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DraftKings Daily Fantasy Baseball Picks (9/21/19): MLB DFS Lineups

Saturday brings us a full 15-game slate. Six of those games fall in the early part of the slate with the other nine making up the main featured slate for the day.

The featured slate brings us four monster favorites in the form of the Astros, Twins, Athletics and Dodgers, with all of them better than -300. We also have two teams with odds better than -200 in the Brewers and Braves, so there are plenty of pitching options to choose from. The biggest expected run totals on this slate can be found in Baltimore, Cleveland and Minnesota, but with plenty of pitching mismatches on the slate there are many opportunities outside of those three games.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 9/21/19. The lineup picks will range from some of the elite players to mid-priced options and value plays. Be sure to also check out all the Vegas Odds for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @benrolfe15.

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DraftKings DFS Starting Pitchers

Sean Manaea, OAK (vs. TEX) - $9,800

Manaea’s return from the disabled list could not really have gone much better. Three starts, 18 innings and just one earned run allowed with 21 strikeouts. Now he is facing a Rangers team with just three earned runs in their current three-game road trip. This should be both a nice floor and ceiling play on today’s slate.

Wade Miley, HOU (vs. LAA) - $5,700 

Miley is not far away from a rough stretch in which he allowed 12 earned runs for just one out across two starts. However, he bounced back last time out with a four-strikeout, two earned run, six innings outing at the Royals last time out. The Angels have all but given up on the season and Miley should be able to take advantage.

 

DraftKings DFS Infielders

C - Roberto Perez, CLE (vs. PHI) - $3,700

A solid, if unimpressive, season for Perez has at been headlines by his numbers against left-handed pitchers. This season he has a .252 batting average, .228 ISO and a .347 wOBA with lefties on the mound.

1B - Daniel Vogelbach, SEA (@ BAL) - $4,000 

It has been a nice season for Vogelbach against right-handed pitchers with 25 of his 30 home runs coming off them. His numbers against righties this season stand as a .231 batting average, .271 ISO, and .364 wOBA.

2B - Max Muncy, LAD (vs. COL) - $4,400 

Muncy’s numbers against righties are not spectacular but against Chi-Chi Gonzalez we aren’t looking for spectacular. Muncy has 22 home runs, a .256 ISO and a .362 wOBA.

3B - Josh Donaldson, ATL (vs. SF) - $4,100

Donaldson has nice numbers against righties this year. So far he has a .267 batting average, a .274 ISO and a .379 wOBA. He also has a whopping .332 ISO and .429 wOBA this season.

SS - Corey Seager, LAD (vs. COL) - $4,100

Seager is another hitter with solid numbers against right-handed pitchers. The young shortstop has a .285 batting average, .226 ISO and a .354 wOBA when righties are on the mound this year.

 

DraftKings DFS Outfielders

Mark Canha, OAK (vs. TEX) - $4,200

Canha’s value against lefties is due to his ability to get the ball out of the park. He has eight home runs against lefties this year, giving him a .248 ISO. He has also been good at clearing the fences at home, with a .276 ISO.

Joc Pederson, LAD (vs. COL) - $4,100

September has been good to Pederson. He has six home runs and an impressive .375 batting average so far this month. All 32 of his home runs this year have come when facing right-handed hitters, and 24 of them have come at home. He has a .304 ISO against righties and a .386 ISO as home this season.

Jake Marisnick, HOU (vs. LAA) - $3,500

Marisnick is a hitter I have used a few times this year against lefties because of his price. He has a .204 ISO against lefties and is part of one of the best lineups in the majors so for this price it is worth the gamble.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Patrik Laine

Looking Forward to Free Agency
Jeremy Lauzon

Returns to Action Tuesday
Zach Werenski

Wins 2025-26 Norris Trophy
Aaron Judge

Out on Tuesday With Rib/Shoulder Injury
Adam Randall

Well-Positioned for Dynasty Success in Baltimore?
Nicholas Singleton

Could Be the Running Back of the Future in Tennessee
Bryce Lance

Is Bryce Lance Currently Undervalued by Dynasty Managers?
Mike Washington Jr.

