Jason Bales' week 16 DraftKings lineup picks. Daily fantasy football sleepers, value picks and lineups advice for DraftKings DFS games and tournaments.

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 16 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 16. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on FantasyAces, make a $20 deposit, and enter any game will receive BOTH our full season NFL and NBA Premium Passes for free, a $119.99 value. Just email [email protected] with your new FantasyAces username - and boom, that's it! We will email you with your Premium Passes.

• 2025 fantasy football rankings
• Running back (RB) fantasy football rankings
• Wide receiver (WR) fantasy football rankings
• Tight end (TE) fantasy football rankings
• Quarterback (QB) fantasy football rankings
• Defense (D/ST) fantasy football rankings
• NFL rookie fantasy football rankings
• Best ball fantasy football rankings
• Superflex fantasy football rankings
• Dynasty fantasy football rankings

DraftKings Quarterbacks - Week 16 DFS Picks

Andrew Luck (at OAK, $7,000)

The Oakland Raiders are far from great defensively, especially against opposing quarterbacks, which makes Andrew Luck one of the better plays of the week. Against the New York Jets, three games ago, the Indianapolis Colts star posted just under 30 fantasy points in only 28 pass attempts. He completed 22 of those 28 pass attempts for over 275 yards and four touchdowns. On top of Luck's impressive ability to find open wide receivers, he also has what it takes to make plays with his feet. His added rushing ability is something that a majority of NFL quarterbacks do not possess. His price tag is a little bit high, but Luck can be used in all leagues this week.

Tyrod Taylor (vs MIA, $5,400) 

This is a huge game for the Miami Dolphins, but unfortunately Ryan Tannehill will not be ready to return under the helm. That leaves Matt Moore, meaning that the Buffalo Bills should control the ball for a majority of this game. Tyrod Taylor is a high-upside quarterback option in tournaments this week. He has over 15 fantasy points in three of his last four games, and he posted over 25 fantasy points against the Seattle Seahawks a few weeks ago. His price tag is very reasonable, as well.

DraftKings Running Backs - Week 16 DFS Picks

Ezekiel Elliott (vs DET, $7,900) 

Ezekiel Elliott is one of the best running backs in the league, and he is still a rookie. Against the Tampa Bay Buccaneers last week, he posted over 30 fantasy points on 23 rush attempts. He rushed for over 150 yards and one touchdown. This week, the Dallas Cowboys will rely on him to beat the Detroit Lions. With a win this week, the Cowboys clinch the division and home field advantage in the playoffs. Against the Pittsburgh Steelers a few games back, Zeke posted over 4o fantasy points on 21 carries. His upside is limitless, and he can be used in both 50/50 contests and tournaments.

Mark Ingram (vs TB, $4,400)

Mark Ingram is a high-upside tournament option this week against the Tampa Bay Buccaneers. As previously mentioned, the Bucs allowed over 150 yards and a touchdown last week to Ezekiel Elliott. Mark Ingram is far from Zeke's talent level, but the Bucs rush defense is horrible, and Ingram could take advantage. Against the Los Angeles Rams, four games ago, he posted over 30 fantasy points on 14 carries. He is heavily involved in the New Orleans Saints pass attack, and that should help him hit value. Do not use him in cash games.

DraftKings Wide Receivers - Week 16 DFS Picks

Antonio Brown (vs BAL, $8,200)

Antonio Brown is the best wide receiver option on the board this week. He gets a solid matchup against the Baltimore Ravens, and his price tag is very low. There is a reason for that change in price - Brown has struggled over his last couple of games, failing to reach 100 receiving yards in five straight games now. Six games ago, he posted over 150 receiving yards and a touchdown on 18 targets against the Dallas Cowboys. His upside is tremendous, and the Steelers are going to start forcing him the ball. Brown is one of the most talented wide receivers in the league, and he should turn around his mini-slump this week.

DeAndre Hopkins (vs CIN, $5,200)

Speaking of highly-talented wide receivers that have been struggling of recent, DeAndre Hopkins is available this week. Against the Jacksonville Jaguars, he was targeted 17 times, catching eight passes for 87 yards. His horrible season is a product of Brock Osweiler's horrible performance under the helm. Osweiler has officially been benched. Tom Savage will start this week for the Houston Texans, and he is going to force the ball to his star wide receiver. Use Hopkins in both 50/50 contests and tournaments against the Cincinnati Bengals.

DraftKings Tight Ends - Week 16 DFS Picks

Delanie Walker (at JAX, $4,300) 

Delanie Walker is one of the more talented tight ends in the league, and he gets a great matchup this week against the Jacksonville Jaguars. He has seven targets in both of his last two games, but he only has nine catches total. With three touchdowns in his last six games, his upside should be obvious. Walker's price tag is very reasonable, and he can be rostered in all leagues.

DraftKings Defenses - Week 16 DFS Picks

San Diego Chargers Defense (at CLE, $3,400)

Defenses are very difficult to predict. That said, the San Diego Chargers are moderately priced and get a good matchup against the Cleveland Browns. The Browns are one of the worst teams in NFL history, so even the Chargers horrible defense should score. The Chargers have at least one interception in four straight games, and that is enough to warrant them consideration in all contests .