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DraftKings Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

Jason Bales' week 16 DraftKings lineup picks. Daily fantasy football sleepers, value picks and lineups advice for DraftKings DFS games and tournaments.

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 16 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 16. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on FantasyAces, make a $20 deposit, and enter any game will receive BOTH our full season NFL and NBA Premium Passes for free, a $119.99 value. Just email [email protected] with your new FantasyAces username - and boom, that's it! We will email you with your Premium Passes.

Be sure to check all of our fantasy football rankings for 2025:

 

DraftKings Quarterbacks - Week 16 DFS Picks

Andrew Luck (at OAK, $7,000)

The Oakland Raiders are far from great defensively, especially against opposing quarterbacks, which makes Andrew Luck one of the better plays of the week. Against the New York Jets, three games ago, the Indianapolis Colts star posted just under 30 fantasy points in only 28 pass attempts. He completed 22 of those 28 pass attempts for over 275 yards and four touchdowns. On top of Luck's impressive ability to find open wide receivers, he also has what it takes to make plays with his feet. His added rushing ability is something that a majority of NFL quarterbacks do not possess. His price tag is a little bit high, but Luck can be used in all leagues this week.

Tyrod Taylor (vs MIA, $5,400) 

This is a huge game for the Miami Dolphins, but unfortunately Ryan Tannehill will not be ready to return under the helm. That leaves Matt Moore, meaning that the Buffalo Bills should control the ball for a majority of this game. Tyrod Taylor is a high-upside quarterback option in tournaments this week. He has over 15 fantasy points in three of his last four games, and he posted over 25 fantasy points against the Seattle Seahawks a few weeks ago. His price tag is very reasonable, as well.

 

DraftKings Running Backs - Week 16 DFS Picks

Ezekiel Elliott (vs DET, $7,900) 

Ezekiel Elliott is one of the best running backs in the league, and he is still a rookie. Against the Tampa Bay Buccaneers last week, he posted over 30 fantasy points on 23 rush attempts. He rushed for over 150 yards and one touchdown. This week, the Dallas Cowboys will rely on him to beat the Detroit Lions. With a win this week, the Cowboys clinch the division and home field advantage in the playoffs. Against the Pittsburgh Steelers a few games back, Zeke posted over 4o fantasy points on 21 carries. His upside is limitless, and he can be used in both 50/50 contests and tournaments.

Mark Ingram (vs TB, $4,400)

Mark Ingram is a high-upside tournament option this week against the Tampa Bay Buccaneers. As previously mentioned, the Bucs allowed over 150 yards and a touchdown last week to Ezekiel Elliott. Mark Ingram is far from Zeke's talent level, but the Bucs rush defense is horrible, and Ingram could take advantage. Against the Los Angeles Rams, four games ago, he posted over 30 fantasy points on 14 carries. He is heavily involved in the New Orleans Saints pass attack, and that should help him hit value. Do not use him in cash games.

 

DraftKings Wide Receivers - Week 16 DFS Picks

Antonio Brown (vs BAL, $8,200)

Antonio Brown is the best wide receiver option on the board this week. He gets a solid matchup against the Baltimore Ravens, and his price tag is very low. There is a reason for that change in price - Brown has struggled over his last couple of games, failing to reach 100 receiving yards in five straight games now. Six games ago, he posted over 150 receiving yards and a touchdown on 18 targets against the Dallas Cowboys. His upside is tremendous, and the Steelers are going to start forcing him the ball. Brown is one of the most talented wide receivers in the league, and he should turn around his mini-slump this week.

DeAndre Hopkins (vs CIN, $5,200)

Speaking of highly-talented wide receivers that have been struggling of recent, DeAndre Hopkins is available this week. Against the Jacksonville Jaguars, he was targeted 17 times, catching eight passes for 87 yards. His horrible season is a product of Brock Osweiler's horrible performance under the helm. Osweiler has officially been benched. Tom Savage will start this week for the Houston Texans, and he is going to force the ball to his star wide receiver. Use Hopkins in both 50/50 contests and tournaments against the Cincinnati Bengals.

 

DraftKings Tight Ends - Week 16 DFS Picks

Delanie Walker (at JAX, $4,300) 

Delanie Walker is one of the more talented tight ends in the league, and he gets a great matchup this week against the Jacksonville Jaguars. He has seven targets in both of his last two games, but he only has nine catches total. With three touchdowns in his last six games, his upside should be obvious. Walker's price tag is very reasonable, and he can be rostered in all leagues.

DraftKings Defenses - Week 16 DFS Picks

San Diego Chargers Defense (at CLE, $3,400)

Defenses are very difficult to predict. That said, the San Diego Chargers are moderately priced and get a good matchup against the Cleveland Browns. The Browns are one of the worst teams in NFL history, so even the Chargers horrible defense should score. The Chargers have at least one interception in four straight games, and that is enough to warrant them consideration in all contests .




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REAL-TIME FANTASY NEWS

San Francisco Giants

Tony Vitello Named New Manager of the Giants
Anthony Edwards

Active Against Trail Blazers
Grayson Allen

Active for Suns’ Opening Night Game
Kevin Porter Jr.

Won't Return on Wednesday Evening
Anthony Edwards

a Game-Time Decision for Wednesday
Daniel Gafford

Ruled Out for Mavericks Season Opener
Alexander Romanov

Expected to Miss Two More Games
Pierre Engvall

Ruled Out for the Season
Luguentz Dort

Questionable for Thursday Versus Pacers
Adin Hill

Out Week-to-Week
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Sits Out Another Game Wednesday
Caris LeVert

Cleared for Wednesday's Game
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Available Wednesday Night
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Out on Wednesday
Ryan Kalkbrenner

Starting on Wednesday
Stefan Noesen

Makes Season Debut Wednesday
Jaylen Brown

Available Versus Philadelphia
OG Anunoby

Available to Play in Season Opener
Alex Caruso

Placed in Concussion Protocol Wednesday
Joel Embiid

on a Minutes Cap Versus Boston
Kel'el Ware

Available for Season Opener
De'Andre Hunter

Absent on Wednesday
Karl-Anthony Towns

to Play in Season Opener
Jaylen Waddle

Dolphins Don't Have Plans to Trade Jaylen Waddle
Francisco Lindor

has Elbow Surgery, Expected to be Ready for Spring Training
Mike Conley

Moves to Bench to Start Season
Aaron Jones Sr.

Considered Questionable to Play on Thursday
Donte DiVincenzo

Opening Season as a Starter
Giannis Antetokounmpo

Dowgraded to Probable on Wednesday
Karl-Anthony Towns

Upgraded to Questionable For Season Opener
PGA

Alex Noren is a Smash Play at Bank of Utah Championship
Jalen Suggs

Good to Go on Wednesday Night
Karl-Anthony Towns

Now Doubtful for the Opener
Mike Evans

Could be Back in Under Eight Weeks
Bucky Irving

Will Not Play in Week 8
Jayden Daniels

Will Not Play on Monday Night Against Chiefs
Darren Waller

Dolphins Place Darren Waller on Injured Reserve
Maverick McNealy

Look Out For Maverick McNealy This Week in Utah
Justin Lower

Unlikely to Flip The Script at Bank of Utah Championship
Stephan Jaeger

Looking for Repeat Performance in Utah
CFB

Behren Morton Will be Listed as Questionable on Wednesday
Max McGreevy

a Longer Shot to Contend in Utah
Jackson Suber

on the Bubble for the PGA in 2026
Greyson Sigg

Improving at the Right Time This Fall
Seamus Power

Hopes to Make More Birdies This Week
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May Struggle Once Again in Utah
Beau Hossler