Carries Dynasty Sleeper Appeal Entering 2026
Adonai Mitchell

Is Adonai Mitchell Still Worthy of a Dynasty Roster Spot?
Tony Pollard

Dynasty Stock Rising in Improving Tennessee Offense?
Josh Hader

Set to Return from Injured List on Tuesday
Chris Brazzell II

a Year 1 Breakout Candidate in Carolina?
Ja'Kobi Lane

a Great Fit for Ravens, Potential Steal in Rookie Drafts
Josh Jacobs

Back at Practice on Tuesday
Max Klare

Crowded Tight End Room Impacting Max Klare's Dynasty Stock?
Romeo Doubs

Still a Solid Dynasty Option in New England?
CFB

SEC Coach Calls Buster Faulkner a "Home-Run Hire"
CFB

Auburn a Sleeper in the SEC Under Alex Golesh?
CFB

Noah Fifita Primed for Strong 2026 Campaign
CFB

Oregon Assistant Coach Charged with DUII, Reckless Driving
Makai Lemon

Set for Major Role in Debut Season?
CFB

Tight End Nick Pollack Commits to Clemson
Drake Maye

Does Latest Addition Put Drake Maye Among the Upper Echelon of Fantasy Elite?
Jalen Hurts

Could Face Regression After Loss of Top Pass Catcher
DeVonta Smith

Poised for WR1 Role in the Aftermath of Trade?
Daniel Jones

Participating in 7-on-7s
Akshay Bhatia

Needs the Driver to be True in Ohio
Aaron Rai

Primed to take on the Memorial Tournament
J.J. Spaun

Rebounded at Charles Schwab Challenge
Xander Schauffele

One to Watch This Week in Ohio
Hideki Matsuyama

Putter Could be Vital at the Memorial
Nicolai Hojgaard

Rust Concerns at Muirfield Village
Ryan Gerard

Surfaces After Long Cold Stretch with Top 10 Result
Wyndham Clark

May Struggle at the Memorial Tournament
Elly De La Cruz

to Miss 2-4 Weeks of Action
Chase Burns

is Scratched Due to Illness
A.J. Brown

Traded to Patriots in Blockbuster Deal
Deiveson Figueiredo

Suffers Second-Round Submission Loss
Song Yadong

Gets Second-Round Submission Win
Russell Wilson

Taking a Job with CBS for 2026 Season
JuJu Smith-Schuster

Giants Adding JuJu Smith-Schuster on a One-Year Deal
Zhang Mingyang

Suffers Back-To-Back Losses
Alonzo Menifield

Gets Back In The Win Column
Braxton Berrios

New York Giants Agree to One-Year Deal with Braxton Berrios
Odell Beckham Jr.

Signing with Giants
Tallison Teixeira

Suffers First-Round Knockout Loss
Sergei Pavlovich

Scores First-Round Knockout Win
Cameron Smotherman

Suffers Third Loss In A Row
Edwin Arroyo

Reds Promote Top Infield Prospect Edwin Arroyo, Viewed as Priority Pick Up Ahead of MLB Debut
Kai Asakura

Earns His First UFC Win
Elly De La Cruz

Placed on IL with Right Hamstring Tightness
Denny Hamlin

Earns the first Nashville Cup Series Victory of his Career on Sunday
Christopher Bell

