Jason Bales' week 10 DraftKings lineup picks. Daily fantasy football sleepers, value picks and lineups advice for DraftKings DFS games and tournaments.

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 10 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 10. Good luck with your DraftKings DFS lineups!

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• 2025 fantasy football rankings
• Running back (RB) rankings
• Wide receiver (WR) rankings
• Quarterback (QB) rankings
• Tight end (TE) rankings
• Defense (D/ST) rankings
• Kicker (K) rankings
• FLEX rankings
• Dynasty rankings

DraftKings Quarterbacks - Week 10 DFS Picks

Ben Roethlisberger (vs DAL, $6,800) 

Ben Roethlisberger has been dealing with an injury over the last couple of weeks, but he is back at the helm for the Pittsburgh Steelers. In his latest game, he attempted 45 passes, completing 23 of them for over 250 yards and a touchdown. If that doesn't scream that he is fully healthy, nothing does. He gets a good matchup against the Dallas Cowboys this week, a team that is hindered by injuries in their secondary, and he should be able to pick them apart. This will be a difficult game for the Steelers to win, forcing Big Ben to throw the ball early and often. Use him in tournaments.

Jay Cutler (at TB, $5,300) 

Jay Cutler returned last week to beat the Minnesota Vikings on Monday night. He threw for over 250 yards and a touchdown, posting 14.3 fantasy points. His price tag is very low because he has been out for so long and struggled prior to that. Regardless of his struggles, he has huge upside. The Tampa Bay Bucs' defense is terrible, and this should turn into a shootout. If it does, Cutler should surpass value. Use him in tournaments.

DraftKings Running Backs - Week 10 DFS Picks

David Johnson (vs SF, $8,400)

David Johnson is far too talented to pass on him this week against the San Francisco 49ers. He posted almost 20 fantasy points in his last game, which was against the Carolina Panthers, and he only ran for 24 yards on 10 attempts. He is a very valuable asset in the Arizona Cardinals' passing attack, and he will continue to be utilized in that way. He has five touchdowns in his last four games. Use him in both 50/50 contests and tournaments, even though his price tag is high.

Darren Sproles (vs ATL, $4,300) 

Darren Sproles is starting to be utilized more and more in the Philadelphia Eagles' offense. Last week, he ran the ball 13 times for 57 yards and caught three passes for 14 yards. Even more encouraging was his nine targets. The week prior, he had seven targets. If he continues to play such a huge role in the Eagles' pass attack, he will eventually explode for a big game. If the ball is in Sproles' hands, he has a chance to score. His price tag is very low, and the Atlanta Falcons' defense is not good. Use him in tournaments.

DraftKings Wide Receivers - Week 10 DFS Picks

Alshon Jeffery (at TB, $6,600) 

With Jay Cutler back, Alshon Jeffery is going to benefit. He is a big, fast wide receiver that loves to run straight down the field. Cutler can throw the deep ball. This week, Cutler should be able to connect with Jeffery on multiple occasions, as the Tampa Bay Bucs' defense is porous. In his last game, Jeffery posted over 15 fantasy points. His upside is even higher than that, as the Bears could turn this game into a potential shootout. Use Jeffery in all formats.

Kenny Britt (at NYJ, $4,900)

Kenny Britt gets a tough matchup against the New York Jets, but he has been solid of recent. In his last three games, he has 14.9, a little over seven, and 35.6 fantasy points. He is seeing almost double-digit targets per game, and he has three touchdowns in his last three games. His price tag is still low, and the Los Angeles Rams should be able to figure out a way to get him the ball. Use him in both 50/50 contests and tournaments, even though he is a little bit risky.

DraftKings Tight Ends - Week 10 DFS Picks

Delanie Walker (vs GB, $4,600)

Delanie Walker is one of the best tight ends in the league. He posted over 15 fantasy points in two of his last three games, scoring a touchdown in both of those games. Against the Indianapolis Colts, he posted over 20 fantasy points, which is incredible for a tight end that is not named Rob Gronkowski. The Green Bay Packers struggle to defend opposing tight ends, and Walker should be able to find some space to work. His price tag is very reasonable. Use him in all formats.

DraftKings Defenses - Week 10 DFS Picks

LA Rams Defense (at NYJ, $2,900)

The Los Angeles Rams are not one of the better teams in the league, but the New York Jets are horrible offensively. The Rams' defense is very cheap this week, and since defenses are so unpredictable, it is worth using them in tournaments. They do have double-digit fantasy points in three games this season. The Jets turn the ball over quite often, and that is all a defense needs to have a big week.