Up and Down Heading to Bank of Utah Championship
Adam Hadwin

Looking to Find the Weekend in Utah
Christiaan Bezuidenhout

Enjoying the Fall Golf Season
Brad Marchand

Delivers Two Assists on Special Night
Adrian Kempe

Lifts Kings to Victory Tuesday
Justin Brazeau

Records Three Points Against Canucks
Jack Hughes

Pots Third Career Hat Trick
TOR

Chris Tanev Could Miss Time With Upper-Body Injury
Jack McBain

Evaluated for Upper-Body Injury
Tom Hoge

Sputtering into Bank of Utah Championship
Sahith Theegala

On the Upswing Heading into Utah
Andrew Putnam

Looks to Find Form in Utah
Matt McCarty

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Struggling to Find Form Ahead of Bank of Utah Championship
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Jonathan Marchessault

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Darcy Kuemper

Available Tuesday
Corey Perry

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Matt Duchene

Misses Tuesday's Action
Alexander Romanov

Unavailable Versus Sharks
Brock Boeser

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Jared McCann

Out on Tuesday
Jason Day

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Plans to be Ready for World Series
Tyrod Taylor

Aaron Glenn "Moving Toward" Naming Tyrod Taylor the Starting QB
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Finds the End Zone Twice on Monday Night
Jaxon Smith-Njigba

Continues Elite Production
Chris Godwin

Bucky Irving May Not Play This Week
Michael Penix Jr.

Expected to Be "Good to Go" for Sunday
Nick Foligno

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Nico Collins

Ruled Out Late on Monday Night With Concussion
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Suffers Head Injury on Monday Night
Jahmyr Gibbs

Blows Up For 218 Total Yards, Two Touchdowns in Win
Mike Evans

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Brandon Woodruff

Expects to Be Ready for Opening Day
Mike Evans

Ruled Out Monday With Concussion, Shoulder Injury
Mike Evans

Making his Return in Primetime Against Detroit
Emeka Egbuka

Officially Active on Monday Night
Michael Penix Jr.

Dealing With Bone Bruise in Foot, Considered Day-to-Day
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Avoids Long-Term Injury, Status Unknown for Week 8
Reinier de Ridder

Reinier De Ridder Suffers His First UFC Loss
Brendan Allen

Wins Back-To-Back Fights
Kevin Holland

Drops Decision
Mike Malott

Wins Third Fight In A Row
Marlon Vera

Loses Third Consecutive Fight
Aiemann Zahabi

Gets A Razor-Thin Split Decision Win
Jasmine Jasudavicius

Suffers First-Round TKO Loss
Manon Fiorot

Gets Back In The Win Column
Davey Grant

Suffers Submission Loss
Charles Jourdain

Gets First-Round Submission Win
Matt Frevola

Gets Dominated At UFC Vancouver
Matt Frevola

Kyle Nelson Dominates Matt Frevola
George Springer

Returns to Lineup for Game 6 of ALCS
CFB

Colorado State Fires Head Coach Jay Norvell After Four Seasons
CFB

Florida Fires Head Coach Billy Napier After Four Years
Chase Elliott

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William Byron

Seeks First Win at Talladega to Overcome Las Vegas Crash
Chase Briscoe

Likely to Finish Worse Than he Starts
Kyle Larson

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Tyler Reddick

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Ross Chastain

Poor Qualifying Makes him a Strong DFS Option at Talladega
Chris Buescher

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Ty Gibbs

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Daniel Suarez

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Josh Berry

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Austin Dillon

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Undergoes Sports Hernia Surgery
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Jackson Chourio

Back in Game 4 Lineup Against Dodgers
Iván Herrera

Ivan Herrera Has Bone Spurs Removed From his Elbow
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Reinier de Ridder

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Looks For His Third Consecutive Win
Kevin Holland

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Aiemann Zahabi

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Jasmine Jasudavicius

Looks To Extend Her Win Streak
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Aoriqileng

Aori Aoriqileng Looks To Rebound

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