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FanDuel NFL DFS Lineup Picks (Week 16): Daily Fantasy Football Advice

Tom Vecchio highlights the top FanDuel NFL DFS lineup picks for Week 16, and a couple of sleepers to consider while building daily rosters.

RotoBallers, welcome to Week 16 of the daily fantasy football season. In this column, you will find my recommended FanDuel DFS Lineup Picks to target for Week 16 of the NFL season. You can also click here to find more DFS analysis articles and tools.

The goal is to identify players to start on FanDuel this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the FanDuel price.

Let's find some DFS lineup sleepers, and win on FanDuel. Good luck in Week 16! Find me @DFS_Tom if you have any questions.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

FanDuel Quarterbacks - Week 16 DFS Picks

Baker Mayfield - QB, CLE vs CIN (FD - $7,700)

Mayfield has posted multiple touchdowns in six of his last eight games, along with attempting 30 or more passes in five of those games, showing the ball is in his hands plenty each and every week. There is a bit of narrative street going on in this game, as he is up against his former coach Hue Jackson, who is now on the Bengals coaching staff. The last time he played the Bengals he posted four touchdowns, which shouldn't come as a surprise since they have the 26th DVOA versus the pass this season. He is cash game viable this week, as the Browns have an implied team total set at 26, which is seventh highest on the entire week.

Taylor Heinicke - QB, CAR vs ATL (FD - $6,000)

If no one else wants to say it this week, then I'll be willing to, Heinicke is in play for DFS against the Falcons. Yes, a backup quarterback with only four passing attempts this season is a viable option for a few reasons. Number one, he is the absolute minimum salary on FanDuel this week, which opens up a ton in terms of roster construction and jamming in the top running backs and wide receivers. Number two, he is up against the Falcons, who are giving up 21.2 fantasy points per game to quarterbacks this season, which is second worst in the league. Don't have heavy exposure to him, but he makes an interesting salary saver this week.

 

FanDuel Running Backs - Week 16 DFS Picks

Dalvin Cook - RB, MIN @ DET (FD - $7,100)

Cook is looking as healthy as ever and coming off a monster game where he posted 136 yards and two touchdowns. He is in a spot to continue that level of production since he is facing off against the Lions, who have the 17th DVOA versus the rush and are allowing 25.7 fantasy points per game to opposing running backs. The Vikings are in a spot where they need to be winning games to secure their playoff spot, so Cook should see plenty of touches against this soft Detroit defense.

Alvin Kamara - RB, NO vs PIT (FD - $8,100)

The Saints are finally back at home and on the main slate, so we are able to get exposure to their offense, who come in with an implied team total set at 29, which is highest on the entire week. It's been a few weeks since we've been able to roster some Saints' players, so let's get Kamara into our lineups. He hasn't posted a massive game in a few weeks, but the Saints are looking to lock up the number one seed in the NFC and have a solid chance to do so against a Steelers team who is primed for a letdown game and come in with the 21st DVOA versus the pass. Perfect spot to attack them is with Kamara through the passing game, a spot where he has excelled all season.

 

FanDuel Wide Receivers - Week 16 DFS Picks

DeAndre Hopkins - WR, HOU @ PHI (FD - $8,900)

Hopkins might be the best high-dollar player on the slate this week and you should be doing whatever you can to get him into as many lineups as possible. He will be facing off against the Eagles, who are giving up 42.3 fantasy points per game to wide receivers this season, which is second worst in the entire league. He comes in with double-digit targets in three straight games, two of those games over 90 yards, and three touchdowns in this span. The Texans are looking to lock up the number two seed in the AFC and this is a winnable game for them on the road in Philly.

Robby Anderson - WR, NYJ vs GB (FD - $5,900)

Anderson is on the cheaper side of things this week and should be viable in all formats considering some of his recent production and the favorable matchup he has in front of him. Anderson has seven or more targets in six of his last seven games and comes in with a two-game touchdown streak. He is facing off against the Packers who have the 24th DVOA versus the pass, which should play into his favor with his 15.62 aDOT this season, showing he is getting the ball downfield and always a threat for a big play.

 

FanDuel Tight End - Week 16 DFS Pick

Eric Ebron - TE, IND vs NYG (FD - $6,100)

Ebron has been a popular option over the past few weeks and while no one is truly happy about that, it makes sense with the volume he is seeing. Ebron comes in with seven or more targets in three of his last four games and holds a 17% market share of targets, which is second highest on the team, only behind T.Y. Hilton. Ebron has shown to be a favorite target for Luck, which should make him a popular stacking option this week against a bad Giants secondary.

 

FanDuel Defense - Week 16 DFS Pick

Dallas Cowboys Defense versus Tampa Bay Buccaneers (FD - $3,700)

The Cowboys are coming off a rough road loss to the Colts, but now back at home and should be able to put up a good showing this week. They are up against Jameis Winston and the Buccaneers, who has thrown 10 interceptions in his five road games this season. We could be in for much of the same this week, since the Cowboys are generating plenty of pressure on quarterbacks, with multiple sacks in six of their last seven games.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

NHL

Mitch Marner Delivers Two Assists in Comeback Victory
Mark Stone

Returns With Multi-Point Effort
Valeri Nichushkin

Exits Early Sunday
Nathan MacKinnon

Hurt in Game 3 Loss
Isaiah Hartenstein

Provides Steady Production in Defeat
Chet Holmgren

Has a Quiet Offensive Night on Sunday
Shai Gilgeous-Alexander

Held Under 20 Points in Game 4
Stephon Castle

Hands Out Six Assists in Game 4 Win
Devin Vassell

Tallies 13 Points in Game 4 Win
De'Aaron Fox

Records Double-Double as Spurs Even Series
Victor Wembanyama

Sets Tone Early as Spurs Force a Pivotal Game 5
Isaac Guerendo

Could be a Drop Candidate in Dynasty Leagues in 2026
Jayden Higgins

' Dynasty Arrow is Pointing Up With Clear Path to WR2 Role in Houston
Jakobi Meyers

a Sell-High Candidate in Dynasty Formats?
Drake Maye

to Make a Big Leap in 2026 in Second Season With Josh McDaniels?
Jamal Murray

Earns First Career All-NBA Selection
Kevin Durant

Becomes First Player to Make All-NBA Team With Five Franchises
Shai Gilgeous-Alexander

Victor Wembanyama Lead All-NBA First Team
Taylor Hall

Enjoying Life in Carolina
Mark Stone

Returns to Action Sunday
Cale Makar

Rejoins Avalanche Lineup Sunday
Cason Wallace

Joins Starting Unit Sunday
De'Aaron Fox

Doesn't "Feel Great" Entering Game 4
Jalen Williams

Won't Play Sunday
Christian Watson

Is Christian Watson on the Verge of a Legitimate Breakout?
Khalil Shakir

Dynasty Value in Decline
Travis Hunter

Still a Risky Buy, Even at his Sunken Dynasty Cost
Gunnar Helm

a Dynasty Sleeper with Room to Grow
Drake Maye

Is Drake Maye Becoming the Most Valuable Player in Superflex Dynasty Leagues?
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Pat Freiermuth

Steelers Restructure Pat Freiermuth's Contract
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
Jordan Mason

a Short-Term Dynasty Depth Piece
Dontayvion Wicks

Can Dontayvion Wicks Stand Out in Another Crowded Offense?
Chuba Hubbard

Dynasty Value Back on the Rise
Juwan Johnson

an Overlooked Buy Candidate for Contending Dynasty Managers
Kimani Vidal

Easily Acquirable as a High-Value Insurance Back
Evan Mobley

Tallies Series-High 24 Points on Saturday
Donovan Mitchell

Struggles at the Line Saturday
Karl-Anthony Towns

Continues Playmaking Surge on Saturday
OG Anunoby

Delivers Clean Shooting Line Saturday
Mikal Bridges

Fills Box Score in Game 3 Win
Jalen Brunson

Pushes Knicks Closer to NBA Finals
Orlando Magic

Magic Interview Jeff Van Gundy for Head-Coaching Position
Phillip Danault

Extends Point Streak to Three Games
Josh Anderson

Nets Two Goals in Painful Loss
Jalen Chatfield

Delivers Two Assists in Crucial Win
Mark Jankowski

Contributes Two Assists in Game 2 Victory
Eric Robinson

Scores in Second Consecutive Game
Nikolaj Ehlers

Tallies Two Goals as Hurricanes Bounce Back Saturday
Giannis Antetokounmpo

Magic Reportedly Have Giannis Antetokounmpo on Their Radar
Ja'Tavion Sanders

a Dynasty Dart Throw With Potential Untapped Upside
Geno Smith

a Low-Cost Dynasty Add Who Still Comes with Risk
C.J. Stroud

Still a Capable and Undervalued Dynasty QB2
Bhayshul Tuten

More Big Plays in 2026 Could Transform Bhayshul Tuten into a Dynasty Steal
Joe Mixon

Is Joe Mixon's NFL Career Over?
MLB

Orioles-Tigers Game Postponed on Saturday
RJ Harvey

to be Relegated to Third-Down Role After Rookie RB Addition?
MLB

Rays-Yankees Postponed on Saturday
Nazem Kadri

Contributes an Assist in Losing Effort
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Mickey Moniak

Heads to Injured List With Ankle Sprain
Frederik Andersen

Hurricanes Keep Faith in Frederik Andersen
Devon Levi

Attracting Interest From Senators
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
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