Finishes as the Runner-Up at Nashville
Chase Briscoe

Earns First Career Podium Finish at Nashville
Ryan Blaney

Scores A Solid Top-10 Finish at Nashville
Kyle Larson

Top-10 Streak at Nashville Ends after Late Flat Tire Spin
Elly De La Cruz

Exits with Hamstring Tightness
Tyler Reddick

Is One of the Top Favorites to Win at Nashville
Kyle Larson

May Continue his Top-10 Consistency at Nashville this week
Christopher Bell

Is One of the Top Competitors for the Win at Nashville
Chase Briscoe

Is A Must Start for Nashville DFS Lineups
Chase Elliott

has Plenty of Upside for Nashville DFS Lineups
William Byron

Is William Byron A Playable DFS Option for Nashville Lineups?
Carson Hocevar

Is Likely to have Another Solid Result at Nashville
NASCAR

Should Fantasy Players Roster Bubba Wallace at Nashville?
Chris Buescher

Is A Decent All-Around DFS Option for Nashville Lineups
Daniel Suarez

is Likely to Drop Positions during the Cracker Barrel 400
Garrett Crochet

Suffers Setback, Likely to Undergo MRI for Lat Tightness
Denny Hamlin

Could Denny Hamlin Dominate at Nashville?
Ryan Blaney

Is a DFS Tournament Option at Nashville
Ty Gibbs

Don't Overlook Ty Gibbs at Nashville
Joey Logano

Could Show Life at Nashville
Ross Chastain

Needs a Good Run at Nashville
Chet Holmgren

Fails to Step Up in the Season Finale
Cason Wallace

Ends Postseason with Strong Showing
Shai Gilgeous-Alexander

Caps MVP Season with Game 7 Exit
Stephon Castle

Continues Postseason Run with 16 Points
Julian Champagnie

Shines in Series-Clinching Win
De'Aaron Fox

Provides Secondary Punch in Game 7 Triumph
Victor Wembanyama

Earns Conference Finals MVP in Spurs' Game 7 Win
NBA

Warriors Prioritize Depth Around Returning Steve Kerr
Donovan Mitchell

Remains Cleveland's Top Priority
Adou Thiero

Remains a Lakers Development Project
NBA

76ers Hire Mike Gansey as President of Basketball Operations
NBA

Chicago Bulls Explore Kevin Young as Coaching Candidate
Kyrie Irving

Reports He's Nearing Full Strength in ACL Recovery
Lane Hutson

Posts a Power-Play Assist in Game 5 Loss
Cole Caufield

Nets a Power-Play Goal in Season-Ending Loss
Seth Jarvis

Closes Out East Finals With Multi-Point Game
Logan Stankoven

Notches Three Points in Big Game 5 Win
Taylor Hall

Racks Up Three Points in Series-Clinching Win
Frederik Andersen

Remains Stellar as Hurricanes Clinch Finals Berth
Jacob Gonzalez

is Heading to the Big Leagues
Munetaka Murakami

Exits with Hamstring Tightness
Mitchell Robinson

Plans to Play in Game 1 After Finger Surgery
Ajay Mitchell

Ruled Out for Game 7
Jalen Williams

Unavailable in Decisive Game 7
NBA

Magic Finalizing Hire of Sean Sweeney as Head Coach
Eury Pérez

Eury Perez is Placed on 15-Day Injured List
Deiveson Figueiredo

Set For UFC Macau Main Event
MMA

Yadong Song Returns At UFC Macau
Alonzo Menifield

An Underdog At UFC Macau
Zhang Mingyang

Set For UFC Macau Co-Main Event
Tallison Teixeira

Looks To Win Back-To-Back Fights
Sergei Pavlovich

A Favorite At UFC Macau
Cameron Smotherman

Looks To Bounce Back
Kai Asakura

Looks To Get Back In The Win Column
CFB

Faizon Brandon In Position to Start Week 1
CFB

Dane Weber Commits to Cal
CFB

Joey McGuire Attempts to Add Texas to Schedule
CFB

Mike Leach on 2027 College Football Hall of Fame Ballot
CFB

Maryland, Baylor Schedule Home-and-Home
CFB

Taron Dickens Decommits From North Carolina
Jalen Williams

Limited in Game 6 Return
Jared McCain

Provides Bench Spark in Game 6 Loss
Shai Gilgeous-Alexander

Posts Lowest-Scoring Night of His MVP Season
De'Aaron Fox

Struggles From the Field Thursday
MLB

MLB Proposes Hard Salary Cap as Part of Next CBA
Kenley Jansen

Tigers Place Kenley Jansen on Injured List With Pelvic Inflammation
Teoscar Hernández

Teoscar Hernandez Heading to Injured List With Hamstring Strain
MON

Lane Hutson Struggles in Game 4 Loss
CAR

Logan Stankoven Nets Eighth Postseason Goal
CAR

Sebastian Aho Pots Game-Winner on Power Play
CAR

Nikolaj Ehlers Tallies Two Helpers in Impressive Road Win
CAR

Shayne Gostisbehere Records Two Assists in Game 4 Win
CAR

Frederik Andersen Establishes Hurricanes New Postseason Shutout Record
Yordan Alvarez

Continues Homer Barrage With Two More Long Balls on Wednesday
Cristopher Sánchez

Cristopher Sanchez Makes History With Seven More Shutout Innings Against Padres
Teoscar Hernández

Teoscar Hernandez Lifted From Wednesday's Game Early With Hamstring Strain
Kenley Jansen

Exits Relief Appearance on Wednesday With Groin Injury
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF