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DraftKings and FanDuel Daily Fantasy Basketball Picks (10/21/22): NBA DFS Lineups

The top daily fantasy basketball lineup picks for DraftKings and FanDuel on October 21st, 2022. John Brubaker provides NBA DFS analysis and sleeper picks for building optimal DFS rosters.

Happy Friday, RotoBallers! The NBA season is finally here, and we have a whopping 11 games slotted for this evening. It's a new season, with players switching teams, rookies joining the fold, and rotations mixing and matching as teams learn to gel. My model will take time to adjust to these changes, but it's my duty to give you all the best picks possible. I had a nice night on opening night, so I'll look to keep that momentum going forward into today. 

Tonight, we have an 11-game slate for the first weekend slate of the season. With both FanDuel and DraftKings having multi-position eligibility players, and we'll have to attack slates accordingly to make our lineups as optimal as possible. That's where I come in! I'll look to find my personal top plays and values for tonight's slate. Things can change during the day as well, so I'll do my best to update as news comes out!

Here are my daily fantasy basketball lineup picks for FanDuel and DraftKings on 10/21/22. Keep an eye on RotoBaller’s NBA injury news and also our full NBA injury report today to stay up to date before lineups are locked.

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DraftKings and FanDuel Guards - NBA DFS Lineup Picks

Devin Booker, at POR (FD: $8,300, DK: $8,900)

I'll start off tonight's slate with Devin Booker. Booker had a solid opening night on Monday night, logging 28 points, four rebounds, and nine assists across 40 minutes in what was an improbable comeback against the Mavericks. I'm looking for more of the same from him tonight, as my model projects him for 34 minutes and a usage rate of 30.18%. He'll take on the Blazers, who rank 19th in shooting guard efficiency, and this should end up a high-scoring affair.

Tyrese Haliburton, vs SAS (FD: $7,900, DK: $7,900)

I'll take a look at Tyrese Haliburton tonight as well, as the Pacers will take on the Spurs in what my buddy referred to as "the Tank Olympics." Haliburton logged 35 minutes in the season opener against the Wizards, finishing with a stat line of 26 points, four rebounds, and seven assists. My model has him projected for 36.3 minutes tonight and a 22.5% usage rate. I think that usage rate will go up as the season goes on, and this should be another high-scoring game with a total sitting at 231.5.

Coby White, at WAS (FD: $3,700, DK: $4,100)

I'll finish things up at the guard positions with Coby White. White, who is coming off the bench as a backup for Ayo Dosunmu, logged ten points and two rebounds across 24 minutes on Wednesday night. I have him projected for 27.8 minutes tonight against the Wizards though, as well as a usage rate near 18%. I wouldn't recommend this play in cash, but I do think he could be a sneaky GPP play as he comes in super cheap and has projections north of 5x on both sites.

Also consider: Kyle Lowry (FD: $5,300, DK: $5,400), Tyler Herro (FD: $6,200, DK: $6,300)

 

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DraftKings and FanDuel Forwards - NBA DFS Lineup Picks

Pascal Siakam, at BKN (FD: $8,500, DK: $8,100)

I'll start off the forwards with "Spicy P" Pascal Siakam, whom I was very high on Wednesday night. Siakam grabbed a double-double in the Raptors' season opener against the Cavs, login 23 points, 11 rebounds, and an assist. I have him projected for 37 minutes tonight with a 32% usage rate, and after seeing what Zion Williamson did to Ben Simmons on Wednesday night, I'm confident in "running it back" with Siakam.

Bojan Bogdanovic, at NY (FD: $4,900, DK: $5,600)

Another "run-back" play here for me, as we'll take a look at Bojan Bogdanovic. After a slow start Wednesday night, Bogdanovic began to heat up and finished with 24 points, five rebounds, and two assists. While I'm not expecting the same results as Wednesday, I do have Bogdanovic projected for 32.9 minutes and a usage rate of 21.67%. His matchup against the Knicks is somewhat in the "middle of the pack," but they ranked 19th in small forward efficiency last season, so I'll look for him to take advantage.

Santi Aldama, at HOU (FD: $4,300, DK: $5,100)

One of the more surprising players of Wednesday night's slate was Santi Aldama. Aldama filled in nicely for Jaren Jackson Jr. against the Knicks, logging 18 points, 11 rebounds, and an assist across 38 minutes. I don't expect him to play 38 minutes tonight, and while my model isn't currently adjusted for his minutes (having him at just a 21.9-minute projection), his 19.94% usage rate is solid enough to pass given his cheap price on both sites.

Also consider: John Collins (FD: $6,100, DK: $6,200), Aaron Gordon (FD: $5,500, DK: $6,200)

 

DraftKings and FanDuel Centers - NBA DFS Lineup Picks

Nikola Jokic, at GSW (FD: $11,300, DK: $11,200)

I, for some reason, was higher on Clint Capela than Jokic on Wednesday night, and boy will I not make that mistake again. While the Nuggets flopped in their season opener, Jokic still logged 27 points, four rebounds, and six assists across 33 minutes against the Jazz. Tonight I have him projected for 34.2 minutes, and I doubt his 32.51% usage rate will waiver as it seems the Nuggets are easing Michael Porter Jr. and Jamal Murray into the fold. I'll look for Joker and the Nuggets to bounce back against the defending champs after what has to be considered an embarrassing loss in their season opener.

Also consider: Deandre Ayton (FD: $7,000, DK: $6,600)



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REAL-TIME FANTASY NEWS

Mitchell Robinson

Available for Game 3
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Bulls Hire Alex Kaufman as Windy City Bulls General Manager
E.J. Liddell

Agrees to Two-Year Deal with Greek Club Aris
Matas Buzelis

Will Play for Lithuania This Summer
Giannis Antetokounmpo

Has Concerns About Heat Roster If Traded to Miami
Bobby Witt Jr.

Exits Early with Knee Soreness
Mitchell Robinson

Has Technical Foul Rescinded After Game 2 Win
Jarquez Hunter

Is it Time for Dynasty Managers to Move on From Jarquez Hunter?
Elijah Arroyo

Worth Buying Low on in Dynasty Formats?
Tre Tucker

Profiles as a Dynasty Sell-High Candidate Entering 2026
Jack Bech

Should Dynasty Managers Target Jack Bech as a Buy-Low Candidate?
Jaydon Blue

a Dynasty Buy-Low Candidate After Underwhelming Rookie Year?
Saquon Barkley

in Line for Larger Pass-Catching Role in 2026?
Karl-Anthony Towns

Eligible for Massive Extension
Isaiah Stewart

Could Draw Trade Interest
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Michigan?
Philadelphia 76ers

Jameer Nelson Promoted to Executive Vice President
Domantas Sabonis

Could be Traded This Summer
Ty Gibbs

Is Ty Gibbs Worth Rostering at Michigan This Week for DFS?
William Byron

Will Start at the Rear at Michigan After Unapproved Adjustments
NASCAR

Should DFS Managers Roster Bubba Wallace at Michigan?
Joey Logano

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Daniel Suarez

Might Have Tournament Appeal for Michigan DFS Lineups
Jonah Coleman

Is Jonah Coleman the Most Valuable Broncos Running Back in Dynasty Leagues?
William Carrier

Suffers Upper-Body Injury in Game 3 Versus Golden Knights
Darius Slayton

Will Darius Slayton Be Phased Out of New-Look Giants Offense?
Sebastian Aho

Records Two Assists in Losing Effort
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Can Keaton Mitchell Carve Out a Large Enough Role for a Fantasy Breakout?
Jordan Staal

Scores in Third Consecutive Game
Shea Theodore

Caps Multi-Point Effort With Game-Winning Goal Saturday
Kayshon Boutte

Will Attend Mandatory Minicamp
Denny Hamlin

Puts DFS Managers in Tough Spot for Michigan
Chase Elliott

Can Chase Elliott Get Back to His Old Ways at Michigan?
Chris Buescher

Looking for Another Solid Run at Michigan
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Collects Two Points in Overtime Win
Jonathon Brooks

to Be Carolina's Lead Back in 2026?
Carson Hocevar

Qualifies Second, Seeking Redemption at Michigan
Ross Chastain

Can DFS Managers Trust Ross Chastain at Michigan?
Mitch Marner

Scores Fastest Hat Trick in Finals History
Brad Keselowski

Has Been Solid at Michigan
Will Smith

Scratched With Neck Stiffness, Expected to Return on Sunday
Kenneth Gainwell

Standing Out at OTAs
Bhayshul Tuten

"Picking Up Steam," More in-Tune With New Scheme
Auston Matthews

Maple Leafs Confident of Keeping Auston Matthews
Andrei Vasilevskiy

Wins Second Vezina Trophy
Brayden McNabb

Uncertain for Game 3 Against Hurricanes
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Is it Time for Dynasty Managers to Drop Will Howard?
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Dynasty Stock is Declining Rapidly Entering 2026
Hunter Greene

Could Return Before the All-Star Break
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Troy Franklin

a Dynasty Hold with Potentially Rough Times Ahead
Dylan Harper

Remains a Bright Spot for San Antonio
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Shoots Well in a Loss to the Knicks
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Scores 29 Points in Game 2 Loss
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Anchors Knicks' Defense in Finals Game 2
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Helps Knicks Secure a Game 2 Victory
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Records Another Finals Double-Double
Jalen Brunson

Overcomes Cold Night to Seal Game 2
Michael Harris II

Dealing With Back Tightness, Not Believed to be Serious
Byron Buxton

Suffers Shoulder Contusion After Colliding With the Wall
Sacramento Kings

Kings Want to Trade Their Larger Contracts
Chicago Bulls

Darius Acuff Jr. Works Out for Bulls
Jaime Jaquez Jr.

Could Get Traded
MIN

Marcus Johansson Returning to Europe
Thomas White

Likely to Miss Rest of Season With Shoulder Capsular Sprain
Mitchell Robinson

is Upgraded to Available for Game 2
Cole Caufield

Earns Lady Byng Trophy
Nick Suzuki

Lands Selke Trophy
Jose Altuve

Astros Reinstate Jose Altuve From the Injured List
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Reed Harris Hoping to Fill Void in Arizona State Receiving Room
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Nick Marsh Gearing Up for Breakout
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Drew Mestemaker Looking to Catapult Oklahoma State Offense in 2026
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Rocco Becht Brings Experience to New-Look Nittany Lions
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Can Trey White, Adam Trick Keep Texas Tech's Defensive Front Elite?
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Devon Dampier is Key to Success for Morgan Scalley in Year 1
Aaron Judge

Yankees Officially Place Aaron Judge on Injured List With Fractured Rib
Francisco Lindor

Expected to Return in "About a Couple Weeks"
Corey Seager

Rangers Activate Corey Seager From the Injured List
Gabriel Bonfim

Set For UFC Vegas 118 Main Event
Belal Muhammad

In Dire Need Of Win
Edmen Shahbazyan

An Underdog At UFC Vegas 118
Shayne Gostisbehere

Dishes Out Two Power-Play Assists in Comeback Win
Brendan Allen

Looks For His Third Win In A Row
Seth Jarvis

Ties Finals With Power-Play Goal
Mark Stone

Scores Sixth Playoff Goal in Overtime Defeat
Tom Nolan

Searches For His Fifth Consecutive Win
Mitch Marner

Records Two Assists in Game 2 Loss
Farés Ziam

Fares Ziam A Favorite At UFC Vegas 118
Brett Howden

Matches Franchise Record With Another Productive Outing
Brayden McNabb

Hospitalized After Taking Puck to Face
Aaron Judge

Diagnosed with Stress Fracture, Out 4-6 Weeks
Shohei Ohtani

has "Small" Blister, a "Non-Issue" for his Pitching Starts
Brent Rooker

Out on Thursday Due to Knee Soreness
Frederik Andersen

Hurricanes Retain Confidence in Frederik Andersen
Vincent Trocheck

Maple Leafs Interested in Vincent Trocheck
Dylan Larkin

Requests Trade From Red Wings
Corey Seager

Expected to Return This Weekend
Lucas Erceg

Royals to Mix and Match in Ninth With Lucas Erceg Struggling
Aaron Judge

to Undergo Additional Imaging
Ketel Marte

Out on Wednesday With Back, Hamstring Injuries
Corbin Burnes

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Rickie Fowler

Looks To Continue Resurgent Season At Memorial
CFB

Can Eric Singleton Jr. Fully Break Out at Third School?
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Katin Houser Steps into QB1 Role for Illinois
CFB

Savion Hiter an Immediate Impact Freshman for Michigan
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Isaiah Horton Set to Take Over KC Concepcion's Role
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UCLA Transfer Karson Gordon Signs with Austin Peay
CFB

Will Muschamp Bringing New Intensity to Texas Practices
Gary Woodland

Brings Boom-or-Bust Potential to Memorial
Jordan Spieth

Still Searching for a Breakthrough
Alex Smalley

Brings Elite Form to Memorial Tournament
Justin Rose

Looks to Recapture Memorial Tournament Success
Cameron Young

Looks to Get Back to His Contending Ways at Murifield Village
Chris Gotterup

Needs to Find Fairways at Muirfield Village
Si Woo Kim

Looks to Stay Hot at Memorial Tournament
Matt Fitzpatrick

Positioned for Success at Muirfield Village
Keegan Bradley

Looking for Another Strong Finish at Muirfield
Justin Thomas

is an Exciting Play This Week in Ohio
Scottie Scheffler

Looks to Win Memorial Tournament for Third Consecutive Year
Rory McIlroy

Looking for Better Performance at Muirfield Village
Drake Baldwin

Could Return During Braves Next Homestand
Garrett Crochet

Diagnosed With Low-Grade Lat Strain
Russell Henley

Coming to Ohio on the Heels of Latest Victory
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
Aaron Judge

Out on Tuesday With Rib/Shoulder Injury
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SEC Coach Calls Buster Faulkner a "Home-Run Hire"
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Auburn a Sleeper in the SEC Under Alex Golesh?
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Noah Fifita Primed for Strong 2026 Campaign
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Oregon Assistant Coach Charged with DUII, Reckless Driving
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Tight End Nick Pollack Commits to Clemson
Akshay Bhatia

Needs the Driver to be True in Ohio
Aaron Rai

Primed to take on the Memorial Tournament
J.J. Spaun

Rebounded at Charles Schwab Challenge
Xander Schauffele

One to Watch This Week in Ohio
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