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DraftKings and FanDuel Daily Fantasy Basketball Picks (10/21/22): NBA DFS Lineups

The top daily fantasy basketball lineup picks for DraftKings and FanDuel on October 21st, 2022. John Brubaker provides NBA DFS analysis and sleeper picks for building optimal DFS rosters.

Happy Friday, RotoBallers! The NBA season is finally here, and we have a whopping 11 games slotted for this evening. It's a new season, with players switching teams, rookies joining the fold, and rotations mixing and matching as teams learn to gel. My model will take time to adjust to these changes, but it's my duty to give you all the best picks possible. I had a nice night on opening night, so I'll look to keep that momentum going forward into today. 

Tonight, we have an 11-game slate for the first weekend slate of the season. With both FanDuel and DraftKings having multi-position eligibility players, and we'll have to attack slates accordingly to make our lineups as optimal as possible. That's where I come in! I'll look to find my personal top plays and values for tonight's slate. Things can change during the day as well, so I'll do my best to update as news comes out!

Here are my daily fantasy basketball lineup picks for FanDuel and DraftKings on 10/21/22. Keep an eye on RotoBaller’s NBA injury news and also our full NBA injury report today to stay up to date before lineups are locked.

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DraftKings and FanDuel Guards - NBA DFS Lineup Picks

Devin Booker, at POR (FD: $8,300, DK: $8,900)

I'll start off tonight's slate with Devin Booker. Booker had a solid opening night on Monday night, logging 28 points, four rebounds, and nine assists across 40 minutes in what was an improbable comeback against the Mavericks. I'm looking for more of the same from him tonight, as my model projects him for 34 minutes and a usage rate of 30.18%. He'll take on the Blazers, who rank 19th in shooting guard efficiency, and this should end up a high-scoring affair.

Tyrese Haliburton, vs SAS (FD: $7,900, DK: $7,900)

I'll take a look at Tyrese Haliburton tonight as well, as the Pacers will take on the Spurs in what my buddy referred to as "the Tank Olympics." Haliburton logged 35 minutes in the season opener against the Wizards, finishing with a stat line of 26 points, four rebounds, and seven assists. My model has him projected for 36.3 minutes tonight and a 22.5% usage rate. I think that usage rate will go up as the season goes on, and this should be another high-scoring game with a total sitting at 231.5.

Coby White, at WAS (FD: $3,700, DK: $4,100)

I'll finish things up at the guard positions with Coby White. White, who is coming off the bench as a backup for Ayo Dosunmu, logged ten points and two rebounds across 24 minutes on Wednesday night. I have him projected for 27.8 minutes tonight against the Wizards though, as well as a usage rate near 18%. I wouldn't recommend this play in cash, but I do think he could be a sneaky GPP play as he comes in super cheap and has projections north of 5x on both sites.

Also consider: Kyle Lowry (FD: $5,300, DK: $5,400), Tyler Herro (FD: $6,200, DK: $6,300)

 

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DraftKings and FanDuel Forwards - NBA DFS Lineup Picks

Pascal Siakam, at BKN (FD: $8,500, DK: $8,100)

I'll start off the forwards with "Spicy P" Pascal Siakam, whom I was very high on Wednesday night. Siakam grabbed a double-double in the Raptors' season opener against the Cavs, login 23 points, 11 rebounds, and an assist. I have him projected for 37 minutes tonight with a 32% usage rate, and after seeing what Zion Williamson did to Ben Simmons on Wednesday night, I'm confident in "running it back" with Siakam.

Bojan Bogdanovic, at NY (FD: $4,900, DK: $5,600)

Another "run-back" play here for me, as we'll take a look at Bojan Bogdanovic. After a slow start Wednesday night, Bogdanovic began to heat up and finished with 24 points, five rebounds, and two assists. While I'm not expecting the same results as Wednesday, I do have Bogdanovic projected for 32.9 minutes and a usage rate of 21.67%. His matchup against the Knicks is somewhat in the "middle of the pack," but they ranked 19th in small forward efficiency last season, so I'll look for him to take advantage.

Santi Aldama, at HOU (FD: $4,300, DK: $5,100)

One of the more surprising players of Wednesday night's slate was Santi Aldama. Aldama filled in nicely for Jaren Jackson Jr. against the Knicks, logging 18 points, 11 rebounds, and an assist across 38 minutes. I don't expect him to play 38 minutes tonight, and while my model isn't currently adjusted for his minutes (having him at just a 21.9-minute projection), his 19.94% usage rate is solid enough to pass given his cheap price on both sites.

Also consider: John Collins (FD: $6,100, DK: $6,200), Aaron Gordon (FD: $5,500, DK: $6,200)

 

DraftKings and FanDuel Centers - NBA DFS Lineup Picks

Nikola Jokic, at GSW (FD: $11,300, DK: $11,200)

I, for some reason, was higher on Clint Capela than Jokic on Wednesday night, and boy will I not make that mistake again. While the Nuggets flopped in their season opener, Jokic still logged 27 points, four rebounds, and six assists across 33 minutes against the Jazz. Tonight I have him projected for 34.2 minutes, and I doubt his 32.51% usage rate will waiver as it seems the Nuggets are easing Michael Porter Jr. and Jamal Murray into the fold. I'll look for Joker and the Nuggets to bounce back against the defending champs after what has to be considered an embarrassing loss in their season opener.

Also consider: Deandre Ayton (FD: $7,000, DK: $6,600)



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REAL-TIME FANTASY NEWS

MLB

Orioles-Tigers Game Postponed on Saturday
RJ Harvey

to be Relegated to Third-Down Role After Rookie RB Addition?
Baker Mayfield

A Lot of Uncertainty Surrounding Baker Mayfield Going into Fourth Year in Tampa
Brian Robinson Jr.

a Must-Have Handcuff in Dynasty Leagues?
Sam LaPorta

Could be Excellent Buy-Low Candidate for Risk-Tolerant Managers
Jordyn Tyson

on a "Maintenance Plan" During Offseason Workouts
Kenneth Walker III

One of Dynasty's Biggest Risers for 2026
D'Andre Swift

an Underappreciated Dynasty Buy Candidate
Ray Davis

Still a Dynasty Stash Despite a Lack of Standalone Value
Travis Kelce

Now a Low-Cost Dynasty Rental
DJ Moore

a Reasonable Buy Candidate Now That Dynasty Market Has Cooled
MLB

Rays-Yankees Postponed on Saturday
Devin Vassell

Posts 20 Points in Game 3 Loss
De'Aaron Fox

Struggles From Deep in Friday's Loss
Victor Wembanyama

Held to Four Rebounds in Game 3 Loss
Jaylin Williams

Catches Fire From Deep Friday
Jared McCain

Drops Playoff-High 24 Points in Game 3
Nazem Kadri

Contributes an Assist in Losing Effort
Shai Gilgeous-Alexander

Guides Thunder to 2-1 Series Lead
Ajay Mitchell

Does Not Return in Game 3 Win
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Jordan James

Most Likely to be 49ers' RB2 in 2026
Mickey Moniak

Heads to Injured List With Ankle Sprain
Rudy Gobert

Earns Eighth All-Defensive First-Team Selection
Victor Wembanyama

Headlines 2025-26 All-Defensive First Team
Ajay Mitchell

Starting Game 3 Against Spurs
Dylan Harper

Available for Game 3 Against Thunder
De'Aaron Fox

Returns to Action Friday
Jalen Williams

Won't Play Friday Night
Derrick Henry

Remains in RB1 Discussion
Ladd McConkey

is Solid Buy-Low Candidate
Ryan Flournoy

an Intriguing Dynasty Stash Option
Jalen Nailor

is Expected to Have Larger Role in Las Vegas
Frederik Andersen

Hurricanes Keep Faith in Frederik Andersen
Devon Levi

Attracting Interest From Senators
Jacoby Brissett

Cardinals Not Close to a Reworked Deal
Scott Wedgewood

Starting Game 2 Against Golden Knights
Ben Hutton

Scratched for Game 2 Against Avalanche
Mark Stone

Won't Play Friday
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
Cale Makar

Remains Out Friday
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Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
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Jadan Baugh Primed to Lead Florida Offense in 2026
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LSU Hires Ed Orgeron As Special Assistant
NFL

Evan Stewart Pushing Oregon Receiving Corps
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North Carolina and South Carolina Cancel Home-And-Home Series
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Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
New York Giants

Giants, GM Joe Schoen Agree on a Multi-Year Extension
Andrew Thomas

Giants Managing Multiple Injuries for Andrew Thomas
Cam Ward

Loses 10 Pounds in the Offseason
Trevor Story

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Roman Anthony

Dealing With Sprained Ligament in his Finger
Tucker Kraft

a Top Trade Target in Dynasty Leagues?
Evan Mobley

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James Harden

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Karl-Anthony Towns

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Sebastian Aho

Picks Up an Assist in Series-Opening Loss
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Jalen Brunson

Hands Out 14 Assists in Game 2 Win
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Josh Hart

Erupts for Playoff Career-High 26 Points in Game 2
Jaccob Slavin

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Jakub Dobes

Sharp in Game 1 Victory
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Opens Conference Finals With Three-Point Performance
Nick Suzuki

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Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Jrue Holiday

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Alex Tuch

Hopes to Remain in Buffalo
Sidney Crosby

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Robby Snelling

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Jackson Merrill

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Lincoln Riley Believes USC is Ready for Playoff Run
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Notre Dame-Stanford Rivalry Renewed Through 2028
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Ahmad Hardy Says He's "Back to the Road to Success"
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Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
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UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
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Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
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Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
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Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
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Kemario Taylor a Breakout Candidate at Quarterback
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Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
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Rocco Becht The "Unifier" of Penn State's Roster
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Corey Seager

Going on Injured List With Back Injury
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
RANKINGS
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1B
2B
3B
SS
OF
SP
RP

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