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DraftKings Daily Fantasy Baseball Picks (9/21/19): MLB DFS Lineups

Saturday brings us a full 15-game slate. Six of those games fall in the early part of the slate with the other nine making up the main featured slate for the day.

The featured slate brings us four monster favorites in the form of the Astros, Twins, Athletics and Dodgers, with all of them better than -300. We also have two teams with odds better than -200 in the Brewers and Braves, so there are plenty of pitching options to choose from. The biggest expected run totals on this slate can be found in Baltimore, Cleveland and Minnesota, but with plenty of pitching mismatches on the slate there are many opportunities outside of those three games.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 9/21/19. The lineup picks will range from some of the elite players to mid-priced options and value plays. Be sure to also check out all the Vegas Odds for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @benrolfe15.

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DraftKings DFS Starting Pitchers

Sean Manaea, OAK (vs. TEX) - $9,800

Manaea’s return from the disabled list could not really have gone much better. Three starts, 18 innings and just one earned run allowed with 21 strikeouts. Now he is facing a Rangers team with just three earned runs in their current three-game road trip. This should be both a nice floor and ceiling play on today’s slate.

Wade Miley, HOU (vs. LAA) - $5,700 

Miley is not far away from a rough stretch in which he allowed 12 earned runs for just one out across two starts. However, he bounced back last time out with a four-strikeout, two earned run, six innings outing at the Royals last time out. The Angels have all but given up on the season and Miley should be able to take advantage.

 

DraftKings DFS Infielders

C - Roberto Perez, CLE (vs. PHI) - $3,700

A solid, if unimpressive, season for Perez has at been headlines by his numbers against left-handed pitchers. This season he has a .252 batting average, .228 ISO and a .347 wOBA with lefties on the mound.

1B - Daniel Vogelbach, SEA (@ BAL) - $4,000 

It has been a nice season for Vogelbach against right-handed pitchers with 25 of his 30 home runs coming off them. His numbers against righties this season stand as a .231 batting average, .271 ISO, and .364 wOBA.

2B - Max Muncy, LAD (vs. COL) - $4,400 

Muncy’s numbers against righties are not spectacular but against Chi-Chi Gonzalez we aren’t looking for spectacular. Muncy has 22 home runs, a .256 ISO and a .362 wOBA.

3B - Josh Donaldson, ATL (vs. SF) - $4,100

Donaldson has nice numbers against righties this year. So far he has a .267 batting average, a .274 ISO and a .379 wOBA. He also has a whopping .332 ISO and .429 wOBA this season.

SS - Corey Seager, LAD (vs. COL) - $4,100

Seager is another hitter with solid numbers against right-handed pitchers. The young shortstop has a .285 batting average, .226 ISO and a .354 wOBA when righties are on the mound this year.

 

DraftKings DFS Outfielders

Mark Canha, OAK (vs. TEX) - $4,200

Canha’s value against lefties is due to his ability to get the ball out of the park. He has eight home runs against lefties this year, giving him a .248 ISO. He has also been good at clearing the fences at home, with a .276 ISO.

Joc Pederson, LAD (vs. COL) - $4,100

September has been good to Pederson. He has six home runs and an impressive .375 batting average so far this month. All 32 of his home runs this year have come when facing right-handed hitters, and 24 of them have come at home. He has a .304 ISO against righties and a .386 ISO as home this season.

Jake Marisnick, HOU (vs. LAA) - $3,500

Marisnick is a hitter I have used a few times this year against lefties because of his price. He has a .204 ISO against lefties and is part of one of the best lineups in the majors so for this price it is worth the gamble.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Kevin Huerter

Active on Sunday Night
Caris LeVert

Duncan Robinson, Caris LeVert Available Sunday
Dean Wade

Max Strus Replaces Dean Wade in Starting Lineup Sunday
Luke Kornet

Iffy for Monday
Larry Nance Jr.

Won't Play Sunday
De'Aaron Fox

Listed as Questionable for Monday's Action
Jalen Williams

Officially Available for Game 1 Against Spurs
Shai Gilgeous-Alexander

Named MVP for Second Straight Year
Jonah Coleman

is an Intriguing Power Back to Target in Dynasty Leagues
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Darius Slayton

Lacking Long-Term Upside for Dynasty Managers
Keaton Mitchell

a Prime Dynasty Handcuff Option Entering First Season in L.A.
Jadarian Price

Looks Like the Running Back of the Future in Seattle
Isaiah Bond

Dynasty Outlook Clouded by Uncertain Role in Cleveland
James Cook III

Remains a High-End Dynasty RB1 Entering 2026
Lamar Jackson

Poised for Bounce Back Season in 2026
Bucky Irving

Expected to Be Ready for Training Camp
Kyle Williams

Deep Threat Kyle Williams Facing Uphill Battle for Playing Time
Michael Pittman Jr.

Could Receive Short-Term Value Uptick in PPR Leagues
Stefon Diggs

Chiefs, Commanders Could Make Sense for Stefon Diggs
Will Howard

Dynasty Value Dealt a Blow
Jaylen Warren

Should Benefit From Veteran QB's Return to Pittsburgh
Drew Allar

Could Continue to Hold Dynasty Value
Pat Freiermuth

Could See a Small Dynasty Bump With Veteran QB Returning
DK Metcalf

A Dynasty Sell Candidate With Veteran QB Returning?
Bones Hyland

Wants to Stay in Minnesota
Mike Conley

Hints He Will Continue Playing Next Season
Kevin Huerter

Iffy for Sunday Night
Caris LeVert

Questionable for Game 7
Duncan Robinson

Back on Injury Report Ahead of Game 7
Larry Nance Jr.

Likely Out Sunday Due to Illness
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Aaron Rodgers

Signs One-Year Deal With Steelers
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Isaac TeSlaa

Can Isaac TeSlaa Carve Out a Larger Role in Detroit Going Forward?
Troy Franklin

Facing Uphill Battle for Playing Time in Denver
Trevor Lawrence

Should Trevor Lawrence Be Valued as a Dynasty QB1?
Courtland Sutton

in Line for Reduced Role in Denver?
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Duncan Robinson

Nets 14 Points With Four Triples
Cade Cunningham

Contributes 21 Points in Game 6 Win
Jalen Duren

Bounces Back With Double-Double
Anthony Edwards

Finishes Season-Ending Loss With 24 Points
Victor Wembanyama

Tallies 19 Points in Friday's Win
De'Aaron Fox

Highly Effective in Blowout Win
Stephon Castle

Shines in Series-Clincher
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Max Fried

Heading to Injured List With Elbow Bone Bruise
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
Jeremy Lauzon

Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
EDM

Kris Knoblauch Fired as Oilers Head Coach
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Quinn Hughes

Finishes Postseason With 15 Points
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF