TAP FOR 6 MONTHS OF PREMIUM FREE 💰
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

Break The Slate: NFL DFS DraftKings Lineup Picks - Week 16 (Main Slate)

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 16. His top daily fantasy football recommendations to target for DraftKings DFS contests.

Hi RotoBallers and thanks for joining me for Week 16! With three games on Saturday this week, we'll be dealing with an 11-game main slate. While Week 15 offered us tons of great DFS options - and some ridiculously-high DraftKings scores - the pickings are a bit slimmer this week. That said, we still have some intriguing matchups with players that are in great spots.

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are some great plays available, so read on to find out which players are the best for Week 16.

Good luck with your DraftKings DFS lineups, let's Break The Slate together!

Featured Promo: Looking for some more fantasy football action? Adopt a dynasty orphan team over at FFPC. Sign up today and get $25 off any FFPC league. Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 16 Picks

Lamar Jackson - BAL @ CLE ($8,000)

If the Ravens are playing on the main slate, then Lamar Jackson is in consideration for me. It sounds simple, but Jackson has been the "DFS MVP" of this season, showing an unbelievably-consistent combination of floor and ceiling from week to week. The Ravens QB is once again expensive, but there have been very few weeks this year when you would have been disappointed to roster him, as he's averaging almost 30 DK points per game this season. Jackson went over 1,100 rushing yards last week, surpassing Michael Vick for the all-time QB rushing record in a season. He should be able to pad that mark this week against a Browns Defense that has allowed opposing QBs to gain 300 yards on the ground this season and appears to be sleepwalking down the stretch.

Drew Brees - NO @ TEN ($5,900)

Drew Brees heads into Week 16 on a tear. The Saints veteran has posted DK scores of 31.3 and 43.1 over his last two games, and heads to Nashville to face a Titans Defense that is 25th in the NFL in yards allowed per pass. We prefer Brees at home, but we've also seen this Saints offense go on unbelievable high-scoring runs in the past, which makes me content to continue riding the wave in this spot. This matchup carries a projected O/U of 51 with a tight spread and is one of the best games to target on the main slate.

 

DraftKings DFS Running Backs - Week 16 Picks

Joe Mixon - CIN @ MIA ($6,600)

It took 10 weeks, but the Bengals appear to have finally realized what type of player they have in Joe Mixon. Mixon has logged a massive 130 carries since Week 10, which he's converted into 605 rushing yards and three TDs. He brings that hot hand into a beautiful matchup against a Dolphins Defense that has allowed the most rushing yards in the NFL to opposing RBs and is fresh off relinquishing yet another 100-yard game to Saquon Barkley last week. We're getting a quality player in a tremendous matchup at a reasonable price here and I consider Mixon to be one of the top overall plays on this slate.

Deandre Washington - OAK @ LAC ($4,000)

A great opportunity for salary savings here with Oakland's DeAndre Washington. Rookie Josh Jacobs tried to tough it out last week, but won't be active for this matchup against the Chargers, which will throw Washington back into the primary-back role that he served in Jacobs' absence in Week 14. Washington thrived in the role two weeks ago against Tennessee, logging 53 rushing yards and a TD, as well as 43 receiving yards on six catches. We can expect a similar workload for him against a Chargers Defense that's 22nd in the league in DK points allowed to opposing RBs, which makes him a tremendous value option at just $4k.

 

DraftKings DFS Wide Receivers - Week 16 Picks

Michael Thomas - NO @ TEN ($9,300)

No need to get cute here...if you can afford Michael Thomas, roster him. Maybe it sounds like an oversimplification, but like we touched on when discussing Lamar Jackson earlier, if you had rostered Thomas every week this season there would be very few weeks you'd walk away disappointed. The Saints wide receiver has been the most consistent pass catcher in the NFL this season. He leads the league in overall targets at 159 - reeling in an eye popping 133 catches- and is averaging a ridiculous 11.4 targets per game. This Titans secondary has been plagued with injuries and has no one that can challenge Thomas in this matchup, which provides a clear path to another huge outing for the Saints star.

Courtland Sutton - DET @ DEN ($6,200)

Courtland Sutton has ascended to the number-one receiver role for the Denver Broncos over the course of this season thanks to the combination of his explosive play and the departure of Emmanuel Sanders. Sutton has been targeted 107 times this year with a healthy aDOT of 12 yards. It's been a mixed bag for him since Drew Lock stepped into the QB role for the Broncos, as Sutton has snagged 13 of 22 targets for 187 yards and two TDs in Lock's three starts. He draws his best matchup of the "Lock Era" this week against a Lions Defense that has been routinely torched as of late. Detroit ranks 31st in the NFL in receiving yards allowed to opposing WRs and is fresh off a Week 15 game against the Bucs in which they allowed over 100 yards to not one, but TWO Tampa receivers. Sutton is a very explosive player in a prime spot against the Lions...the only concern is the erratic play of his QB.

Mike Williams - OAK @ LAC ($5,000)

I've been banging the Mike Williams drum for several weeks now and DraftKings just refuses to bump his price up enough to make me jump ship. Williams comes in at $5k this week, which is still a pittance to pay for a player with his type of significant downfield role. His aDOT of 18 yards leads the NFL among players with 50 or more targets and his 1,460 total air yards ranks ninth in the league. He gets a gasoline-to-fire matchup against an Oakland Raiders Defense that is allowing an NFL-worst 9.68 yards per target to opposing wide receivers. Williams has had some scary-low volume games this year, but his downfield role against this Raiders secondary makes him an awesome boom-or-bust tournament option this week.

 

DraftKings DFS Tight Ends - Week 16 Picks

Zach Ertz - DAL @ PHI ($6,400)

It's always nice to bargain shop, but one of the main reasons I'm willing to pay up in a DFS roster is "guaranteed" volume. Over Philly's last six games, Zach Ertz has target counts of: 10/13/6/14/11/11. This is the type of usage that I'll gladly spend up for. Dallas has a solid overall defense, but they also funnel targets to opposing tight ends. The Cowboys rank seventh in the league in DK points allowed to the WR position, but just 27th in DK points allowed to TEs. This is a must-win game for the Eagles and their receiving corps has been ridiculously depleted by injuries, which leads me to believe that Eagles QB Carson Wentz will rely on Ertz heavily in this spot.

Austin Hooper - JAX @ ATL ($4,400)

Austin Hooper was in the midst of a career year before being derailed by an injury in Week 10. He's been underwhelming since returning to the Falcons lineup two weeks ago, but this is a great buy-low spot on the talented TE that is priced at just $4.4k, his lowest tag since Week 4. Hooper has been targeted six times in each of his last two games and is set to take on a Jacksonville defense that has flopped in a huge way this year for a Jags organization that appears to be in turmoil. Jacksonville is tied for the fourth-most TDs relinquished to the TE position and most likely just wants this season to be over. He has been dormant recently, but Hooper possesses as much upside as any tight end on this slate.

 

DraftKings DFS Defenses - Week 16 Picks

Denver Broncos Defense - DET @ DEN ($3,500)

Vic Fangio's first year as head coach of the Broncos hasn't exactly been smooth sailing, but the defensive guru has kept Denver playing hard. Despite tons of injuries to this defensive unit, we know that the Broncos are always a capable unit at Mile High Stadium. That is especially true this week against a Lions team that has been spiraling down the drain since Matthew Stafford went down with an injury. The Broncos will get to square off against David Blough, who is 0-3 since taking over the Lions starting job. I look for Denver to force the inexperienced QB into some mistakes this week.

Washington Redskins Defense - NYG @ WAS ($2,800)

It doesn't really matter who ends up starting at QB for the Giants this week, I'll be comfortable saving salary with this Redskins unit in a home matchup. Washington has been competent on the defensive side of the ball...and that's truly all that's needed against this turnover-prone New York squad. The 'Skins have amassed 19 sacks over their last four games and should have no trouble adding to the tally against a Giants O-line that has struggled all season.

