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Kansas City Chiefs running back Isiah Pacheco (knee) has officially been ruled out of Sunday's marquee matchup with the Bills. The team described Pacheco as week-to-week after an MCL sprain knocked him out of Monday night's win over the Commanders, so the designation comes as no surprise. Kansas City is on a Week 10 bye, so there is a hope that Pacheco could miss only one game, but for as long as he's out, veteran Kareem Hunt is expected to handle the bulk of the team's carries, especially near the goal line. Rookie Brashard Smith is also likely to see an uptick in usage, primarily in third-down and two-minute situations, making him a viable flex option in deeper leagues and PPR formats.--Patrick McGrath
Source: Sam McDowell
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