Isaac Guerendo - 2025 Fantasy Football Sleepers and Undervalued Draft Picks

Isaac Guerendo is a fantasy football sleeper undervalued draft pick for 2025. Read the fantasy football outlook and draft advice for the San Francisco 49ers running back.

RotoBaller Ranking (half-PPR): RB53

Fantasy Draft Analysis: Isaac Guerendo saw time as the 49ers' RB1 while filling in for Christian McCaffrey and Jordan Mason last year. The sophomore rusher is a speedy back who played well in limited action. He averaged 5.0 yards per carry, ran for 420 yards, and scored four rushing touchdowns as a rookie.

Among 70 backs with 50+ carries, Guerendo also finished seventh in Fantasy Points Data Suite's missed tackles forced per attempt (MTF/ATT). This stat essentially measures a running back's ability to create yards for himself, regardless of poor offensive line play or other factors.

Calling Guerendo a league-winner may seem like a stretch, but there is a path toward RB1 value. Guerendo now enters 2025 as the RB2 behind McCaffrey. Given the latter's injury history, Guerendo may see an extended run as a starter in 2025. If he does, he’ll be a hot ticket item on waivers.

Isaac Guerendo is doing his offseason training with Frank Gore and Jonathan Taylor🔥 pic.twitter.com/Q4GbrEg7eu

— Coach Yac 🗣 (@Coach_Yac) April 10, 2025

While Guerendo will not supplant McCaffrey anytime soon, he is talented enough to return RB1 production if McCaffrey goes down. Fantasy gamers should consider Guerendo a priority target in the closing rounds of all drafts as he carries potential league-winning upside.

Stashing the 49ers' backup running back has been fruitful in the past, so run it back in 2025.

- Dave Ventresca

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