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Jose Altuve

to Mainly Play Second Base
Jusuf Nurkić

Jusuf Nurkic Cleared to Suit Up on Saturday Night
Nolan Traoré

Nolan Traore Ruled Out on Sunday
Nicolas Hague

Out Week-to-Week
Yu Darvish

Considering Retirement
Aaron Gordon

Ruled Out Against Memphis
Simon Edvinsson

Misses Second Straight Game
Alexandre Texier

Cleared for Original Six Matchup
Cam Thomas

Won't Play on Sunday Against the Clippers
Anze Kopitar

Still Out Saturday
Drew Doughty

Set to Rejoin Kings Lineup Saturday
Jalen Suggs

Available on Saturday Night
Matt Boldy

Expected to Return Saturday Night
Brad Marchand

Available Saturday
Pittsburgh Steelers

Steelers Finalizing Deal to Make Mike McCarthy Their Head Coach
Paul George

Set to Suit Up Against New York
Ja Morant

Facing Multi-Week Absence With Elbow Sprain
Joel Embiid

On Track to Play vs. Knicks
Daniel Gafford

Expected to Play Saturday vs. Lakers
Jalen Suggs

Expected Back Saturday vs. Cavaliers
Khris Middleton

to Miss Saturday's Game Against Hornets
Bilal Coulibaly

Ruled Out for Fifth Straight Game
José Ramírez

Jose Ramirez Signs Seven-Year Extension With Guardians
Franz Wagner

Misses Second Straight Game
Jonathan Kuminga

Will Not Play Saturday vs. Timberwolves
Jalen Green

Suffers Another Hamstring Setback
Nicolas Claxton

Scheduled for MRI on Injured Finger
Aaron Gordon

Dealing with Hamstring Issue Again
Giannis Antetokounmpo

Set for MRI After Calf Issue
Devin Booker

Injures Ankle on Friday, Requires Assistance Off the Court
RJ Barrett

Starting on Friday
Gunnar Henderson

is Fully Healthy Heading into Spring Training
Herbert Jones

is Returning on Friday
Bo Horvat

Rejoining Islanders Lineup Saturday
Dylan Holloway

Out Friday
Ross Colton

Won't Play Friday
Filip Chytil

Ready to End Three-Month Absence
Mason McTavish

Misses Second Straight Game Friday
Anthony Stolarz

Returns to Action Friday
Oliver Ekman-Larsson

Available Friday
Tyreek Hill

Dolphins Expected to Release Tyreek Hill
Paddy Pimblett

Set For Interim Lightweight Title Fight
Justin Gaethje

An Underdog At UFC 324
Song Yadong

Looks To Win Back-To-Back Fights
MMA

Sean O'Malley Looks To Get Back In The Win Column
Derrick Lewis

Returns At UFC 324
Waldo Cortes-Acosta

Looks For His Third Consecutive Win
Philip Rivers

Interviewing for Bills Head-Coaching Job
NFL

Fernando Mendoza Officially Declares for NFL Draft
CFB

Arch Manning Undergoes Foot Surgery
Dalton Kincaid

Played Through Torn PCL
CFB

College Football Playoff Expected to Remain a 12-Team Field in 2026
Quinn Hughes

Makes History With Three-Assist Effort
Anthony Mantha

Scores Twice Against Oilers
Jet Greaves

Keeps Stars Off Scoreboard With 28 Saves
David Pastrnak

Leads Bruins to Victory With Three-Point Effort
Jonathan Huberdeau

on Track to Return Friday
Darcy Kuemper

Cleared for the Weekend
Zach Benson

Hurt in Thursday's Win
Baltimore Ravens

Ravens Hire Jesse Minter as Their Head Coach
Indianapolis Colts

FBI Investigating the Death of Colts Owner Jim Irsay
MacKenzie Gore

Rangers Acquire MacKenzie Gore From the Nationals
Brandon Sproat

Dealt to Brewers in Four-Player Trade
Jett Williams

Brewers Acquire Jett Williams From Mets
Freddy Peralta

Mets Acquire Freddy Peralta From Brewers
Kyle Tucker

Expected to Bat Second or Third in Dodgers' Lineup
Brandon Aiyuk

has "Played his Last Snap as a Niner"
Cody Bellinger

Signs Five-Year, $162.5 Million Contract With Yankees
Adam Scott

Looks to Overcome Putting Woes at American Express
Billy Horschel

Looking to Rebound at The American Express
Josh Allen

Might Need Foot Surgery
Russell Henley

Looks to Build on Strong Start at The American Express
Jason Day

Looking to Start 2026 Strong at The American Express
Wyndham Clark

Looking to Regain Form at The American Express
Sam Burns

Looks to Continue Success at The American Express
Akshay Bhatia

Looking to Flip the Script at The American Express
Christiaan Bezuidenhout

Looking to Build on Strong Fall in Season Debut
Kurt Kitayama

Hopes To Continue Strong Start to 2026 Season at American Express
CFB

Princewill Umanmielen Expected to Sign with LSU
Scottie Scheffler

Returns To American Express After Missing Last Year's Edition
Robert MacIntyre

Keeps Momentum Rolling Heading Into American Express
Brian Harman

Can Challenge at American Express if His Putter Stays Hot
Ben Griffin

Outstanding Form Continues Heading Into American Express
Matt Fitzpatrick

Continues Playing Well Following Outstanding Finish to 2025 Season
Patrick Cantlay

Looks to Get a Jump Start on His 2026 Season
Blades Brown

Set to Make First PGA Tour Appearance of 2026
Kevin Roy

Has Some Confidence Heading to Southern California
Min Woo Lee

Poised to Make Bigger Impact in 2026
Max Homa

Needs a Better Start for 2026
Tony Finau

Trying to Reverse Disturbing Trend
Cam Davis

Aims for More Accuracy at American Express
Luisangel Acuña

Luisangel Acuna Sent to White Sox in Trade
Luis Robert Jr.

Mets Acquire Luis Robert Jr. from White Sox
Los Angeles Chargers

Mike McDaniel Expected to Become Chargers Offensive Coordinator
Carlos Beltran

Andruw Jones Elected to Baseball Hall of Fame
CFB

Alberto Mendoza Expected to Land at Georgia Tech
Malik Nabers

Giants Hope Malik Nabers Will be Back for Start of Training Camp
CFB

Duke Suing Quarterback Darian Mensah
Cam Skattebo

Should be Ready by OTAs
George Kittle

Expects to Return "Well Before November"
CFB

Alberto Mendoza Entering Transfer Portal
Mookie Betts

Plans to Retire at the End of his Current Contract
Tennessee Titans

Titans Set to Hire Robert Saleh as Next Head Coach
Miami Dolphins

Dolphins Expected to Hire Jeff Hafley as Next Head Coach
Zach Charbonnet

has Torn ACL
Zach Charbonnet

Needs Knee Surgery, Out for Rest of Playoffs
Tennessee Titans

Mike McCarthy a Finalist for Titans Head-Coaching Job?
Colston Loveland

Suffers Concussion in Divisional Round Loss
Kyren Williams

Scores Two Touchdowns in Divisional Round Win
Buffalo Bills

Bills Fire Head Coach Sean McDermott

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP