totals Five Points in Overtime Win
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Suffers Hand Injury Sunday
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Oronde Gadsden

Questionable to Return on Sunday Night With Knee Injury
Luke Kennard

Ending Two-Game Absence Monday
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to Miss Sunday's Action
Aaron Judge

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Munetaka Murakami Officially Being Posted on Friday
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Gabriel Bonfim

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Joseph Morales

A Favorite At UFC Vegas 111
Matt Schnell

Set For UFC Vegas 111 Co-Main Event
Uros Medic

Aims To Win Back-To-Back Fights
Muslim Salikhov

Looks For His Fourth Consecutive Win
Chris Padilla

Looks To Remain Unbeaten In The UFC
Ismael Bonfim

Looks To Get Back In The Win Column
Marco Tulio

Looks To Remain Undefeated In The UFC
Christian Leroy Duncan

Set To Open Up UFC Vegas 111 Main Card
Kyle Tucker

Headlines List of 13 Players to Receive Qualifying Offers
Pete Fairbanks

Becomes a Free Agent
CFB

Luke Fickell Will Return as Wisconsin's Head Coach in 2026
Bo Bichette

Blue Jays Extend Qualifying Offer to Bo Bichette
Craig Stammen

Named Padres New Manager
Jorge Polanco

Declines his 2026 Option to Become a Free Agent
Chris Sale

Braves Picking Up Chris Sale's 2026 Option
Michael Thorbjornsen

Poised to Continue Hot Play in Mexico
Davis Riley

Struggling to Find Form Ahead of World Wide Technology Championship
Taylor Montgomery

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Stephan Jaeger

Offers Strong Value at World Wide Technology Championship
Ben Griffin

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Nick Dunlap

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Michael Brennan

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